Arthropodicidal oxadiazinyl, thiadiazinyl and triazinyl carboxanilides

ABSTRACT

Arthropodicidal carboxanilides of Formula I and II ##STR1## wherein Q is selected from the group ##STR2## A, E, G, X, X 1 , Y, Z, Z 1 , R 2 , R 3 , R 4 , R 5 , R 6  and n are as defined in the text, arthropodicidal compositions containing said compounds and a method for using the compounds to control arthropods.

This is the national stage of PCT/U.S. Ser. No. 91/09164, filed Dec. 17,1991 which is a continuation of Ser. No. 07/714,401, filed Jun. 11,1991, now abandoned, which is a continuation of Ser. No. 07/632,438,filed Dec. 21, 1990, now abandoned.

BACKGROUND OF THE INVENTION

Arthropodicidal carboxanilides, compositions containing them, and use ofthe carboxanilides to control arthropods. Relevant to this invention areWO 88/07,994 and EPA 330,678 which disclose insecticidal pyrazolines andWO 90/07495 which discloses insecticidal semicarbazone arthropodicides.

SUMMARY OF THE INVENTION

The invention pertains to compounds of Formula I and II, including allgeometric and stereoisomers, agriculturally suitable salts thereof,agricultural compositions containing them and their use for the controlof arthropods in both agronomic and non-agronomic uses. The term"compounds" will be understood to include all such isomers and saltsthereof. The compounds are: ##STR3## wherein: Q is selected from thegroup ##STR4## A is H; E is selected from the group H and C₁ -C₃ alkyl;or

A and E can be taken together to form --CH₂ --, --CH₂ CH₂ --, --O--,--S--, --S(O)--, --S(O)₂ --, --NR⁷ --, --OCH₂ --, --SCH₂ --, --N(R⁷)CH₂--, substituted --CH₂ --, and substituted --CH₂ CH₂ -- the substituentsindependently selected from 1-2 halogen and 1-2 methyl;

G is selected from the group ##STR5## X is selected from the group O, Sand N--X² ; X¹ is selected from the group Cl, Br, OR⁸, SR⁸ and NR⁸ R⁹ ;

X² is selected from the group R⁸, OH, OR⁸, CN, SO₂ R⁸, SO₂ Ph, OC(O)NR⁹R¹⁰, OC(O)OR⁸, NR⁹ R¹⁰ and phenyl optionally substituted with R¹¹ ;

Y is selected from the group H; C₁ -C₆ alkyl, benzyl; C₂ -C₆alkoxyalkyl; C₂ -C₆ alkenyl; C₂ -C₆ alkynyl; C₁ -C₆ alkyl optionallysubstituted by halogen, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, CN, NO₂,S(O)_(r) R³², COR³², CO₂ R³², phenyl optionally substituted by halogen,CN, C₁ -C₂ haloalkyl and C₁ -C₂ haloalkoxy; C₃ -C₆ cycloalkyl; C₃ -C₆cyclohaloalkyl; C₃ -C₆ cycloalkylalkyl; CHO; C₂ -C₆ alkylcarbonyl; C₂-C₆ alkoxycarbonyl; C₂ -C₆ haloalkylcarbonyl; COR³⁶ ; CO₂ R³⁶ ; C₁ -C₆alkylthio; C₁ -C₆ haloalkylthio; phenylthio; R¹² OC(O)N(R¹³)S-- and R¹⁴(R¹⁵) NS--;

A¹ is H;

A¹ and Y can be taken together to form --(CH₂)_(t) --;

Z is C or N:

Z¹ is O, S or NR³¹ ;

R¹ and R² are independently selected from the group H, C₁ -C₆ alkyl, C₁-C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃-C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, N₃, SCN, NO₂, OR¹⁷,SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷,C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, NR¹⁸ C(O)R¹⁷, OC(O)NHR¹⁷, NR¹⁸C(O)NHR¹⁷, NR¹⁸ SO₂ R¹⁷, phenyl optionally substituted with 1 to 3substituents independently selected from W, and benzyl optionallysubstituted with 1 to 3 substituents independently selected from W; orwhen m or n is 2, (R¹)₂ can be taken together, or (R²)₂ can be takentogether as --OCH₂ O--, --OCF₂ O--, --OCH₂ CH₂ O--, --CH₂ C(CH₃)₂ O--,--CF₂ CF₂ O or --OCF₂ CF₂ O-- to form a cyclic bridge; provided thatwhen R¹ or R² is S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷ or OS(O)₂ R¹⁷ then R¹⁷ isother than H;

R³ is selected from the group H, J, N₃, NO₂, halogen, N(R²²)R²³,C(R³⁴)═N--O--R³⁵, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆haloalkenyl, C₂ -C₆ alkynyl, C₂ -C₆ alkoxylalkyl, C₃ -C₈alkoxycarbonylalkyl, CO₂ R¹⁷, OR¹⁹, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, C(S)NR¹⁷ R¹⁸,C(S)R¹⁷, C(S)SR¹⁷, CN, Si(R²⁸) (R²⁹) R²⁷, SR²⁷, S(O)R²⁷, SO₂ R²⁷, --P(O)(OR²⁷)₂, phenyl, phenyl substituted with (R¹⁶)_(p), benzyl and benzylsubstituted with 1 to 3 substituents independently selected from W; orR³ is C₂ -C₆ epoxyalkyl optionally substituted with a group selectedfrom C₁ -C₃ alkyl, CN, C(O)R²⁴, CO₂ R²⁴ and phenyl optionallysubstituted with W; or R³ is C₁ -C₆ alkyl substituted with a groupselected from C(O)N(R²⁵) R²⁶, C(O)R²⁵, SR²⁷, S(O)R²⁷, SO₂ R²⁷, SCN, CN,C₁ -C₂ haloalkoxy, Si(R²⁸) (R²⁹)R³⁰, N(R²²)R²³, NO₂, OC(O)R²⁵, --P(O)(OR²⁷)₂ and J;

J is selected from the group saturated, partially unsaturated oraromatic 5- or 6-membered heterocyclic ring, bonded through carbon ornitrogen, containing 1-4 heteroatoms independently selected from thegroup consisting of 0-2 oxygen, 0-2 sulfur and 0-4 nitrogen, thissubstituent optionally containing one carbonyl and optionallysubstituted with one or more members selected from W;

R⁴ and R⁵ are independently selected from the group H, C₁ -C₄ alkyl,COR²⁰ and C₂ -C₄ alkoxycarbonyl; or

R⁴ and R⁵ can be taken together to form ═O or ═S;

R⁶ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄alkylcarbonyl, C₂ -C₄ haloalkoxycarbonyl, C₂ -C₄ alkoxycarbonyl C₂ -C₄haloalkoxycarbonyl, COR³⁶, CO₂ R³⁶, C₂ -C₅ alkylaminocarbonyl, C₃ -C₆cycloalkyl, C₃ -C₆ halocycloalkyl, C₄ -C₇ alkylcycloalkyl, C₄ -C₇haloalkylcycloalkyl, C₁ -C₄ alkylsulfonyl, C₁ -C₄ haloalkylsulfonyl andSO₂ Ph optionally substituted with Cl, Br or CH₃ ;

R⁷ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄alkenyl, C₂ -C₄ haloalkenyl, SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, C(O)R¹⁷, CO₂ R¹⁷,C(O)NR¹⁷ R²¹, C(S)NR¹⁷ R²¹, C(S)R¹⁷, C(S)OR¹⁷, --P(O) (OR¹⁷)₂, --P(S)(OR¹⁷)₂, P(O) (R¹⁷)OR¹⁷, P(O) (R¹⁷)SR²¹, and optionally substitutedphenyl and benzyl wherein the substituent(s) are selected from F, Cl,Br, CH₃, CF₃ or OCF₃ ; provided that when R⁷ is other than C(O)R¹⁷,C(O)NR¹⁷ R²¹ or C(S)NR¹⁷ R²¹ then R¹⁷ is other than H;

R⁸ is selected from the group C₁ -C₃ alkyl, C₂ -C₄ alkenyl, C₂ -C₄alkynyl, C₁ -C₃ haloalkyl, C₂ -C₄ haloalkenyl, C₃ -C₆ cycloalkyl; C₁ -C₃alkyl substituted with OCH₃, OCH₂ CH₃, NO₂, CN, CO₂ CH₃, CO₂ CH₂ CH₃,SCH₃ or SCH₂ CH₃ and benzyl optionally substituted with R¹¹ ;

R⁹ is selected from the group H, C₁ -C₄ alkyl C₁ -C₄ haloalkyl, C₂ -C₄alkoxycarbonyl, and optionally substituted phenyl and pyridine whereinthe substituent(s) are selected from R¹⁵ ; or

R⁸ and R⁹ can be taken together to form --(CH₂)₄ --, --(CH₂)₅ -- or--CH₂ CH₂ OCH₂ CH₂ -- each of which is optionally and independentlysubstituted with 1 or 2 CH₃ groups;

R¹⁰ is selected from the group H and C₁ -C₄ alkyl; or

R⁹ and R¹⁰ can be taken together to form --(CH₂)₄ --, --(CH₂)₅ -- or--CH₂ CH₂ OCH₂ CH₂ -- each of which is optionally and independentlysubstituted with 1 or 2 CH₃ groups;

R¹¹ is selected from halogen, CN, C₁ -C₃ haloalkyl and C₁ -C₃haloalkoxy;

R¹² is C₁ -C₆ alkyl;

R¹³ is C₁ -C₄ alkyl;

R¹⁴ and R¹⁵ are independently C₁ -C₄ alkyl; or R¹⁴ and R¹⁵ can be takentogether as --CH₂ CH₂ CH₂ CH₂ CH₂ -- or --CH₂ CH₂ OCH₂ CH₂ --;

R¹⁶ is selected from the group C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, halogen, CN, N₃, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)R¹⁷, S(O)₂R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸,NR¹⁷ R¹⁸, NR¹⁸ C(O)R¹⁷, OC(O)NHR¹⁷, NR¹⁸ C(O)NHR¹⁷, NR¹⁸ SO₂ R¹⁷, phenyloptionally substituted with 1 to 3 substituents independently selectedfrom W, and benzyl optionally substituted with 1 to 3 substituentsindependently selected from W; or when p is 2, (R¹⁶)₂ can be takentogether as --OCH₂ O--, --OCF₂ O--, --OCH₂ CH₂ O--, --CH₂ C(CH₃)₂ O--,--CF₂ CF₂ O or --OCF₂ CF₂ O-- to form a cyclic bridge; provided thatwhen R¹⁶ is S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷ or OS(O)₂ R¹⁷ then R¹⁷ is otherthan H;

R¹⁷ is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, and optionally substituted phenyl and benzyl wherein thesubstituents are 1 to 3 substituents independently selected from W;

R¹⁸ is selected from the group H and C₁ -C₄ alkyl; or R¹⁷ and R¹⁸ whenattached to the same atom, can be taken together as --(CH₂)₄ --,--(CH₂)₅ --, or --CH₂ CH₂ OCH₂ CH₂ --;

R¹⁹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl, C₂ -C₄alkynyl, C₂ -C₄ alkylcarbonyl, C₂ -C₄ alkoxycarbonyl and C₁ -C₄alkylsulfonyl;

R²⁰ is C₁ -C₃ alkyl;

R²¹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl and C₂-C₄ alkynyl;

R²² is selected from the group H, C₂ -C₇ alkylcarbonyl, C₂ -C₇alkoxycarbonyl, optionally substituted C₁ -C₄ alkyl, optionallysubstituted C₂ -C₄ alkenyl, and optionally substituted C₂ -C₄ alkynyl,the substituents selected from C₁ -C₂ alkoxy, CN, C(O)R³⁰ and C(O)₂ R²⁷;

R²³ is selected from the group H, C₁ -C₃ alkyl, phenyl, phenylsubstituted with W, benzyl and benzyl substituted with W;

R²⁴ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl and C₂-C₄ alkynyl;

R²⁵ and R²⁶ are independently selected from the group H and C₁ -C₂alkyl;

R²⁷ is selected from the group C₁ -C₃ alkyl, phenyl and phenylsubstituted with W;

R²⁸ is C₁ -C₃ alkyl;

R²⁹ is C₁ -C₃ alkyl;

R³⁰ is selected from the group H, C₁ -C₃ alkyl, phenyl and phenylsubstituted by W;

R³¹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkylcarbonyl orC₂ -C₄ alkoxycarbonyl;

R³² is selected from the group C₁ -C₃ alkyl;

R³⁴ is selected from the group H, Cl, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁-C₂ thioalkyl and CN;

R³⁵ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₃ alkylcarbonyl andC₂ -C₃ alkoxycarbonyl;

R³⁶ is selected from the group phenyl and phenyl substituted with W;

W is selected from the group halogen, CN, NO₂, C₁ -C₂ alkyl, C₁ -C₂haloalkyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy, C₁ -C₂ alkylthio, C₁ -C₂haloalkylthio, C₁ -C₂ alkylsulfonyl and C₁ -C₂ haloalkylsulfonyl;

m is 1 to 3;

n is 1 to 3;

p is 1 to 3;

r is 0, 1 or 2;

t is 2 or 3; and

u is 1 or 2.

Exemplary values of J include: ##STR6##

Preferred Compounds A are those of Formulae I and II wherein:

R¹ is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, SO₂ R¹⁷, CO₂ R¹⁷,C(O)R¹⁷, phenyl optionally substituted with 1 to 3 substituentsindependently selected from W, and benzyl optionally substituted with 1to 3 substituents independently selected from W; with one R¹ substituentin the 4-position, or when m is 2 then (R¹)₂ can be taken together as--CH₂ C(CH₃)₂ O--, --OCH₂ CH₂ O--, --OCF₂ CF₂ O--, or --CF₂ CF₂ O-- toform a 5- or 6-membered fused ring;

R² is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷,OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸,phenyl optionally substituted with 1 to 3 substituents independentlyselected from W, and benzyl optionally substituted with 1 to 3substituents independently selected from W;

R³ is selected from the group H, C₁ -C₄ alkyl, C₃ -C₄alkoxycarbonylalkyl CO₂ R¹⁷, C(O)R¹⁷, phenyl and phenyl substituted by(R¹⁶)_(p) ;

R¹⁶ is selected from the group C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷,OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸,phenyl optionally substituted with 1 to 3 substituents independentlyselected from W, and benzyl optionally substituted with 1 to 3substituents independently selected from W;

R¹⁷ is selected from the group C₁ -C₄ alkyl, C₁ -C₂ haloalkyl, C₃ -C₄alkenyl and propargyl;

R¹⁸ is selected from the group H and CH₃ ;

X¹ is selected from the group C₁, OR⁸, SR⁸ and N(CH₃)₂ ;

X² is selected from the group R⁸, OR⁸ and N(CH₃)₂ ;

m is 1 or 2;

n is 1 or 2; and

p is 1 or 2.

Preferred Compounds B are those of Preferred A wherein G is selectedfrom the group G-2, G-3, G-7 and G-9. Preferred Compounds C are those ofPreferred B wherein J is selected from the group J-1, J-2, J-8, J-9 andJ-16. Preferred Compounds D are those of Preferred C wherein A and E aretaken together to form --O--, --CH₂ --, --CH₂ CH₂ --, --OCH₂ --, --S--,--SCH₂ -- or NR⁷ ; R⁷ is selected from the group H, Me, SO₂ R¹⁷, CO₂ R¹⁷and CON(R¹⁷)R²¹. Preferred Compounds E are Compounds D of Formula Iwherein Z¹ is O. Preferred Compounds F are Compounds D of Formula Iwherein Z¹ is S. Preferred Compounds G are Compounds D of Formula Iwherein Z¹ is NR³¹. Preferred Compounds H are those of Preferred Ewherein Q is Q-1. Preferred Compounds I are those of Preferred E whereinQ is Q-2. Preferred Compounds J are those of Preferred E wherein Y is C₁-C₆ alkyl. Preferred Compounds K are those of Preferred J wherein Y isCH₃.

Specifically preferred are compounds:

(L) methyl7-chloro-2,3-dihydro-2-[[4-trifluoromethoxy)phenylamino]carbonyl]indeno[1,2-e]-[1,3,4]oxadiazine-4a(5H)-carboxylate;

(M) methyl7-chloro-2,5-dihydro-2-[N-methyl-N-[4-(trifluoromethoxy)phenyl]aminocarbonyl]indeno-[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate;

(N) methyl7-chloro-2,5-dihydro-2-[[N-methyl-N-[4-trifluoromethyl)phenyl]amino]carbonyl]indeno-[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate;

(O)7-fluoro-4a-(4-fluorophenyl)-4a,5-dihydro-N-[4-(trifluoromethoxy)phenyl]indeno[1,2-e][1,3,4]-oxadiazine-2(3H)-carboxamide;and

(P)7-chloro-4a,5-dihydro-4a-methyl-N-[4-(trifluoromethoxy)phenyl]indeno[1,2-e][1,3,4]oxadiazine-2(3H)-carboxamide.

In the above definitions, the term "alkyl", used either alone or incompounds words such as "alkylthio" or "haloalkyl", denotes straightchain or branched alkyl, such as methyl, ethyl, n-propyl, isopropyl orthe different butyl, pentyl, hexyl isomers. Alkoxy denotes methoxy,ethoxy, n-propyloxy, isopropyloxy and the different butoxy or pentoxyisomers. Alkenyl denotes straight chain or branched alkenes, such asvinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl,pentenyl and hexenyl isomers. Alkynyl denotes straight chain or branchedalkynes, such as ethynyl, 1-propynyl, 3-propynyl and the differentbutynyl, pentynyl and hexynyl isomers. Alkylthio denotes methylthio,ethylthio and the different propylthio, butylthio, pentylthio andhexylthio isomers. Alkylsulfinyl, alkylsulfonyl, alkylamino, and thelike are defined analogously to the above examples. Cycloalkyl denotescyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen", either alone or in compound words such as"haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further,when used in compound words such as "haloalkyl" said alkyl may bepartially or fully substituted with halogen atoms, which may be the sameor different. Examples of haloalkyl include CH₂ CH₂ F, CF₂ CF₂ and CH₂CHFCl. The terms "halocycloalkyl", "haloalkenyl" and "haloalkynyl" aredefined analogously to the term "haloalkyl".

The total number of carbon atoms in a substituent group is indicated bythe "C_(i) -C_(j) " prefix where i and j are numbers from 1 to 8. Forexample, C₁ -C₃ alkylsulfonyl designates methylsulfonyl throughpropylsulfonyl; C₂ alkoxyalkoxy designates OCH₂ OCH₃ ; C₄ alkoxyalkoxydesignates the various isomers of an alkoxy group substituted with asecond alkoxy group containing a total of 4 carbon atoms, examplesincluding OCH₂ OCH₂ CH₂ CH₃ and OCH₂ CH₂ OCH₂ CH₃ ; C₂ cyanoalkyldesignates CH₂ CN and C₃ cyanoalkyl designates CH₂ CH₂ CN and CH(CN)CH₃; C₂ alkylcarbonyl designates C(O)CH₃ and C₄ alkylcarbonyl includesC(O)CH₂ CH₂ CH₃ and C(O)CH(CH₃)₂ ; C₂ alkoxycarbonyl designates C(O)OCH₃and C₄ alkoxycarbonyl designates C(O)OCH₂ CH₂ CH₃ and C(O)OCH(CH₃)₂ ;and as a final example, C₃ alkoxycarbonylalkyl designates CH₂ CO₂CH.sub. 3 and C₄ alkoxycarbonylalkyl includes CH₂ CH₂ CO₂ CH₃, CH₂ CO₂CH₂ CH₃ and CH(CH₃)CO₂ CH₃.

DETAILS OF THE INVENTION

Compounds of Formulae I and II are prepared as described in Schemes 1through 30 with substituents as previously defined, unless otherwisenoted. The substituents R⁴ and R⁵ have been depicted as hydrogen for thepurposes of clarity but also included are the values of thesesubstituents as previously defined.

Compounds of Formula II (Q-1) can be prepared by the reaction ofimidoylhalides of Formula II (Q-1) with sulfur, oxygen and nitrogennucleophiles of Formula III as illustrated in Scheme 1. Typicalreactions involve the combination of equimolar amounts of II (Q-1) andIII in the presence of a base such as an alkali metal, tertiary amine,metal hydride and the like in conventional organic solvents, includingether, tetrahydrofuran, 1,2-dimethoxyethane, methylene chloride,chloroform, N,N-dimethylformamide and dimethylsulfoxide. The reactioncan be conducted at temperatures ranging from -20° C. to 100° C. withtemperatures in the range of -10° C. to 30° C. generally beingpreferred. One skilled in the art will recognize that reactions of thisgeneral type can be extended to other nucleophilic reagents. ##STR7##

The imidoylhalides of Formula II (Q-1) can be prepared by the reactionof Formula I (Q-1) compounds with an appropriate halogenating agent suchas phosphorous trichloride, phosphorous pentachloride, phosphoroustribromide, phosphorous pentabromide, thionyl chloride, sulfurylchloride, triphenyl phosphine and carbon tetrachloride (Wolkoff, Can. J.Chem., 1975, 53, 1333) and the like (see Fieser and Fieser, Reagents forOrganic Synthesis, Vol. I, 1967) as illustrated in Scheme 2. Typicalreactions involve the combination of Formula I (Q-1) compounds with anexcess of the halogenating agent ranging from 1.1 to 10 equivalents,with 2 to 4 equivalents being preferred. The reaction can be conductedin the absence of a solvent or in the presence of a conventional organicsolvent such as benzene, toluene, xylene, chloroform, methylenechloride, hexane and the like. The reaction temperature can range from-10° C. to 200° C. with 35° C. to 100° C. being preferred. The reactionis generally complete after 24 hours. ##STR8##

Alternatively, compounds of Formula II (Q-1), when X¹ is equal to R⁸ -Scan be prepared by the reaction of compounds of the Formula I (Q-1)where X is equal to S with an electrophile of the Formula IV in thepresence of a suitable base, as illustrated in Scheme 3. Typicalreactions involve the combination of equimolar amounts of Formula I(Q-1) compounds and the appropriate electrophile of Formula IV. A basesuch as an alkali metal, tertiary amine or metal hydride can be used.##STR9##

Compounds of Formula I (Q-1) where X is S or O can be prepared by thereaction of Formula V compounds with isocyanates of Formula VI. Typicalreactions involve the combination of equimolar amounts of V and VI in aconventional organic solvent such as but not limited to ethyl acetate,methylene chloride, chloroform, benzene or toluene. A base such as analkali metal, tertiary amine, alkali metal alkoxide or metal hydride canbe used. Scheme 4 illustrates this transformation. ##STR10##

Alternatively, compounds of Formula I (Q-1), where A and E are takentogether to form a 1- or 2-atom bridge, as previously described, can beprepared by the reaction of semicarbazones of Formula VII with compoundsof Formula VIII. Typical reactions involve the combination of an excessin molar amounts of a Formula VIII compound (1.1 equivalents to 40equivalents) with 1 equivalent of a Formula VII compound in the presenceof less than one molar equivalent of an acid catalyst (0 equivalents to0.9 equivalents). Typical acid catalysts include alkyl or aryl sulfonicacids (such as methyl, camphor or p-toluene sulfonic) and mineral acids(such as hydrochloric or sulfuric). Conventional, polar organic solventssuch as acetonitrile, dimethylformamide, tetrahydrofuran, methanol orethanol can be used. The reaction temperature can vary from 0° C. to thereflux temperature of the particular solvent being used and the reactionis usually complete in less than 24 hours. Scheme 5 illustrates thistransformation. ##STR11## wherein: R⁴ and R⁵ are not taken together toform ═O or ═S.

Alternatively, compounds of Formula I (Q-1), where A and E are takentogether to form a 1- or 2-atom bridge, as previously described, can beprepared by the reaction of compounds of Formula VII with compounds ofFormula IX (see Scheme 6). Typical reactions involve combination of anexcess in molar amounts of a Formula IX compound (1.1 equivalents to 5.0equivalents) with one equivalent of a Formula VII compound in thepresence of a base such as a tertiary amine (such as triethylamine,pyridine or DBU), an alkali metal, an alkali metal hydride or an alkalimetal alkoxide or hydroxide (such as sodium methoxide,potassium-t-butoxide, sodium hydroxide or potassium hydroxide).Conventional, polar organic solvents such as methanol, ethanol,propanol, dimethylformamide, THF, dichloromethane or acetonitrile can beused. The reaction temperatures can vary from 0° C. to the refluxtemperature of the particular solvent being used and the reaction isusually complete in less than 24 hours.

Alternatively, when Z¹ =NR³¹, R⁴ and R⁵ =H and L¹ and L² are takentogether as ═NMe₂.sup.⊕ I.sup.⊖ the reaction can be performed in theabsence of base in aprotic solvents such as THF, dioxane and the like.Equimolar amounts of VII and IX are used and the reaction is usuallycomplete in 72 hours. ##STR12## wherein: L¹, L² are Cl, Br, I,imidazole, or L¹ and L² may be taken together to equal ═O, ═S or═N(CH₃)₂.sup.⊕ I.sup.⊖ (where Z¹ is NR³¹) provided that R⁴ and R⁵ arenot taken together to form ═O.

Compounds of Formula V, where A and E are taken together to form a 1- or2-atom bridge, as previously described, can be prepared by the reactionof Formula X compounds with either compounds of Formula VIII orcompounds of Formula IX using methods analogous to those shown for thepreparation of Formula I (Q-1) compounds in Schemes 5 and 6. Thepreparation of Formula V compounds is shown in Scheme 7. ##STR13##

Compounds of Formula VII where X is O or S can be prepared by thereaction of Formula X compounds with isocyanates of Formula VI as shownin Scheme 8. Typical reactions involve the combination of equimolaramounts of X and VI in the presence of 1 molar equivalent of water in apolar organic solvent such as tetrahydrofuran or dimethylformamide. Thereaction is usually complete in less than 24 hours.

SCHEME 8

    X+VI→VII X═O, S

Alternatively, Formula VII compounds where X is O or S can be preparedby the reaction of compounds of Formula XI with semicarbazides ofFormula XII. Conditions for this reaction optionally include an acidcatalyst such as hydrochloric, sulfuric or p-toluene sulfonic acid.Reaction temperatures can range from 0° to 150° C. with the refluxtemperature of the solvent used generally preferred. Suitable solventsinclude, but are not limited to, methanol, ethanol, isopropanol,tetrahydrofuran and dioxane. Scheme 9 illustrates this transformation.##STR14##

The preparation of Formula X compounds can be accomplished by thereaction of Formula XI compounds with an excess of equivalents (1.1 to10.0 equivalents) of hydrazine, hydrazine monohydrate, hydrazineacetate, hydrazine hydrochloride and the like. The reaction is conductedin an alcohol solvent such as methanol, ethanol, n-propanol,isopropanol, n-butanol and the like or acetic acid and the temperatureis governed by the reflux temperature of the particular solvent. Thereaction is generally complete in 24 hours. Scheme 10 illustrates thistransformation. ##STR15##

Compounds of Formula XI where X³ is O can be prepared by theα-hydroxylation of ketones of Formula XIII using procedures that arewell-known to one skilled in the art (e.g., J. Am. Chem. Soc., 1974, 96,5944; Tetrahedron Lett., 1988, 29, 2835; J. Org. Chem., 1986, 51, 2402).Scheme 11 illustrates this transformation. ##STR16##

Numerous alternative procedures exist for the preparation ofα-hydroxyketones of Formula XI (where X³ is O). Such procedures arewell-known to one skilled in the art (March, Advanced Organic Chemistry,3rd Edition, 1985, p. 1164). Compounds of Formula XI where X³ is O, R³is aryl and E is H are benzoins whose preparations are well-known to oneskilled in the art.

α-Keto sulfides of Formula XI where X³ is S can be prepared from ketonesof Formula XIII using procedures known to the art (J. Am. Chem. Soc.,1985, 107, 4175; J. Org. Chem., 1988, 53, 3125).

α-Amino ketones of Formula XI where X³ is NR³¹ can be prepared fromketones of Formula XIII using procedures known in the art (J. Chem.Soc., 1959, 1479; Synthesis, 1972, 191).

Compounds XI where X³ is NHR³¹⊕ Cl.sup.⊖, can be prepared by thereaction of Formula XIII compounds with compounds of the type XIIIausing a procedure similar to those described in the art (Synthesis,1991, 327). The conditions for this reaction are the combination ofequimolar amounts of Formulae XIII and XIIIa derivatives in the presenceof a base as a catalyst, such as, but not limited to, DABCO, DBU, sodiumhydroxide and the like. Suitable solvents include, but are not limitedto, toluene, dioxane and water. Scheme 11a illustrates thistransformation. ##STR17##

The starting ketones of Formula XIII are known in the art or can beobtained by methods analogous to known procedures. Those skilled in theart will recognize the Formula XIII compounds to include indanones,tetralones, chromanones, thiochromanones, benzofuran-3-ones,isochromanones and others.

One skilled in the art will recognize that the transformation of FormulaXIII compounds into Formula XI compounds may require the use ofprotecting groups to prevent unwanted side reactions of functionalitiesthat may be sensitive to the reaction conditions (for example, anindoxyl nitrogen atom may require a protecting group to render itunreactive in an α-hydroxylation of the carbonyl group). Since numerousalternative synthetic methods for the preparations of Formula XIcompounds exist, a further discussion of protecting-group chemistry willbe omitted.

Semicarbazides of Formula XII where X is O or S and G is G-9 can beprepared using procedures well-known to those skilled in the art.Formula XII compounds where X is O or S and G is G-1 to G-8 can beprepared by using the procedure shown in Scheme 12. ##STR18## wherein: Gis G-1 through G-8 and L¹ and L² are as already defined.

Typical reaction conditions involve the reaction of equimolar amounts ofan amine of Formula XIV with a compound of Formula XV (usually,1,1'-carbonyldiimidazole or thiophosgene are preferred) in a suitablesolvent at a temperature between -20° C. and 50° C. Suitable solventsinclude, but are not limited to, methylene chloride, chloroform,tetrahydrofuran or dioxane. The reaction product, XVI, is used withoutpurification and is treated with an excess of a molar amount ofhydrazine or hydrazine hydrate in an alcohol solvent such as methanol,ethanol or isopropanol at a temperature from 0° to 110° C. with thepreferred temperature being the boiling point of the solvent used. Theformation of semicarbazide XII is usually complete within 72 hours.

Compounds of Formula I, where Q is Q-1 and G is equal to G-1 through G-8can be prepared by treating intermediates of Formula V with triphosgene(O═C(OCCl₃)₂) or phosgene and NH₂ -G in the presence of a base such aspyridine as outlined in Scheme 13. ##STR19##

Compounds of Formula II (Q-2) can be prepared from Formula II (Q-2)imidoylhalide derivatives in an analogous fashion such as that describedfor the preparation of Formula II (Q-1) imidoylhalide compounds; seeScheme 14. ##STR20##

Formula II (Q-2) imidoylhalide compounds can be prepared from Formula I(Q-2) compounds in an analogous fashion as that described for Formula II(Q-1) compounds; see Scheme 15. ##STR21##

Compounds of Formula I (Q-2) can be prepared by the reaction of the acidchloride XVI with a substituted aniline of Formula XVII in equimolarproportions in the presence of an excess of an acid scavenger, such astertiary alkylamines or pyridines, but not limited to these, in anaprotic organic solvent such as ether, tetrahydrofuran, chloroform,methylene chloride, benzene and/or toluene. Scheme 16 illustrates thistransformation. ##STR22##

Compounds of the Formula XVI can be prepared from compounds of theFormula XVIII through conventional methodology generally used for theconversion of esters to their corresponding acid chlorides asillustrated in Scheme 17. ##STR23##

Formula XVIII derivatives (where A is equal to H) can be prepared by thereaction of Formula XIX compounds with an equimolar or greater amount ofa Formula XX compound in the presence of an acid catalyst (with 0.05 to0.2 molar equivalents preferred). The reaction can be carried out in avariety of polar organic solvents, including, but not limited to,tetrahydrofuran, acetonitrile, methanol or ethanol at a temperature ofbetween 0° and 80° C. with the preferred temperature being the refluxtemperature of the solvent. This reaction is illustrated by Scheme 18.##STR24##

Compounds of Formula XIX where Z¹ is O can be prepared by treatment ofFormula XXI compounds with a carboxylic acid such as formic, acetic orbenzoic acid in the presence of 0 to 2.0 equivalents of a baseincluding, but not limited to, potassium carbonate, sodium carbonate orsodium hydroxyde. Suitable solvents for the reaction include, but arenot limited to, ethanol, tetrahydrofuran or dimethylformamide. The esterXXII formed in the initial reaction is subsequently hydrolyzed to thealcohol XIX (Z¹ is O) using a base such as sodium ethoxide in a solventsuch as ethanol. Thiols of the Formula XIX (where Z¹ is S) can beprepared using analogous procedures starting with a thiocarboxylic acid(such as thiolacetic acid). The preparations of Formula XIX compounds(Z¹ is O or S) are illustrated by Scheme 19. ##STR25## wherein: Z¹ is Oor S;

R³² is H, alkyl or aryl.

Compounds of Formula XIX where Z¹ is NR³¹ can be prepared usingprocedures analogous to those shown in Scheme 19 using either ammonia ora primary amine (R³¹ NH₂) in place of the carboxylic or thiocarboxylicacid.

Compounds of Formula XXI can be prepared from compounds of the FormulaXXIII by the reaction with an equimolar amount of XXIV in conventionalorganic solvents such as, but not limited to, ether, tetrahydrofuran,methanol, ethanol, methylene chloride, benzene and toluene. Typicalreaction temperatures can range from room temperature to the refluxtemperature of the particular solvent utilized and the reaction isusually complete in 24 hours. Scheme 20 illustrates this reaction.##STR26##

Formula XXIII compounds can be prepared from Formula XXV derivatives bya diazotization/reduction reaction well documented in the literature(see Organic Functional Group Preparation, 1983, pp. 452-453 andreferences cited therein). Scheme 21 illustrates this transformation.##STR27##

Formula XXV compounds are known in the art or can be obtained by methodsanalogous to known procedures. Those skilled in the art will recognizeFormula XXV compounds to be substituted anilines or aminopyridines.

Compounds of Formula I (Q-3) can be prepared by the reaction of tri- andtetravalent metal species such as titanium, silicon, tin and the like incombination with reducing agents such as sodium, lithium, or zincborohydride, lithium aluminum hydride and the like with compounds ofFormula I (Q-1) as illustrated in Scheme 22. Literature precedent foranalogous reactions can be found in J.Org. Chem., 1987, 54, 3750, andSynthesis, 1980, 695. Typical reactions involve the addition of 1equivalent of a compound of Formula I (Q-1) to a solution of 1.1 to 4.0equivalents of titanium tetrachloride, with 1.5 to 2.5 equivalents beingpreferred, and 2.1 to 6.0 equivalents of sodium borohydride with 3.5 to4.5 equivalents being preferred.

Conventional organic solvents such as ether, tetrahydrofuran,dimethoxyethane, methylene chloride and chloroform can be used with1,2-dimethoxyethane being preferred. The reaction can be conducted attemperatures ranging from -70° C. to 50° C. with -10° C. to 30° C. beingpreferred. The reaction time can be 0.1 hour to 48 hours with 2 to 4hours being preferred. ##STR28##

Formula I (Q-3) derivatives can be converted into Formula II (Q-3)compounds in an analogous fashion as described for the conversion ofFormula I (Q-1) compounds into Formula II (Q-1) derivatives.

Formulae I (Q-4) and II (Q-4) compounds can be prepared in an analogousfashion as described for the preparation of Formulae I (Q-3) and II(Q-3) derivatives.

Additionally, compounds of Formula I, where Q is Q-1, A is H, Z is CH, Eis H and R³ is H, alkyl or aryl, can be prepared as outlined in Scheme23. This is generally accomplished by the reaction of equimolar amountsof a heterocycle such as XXVI with an aryl isocyanate or isothiocyanateof Formula VI in conventional organic solvents such as ether ortetrahydrofuran. The Formula I compounds of Scheme 23, where E is H, canbe converted to the analogs where E is C₁ -C₃ alkyl by alkylation of thedianion with a C₁ -C₃ alkyl halide as shown. This is typically done bytreatment of the compound where E is H with at least two equivalents ofa strong base such as lithium diisopropylamide at low temperatures inthe range of 0° to -78° C. in a solvent such as tetrahydrofuran. Analkyl halide (typically the iodide) is then added to the preformeddianion affording, after workup, compounds of Formula I where Q is Q-1,A is H and E is C₁ -C₃ alkyl. ##STR29##

Alkylation of the dianion of compounds such as XXVII is another usefulmethod for the introduction of a variety of R³ groups, this method isoutlined in Scheme 24. The R³ groups generally prepared by this methodare derived from alkylating reagents R³ -L (where L is Cl, Br or I) andinclude, e.g., alkyl halides, substituted alkyl halides, acyl halides,alkylchloroformates, sulfenyl and sulfonyl halides, dialkylcarbamoylhalides and the like. Typical procedures are analogous to that describedin Scheme 23 and include the use of strong base at low temperature. Asecond substituent E (where E is C₁ -C₃ alkyl) can also be introduced ina similar fashion. ##STR30##

Compounds of Formula I, where Q is Q-1 and R⁴ and R⁵ are taken togetherto form a carbonyl group (such as compound XXVIII) can be prepared bythe reaction of an amide such as V, where R⁴ and R⁵ are taken togetherto form ═O, with an aryl isocyanate or isothiocyanate. This method isoutlined in Scheme 25. This reaction can be run in a variety ofconventional organic solvents such as ether, tetrahydrofuran or ethylacetate and is preferably conducted at the reflux temperature of thesolvent. It is also preferable, and in some cases necessary, to add acatalytic amount of an amine base such as triethylamine, pyridine orpreferably N,N-dimethylaminopyridine. ##STR31##

Compounds of Formulae I (Q-5) and II (Q-5) can be prepared by thereaction of Formulae I (Q-1) and II (Q-1) derivatives where Z¹ is NH andR⁴ is H with an oxidizing agent, such as dichlorodicyanobenzoquinone(DDQ) (see Fieser and Fieser, Reagents for Organic Synthesis, 1967, Vol.I, pp. 215-219). The reaction involves the combination of an excess ofmolar equivalents of DDQ with one molar equivalent of Formula I (Q-1) orFormula II (Q-1) compounds where Z¹ is NH and R⁴ is H in a suitablesolvent such as, but not limited to, methanol, ethanol, acetone andbenzene. The reaction is conducted at room temperature to refluxtemperature of the particular solvent utilized. The reaction is usuallycomplete in 24 hours. Scheme 25a illustrates this reaction. ##STR32##

Compounds of Formulae I (Q-6) and II (Q-6) can be prepared in ananalogous fashion as described in Scheme 25a for Formulae I (Q-5) and II(Q-5) derivatives.

Formulae I compounds where Y is other than H, can be prepared bystandard alkylation, acylation or sulfenylation methods well documentedin the literature.

Formula I compounds where Y and A¹ are taken together to form--(CH₂)_(t) -- can be prepared by coupling of a Formula V compound withan indoline (t is 2) or tetrahydroquinoline (t is 3) of Formula XXIX inthe presence of phosgene or a phosgene equivalent. Typical reactionconditions involve combination of di- or triphosgene with the Formula Vcompound in a solvent such as tetrahydrofuran or chloroform followed byaddition of the indoline or tetrahydroquinoline of Formula XXIX. Thischemistry is depicted in Scheme 26. ##STR33##

The indoline (t is 2) and tetrahydroquinoline (t is 3) of Formula XXIXare well known in the art as well as procedures for their preparation.

Alternatively, compounds of Formula I where Y and A¹ are taken togetherto form --(CH₂)_(t) -- can be prepared by the reactions semicarbazonesof Formula XXX with compounds of Formula VIII, as depicted in Scheme 27.Procedures for this transformation are analogous to those described forScheme 5. ##STR34##

Compounds of Formula XXX can be prepared by the reaction of Formula XIcompounds with semicarbazides of Formula XXXI using procedures analogousto those described for Scheme 9. The formation of Formula XXX compoundsis depicted in Scheme 28. ##STR35##

The formation of Formula XXXI semicarbazides can be achieved usingprocedures analogous to those described in Scheme 12 for Formula XIIcompounds.

Alternatively, compounds of Formula I can be prepared by the reaction ofFormula XXXII compounds with anilines of Formula XVII as depicted inScheme 29. ##STR36## wherein: L³ is an alkoxy or aryloxy leaving groupand Z¹ is O or S.

Typical reaction conditions involve the reaction of XXXII with between 1to 5 molar equivalents of XVII in a suitable solvent in the presence of0 to 10 molar equivalents of a base such as pyridine, potassiumcarbonate or triethylamine. Suitable solvents include THF, DMF andacetonitrile.

Formula XXXII compounds can be prepared by the reaction of a FormulaXXXIII compound with an alkyl or aryl chloroformate of Formula XXXIV, asdepicted in Scheme 30. The reaction is generally carried out using anexcess of one molar equivalent of XXXIV in a non-nucleophilic solventsuch as benzene or xylenes. Alternatively, the reaction can be carriedout in the absence of solvent. Reactions are generally run attemperatures between 20°-100° C. ##STR37## wherein: L³ is an alkoxy oraryloxy group and Z¹ is O or S.

Formula XXXIII compounds are oxadiazines and thiadiazines whosepreparations are known to the literature (see, e.g., Synthesis, 1988,208; Synthesis, 1990, 491).

The following Examples further illustrate the invention.

EXAMPLE 1 Step A: 3-Chloro-α-(4-chlorophenyl)benzenepropanoic acid

To a solution of 6.8 g (0.17 mol) of 60% sodium hydride in 150 ml ofdimethylformamide under nitrogen was added 30.0 g (0.162 mol) of methyl4-chlorophenylacetate dropwise such that hydrogen evolution was moderateand the temperature of the reaction was maintained at less than 50° C.Once hydrogen evolution had ceased, a solution of 33.2 g (0.162 m) of3-chlorobenzylbromide in 30 ml of dimethylformamide was added verycautiously such that the reaction temperature was maintained at lessthan 60° C. The reaction was maintained at 50° to 60° C. with stirringovernight after which time it was partitioned between 5% aqueous NaHCO₃and diethyl ether, the aqueous extracts were washed twice with ether andthe combined organic extracts were then washed with water. The etherextracts were dried over MgSO₄, filtered and concentrated to afford 48.0g of a brown oil.

The crude product was combined with 300 ml of methanol, 40 ml of waterand 20 ml of 50% aqueous sodium bydroxide and refluxed overnight. Afterthis time the reaction was concentrated and the crude residuepartitioned between water and ether. The aqueous extracts were acidifiedwith conc. hydrochloric acid and extracted several times with ether. Theether extracts were dried over MgSO₄, filtered and concentrated to 48.8g of a yellow, oily solid.

¹ H NMR (CDCl₃) δ3.0 (dd, 1H), 3.3 (m, 1H), 3.84 (t, 1H), 6.77 (d, 1H),6.9-7.4 (m).

Step B: 5-Chloro-2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one

The crude product from Step A was combined with 50 ml of thionylchloride and then heated at reflux for 2 hours. Thionyl chloride wasremoved by concentration at reduced pressure and then the mixture wasconcentrated several times from carbon tetrachloride. The residue wascombined with 200 ml of dichloroethane, cooled under nitrogen to 0° C.,and 24.5 g of aluminum trichloride was then added. After stirringovernight the reaction was poured onto a mixture of ice in 1Nhydrochloric acid, extracted three times with ether and chromatographedon silica gel (10% ethyl acetate/hexane) to afford 18.6 g of a yellowoily solid.

¹ H NMR (CDCl₃) δ3.20 (dd, 1H), 3.68 (dd, 1H), 3.90 (dd, 1H), 6.9-7.6(m, 6H), 7.75 (d, 1H).

Step C: 5-Chloro-2-(4-chlorophenyl)-2,3-dihydro-2-hydroxy-1H-inden-1-one

A solution of 2.4 g (0.009 moles) of the product obtained from Step Band 20 mL of toluene was added with stirring to a mixture of 1.8 g(0.010 moles) of triethylphosphite, 0.1 g (0.0004 moles) ofbenzyltriethyl ammonium chloride, 100 mL of toluene and 50 mL of 50%aqueous sodium hydroxide solution. A steady stream of air was introducedinto the vigorously stirred reaction mixture at room temperature for 1hour. The resulting mixture was partitioned between 100 mL of Et₂ O and200 mL of water and the aqueous layer was extracted with two 100 mLportions of Et₂ O. The combined organic layers were washed twice with100 mL of water, twice with saturated aqueous sodium bisulfite solution,dried over MgSO₄ and concentrated. The resulting crude product waschromatographed on silica gel using 2:1 hexanes-ethyl acetate to give1.2 g of an oil that solidified on standing.

¹ H NMR (CDCl₃) δ3.23 (broadened s, 1H), 3.54 (apparent s, 2H), 7.25(abq, 4H), 7.44 (d, 1H), 7.53 (broadened s, 1H), 7.78 (d, 1H).

Step D:2-[5-Chloro-2-(4-chlorophenyl)-2,3-dihydro-2-hydroxy-1H-inden-1-ylidene]-N-[4-(trifluoromethyl)phenyl]hydrazine-carboxamide

A solution of 1.0 g (0.003 moles) of the product obtained in Step C,0.66 mL (0.014 moles) of hydrazine monohydrate and 17 mL of ethanol washeated at reflux for 3 hours. The resulting solution was partitionedbetween water and CH₂ Cl₂ and the aqueous layer was extracted with CH₂Cl₂. The combined organic layers were washed twice with water, driedover MgSO₄ and concentrated. The residue was chromatographed on silicagel using 1:1 hexanes-ethyl acetate to give 0.53 g of a yellow solid.

A solution of 0.5 g of the above product, 0.24 mL (0.0016 moles) ofα,α,α-trifluoro-p-tolyl isocyanate, 25 mL of tetrahydrofuran and 1 mL ofwater was stirred at room temperature for one hour and thenconcentrated. The residue was suspended in acetonitrile and concentratedto give 0.60 g of a white solid, melting point, 225° C. (decomposes).

¹ H NMR (d₆ -DMSO) δ3.3 (d, 1H, partially obscured by H₂ O peak), 3.55(d, 1H), 7.3-7.5 (m, 7H), 7.64 (d, 2H), 7.82 (d, 2H), 8.00 (d, 1H), 9.52(broadened s, 1H).

Step E:7-Chloro-4a-(4-chlorophenyl)-4a,5-dihydro-N-[4-trifluoromethyl)phenyl]-indeno[1,2-e]-[1,3,4]oxadiazine-2(3H)-carboxamide

A mixture of 0.30 g (0.0006 moles) of the product obtained in Step D,0.36 g (0.012 moles) of paraformaldehyde, 50 mg of p-toluene sulfonicacid monohydrate and 30 mL of acetonitrile was refluxed for 1 hour. Theresulting mixture was partitioned between CH₂ Cl₂ and saturated aqueoussodium bicarbonate and the aqueous layer was extracted twice with CH₂Cl₂. The combined organic layers were dried over MgSO₄ and concentratedto give an oil that was chromatographed on silica gel using 4:1hexanes-ethyl acetate to give 0.23 g of an oil that solidified onstanding, melting point, 213°-214° C.

¹ H NMR (CDCl₃) δ3.39 (d, 1H), 3.58 (d, 1H), 4.54 (d, 1H), 5.78 (d, 1H),7.20-7.42 (m, 6H), 7.61 (abq, 4H), 7.72 (d, 1H), 8.58 (broadened s, 1H).

EXAMPLE 2 Step A: Methyl5-chloro-2,3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylate

Sodium hydride (24 g of 60% solution in oil, 0.6 moles) was washed withhexanes to remove the oil. The resulting washed NaH was suspended in 200mL of DMF and then treated with a solution of 50 g (0.3 moles) of5-chloro-1-indanone and 150 mL of DMF at such a rate that reactiontemperature remained below 35° C. The resulting mixture was stirred for30 min and then treated with 38 mL (0.45 moles) of dimethyl carbonateadded over 15 min. The resulting mixture was stirred at room temperaturefor 1.5 h and then allowed to stand overnight. The reaction mixture waspoured carefully into a mixture of 100 mL of concentrated HCl and about1000 mL of ice. Then, 500 mL of ether was added and the aqueous layerwas extracted twice with ether. The combined organic layers were washedwith three portions of H₂ O, dried (MgSO₄) and concentrated to give 64.6g of a brown oil.

A solution of 5.0 g (0.022 moles) of the above product and 70 mL ofmethylene chloride was treated with 10 g (ca. 0. 032 moles) of 50-60%m-chloroperbenzoic acid (Aldrich) at room temperature. After 1 h, thereaction was cooled to 0° C. and quenched by careful addition ofsaturated aqueous sodium carbonate. The layer was washed twice withsaturated aqeuous sodium carbonate, once with saturated sodiumbisulfite, dried (MgSO₄) and concentrated to give 4.0 g of a yellowsolid.

IR (CCl₄ solution) 3560, 1770, 1745 cm⁻¹.

¹ H NMR (CDCl₃, 200 mHz) δ7.73 (d, 1H), 7.50 (br s, 1H), 7.42 (d, 1H),4.04 (s, 1H, exchangeable with D₂ O), 3.75 (s, 3H), 3.69 (d, 1H), 3.24(d, 1H).

Step B: Methyl5-chloro-2,3-dihydro-2-hydroxy-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]hydrozono]-1H-indene-2-carboxylate

A solution of 1 g (0.004 moles) of the product from Step A and 10 mL ofmethanol was added to a solution of 0.61 mL (0.012 moles) of hydrazinemonohydrate, 0.72 mL (0.012 moles) of glacial acetic acid and 20 mL ofmethanol at 0° C. The resulting mixture was refluxed for 2 h, cooled toroom temperature and partitioned between 200 mL of methylene chlorideand 200 mL of water. The aqueous layer was extracted with methylenechloride and the combined organic layers were washed twice with water,dried (K₂ CO₃) and concentrated to give 0.6 g of a yellow solid.

A solution of 0.5 g (0.002 moles) of the above product and 20 mL of THFwas treated with a solution of 0.4 g (0.002 moles)4-(trifluoromethoxy)phenyl isocyanate and 5 mL of THF. Two drops ofwater were added and the resulting solution was stirred at roomtemperature for 30 min. The reaction was then concentrated to give 0.90g of slightly impure product that was used in the next step withoutfurther purification. An analytical sample was prepared byrecrystallization from THF-hexanes, mp 233°-235° C.

¹ H NMR (200 MHz, d₆ -DMSO) δ9.43 (s, 1H), 9.40 (s, 1H), 7.93 (d, 1H),7.78 (d, 2H), 7.45 (apparent d, 3H), 7.33 (d, 2H), ca. 3.67 (d, 1H),3.66 (s, 3H), 3.22 (d, 1H).

Step C: Methyl7-chloro-2,5-dihydro-2-[[[4-trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e]-[1,3,4]oxadiazine-4a(3H)-carboxylate

A mixture of 0.85 g (0.002 moles) of the product from Step B, 0.9 g ofparaformaldehyde, 0.05 g of p-toluene sulfonic acid monohydrate and 50mL of acetonitrile was heated at reflux for 1 h. The resulting mixturewas cooled to room temperature and partitioned between CH₂ Cl₂ andsaturated aqueous sodium bicarbonate. The aqueous layer was extractedwith CH₂ Cl₂ and the combined organics were washed with saturatedaqueous NaHCO₃, dried (MgSO₄) and concentrated. The residue was purifiedby flash chromatography on silica gel using 4:1 hexanes-EtOAc to give0.50 g of a pale yellow solid, mp 99°-101° C. Trituration with hothexanes gave a white solid melting at 126.5°-128.0° C.

¹ H NMR (200 MHz, CDCl₃) δ8.37 (br s, 1H), 7.66-7.50 (m, 3H), 7.35 (d,1H), 7.32 (s, 1H), 7.18 (d, 2H), 5.92 (d, 1H), 5.05 (d, 1H), 3.73 (s,3H), 3.52 (d, 1H), 3.27 (d, 1H).

Step D: Methyl7-chloro-2,5-dihydro-2-[[N-methyl-N-[4-(trifluoromethoxy)phenyl]amino]carbonyl]-indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate

A solution of 1.0 g (0.002 moles) of the product from Step C and 10.5 mLof DMF was treated with 0.2 g (0.005 moles) of 60% NaH (in oil) at 0° C.After stirring for 10 min, 1.2 mL (0.02 moles) of iodomethane was added.The resulting mixture was stirred at room temperature for 2 h and thenpoured into ice-cold 1N HCl and extracted with three portions of ether.The combined organics were washed with water, dried (MgSO₄) andconcentrated to give a crude yellow solid which was triturated withmethanol to give 0.70 g of a yellow solid, mp 130°-131° C.

¹ H NMR (200 MHz, CDCl₃) δ7.20 (apparent s, 1H), 7.16 (apparent s, 5H),6.84 (d, 1H), 5.29 (abq, 2H), 3.67 (s, 3H), 3.38 (overlapping d, 1H ands, 3H), 3.13 (d, 1H).

EXAMPLE 3 Step A: Methyl2-amino-5-chloro-2,3-dihydro-1-oxo-1H-indene-2-carboxylate hydrochloride

An ice cold solution of 11.4 g (100.8 mmol) of hydroxylamine-O-sulfonicacid in 102 mL of water and 50 mL of sodium hydroxide solution (2N) wasadded in one portion to 10 g (102 mmol) of cyclohexanone in 180 mL oftoluene and 50 mL of sodium hydroxide solution (2N) at 0° C. The mixturewas stirred for 10 minutes. The organic layer was removed and dried overmagnesium sulphate. Then, 7 g (31.3 mmol) of methyl5-chloro-2,3-dihydro-1-oxo-2-1H-indene-2-carboxylate was added to a 155mL portion of the solution; and 0.1 g (0.89 mmol) DABCO was then addedin one portion to the mixture which was stirred for 1 h at 5° C. Themixture was washed twice with 50 mL portions of hydrochloric acid (1N).The acid layer was evaporated under reduced pressure to give 4.37 g of asolid, m.p. 145° to 148° C. (dec).

¹ H NMR (free base)(200 MHz, CDCl₃) δ7.73 (d, 1H), 7.48 (s, 1H), 7.41(d, 1H), 3.69 (s, 3H), 3.68 (1/2 ABq, 1H), and 3.05 (1/2 ABq, 1H).

Step B: Methyl2-amino-5-chloro-2,3-dihydro-1-[[[[-4-(trifluoromethoxy)phenyl]amino]carbonyl]-hydrazono]-1H-indene-2-carboxylate

A mixture of 2 g (7.24 mmol) of the product from Step A and 1.83 g (7.78mmol) of 4-(4-trifluoromethoxy)phenylsemicarbazide in 18 mL of ethanolwas boiled for 2 h. The mixture was allowed to cool and was stirred atroom temperature overnight. The mixture was poured into 200 mL ofsaturated sodium bicarbonate solution and then extracted with 3×100 mLof ethyl acetate. The combined extracts were dried and evaporated andthe material washed with ether to give 1.0 g of an off-white solid, ofwhich a small portion was further purified by chromatography on silicagel (ethyl acetate/ethanol 5:1), m.p. 156.5° to 158° C. (dec).

¹ H NMR (200 MHz, CDCl₃) δ8.4 (s, 1H), 8.20 (s, 1H), 7.83 (d, 1H), 7.56(d, 2H), 7.42-7.18 (m, 4H), 3.73-3.65 (m, 4H), 3.05 (1/2 ABq, 1H).

Step C:7-chloro-2,3,4,5-tetrahydro-2-[[(4-trifluoromethoxy)phenylamino]carbonyl]-4aH-indeno[2,1-e]-1,2,4-triazine-4a-carboxylicacid, methyl ester

A slurry of 0.12 g (6.48 mmol) of Eschenmoser's salt in 3 mL oftetrahydrofuran was added to 0.3 g (6.57 mmol) of the product from StepB in 2 mL of tetrahydrofuran at room temperature. The mixture wasstirred at room temperature for 65 h. The mixture was poured into 100 mLof saturated sodium bicarbonate solution and extracted with 3×50 mL ofethyl acetate. The combined extracts were dried and evaporated.Chromatography on silica gel (eluted with ethyl acetate/hexanes 1:1)gave 0.14 g of a white solid, m.p. 135° to 140° C. (dec).

IR (mineral oil): 3372, 3298, 1751, 1658, 1631, 1603, 1535, 1415, 1315,1266, 1199, 1109, 1009, 967, 919, 889, and 826 cm⁻¹.

¹ H NMR (200 MHz, CDCl₃) δ8.43 (s, 1H), 7.64-7.14 (m, 7H), 5.38 (1/2ABq, 1H), 4.39 (1/2 ABq, 1H), 3.71 (s, H), 3.53 (1/2 ABq, 1H), 3.08 (1/2ABq, 1H), 2.40 (bs, 1H).

By the general procedures described herein, or obvious modificationsthereof, the compounds of Tables 1 through 72 can be prepared.

In Tables 1 through 72, the following notations have been used.##STR38##

                                      TABLE 1                                     __________________________________________________________________________    R.sup.1                                                                            R.sup.3                                                                              Y      R.sup.1                                                                            R.sup.3                                                                              Y                                              __________________________________________________________________________    Cl   Me     H      OCF.sub.3                                                                          Me     COEt                                           Br   Me     H      Cl   Me     CO.sub.2 Me                                    CF.sub.3                                                                           Me     H      Br   Me     CO.sub.2 Me                                    OCF.sub.3                                                                          Me     H      CF.sub.3                                                                           Me     CO.sub.2 Me                                    Cl   Me     Me     OCF.sub.3                                                                          Me     CO.sub.2 Me                                    Br   Me     Me     Cl   Me     CO.sub.2 Et                                    CF.sub.3                                                                           Me     Me     Br   Me     CO.sub.2 Et                                    OCF.sub.3                                                                          Me     Me     CF.sub.3                                                                           Me     CO.sub.2 Et                                    Cl   Me     Et     OCF.sub.3                                                                          Me     CO.sub.2 Et                                    Br   Me     Et     Cl   Me     CH.sub.2 OMe                                   CF.sub.3                                                                           Me     Et     Br   Me     CH.sub.2 OMe                                   OCF.sub.3                                                                          Me     Et     CF.sub.3                                                                           Me     CH.sub.2 OMe                                   Cl   Me     n-Pr   OCF.sub.3                                                                          Me     CH.sub.2 OMe                                   Br   Me     n-Pr   Cl   Me     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Me     n-Pr   Br   Me     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Me     n-Pr   CF.sub.3                                                                           Me     CH.sub.2 CHCH.sub.2                            Cl   Me     COMe   OCF.sub.3                                                                          Me     CH.sub.2 CHCH.sub.2                            Br   Me     COMe   Cl   Me     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Me     COMe   Br   Me     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Me     COMe   CF.sub.3                                                                           Me     CH.sub.2 SCH.sub.3                             Cl   Me     COEt   OCF.sub.3                                                                          Me     CH.sub.2 SCH.sub.3                             Br   Me     COEt   OCF.sub.2 H                                                                        Me     H                                              CF.sub.3                                                                           Me     COEt   OCF.sub.2 H                                                                        Me     Me                                             Cl   Et     H      OCF.sub.3                                                                          Et     COEt                                           Br   Et     H      Cl   Et     CO.sub.2 Me                                    CF.sub.3                                                                           Et     H      Br   Et     CO.sub.2 Me                                    OCF.sub.3                                                                          Et     H      CF.sub.3                                                                           Et     CO.sub.2 Me                                    Cl   Et     Me     OCF.sub.3                                                                          Et     CO.sub.2 Me                                    Br   Et     Me     Cl   Et     CO.sub.2 Et                                    CF.sub.3                                                                           Et     Me     Br   Et     CO.sub.2 Et                                    OCF.sub.3                                                                          Et     Me     CF.sub.3                                                                           Et     CO.sub.2 Et                                    Cl   Et     Et     OCF.sub.3                                                                          Et     CO.sub.2 Et                                    Br   Et     Et     Cl   Et     CH.sub.2 OMe                                   CF.sub.3                                                                           Et     Et     Br   Et     CH.sub.2 OMe                                   OCF.sub.3                                                                          Et     Et     CF.sub.3                                                                           Et     CH.sub.2 OMe                                   Cl   Et     n-Pr   OCF.sub.3                                                                          Et     CH.sub.2 OMe                                   Br   Et     n-Pr   Cl   Et     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Et     n-Pr   Br   Et     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Et     n-Pr   CF.sub.3                                                                           Et     CH.sub.2 CHCH.sub.2                            Cl   Et     COMe   OCF.sub.3                                                                          Et     CH.sub.2 CHCH.sub.2                            Br   Et     COMe   Cl   Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COMe   Br   Et     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Et     COMe   CF.sub.3                                                                           Et     CH.sub.2 SCH.sub.3                             Cl   Et     COEt   OCF.sub.3                                                                          Et     CH.sub.2 SCH.sub.3                             Br   Et     COEt   OCF.sub.2 H                                                                        Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COEt   OCF.sub.2 H                                                                        Me     Et                                             OCF.sub.2 H                                                                        Et     H      OCF.sub.2 H                                                                        Me     n-Pr                                           OCF.sub.2 H                                                                        Et     Me     OCF.sub.2 H                                                                        Me     COMe                                           OCF.sub.2 H                                                                        Et     Et     OCF.sub.2 H                                                                        Me     COEt                                           OCF.sub.2 H                                                                        Et     n-Pr   OCF.sub.2 H                                                                        Me     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Et     COMe   OCF.sub.2 H                                                                        Me     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Et     COEt   OCF.sub.2 H                                                                        Me     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                        Me     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Et     CO.sub.2 Et                                                                          OCF.sub.2 H                                                                        Me     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Et     CH.sub.2 OMe                                                      OCF.sub.2 H                                                                        Et     CH.sub.2 CHCH.sub.2                                               Cl   n-Pr   H      OCF.sub.3                                                                          n-Pr   COEt                                           Br   n-Pr   H      Cl   n-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           n-Pr   H      Br   n-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          n-Pr   H      CF.sub.3                                                                           n-Pr   CO.sub.2 Me                                    Cl   n-Pr   Me     OCF.sub.3                                                                          n-Pr   CO.sub.2 Me                                    Br   n-Pr   Me     Cl   n-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           n-Pr   Me     Br   n-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          n-Pr   Me     CF.sub.3                                                                           n-Pr   CO.sub.2 Et                                    Cl   n-Pr   Et     OCF.sub.3                                                                          n-Pr   CO.sub.2 Et                                    Br   n-Pr   Et     Cl   n-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           n-Pr   Et     Br   n-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          n-Pr   Et     CF.sub.3                                                                           n-Pr   CH.sub.2 OMe                                   Cl   n-Pr   n-Pr   OCF.sub.3                                                                          n-Pr   CH.sub.2 OMe                                   Br   n-Pr   n-Pr   Cl   n-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           n-Pr   n-Pr   Br   n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          n-Pr   n-Pr   CF.sub.3                                                                           n-Pr   CH.sub.2 CHCH.sub.2                            Cl   n-Pr   COMe   OCF.sub.3                                                                          n-Pr   CH.sub.2 CHCH.sub.2                            Br   n-Pr   COMe   Cl   n-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           n-Pr   COMe   Br   n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          n-Pr   COMe   CF.sub.3                                                                           n-Pr   CH.sub.2 SCH.sub.3                             Cl   n-Pr   COEt   OCF.sub.3                                                                          n-Pr   CH.sub.2 SCH.sub.3                             Br   n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   COEt                                           CF.sub.3                                                                           n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        n-Pr   H      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        n-Pr   Me     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        n-Pr   Et     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        n-Pr   n-Pr   OCF.sub.2 H                                                                        n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        n-Pr   COMe                                                              Cl   i-Pr   H      OCF.sub.3                                                                          i-Pr   COEt                                           Br   i-Pr   H      Cl   i-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           i-Pr   H      Br   i-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Pr   H      CF.sub.3                                                                           i-Pr   CO.sub.2 Me                                    Cl   i-Pr   Me     OCF.sub.3                                                                          i-Pr   CO.sub.2 Me                                    Br   i-Pr   Me     Cl   i-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           i-Pr   Me     Br   i-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Pr   Me     CF.sub.3                                                                           i-Pr   CO.sub.2 Et                                    Cl   i-Pr   Et     OCF.sub.3                                                                          i-Pr   CO.sub.2 Et                                    Br   i-Pr   Et     Cl   i-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Pr   Et     Br   i-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Pr   Et     CF.sub.3                                                                           i-Pr   CH.sub.2 OMe                                   Cl   i-Pr   n-Pr   OCF.sub.3                                                                          i-Pr   CH.sub.2 OMe                                   Br   i-Pr   n-Pr   Cl   i-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Pr   n-Pr   Br   i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Pr   n-Pr   CF.sub.3                                                                           i-Pr   CH.sub.2 CHCH.sub.2                            Cl   i-Pr   COMe   OCF.sub.3                                                                          i-Pr   CH.sub.2 CHCH.sub.2                            Br   i-Pr   COMe   Cl   i-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Pr   COMe   Br   i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Pr   COMe   CF.sub.3                                                                           i-Pr   CH.sub.2 SCH.sub.3                             Cl   i-Pr   COEt   OCF.sub.3                                                                          i-Pr   CH.sub.2 SCH.sub.3                             Br   i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   COEt                                           CF.sub.3                                                                           i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Pr   H      OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Pr   Me     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        i-Pr   Et     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Pr   n-Pr   OCF.sub.2 H                                                                        i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Pr   COMe                                                              Cl   i-Bu   H      OCF.sub.3                                                                          i-Bu   COEt                                           Br   i-Bu   H      Cl   i-Bu   CO.sub.2 Me                                    CF.sub.3                                                                           i-Bu   H      Br   i-Bu   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Bu   H      CF.sub.3                                                                           i-Bu   CO.sub.2 Me                                    Cl   i-Bu   Me     OCF.sub. 3                                                                         i-Bu   CO.sub.2 Me                                    Br   i-Bu   Me     Cl   i-Bu   CO.sub.2 Et                                    CF.sub.3                                                                           i-Bu   Me     Br   i-Bu   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Bu   Me     CF.sub.3                                                                           i-Bu   CO.sub.2 Et                                    Cl   i-Bu   Et     OCF.sub.3                                                                          i-Bu   CO.sub.2 Et                                    Br   i-Bu   Et     Cl   i-Bu   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Bu   Et     Br   i-Bu   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Bu   Et     CF.sub.3                                                                           i-Bu   CH.sub.2 OMe                                   Cl   i-Bu   n-Pr   OCF.sub.3                                                                          i-Bu   CH.sub.2 OMe                                   Br   i-Bu   n-Pr   Cl   i-Bu   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Bu   n-Pr   Br   i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Bu   n-Pr   CF.sub.3                                                                           i-Bu   CH.sub.2 CHCH.sub.2                            Cl   i-Bu   COMe   OCF.sub.3                                                                          i-Bu   CH.sub.2 CHCH.sub.2                            Br   i-Bu   COMe   Cl   i-Bu   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Bu   COMe   Br   i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Bu   COMe   CF.sub.3                                                                           i-Bu   CH.sub.2 SCH.sub.3                             Cl   i-Bu   COEt   OCF.sub.3                                                                          i-Bu   CH.sub.2 SCH.sub.3                             Br   i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   COEt                                           CF.sub.3                                                                           i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Bu   H      OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Bu   Me     OCF.sub.2 H                                                                        i-Bu   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        i-Bu   Et     OCF.sub.2 H                                                                        i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Bu   n-Pr   OCF.sub.2 H                                                                        i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Bu   COMe                                                              Cl   CO.sub.2 Me                                                                          H      OCF.sub.3                                                                          CO.sub.2 Me                                                                          COEt                                           Br   CO.sub.2 Me                                                                          H      Cl   CO.sub.2 Me                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          H      Br   CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          H      CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Me                                                                          Me     Cl   CO.sub.2 Me                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          Me     Br   CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          Me     CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Me                                                                          Et     Cl   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Me                                                                          Et     Br   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Me                                                                          Et     CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Me                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Br   CO.sub. 2 Me                                                                         n-Pr   Cl   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Me                                                                          n-Pr   Br   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Me                                                                          COMe   Cl   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Me                                                                          COMe   Br   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub. 2 SCH.sub.3                            OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COMe                                                              Cl   CO.sub.2 Et                                                                          H      OCF.sub.3                                                                          CO.sub.2 Et                                                                          COEt                                           Br   CO.sub.2 Et                                                                          H      Cl   CO.sub.2 Et                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          H      Br   CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          H      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Et                                                                          Me     Cl   CO.sub.2 Et                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          Me     Br   CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          Me     CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Et                                                                          Et     Cl   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Et                                                                          Et     Br   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Et                                                                          Et     CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Br   CO.sub.2 Et                                                                          n-Pr   Cl   CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Et                                                                          n-Pr   Br   CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Et                                                                          COMe   Cl   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Et                                                                          COMe   Br   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COMe                                                              Cl   Ph     H      OCF.sub.3                                                                          Ph     COEt                                           Br   Ph     H      Cl   Ph     CO.sub.2 Me                                    CF.sub.3                                                                           Ph     H      Br   Ph     CO.sub.2 Me                                    OCF.sub.3                                                                          Ph     H      CF.sub.3                                                                           Ph     CO.sub.2 Me                                    Cl   Ph     Me     OCF.sub.3                                                                          Ph     CO.sub.2 Me                                    Br   Ph     Me     Cl   Ph     CO.sub.2 Et                                    CF.sub.3                                                                           Ph     Me     Br   Ph     CO.sub.2 Et                                    OCF.sub.3                                                                          Ph     Me     CF.sub.3                                                                           Ph     CO.sub.2 Et                                    Cl   Ph     Et     OCF.sub.3                                                                          Ph     CO.sub.2 Et                                    Br   Ph     Et     Cl   Ph     CH.sub.2 OMe                                   CF.sub.3                                                                           Ph     Et     Br   Ph     CH.sub.2 OMe                                   OCF.sub.3                                                                          Ph     Et     CF.sub.3                                                                           Ph     CH.sub.2 OMe                                   Cl   Ph     n-Pr   OCF.sub.3                                                                          Ph     CH.sub.2 OMe                                   Br   Ph     n-Pr   Cl   Ph     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Ph     n-Pr   Br   Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Ph     n-Pr   CF.sub.3                                                                           Ph     CH.sub.2 CHCH.sub.2                            Cl   Ph     COMe   OCF.sub.3                                                                          Ph     CH.sub.2 CHCH.sub.2                            Br   Ph     COMe   Cl   Ph     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Ph     COMe   Br   Ph     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Ph     COMe   CF.sub.3                                                                           Ph     CH.sub.2 SCH.sub.3                             Cl   Ph     COEt   OCF.sub.3                                                                          Ph     CH.sub.2 SCH.sub.3                             Br   Ph     COEt   OCF.sub.2 H                                                                        Ph     COEt                                           CF.sub.3                                                                           Ph     COEt   OCF.sub.2 H                                                                        Ph     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Ph     H      OCF.sub.2 H                                                                        Ph     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Ph     Me     OCF.sub.2 H                                                                        Ph     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Ph     Et     OCF.sub.2 H                                                                        Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Ph     n-Pr   OCF.sub.2 H                                                                        Ph     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Ph     COMe                                                              Cl   4-ClPh H      OCF.sub.3                                                                          4-ClPh COEt                                           Br   4-ClPh H      Cl   4-ClPh CO.sub.2 Me                                    CF.sub.3                                                                           4-ClPh H      Br   4-ClPh CO.sub.2 Me                                    OCF.sub.3                                                                          4-ClPh H      CF.sub.3                                                                           4-ClPh CO.sub.2 Me                                    Cl   4-ClPh Me     OCF.sub.3                                                                          4-ClPh CO.sub.2 Me                                    Br   4-ClPh Me     Cl   4-ClPh CO.sub.2 Et                                    CF.sub.3                                                                           4-ClPh Me     Br   4-ClPh CO.sub.2 Et                                    OCF.sub.3                                                                          4-ClPh Me     CF.sub.3                                                                           4-ClPh CO.sub.2 Et                                    Cl   4-ClPh Et     OCF.sub.3                                                                          4-ClPh CO.sub.2 Et                                    Br   4-ClPh Et     Cl   4-ClPh CH.sub.2 OMe                                   CF.sub.3                                                                           4-ClPh Et     Br   4-ClPh CH.sub.2 OMe                                   OCF.sub.3                                                                          4-ClPh Et     CF.sub.3                                                                           4-ClPh CH.sub.2 OMe                                   Cl   4-ClPh n-Pr   OCF.sub.3                                                                          4-ClPh CH.sub.2 OMe                                   Br   4-ClPh n-Pr   Cl   4-ClPh CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-ClPh n-Pr   Br   4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-ClPh n-Pr   CF.sub.3                                                                           4-ClPh CH.sub.2 CHCH.sub.2                            Cl   4-ClPh COMe   OCF.sub.3                                                                          4-ClPh CH.sub.2 CHCH.sub.2                            Br   4-ClPh COMe   Cl   4-ClPh CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-ClPh COMe   Br   4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-ClPh COMe   CF.sub.3                                                                           4-ClPh CH.sub.2 SCH.sub.3                             Cl   4-ClPh COEt   OCF.sub.3                                                                          4-ClPh CH.sub.2 SCH.sub.3                             Br   4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh COEt                                           CF.sub.3                                                                           4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-ClPh H      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-ClPh Me     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-ClPh Et     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-ClPh n-Pr   OCF.sub.2 H                                                                        4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-ClPh COMe                                                              Cl   4-FPh  H      OCF.sub.3                                                                          4-FPh  COEt                                           Br   4-FPh  H      Cl   4-FPh  CO.sub.2 Me                                    CF.sub.3                                                                           4-FPh  H      Br   4-FPh  CO.sub.2 Me                                    OCF.sub.3                                                                          4-FPh  H      CF.sub.3                                                                           4-FPh  CO.sub.2 Me                                    Cl   4-FPh  Me     OCF.sub.3                                                                          4-FPh  CO.sub.2 Me                                    Br   4-FPh  Me     Cl   4-FPh  CO.sub.2 Et                                    CF.sub.3                                                                           4-FPh  Me     Br   4-FPh  CO.sub.2 Et                                    OCF.sub.3                                                                          4-FPh  Me     CF.sub.3                                                                           4-FPh  CO.sub.2 Et                                    Cl   4-FPh  Et     OCF.sub.3                                                                          4-FPh  CO.sub.2 Et                                    Br   4-FPh  Et     Cl   4-FPh  CH.sub.2 OMe                                   CF.sub.3                                                                           4-FPh  Et     Br   4-FPh  CH.sub.2 OMe                                   OCF.sub.3                                                                          4-FPh  Et     CF.sub.3                                                                           4-FPh  CH.sub.2 OMe                                   Cl   4-FPh  n-Pr   OCF.sub.3                                                                          4-FPh  CH.sub.2 OMe                                   Br   4-FPh  n-Pr   Cl   4-FPh  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-FPh  n-Pr   Br   4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-FPh  n-Pr   CF.sub.3                                                                           4-FPh  CH.sub.2 CHCH.sub.2                            Cl   4-FPh  COMe   OCF.sub.3                                                                          4-FPh  CH.sub.2 CHCH.sub.2                            Br   4-FPh  COMe   Cl   4-FPh  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-FPh  COMe   Br   4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-FPh  COMe   CF.sub. 3                                                                          4-FPh  CH.sub.2 SCH.sub.3                             Cl   4-FPh  COEt   OCF.sub.3                                                                          4-FPh  CH.sub.2 SCH.sub.3                             Br   4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  COEt                                           CF.sub.3                                                                           4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-FPh  H      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-FPh  Me     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-FPh  Et     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-FPh  n-Pr   OCF.sub.2 H                                                                        4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-FPh  COMe                                                              Cl   CHCH.sub.2                                                                           H      OCF.sub.3                                                                          CHCH.sub.2                                                                           COEt                                           Br   CHCH.sub.2                                                                           H      Cl   CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                           CHCH.sub.2                                                                           H      Br   CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           H      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                    Cl   CHCH.sub.2                                                                           Me     OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                    Br   CHCH.sub.2                                                                           Me     Cl   CHCH.sub.2                                                                           CO.sub.2 Et                                    CF.sub.3                                                                           CHCH.sub.2                                                                           Me     Br   CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           Me     CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Et                                    Cl   CHCH.sub.2                                                                           Et     OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 Et                                    Br   CHCH.sub.2                                                                           Et     Cl   CHCH.sub.2                                                                           CH.sub.2 OMe                                   CF.sub.3                                                                           CHCH.sub.2                                                                           Et     Br   CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.3                                                                          CHCH.sub.2                                                                           Et     CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 OMe                                   Cl   CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 OMe                                   Br   CHCH.sub.2                                                                           n-Pr   Cl   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CHCH.sub.2                                                                           n-Pr   Br   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Cl   CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Br   CHCH.sub.2                                                                           COMe   Cl   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CHCH.sub.2                                                                           COMe   Br   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CHCH.sub.2                                                                           COMe   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Cl   CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Br   CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COEt                                           CF.sub.3                                                                           CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           Et     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COMe                                                              Cl   C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                           Br   C(CH.sub.3)CH.sub.2                                                                  H      Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  H      Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Br   C(CH.sub.3)CH.sub.2                                                                  Me     Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Me     Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Br   C(CH.sub.3)CH.sub.2                                                                  Et     Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Et     Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     CF.sub. 3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Cl   C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Br   C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Cl   C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Br   C(CH.sub.3)CH.sub.2                                                                  COMe   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COMe   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Cl   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Br   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COEt                                           CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COMe                                                              CF.sub.3                                                                           Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Me     CO(n-Pr)                                                                             CF.sub.3                                                                           n-Pr   CO(n-Pr)                                       CF.sub.3                                                                           Me     CO(i-Pr)                                                                             CF.sub.3                                                                           n-Pr   CO(i-Pr)                                       CF.sub.3                                                                           Me     CO(t-Bu)                                                                             CF.sub.3                                                                           n-Pr   CO(t-Bu)                                       CF.sub.3                                                                           Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Me     CO(n-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Me     CO(i-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Me     CO(t-Bu)                                                                             OCF.sub.3                                                                          n-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (t-Bu)                                CF.sub.3                                                                           Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Et     CO.sub. 2 (i-Pr)                                                                     CF.sub.3                                                                           i-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Et     CO(n-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(n-Pr)                                       CF.sub.3                                                                           Et     CO(i-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(i-Pr)                                       CF.sub.3                                                                           Et     CO(t-Bu)                                                                             CF.sub.3                                                                           i-Pr   CO(t-Bu)                                       CF.sub.3                                                                           Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Et     CO(n-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Et     CO(i-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Et     CO(t-Bu)                                                                             OCF.sub.3                                                                          i-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(i-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(t-Bu)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(n-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(i-Pr)                                       OCF.sub.2 H                                                                        Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                CF.sub.3                                                                           i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                CF.sub.3                                                                           i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(n-Pr)                                       CF.sub.3                                                                           i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(i-Pr)                                       CF.sub.3                                                                           i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(t-Bu)                                       CF.sub.3                                                                           i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                       OCF.sub.3                                                                          i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (n-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (i-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                           Ph     CO(n-Pr)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                           Ph     CO(i-Pr)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                           Ph     CO(t-Bu)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(n-Pr)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(i-Pr)                                       OCF.sub.3                                                                          CO.sub.2 He                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                          Ph     CO(t-Bu)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(i-Pr)                                       OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(t-Bu)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(n-Pr)                                       CF.sub.3                                                                           4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(i-Pr)                                       CF.sub.3                                                                           4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(t-Bu)                                       CF.sub.3                                                                           4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(n-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(i-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(t-Bu)                                       OCF.sub.3                                                                          4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                           4-FPh  CO(i-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       CF.sub.3                                                                           4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       CF.sub.3                                                                           4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.3                                                                          4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-ClPh CO(t-Bu)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(n-Pr)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(i-Pr)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(t-Bu)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (t-Bu)                                __________________________________________________________________________

                                      TABLE 2                                     __________________________________________________________________________     ##STR39##                                                                    R.sup.1                                                                            R.sup.3                                                                              Y      R.sup.1                                                                            R.sup.3                                                                              Y                                              __________________________________________________________________________    Cl   Me     H      OCF.sub.3                                                                          Me     COEt                                           Br   Me     H      Cl   Me     CO.sub.2 Me                                    CF.sub.3                                                                           Me     H      Br   Me     CO.sub.2 Me                                    OCF.sub.3                                                                          Me     H      CF.sub.3                                                                           Me     CO.sub.2 Me                                    Cl   Me     Me     OCF.sub.3                                                                          Me     CO.sub.2 Me                                    Br   Me     Me     Cl   Me     CO.sub.2 Et                                    CF.sub.3                                                                           Me     Me     Br   Me     CO.sub.2 Et                                    OCF.sub.3                                                                          Me     Me     CF.sub.3                                                                           Me     CO.sub.2 Et                                    Cl   Me     Et     OCF.sub.3                                                                          Me     CO.sub.2 Et                                    Br   Me     Et     Cl   Me     CH.sub.2 OMe                                   CF.sub.3                                                                           Me     Et     Br   Me     CH.sub.2 OMe                                   OCF.sub.3                                                                          Me     Et     CF.sub.3                                                                           Me     CH.sub.2 OMe                                   Cl   Me     n-Pr   OCF.sub.3                                                                          Me     CH.sub.2 OMe                                   Br   Me     n-Pr   Cl   Me     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Me     n-Pr   Br   Me     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Me     n-Pr   CF.sub.3                                                                           Me     CH.sub.2 CHCH.sub.2                            Cl   Me     COMe   OCF.sub.3                                                                          Me     CH.sub.2 CHCH.sub.2                            Br   Me     COMe   Cl   Me     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Me     COMe   Br   Me     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Me     COMe   CF.sub.3                                                                           Me     CH.sub.2 SCH.sub.3                             Cl   Me     COEt   OCF.sub.3                                                                          Me     CH.sub.2 SCH.sub.3                             Br   Me     COEt   OCF.sub.2 H                                                                        Me     H                                              CF.sub.3                                                                           Me     COEt   OCF.sub.2 H                                                                        Me     Me                                             Cl   Et     H      OCF.sub.3                                                                          Et     COEt                                           Br   Et     H      Cl   Et     CO.sub.2 Me                                    CF.sub.3                                                                           Et     H      Br   Et     CO.sub.2 Me                                    OCF.sub.3                                                                          Et     H      CF.sub.3                                                                           Et     CO.sub.2 Me                                    Cl   Et     Me     OCF.sub.3                                                                          Et     CO.sub.2 Me                                    Br   Et     Me     Cl   Et     CO.sub.2 Et                                    CF.sub.3                                                                           Et     Me     Br   Et     CO.sub.2 Et                                    OCF.sub.3                                                                          Et     Me     CF.sub.3                                                                           Et     CO.sub.2 Et                                    Cl   Et     Et     OCF.sub.3                                                                          Et     CO.sub.2 Et                                    Br   Et     Et     Cl   Et     CH.sub.2 OMe                                   CF.sub.3                                                                           Et     Et     Br   Et     CH.sub.2 OMe                                   OCF.sub.3                                                                          Et     Et     CF.sub.3                                                                           Et     CH.sub.2 OMe                                   Cl   Et     n-Pr   OCF.sub.3                                                                          Et     CH.sub.2 OMe                                   Br   Et     n-Pr   Cl   Et     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Et     n-Pr   Br   Et     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Et     n-Pr   CF.sub.3                                                                           Et     CH.sub.2 CHCH.sub.2                            Cl   Et     COMe   OCF.sub.3                                                                          Et     CH.sub.2 CHCH.sub.2                            Br   Et     COMe   Cl   Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COMe   Br   Et     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Et     COMe   CF.sub.3                                                                           Et     CH.sub.2 SCH.sub.3                             Cl   Et     COEt   OCF.sub.3                                                                          Et     CH.sub.2 SCH.sub.3                             Br   Et     COEt   OCF.sub.2 H                                                                        Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COEt   OCF.sub.2 H                                                                        Me     Et                                             OCF.sub.2 H                                                                        Et     H      OCF.sub.2 H                                                                        Me     n-Pr                                           OCF.sub.2 H                                                                        Et     Me     OCF.sub.2 H                                                                        Me     COMe                                           OCF.sub.2 H                                                                        Et     Et     OCF.sub.2 H                                                                        Me     COEt                                           OCF.sub.2 H                                                                        Et     n-Pr   OCF.sub.2 H                                                                        Me     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Et     COMe   OCF.sub.2 H                                                                        Me     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Et     COEt   OCF.sub.2 H                                                                        Me     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                        Me     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Et     CO.sub.2 Et                                                                          OCF.sub.2 H                                                                        Me     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Et     CH.sub.2 OMe                                                      OCF.sub.2 H                                                                        Et     CH.sub.2 CHCH.sub.2                                               Cl   n-Pr   H      OCF.sub.3                                                                          n-Pr   COEt                                           Br   n-Pr   H      Cl   n-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           n-Pr   H      Br   n-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          n-Pr   H      CF.sub.3                                                                           n-Pr   CO.sub.2 Me                                    Cl   n-Pr   Me     OCF.sub.3                                                                          n-Pr   CO.sub.2 Me                                    Br   n-Pr   Me     Cl   n-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           n-Pr   Me     Br   n-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          n-Pr   Me     CF.sub.3                                                                           n-Pr   CO.sub.2 Et                                    Cl   n-Pr   Et     OCF.sub.3                                                                          n-Pr   CO.sub.2 Et                                    Br   n-Pr   Et     Cl   n-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           n-Pr   Et     Br   n-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          n-Pr   Et     CF.sub.3                                                                           n-Pr   CH.sub.2 OMe                                   Cl   n-Pr   n-Pr   OCF.sub.3                                                                          n-Pr   CH.sub.2 OMe                                   Br   n-Pr   n-Pr   Cl   n-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           n-Pr   n-Pr   Br   n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          n-Pr   n-Pr   CF.sub.3                                                                           n-Pr   CH.sub.2 CHCH.sub.2                            Cl   n-Pr   COMe   OCF.sub.3                                                                          n-Pr   CH.sub.2 CHCH.sub.2                            Br   n-Pr   COMe   Cl   n-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           n-Pr   COMe   Br   n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          n-Pr   COMe   CF.sub.3                                                                           n-Pr   CH.sub.2 SCH.sub.3                             Cl   n-Pr   COEt   OCF.sub.3                                                                          n-Pr   CH.sub.2 SCH.sub.3                             Br   n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   COEt                                           CF.sub.3                                                                           n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        n-Pr   H      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        n-Pr   Me     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        n-Pr   Et     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        n-Pr   n-Pr   OCF.sub.2 H                                                                        n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        n-Pr   COMe                                                              Cl   i-Pr   H      OCF.sub.3                                                                          i-Pr   COEt                                           Br   i-Pr   H      Cl   i-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           i-Pr   H      Br   i-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Pr   H      CF.sub.3                                                                           i-Pr   CO.sub.2 Me                                    Cl   i-Pr   Me     OCF.sub.3                                                                          i-Pr   CO.sub.2 Me                                    Br   i-Pr   Me     Cl   i-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           i-Pr   Me     Br   i-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Pr   Me     CF.sub.3                                                                           i-Pr   CO.sub.2 Et                                    Cl   i-Pr   Et     OCF.sub.3                                                                          i-Pr   CO.sub.2 Et                                    Br   i-Pr   Et     Cl   i-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Pr   Et     Br   i-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Pr   Et     CF.sub.3                                                                           i-Pr   CH.sub.2 OMe                                   Cl   i-Pr   n-Pr   OCF.sub.3                                                                          i-Pr   CH.sub.2 OMe                                   Br   i-Pr   n-Pr   Cl   i-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Pr   n-Pr   Br   i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Pr   n-Pr   CF.sub.3                                                                           i-Pr   CH.sub.2 CHCH.sub.2                            Cl   i-Pr   COMe   OCF.sub.3                                                                          i-Pr   CH.sub.2 CHCH.sub.2                            Br   i-Pr   COMe   Cl   i-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Pr   COMe   Br   i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Pr   COMe   CF.sub.3                                                                           i-Pr   CH.sub.2 SCH.sub.3                             Cl   i-Pr   COEt   OCF.sub.3                                                                          i-Pr   CH.sub.2 SCH.sub.3                             Br   i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   COEt                                           CF.sub.3                                                                           i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Pr   H      OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Pr   Me     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        i-Pr   Et     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Pr   n-Pr   OCF.sub.2 H                                                                        i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Pr   COMe                                                              Cl   i-Bu   H      OCF.sub.3                                                                          i-Bu   COEt                                           Br   i-Bu   H      Cl   i-Bu   CO.sub.2 Me                                    CF.sub.3                                                                           i-Bu   H      Br   i-Bu   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Bu   H      CF.sub.3                                                                           i-Bu   CO.sub.2 Me                                    Cl   i-Bu   Me     OCF.sub.3                                                                          i-Bu   CO.sub.2 Me                                    Br   i-Bu   Me     Cl   i-Bu   CO.sub.2 Et                                    CF.sub.3                                                                           i-Bu   Me     Br   i-Bu   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Bu   Me     CF.sub.3                                                                           i-Bu   CO.sub.2 Et                                    Cl   i-Bu   Et     OCF.sub.3                                                                          i-Bu   CO.sub.2 Et                                    Br   i-Bu   Et     Cl   i-Bu   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Bu   Et     Br   i-Bu   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Bu   Et     CF.sub.3                                                                           i-Bu   CH.sub.2 OMe                                   Cl   i-Bu   n-Pr   OCF.sub.3                                                                          i-Bu   CH.sub.2 OMe                                   Br   i-Bu   n-Pr   Cl   i-Bu   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Bu   n-Pr   Br   i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Bu   n-Pr   CF.sub.3                                                                           i-Bu   CH.sub.2 CHCH.sub.2                            Cl   i-Bu   COMe   OCF.sub.3                                                                          i-Bu   CH.sub.2 CHCH.sub.2                            Br   i-Bu   COMe   Cl   i-Bu   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Bu   COMe   Br   i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Bu   COMe   CF.sub.3                                                                           i-Bu   CH.sub.2 SCH.sub.3                             Cl   i-Bu   COEt   OCF.sub.3                                                                          i-Bu   CH.sub.2 SCH.sub.3                             Br   i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   COEt                                           CF.sub.3                                                                           i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Bu   H      OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Bu   Me     OCF.sub.2 H                                                                        i-Bu   CH.sub. 2 OMe                                  OCF.sub.2 H                                                                        i-Bu   Et     OCF.sub.2 H                                                                        i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Bu   n-Pr   OCF.sub.2 H                                                                        i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Bu   COMe                                                              Cl   CO.sub.2 Me                                                                          H      OCF.sub.3                                                                          CO.sub.2 Me                                                                          COEt                                           Br   CO.sub.2 Me                                                                          H      Cl   CO.sub.2 Me                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          H      Br   CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          H      CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Me                                                                          Me     Cl   CO.sub.2 Me                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          Me     Br   CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          Me     CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Me                                                                          Et     Cl   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Me                                                                          Et     Br   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Me                                                                          Et     CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Me                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Br   CO.sub.2 Me                                                                          n-Pr   Cl   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Me                                                                          n-Pr   Br   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Me                                                                          COMe   Cl   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Me                                                                          COMe   Br   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COMe                                                              Cl   CO.sub.2 Et                                                                          H      OCF.sub.3                                                                          CO.sub.2 Et                                                                          COEt                                           Br   CO.sub.2 Et                                                                          H      Cl   CO.sub.2 Et                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          H      Br   CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          H      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Et                                                                          Me     Cl   CO.sub.2 Et                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          Me     Br   CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          Me     CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Et                                                                          Et     Cl   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Et                                                                          Et     Br   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Et                                                                          Et     CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Br   CO.sub.2 Et                                                                          n-Pr   Cl   CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Et                                                                          n-Pr   Br   CO.sub. 2 Et                                                                         CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Et                                                                          COMe   Cl   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Et                                                                          COMe   Br   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COMe                                                              Cl   Ph     H      OCF.sub.3                                                                          Ph     COEt                                           Br   Ph     H      Cl   Ph     CO.sub.2 Me                                    CF.sub.3                                                                           Ph     H      Br   Ph     CO.sub.2 Me                                    OCF.sub.3                                                                          Ph     H      CF.sub.3                                                                           Ph     CO.sub.2 Me                                    Cl   Ph     Me     OCF.sub.3                                                                          Ph     CO.sub.2 Me                                    Br   Ph     Me     Cl   Ph     CO.sub.2 Et                                    CF.sub.3                                                                           Ph     Me     Br   Ph     CO.sub.2 Et                                    OCF.sub.3                                                                          Ph     Me     CF.sub.3                                                                           Ph     CO.sub.2 Et                                    Cl   Ph     Et     OCF.sub.3                                                                          Ph     CO.sub.2 Et                                    Br   Ph     Et     Cl   Ph     CH.sub.2 OMe                                   CF.sub.3                                                                           Ph     Et     Br   Ph     CH.sub.2 OMe                                   OCF.sub.3                                                                          Ph     Et     CF.sub.3                                                                           Ph     CH.sub.2 OMe                                   Cl   Ph     n-Pr   OCF.sub.3                                                                          Ph     CH.sub.2 OMe                                   Br   Ph     n-Pr   Cl   Ph     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Ph     n-Pr   Br   Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Ph     n-Pr   CF.sub.3                                                                           Ph     CH.sub.2 CHCH.sub.2                            Cl   Ph     COMe   OCF.sub.3                                                                          Ph     CH.sub.2 CHCH.sub.2                            Br   Ph     COMe   Cl   Ph     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Ph     COMe   Br   Ph     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Ph     COMe   CF.sub.3                                                                           Ph     CH.sub.2 SCH.sub.3                             Cl   Ph     COEt   OCF.sub.3                                                                          Ph     CH.sub.2 SCH.sub.3                             Br   Ph     COEt   OCF.sub.2 H                                                                        Ph     COEt                                           CF.sub.3                                                                           Ph     COEt   OCF.sub.2 H                                                                        Ph     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Ph     H      OCF.sub.2 H                                                                        Ph     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Ph     Me     OCF.sub.2 H                                                                        Ph     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Ph     Et     OCF.sub.2 H                                                                        Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Ph     n-Pr   OCF.sub.2 H                                                                        Ph     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Ph     COMe                                                              Cl   4-ClPh H      OCF.sub.3                                                                          4-ClPh COEt                                           Br   4-ClPh H      Cl   4-ClPh CO.sub.2 Me                                    CF.sub.3                                                                           4-ClPh H      Br   4-ClPh CO.sub.2 Me                                    OCF.sub.3                                                                          4-ClPh H      CF.sub.3                                                                           4-ClPh CO.sub.2 Me                                    Cl   4-ClPh Me     OCF.sub.3                                                                          4-ClPh CO.sub.2 Me                                    Br   4-ClPh Me     Cl   4-ClPh CO.sub.2 Et                                    CF.sub.3                                                                           4-ClPh Me     Br   4-ClPh CO.sub.2 Et                                    OCF.sub.3                                                                          4-ClPh Me     CF.sub.3                                                                           4-ClPh CO.sub.2 Et                                    Cl   4-ClPh Et     OCF.sub.3                                                                          4-ClPh CO.sub.2 Et                                    Br   4-ClPh Et     Cl   4-ClPh CH.sub.2 OMe                                   CF.sub.3                                                                           4-ClPh Et     Br   4-ClPh CH.sub.2 OMe                                   OCF.sub.3                                                                          4-ClPh Et     CF.sub.3                                                                           4-ClPh CH.sub.2 OMe                                   Cl   4-ClPh n-Pr   OCF.sub.3                                                                          4-ClPh CH.sub.2 OMe                                   Br   4-ClPh n-Pr   Cl   4-ClPh CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-ClPh n-Pr   Br   4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-ClPh n-Pr   CF.sub.3                                                                           4-ClPh CH.sub.2 CHCH.sub.2                            Cl   4-ClPh COMe   OCF.sub.3                                                                          4-ClPh CH.sub.2 CHCH.sub.2                            Br   4-ClPh COMe   Cl   4-ClPh CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-ClPh COMe   Br   4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-ClPh COMe   CF.sub.3                                                                           4-ClPh CH.sub.2 SCH.sub.3                             Cl   4-ClPh COEt   OCF.sub.3                                                                          4-ClPh CH.sub.2 SCH.sub.3                             Br   4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh COEt                                           CF.sub.3                                                                           4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-ClPh H      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-ClPh Me     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-ClPh Et     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-ClPh n-Pr   OCF.sub.2 H                                                                        4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-ClPh COMe                                                              Cl   4-FPh  H      OCF.sub.3                                                                          4-FPh  COEt                                           Br   4-FPh  H      Cl   4-FPh  CO.sub.2 Me                                    CF.sub.3                                                                           4-FPh  H      Br   4-FPh  CO.sub.2 Me                                    OCF.sub.3                                                                          4-FPh  H      CF.sub.3                                                                           4-FPh  CO.sub.2 Me                                    Cl   4-FPh  Me     OCF.sub.3                                                                          4-FPh  CO.sub.2 Me                                    Br   4-FPh  Me     Cl   4-FPh  CO.sub.2 Et                                    CF.sub.3                                                                           4-FPh  Me     Br   4-FPh  CO.sub.2 Et                                    OCF.sub.3                                                                          4-FPh  Me     CF.sub.3                                                                           4-FPh  CO.sub.2 Et                                    Cl   4-FPh  Et     OCF.sub.3                                                                          4-FPh  CO.sub.2 Et                                    Br   4-FPh  Et     Cl   4-FPh  CH.sub.2 OMe                                   CF.sub.3                                                                           4-FPh  Et     Br   4-FPh  CH.sub.2 OMe                                   OCF.sub.3                                                                          4-FPh  Et     CF.sub.3                                                                           4-FPh  CH.sub.2 OMe                                   Cl   4-FPh  n-Pr   OCF.sub.3                                                                          4-FPh  CH.sub.2 OMe                                   Br   4-FPh  n-Pr   Cl   4-FPh  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-FPh  n-Pr   Br   4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-FPh  n-Pr   CF.sub.3                                                                           4-FPh  CH.sub.2 CHCH.sub.2                            Cl   4-FPh  COMe   OCF.sub.3                                                                          4-FPh  CH.sub.2 CHCH.sub.2                            Br   4-FPh  COMe   Cl   4-FPh  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-FPh  COMe   Br   4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-FPh  COMe   CF.sub.3                                                                           4-FPh  CH.sub.2 SCH.sub.3                             Cl   4-FPh  COEt   OCF.sub.3                                                                          4-FPh  CH.sub.2 SCH.sub.3                             Br   4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  COEt                                           CF.sub.3                                                                           4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-FPh  H      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-FPh  Me     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-FPh  Et     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-FPh  n-Pr   OCF.sub.2 H                                                                        4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-FPh  COMe                                                              Cl   CHCH.sub.2                                                                           H      OCF.sub.3                                                                          CHCH.sub.2                                                                           COEt                                           Br   CHCH.sub.2                                                                           H      Cl   CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                           CHCH.sub.2                                                                           H      Br   CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           H      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                    Cl   CHCH.sub.2                                                                           Me     OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                    Br   CHCH.sub.2                                                                           Me     Cl   CHCH.sub.2                                                                           CO.sub.2 Et                                    CF.sub.3                                                                           CHCH.sub.2                                                                           Me     Br   CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           Me     CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Et                                    Cl   CHCH.sub.2                                                                           Et     OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 Et                                    Br   CHCH.sub.2                                                                           Et     Cl   CHCH.sub.2                                                                           CH.sub.2 OMe                                   CF.sub.3                                                                           CHCH.sub.2                                                                           Et     Br   CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.3                                                                          CHCH.sub.2                                                                           Et     CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 OMe                                   Cl   CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 OMe                                   Br   CHCH.sub.2                                                                           n-Pr   Cl   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CHCH.sub.2                                                                           n-Pr   Br   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Cl   CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Br   CHCH.sub.2                                                                           COMe   Cl   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CHCH.sub.2                                                                           COMe   Br   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CHCH.sub.2                                                                           COMe   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Cl   CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Br   CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COEt                                           CF.sub.3                                                                           CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CHCH.sub. 2                                                                          Et     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COMe                                                              Cl   C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                           Br   C(CH.sub.3)CH.sub.2                                                                  H      Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  H      Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Br   C(CH.sub.3)CH.sub.2                                                                  Me     Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Me     Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Br   C(CH.sub.3)CH.sub.2                                                                  Et     Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Et     Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Cl   C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Br   C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Cl   C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Br   C(CH.sub.3)CH.sub.2                                                                  COMe   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COMe   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Cl   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Br   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COEt                                           CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub. 2 Et                                   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COMe                                                              CF.sub.3                                                                           Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Me     CO(n-Pr)                                                                             CF.sub.3                                                                           n-Pr   CO(n-Pr)                                       CF.sub.3                                                                           Me     CO(i-Pr)                                                                             CF.sub.3                                                                           n-Pr   CO(i-Pr)                                       CF.sub.3                                                                           Me     CO(t-Bu)                                                                             CF.sub.3                                                                           n-Pr   CO(t-Bu)                                       CF.sub.3                                                                           Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Me     CO(n-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Me     CO(i-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Me     CO(t-Bu)                                                                             OCF.sub.3                                                                          n-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (t-Bu)                                CF.sub.3                                                                           Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Et     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Et     CO(n-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(n-Pr)                                       CF.sub.3                                                                           Et     CO(i-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(i-Pr)                                       CF.sub.3                                                                           Et     CO(t-Bu)                                                                             CF.sub.3                                                                           i-Pr   CO(t-Bu)                                       CF.sub.3                                                                           Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Et     CO(n-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Et     CO(i-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Et     CO(t-Bu)                                                                             OCF.sub.3                                                                          i-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(i-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(t-Bu)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(n-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(i-Pr)                                       OCF.sub.2 H                                                                        Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub. 2 (i-Pr)                               CF.sub.3                                                                           i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                CF.sub.3                                                                           i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                CF.sub.3                                                                           i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(n-Pr)                                       CF.sub.3                                                                           i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(i-Pr)                                       CF.sub.3                                                                           i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(t-Bu)                                       CF.sub.3                                                                           i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                       OCF.sub.3                                                                          i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (n-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (i-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                           Ph     CO(n-Pr)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                           Ph     CO(i-Pr)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                           Ph     CO(t-Bu)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(n-Pr)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(i-Pr)                                       OCF.sub.3                                                                          CO.sub.2 He                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                          Ph     CO(t-Bu)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(i-Pr)                                       OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(t-Bu)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub. 2 (n-Pr)                               CF.sub.3                                                                           4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(n-Pr)                                       CF.sub.3                                                                           4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(i-Pr)                                       CF.sub.3                                                                           4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(t-Bu)                                       CF.sub.3                                                                           4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(n-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(i-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(t-Bu)                                       OCF.sub.3                                                                          4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                           4-FPh  CO(i-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub. 2                                                                 CO(i-Pr)                                       CF.sub.3                                                                           4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       CF.sub.3                                                                           4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.3                                                                          4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-ClPh CO(t-Bu)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(n-Pr)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(i-Pr)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub. 2 (i-Pr)                               OCF.sub.2 H                                                                        4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(t-Bu)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (t-Bu)                                __________________________________________________________________________

                                      TABLE 3                                     __________________________________________________________________________     ##STR40##                                                                    R.sup.1                                                                            R.sup.3                                                                              Y      R.sup.1                                                                            R.sup.3                                                                              Y                                              __________________________________________________________________________    Cl   Me     H      OCF.sub.3                                                                          Me     COEt                                           Br   Me     H      Cl   Me     CO.sub.2 Me                                    CF.sub.3                                                                           Me     H      Br   Me     CO.sub.2 Me                                    OCF.sub.3                                                                          Me     H      CF.sub.3                                                                           Me     CO.sub.2 Me                                    Cl   Me     Me     OCF.sub.3                                                                          Me     CO.sub.2 Me                                    Br   Me     Me     Cl   Me     CO.sub.2 Et                                    CF.sub.3                                                                           Me     Me     Br   Me     CO.sub.2 Et                                    OCF.sub.3                                                                          Me     Me     CF.sub.3                                                                           Me     CO.sub.2 Et                                    Cl   Me     Et     OCF.sub.3                                                                          Me     CO.sub.2 Et                                    Br   Me     Et     Cl   Me     CH.sub.2 OMe                                   CF.sub.3                                                                           Me     Et     Br   Me     CH.sub.2 OMe                                   OCF.sub.3                                                                          Me     Et     CF.sub.3                                                                           Me     CH.sub.2 OMe                                   Cl   Me     n-Pr   OCF.sub.3                                                                          Me     CH.sub.2 OMe                                   Br   Me     n-Pr   Cl   Me     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Me     n-Pr   Br   Me     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Me     n-Pr   CF.sub.3                                                                           Me     CH.sub.2 CHCH.sub.2                            Cl   Me     COMe   OCF.sub.3                                                                          Me     CH.sub.2 CHCH.sub.2                            Br   Me     COMe   Cl   Me     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Me     COMe   Br   Me     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Me     COMe   CF.sub.3                                                                           Me     CH.sub.2 SCH.sub.3                             Cl   Me     COEt   OCF.sub.3                                                                          Me     CH.sub.2 SCH.sub.3                             Br   Me     COEt   OCF.sub.2 H                                                                        Me     H                                              CF.sub.3                                                                           Me     COEt   OCF.sub.2 H                                                                        Me     Me                                             Cl   Et     H      OCF.sub.3                                                                          Et     COEt                                           Br   Et     H      Cl   Et     CO.sub.2 Me                                    CF.sub.3                                                                           Et     H      Br   Et     CO.sub.2 Me                                    OCF.sub.3                                                                          Et     H      CF.sub.3                                                                           Et     CO.sub.2 Me                                    Cl   Et     Me     OCF.sub.3                                                                          Et     CO.sub.2 Me                                    Br   Et     Me     Cl   Et     CO.sub.2 Et                                    CF.sub.3                                                                           Et     Me     Br   Et     CO.sub.2 Et                                    OCF.sub.3                                                                          Et     Me     CF.sub.3                                                                           Et     CO.sub.2 Et                                    Cl   Et     Et     OCF.sub.3                                                                          Et     CO.sub.2 Et                                    Br   Et     Et     Cl   Et     CH.sub.2 OMe                                   CF.sub.3                                                                           Et     Et     Br   Et     CH.sub.2 OMe                                   OCF.sub.3                                                                          Et     Et     CF.sub.3                                                                           Et     CH.sub.2 OMe                                   Cl   Et     n-Pr   OCF.sub.3                                                                          Et     CH.sub.2 OMe                                   Br   Et     n-Pr   Cl   Et     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Et     n-Pr   Br   Et     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Et     n-Pr   CF.sub.3                                                                           Et     CH.sub.2 CHCH.sub.2                            Cl   Et     COMe   OCF.sub.3                                                                          Et     CH.sub.2 CHCH.sub.2                            Br   Et     COMe   Cl   Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COMe   Br   Et     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Et     COMe   CF.sub.3                                                                           Et     CH.sub.2 SCH.sub.3                             Cl   Et     COEt   OCF.sub.3                                                                          Et     CH.sub.2 SCH.sub.3                             Br   Et     COEt   OCF.sub.2 H                                                                        Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COEt   OCF.sub.2 H                                                                        Me     Et                                             OCF.sub.2 H                                                                        Et     H      OCF.sub.2 H                                                                        Me     n-Pr                                           OCF.sub.2 H                                                                        Et     Me     OCF.sub.2 H                                                                        Me     COMe                                           OCF.sub.2 H                                                                        Et     Et     OCF.sub.2 H                                                                        Me     COEt                                           OCF.sub.2 H                                                                        Et     n-Pr   OCF.sub.2 H                                                                        Me     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Et     COMe   OCF.sub.2 H                                                                        Me     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Et     COEt   OCF.sub.2 H                                                                        Me     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                        Me     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Et     CO.sub.2 Et                                                                          OCF.sub.2 H                                                                        Me     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Et     CH.sub.2 OMe                                                      OCF.sub.2 H                                                                        Et     CH.sub.2 CHCH.sub.2                                               Cl   n-Pr   H      OCF.sub.3                                                                          n-Pr   COEt                                           Br   n-Pr   H      Cl   n-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           n-Pr   H      Br   n-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          n-Pr   H      CF.sub.3                                                                           n-Pr   CO.sub.2 Me                                    Cl   n-Pr   Me     OCF.sub.3                                                                          n-Pr   CO.sub.2 Me                                    Br   n-Pr   Me     Cl   n-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           n-Pr   Me     Br   n-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          n-Pr   Me     CF.sub.3                                                                           n-Pr   CO.sub.2 Et                                    Cl   n-Pr   Et     OCF.sub.3                                                                          n-Pr   CO.sub.2 Et                                    Br   n-Pr   Et     Cl   n-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           n-Pr   Et     Br   n-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          n-Pr   Et     CF.sub.3                                                                           n-Pr   CH.sub.2 OMe                                   Cl   n-Pr   n-Pr   OCF.sub.3                                                                          n-Pr   CH.sub.2 OMe                                   Br   n-Pr   n-Pr   Cl   n-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           n-Pr   n-Pr   Br   n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          n-Pr   n-Pr   CF.sub.3                                                                           n-Pr   CH.sub.2 CHCH.sub.2                            Cl   n-Pr   COMe   OCF.sub.3                                                                          n-Pr   CH.sub.2 CHCH.sub.2                            Br   n-Pr   COMe   Cl   n-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           n-Pr   COMe   Br   n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          n-Pr   COMe   CF.sub.3                                                                           n-Pr   CH.sub.2 SCH.sub.3                             Cl   n-Pr   COEt   OCF.sub.3                                                                          n-Pr   CH.sub.2 SCH.sub.3                             Br   n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   COEt                                           CF.sub.3                                                                           n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        n-Pr   H      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        n-Pr   Me     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        n-Pr   Et     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        n-Pr   n-Pr   OCF.sub.2 H                                                                        n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        n-Pr   COMe                                                              Cl   i-Pr   H      OCF.sub.3                                                                          i-Pr   COEt                                           Br   i-Pr   H      Cl   i-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           i-Pr   H      Br   i-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Pr   H      CF.sub.3                                                                           i-Pr   CO.sub.2 Me                                    Cl   i-Pr   Me     OCF.sub.3                                                                          i-Pr   CO.sub.2 Me                                    Br   i-Pr   Me     Cl   i-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           i-Pr   Me     Br   i-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Pr   Me     CF.sub.3                                                                           i-Pr   CO.sub.2 Et                                    Cl   i-Pr   Et     OCF.sub.3                                                                          i-Pr   CO.sub.2 Et                                    Br   i-Pr   Et     Cl   i-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Pr   Et     Br   i-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Pr   Et     CF.sub.3                                                                           i-Pr   CH.sub.2 OMe                                   Cl   i-Pr   n-Pr   OCF.sub.3                                                                          i-Pr   CH.sub.2 OMe                                   Br   i-Pr   n-Pr   Cl   i-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Pr   n-Pr   Br   i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Pr   n-Pr   CF.sub.3                                                                           i-Pr   CH.sub.2 CHCH.sub.2                            Cl   i-Pr   COMe   OCF.sub.3                                                                          i-Pr   CH.sub.2 CHCH.sub.2                            Br   i-Pr   COMe   Cl   i-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Pr   COMe   Br   i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Pr   COMe   CF.sub.3                                                                           i-Pr   CH.sub.2 SCH.sub.3                             Cl   i-Pr   COEt   OCF.sub.3                                                                          i-Pr   CH.sub.2 SCH.sub.3                             Br   i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   COEt                                           CF.sub.3                                                                           i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Pr   H      OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Pr   Me     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        i-Pr   Et     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Pr   n-Pr   OCF.sub.2 H                                                                        i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Pr   COMe                                                              Cl   i-Bu   H      OCF.sub.3                                                                          i-Bu   COEt                                           Br   i-Bu   H      Cl   i-Bu   CO.sub.2 Me                                    CF.sub.3                                                                           i-Bu   H      Br   i-Bu   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Bu   H      CF.sub.3                                                                           i-Bu   CO.sub.2 Me                                    Cl   i-Bu   Me     OCF.sub.3                                                                          i-Bu   CO.sub.2 Me                                    Br   i-Bu   Me     Cl   i-Bu   CO.sub.2 Et                                    CF.sub.3                                                                           i-Bu   Me     Br   i-Bu   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Bu   Me     CF.sub.3                                                                           i-Bu   CO.sub.2 Et                                    Cl   i-Bu   Et     OCF.sub.3                                                                          i-Bu   CO.sub.2 Et                                    Br   i-Bu   Et     Cl   i-Bu   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Bu   Et     Br   i-Bu   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Bu   Et     CF.sub.3                                                                           i-Bu   CH.sub.2 OMe                                   Cl   i-Bu   n-Pr   OCF.sub.3                                                                          i-Bu   CH.sub.2 OMe                                   Br   i-Bu   n-Pr   Cl   i-Bu   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Bu   n-Pr   Br   i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Bu   n-Pr   CF.sub.3                                                                           i-Bu   CH.sub.2 CHCH.sub.2                            Cl   i-Bu   COMe   OCF.sub.3                                                                          i-Bu   CH.sub.2 CHCH.sub.2                            Br   i-Bu   COMe   Cl   i-Bu   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Bu   COMe   Br   i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Bu   COMe   CF.sub.3                                                                           i-Bu   CH.sub.2 SCH.sub.3                             Cl   i-Bu   COEt   OCF.sub.3                                                                          i-Bu   CH.sub.2 SCH.sub.3                             Br   i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   COEt                                           CF.sub.3                                                                           i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Bu   H      OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Bu   Me     OCF.sub.2 H                                                                        i-Bu   CH.sub. 2 OMe                                  OCF.sub.2 H                                                                        i-Bu   Et     OCF.sub.2 H                                                                        i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Bu   n-Pr   OCF.sub.2 H                                                                        i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Bu   COMe                                                              Cl   CO.sub.2 Me                                                                          H      OCF.sub.3                                                                          CO.sub.2 Me                                                                          COEt                                           Br   CO.sub.2 Me                                                                          H      Cl   CO.sub.2 Me                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          H      Br   CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          H      CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Me                                                                          Me     Cl   CO.sub.2 Me                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          Me     Br   CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          Me     CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Me                                                                          Et     Cl   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Me                                                                          Et     Br   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Me                                                                          Et     CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Me                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Br   CO.sub.2 Me                                                                          n-Pr   Cl   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Me                                                                          n-Pr   Br   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Me                                                                          COMe   Cl   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Me                                                                          COMe   Br   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COMe                                                              Cl   CO.sub.2 Et                                                                          H      OCF.sub.3                                                                          CO.sub.2 Et                                                                          COEt                                           Br   CO.sub.2 Et                                                                          H      Cl   CO.sub.2 Et                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          H      Br   CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          H      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Et                                                                          Me     Cl   CO.sub.2 Et                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          Me     Br   CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          Me     CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Et                                                                          Et     Cl   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Et                                                                          Et     Br   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Et                                                                          Et     CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Br   CO.sub.2 Et                                                                          n-Pr   Cl   CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Et                                                                          n-Pr   Br   CO.sub. 2 Et                                                                         CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Et                                                                          COMe   Cl   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Et                                                                          COMe   Br   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COMe                                                              Cl   Ph     H      OCF.sub.3                                                                          Ph     COEt                                           Br   Ph     H      Cl   Ph     CO.sub.2 Me                                    CF.sub.3                                                                           Ph     H      Br   Ph     CO.sub.2 Me                                    OCF.sub.3                                                                          Ph     H      CF.sub.3                                                                           Ph     CO.sub.2 Me                                    Cl   Ph     Me     OCF.sub.3                                                                          Ph     CO.sub.2 Me                                    Br   Ph     Me     Cl   Ph     CO.sub.2 Et                                    CF.sub.3                                                                           Ph     Me     Br   Ph     CO.sub.2 Et                                    OCF.sub.3                                                                          Ph     Me     CF.sub.3                                                                           Ph     CO.sub.2 Et                                    Cl   Ph     Et     OCF.sub.3                                                                          Ph     CO.sub.2 Et                                    Br   Ph     Et     Cl   Ph     CH.sub.2 OMe                                   CF.sub.3                                                                           Ph     Et     Br   Ph     CH.sub.2 OMe                                   OCF.sub.3                                                                          Ph     Et     CF.sub.3                                                                           Ph     CH.sub.2 OMe                                   Cl   Ph     n-Pr   OCF.sub.3                                                                          Ph     CH.sub.2 OMe                                   Br   Ph     n-Pr   Cl   Ph     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Ph     n-Pr   Br   Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Ph     n-Pr   CF.sub.3                                                                           Ph     CH.sub.2 CHCH.sub.2                            Cl   Ph     COMe   OCF.sub.3                                                                          Ph     CH.sub.2 CHCH.sub.2                            Br   Ph     COMe   Cl   Ph     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Ph     COMe   Br   Ph     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Ph     COMe   CF.sub.3                                                                           Ph     CH.sub.2 SCH.sub.3                             Cl   Ph     COEt   OCF.sub.3                                                                          Ph     CH.sub.2 SCH.sub.3                             Br   Ph     COEt   OCF.sub.2 H                                                                        Ph     COEt                                           CF.sub.3                                                                           Ph     COEt   OCF.sub.2 H                                                                        Ph     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Ph     H      OCF.sub.2 H                                                                        Ph     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Ph     Me     OCF.sub.2 H                                                                        Ph     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Ph     Et     OCF.sub.2 H                                                                        Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Ph     n-Pr   OCF.sub.2 H                                                                        Ph     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Ph     COMe                                                              Cl   4-ClPh H      OCF.sub.3                                                                          4-ClPh COEt                                           Br   4-ClPh H      Cl   4-ClPh CO.sub.2 Me                                    CF.sub.3                                                                           4-ClPh H      Br   4-ClPh CO.sub.2 Me                                    OCF.sub.3                                                                          4-ClPh H      CF.sub.3                                                                           4-ClPh CO.sub.2 Me                                    Cl   4-ClPh Me     OCF.sub.3                                                                          4-ClPh CO.sub.2 Me                                    Br   4-ClPh Me     Cl   4-ClPh CO.sub.2 Et                                    CF.sub.3                                                                           4-ClPh Me     Br   4-ClPh CO.sub.2 Et                                    OCF.sub.3                                                                          4-ClPh Me     CF.sub.3                                                                           4-ClPh CO.sub.2 Et                                    Cl   4-ClPh Et     OCF.sub.3                                                                          4-ClPh CO.sub.2 Et                                    Br   4-ClPh Et     Cl   4-ClPh CH.sub.2 OMe                                   CF.sub.3                                                                           4-ClPh Et     Br   4-ClPh CH.sub.2 OMe                                   OCF.sub.3                                                                          4-ClPh Et     CF.sub.3                                                                           4-ClPh CH.sub.2 OMe                                   Cl   4-ClPh n-Pr   OCF.sub.3                                                                          4-ClPh CH.sub.2 OMe                                   Br   4-ClPh n-Pr   Cl   4-ClPh CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-ClPh n-Pr   Br   4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-ClPh n-Pr   CF.sub.3                                                                           4-ClPh CH.sub.2 CHCH.sub.2                            Cl   4-ClPh COMe   OCF.sub.3                                                                          4-ClPh CH.sub.2 CHCH.sub.2                            Br   4-ClPh COMe   Cl   4-ClPh CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-ClPh COMe   Br   4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-ClPh COMe   CF.sub.3                                                                           4-ClPh CH.sub.2 SCH.sub.3                             Cl   4-ClPh COEt   OCF.sub.3                                                                          4-ClPh CH.sub.2 SCH.sub.3                             Br   4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh COEt                                           CF.sub.3                                                                           4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-ClPh H      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-ClPh Me     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-ClPh Et     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-ClPh n-Pr   OCF.sub.2 H                                                                        4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-ClPh COMe                                                              Cl   4-FPh  H      OCF.sub.3                                                                          4-FPh  COEt                                           Br   4-FPh  H      Cl   4-FPh  CO.sub.2 Me                                    CF.sub.3                                                                           4-FPh  H      Br   4-FPh  CO.sub.2 Me                                    OCF.sub.3                                                                          4-FPh  H      CF.sub.3                                                                           4-FPh  CO.sub.2 Me                                    Cl   4-FPh  Me     OCF.sub.3                                                                          4-FPh  CO.sub.2 Me                                    Br   4-FPh  Me     Cl   4-FPh  CO.sub.2 Et                                    CF.sub.3                                                                           4-FPh  Me     Br   4-FPh  CO.sub.2 Et                                    OCF.sub.3                                                                          4-FPh  Me     CF.sub.3                                                                           4-FPh  CO.sub.2 Et                                    Cl   4-FPh  Et     OCF.sub.3                                                                          4-FPh  CO.sub.2 Et                                    Br   4-FPh  Et     Cl   4-FPh  CH.sub.2 OMe                                   CF.sub.3                                                                           4-FPh  Et     Br   4-FPh  CH.sub.2 OMe                                   OCF.sub.3                                                                          4-FPh  Et     CF.sub.3                                                                           4-FPh  CH.sub.2 OMe                                   Cl   4-FPh  n-Pr   OCF.sub.3                                                                          4-FPh  CH.sub.2 OMe                                   Br   4-FPh  n-Pr   Cl   4-FPh  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-FPh  n-Pr   Br   4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-FPh  n-Pr   CF.sub.3                                                                           4-FPh  CH.sub.2 CHCH.sub.2                            Cl   4-FPh  COMe   OCF.sub.3                                                                          4-FPh  CH.sub.2 CHCH.sub.2                            Br   4-FPh  COMe   Cl   4-FPh  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-FPh  COMe   Br   4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-FPh  COMe   CF.sub.3                                                                           4-FPh  CH.sub.2 SCH.sub.3                             Cl   4-FPh  COEt   OCF.sub.3                                                                          4-FPh  CH.sub.2 SCH.sub.3                             Br   4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  COEt                                           CF.sub.3                                                                           4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-FPh  H      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-FPh  Me     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-FPh  Et     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-FPh  n-Pr   OCF.sub.2 H                                                                        4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-FPh  COMe                                                              Cl   CHCH.sub.2                                                                           H      OCF.sub.3                                                                          CHCH.sub.2                                                                           COEt                                           Br   CHCH.sub.2                                                                           H      Cl   CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                           CHCH.sub.2                                                                           H      Br   CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           H      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                    Cl   CHCH.sub.2                                                                           Me     OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                    Br   CHCH.sub.2                                                                           Me     Cl   CHCH.sub.2                                                                           CO.sub.2 Et                                    CF.sub.3                                                                           CHCH.sub.2                                                                           Me     Br   CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           Me     CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Et                                    Cl   CHCH.sub.2                                                                           Et     OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 Et                                    Br   CHCH.sub.2                                                                           Et     Cl   CHCH.sub.2                                                                           CH.sub.2 OMe                                   CF.sub.3                                                                           CHCH.sub.2                                                                           Et     Br   CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.3                                                                          CHCH.sub.2                                                                           Et     CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 OMe                                   Cl   CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 OMe                                   Br   CHCH.sub.2                                                                           n-Pr   Cl   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CHCH.sub.2                                                                           n-Pr   Br   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Cl   CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Br   CHCH.sub.2                                                                           COMe   Cl   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CHCH.sub.2                                                                           COMe   Br   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CHCH.sub.2                                                                           COMe   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Cl   CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Br   CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COEt                                           CF.sub.3                                                                           CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CHCH.sub. 2                                                                          Et     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COMe                                                              Cl   C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                           Br   C(CH.sub.3)CH.sub.2                                                                  H      Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  H      Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Br   C(CH.sub.3)CH.sub.2                                                                  Me     Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Me     Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Br   C(CH.sub.3)CH.sub.2                                                                  Et     Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Et     Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Cl   C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Br   C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Cl   C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Br   C(CH.sub.3)CH.sub.2                                                                  COMe   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COMe   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Cl   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Br   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COEt                                           CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub. 2 Et                                   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COMe                                                              CF.sub.3                                                                           Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Me     CO(n-Pr)                                                                             CF.sub.3                                                                           n-Pr   CO(n-Pr)                                       CF.sub.3                                                                           Me     CO(i-Pr)                                                                             CF.sub.3                                                                           n-Pr   CO(i-Pr)                                       CF.sub.3                                                                           Me     CO(t-Bu)                                                                             CF.sub.3                                                                           n-Pr   CO(t-Bu)                                       CF.sub.3                                                                           Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Me     CO(n-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Me     CO(i-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Me     CO(t-Bu)                                                                             OCF.sub.3                                                                          n-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (t-Bu)                                CF.sub.3                                                                           Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Et     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Et     CO(n-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(n-Pr)                                       CF.sub.3                                                                           Et     CO(i-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(i-Pr)                                       CF.sub.3                                                                           Et     CO(t-Bu)                                                                             CF.sub.3                                                                           i-Pr   CO(t-Bu)                                       CF.sub.3                                                                           Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Et     CO(n-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Et     CO(i-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Et     CO(t-Bu)                                                                             OCF.sub.3                                                                          i-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(i-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(t-Bu)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(n-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(i-Pr)                                       OCF.sub.2 H                                                                        Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub. 2 (i-Pr)                               CF.sub.3                                                                           i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                CF.sub.3                                                                           i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                CF.sub.3                                                                           i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(n-Pr)                                       CF.sub.3                                                                           i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(i-Pr)                                       CF.sub.3                                                                           i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(t-Bu)                                       CF.sub.3                                                                           i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                       OCF.sub.3                                                                          i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (n-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (i-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                           Ph     CO(n-Pr)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                           Ph     CO(i-Pr)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                           Ph     CO(t-Bu)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(n-Pr)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(i-Pr)                                       OCF.sub.3                                                                          CO.sub.2 He                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                          Ph     CO(t-Bu)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(i-Pr)                                       OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(t-Bu)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub. 2 (n-Pr)                               CF.sub.3                                                                           4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(n-Pr)                                       CF.sub.3                                                                           4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(i-Pr)                                       CF.sub.3                                                                           4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(t-Bu)                                       CF.sub.3                                                                           4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(n-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(i-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(t-Bu)                                       OCF.sub.3                                                                          4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                           4-FPh  CO(i-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub. 2                                                                 CO(i-Pr)                                       CF.sub.3                                                                           4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       CF.sub.3                                                                           4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (t-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.3                                                                          4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-ClPh CO(t-Bu)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(n-Pr)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(i-Pr)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub. 2 (i-Pr)                               OCF.sub.2 H                                                                        4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(t-Bu)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (t-Bu)                                __________________________________________________________________________

                                      TABLE 4                                     __________________________________________________________________________     ##STR41##                                                                    R.sup.1                                                                            R.sup.3                                                                              Y      R.sup.1                                                                            R.sup.3                                                                              Y                                              __________________________________________________________________________    Cl   Me     H      OCF.sub.3                                                                          Me     COEt                                           Br   Me     H      Cl   Me     CO.sub.2 Me                                    CF.sub.3                                                                           Me     H      Br   Me     CO.sub.2 Me                                    OCF.sub.3                                                                          Me     H      CF.sub.3                                                                           Me     CO.sub.2 Me                                    Cl   Me     Me     OCF.sub.3                                                                          Me     CO.sub.2 Me                                    Br   Me     Me     Cl   Me     CO.sub.2 Et                                    CF.sub.3                                                                           Me     Me     Br   Me     CO.sub.2 Et                                    OCF.sub.3                                                                          Me     Me     CF.sub.3                                                                           Me     CO.sub.2 Et                                    Cl   Me     Et     OCF.sub.3                                                                          Me     CO.sub.2 Et                                    Br   Me     Et     Cl   Me     CH.sub.2 OMe                                   CF.sub.3                                                                           Me     Et     Br   Me     CH.sub.2 OMe                                   OCF.sub.3                                                                          Me     Et     CF.sub.3                                                                           Me     CH.sub.2 OMe                                   Cl   Me     n-Pr   OCF.sub. 3                                                                         Me     CH.sub.2 OMe                                   Br   Me     n-Pr   Cl   Me     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Me     n-Pr   Br   Me     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Me     n-Pr   CF.sub.3                                                                           Me     CH.sub.2 CHCH.sub.2                            Cl   Me     COMe   OCF.sub.3                                                                          Me     CH.sub.2 CHCH.sub.2                            Br   Me     COMe   Cl   Me     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Me     COMe   Br   Me     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Me     COMe   CF.sub.3                                                                           Me     CH.sub.2 SCH.sub.3                             Cl   Me     COEt   OCF.sub.3                                                                          Me     CH.sub.2 SCH.sub.3                             Br   Me     COEt   OCF.sub.2 H                                                                        Me     H                                              CF.sub.3                                                                           Me     COEt   OCF.sub.2H                                                                         Me     Me                                             Cl   Et     H      OCF.sub.3                                                                          Et     COEt                                           Br   Et     H      Cl   Et     CO.sub.2 Me                                    CF.sub.3                                                                           Et     H      Br   Et     CO.sub.2 Me                                    OCF.sub.3                                                                          Et     H      CF.sub.3                                                                           Et     CO.sub.2 Me                                    Cl   Et     Me     OCF.sub.3                                                                          Et     CO.sub.2 Me                                    Br   Et     Me     Cl   Et     CO.sub.2 Et                                    CF.sub.3                                                                           Et     Me     Br   Et     CO.sub.2 Et                                    OCF.sub.3                                                                          Et     Me     CF.sub.3                                                                           Et     CO.sub.2 Et                                    Cl   Et     Et     OCF.sub.3                                                                          Et     CO.sub.2 Et                                    Br   Et     Et     Cl   Et     CH.sub.2 OMe                                   CF.sub.3                                                                           Et     Et     Br   Et     CH.sub.2 OMe                                   OCF.sub.3                                                                          Et     Et     CF.sub.3                                                                           Et     CH.sub.2 OMe                                   Cl   Et     n-Pr   OCF.sub.3                                                                          Et     CH.sub.2 OMe                                   Br   Et     n-Pr   Cl   Et     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Et     n-Pr   Br   Et     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Et     n-Pr   CF.sub.3                                                                           Et     CH.sub.2 CHCH.sub.2                            Cl   Et     COMe   OCF.sub.3                                                                          Et     CH.sub.2 CHCH.sub.2                            Br   Et     COMe   Cl   Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COMe   Br   Et     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Et     COMe   CF.sub.3                                                                           Et     CH.sub.2 SCH.sub.3                             Cl   Et     COEt   OCF.sub.3                                                                          Et     CH.sub.2 SCH.sub.3                             Br   Et     COEt   OCF.sub.2H                                                                         Et     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Et     COEt   OCF.sub.2H                                                                         Me     Et                                             OCF.sub.2 H                                                                        Et     H      OCF.sub.2 H                                                                        Me     n-Pr                                           OCF.sub.2 H                                                                        Et     Me     OCF.sub.2 H                                                                        Me     COMe                                           OCF.sub.2 H                                                                        Et     Et     OCF.sub.2 H                                                                        Me     COEt                                           OCF.sub.2 H                                                                        Et     n-Pr   OCF.sub.2 H                                                                        Me     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Et     COMe   OCF.sub.2 H                                                                        Me     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Et     COEt   OCF.sub.2 H                                                                        Me     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                        Me     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Et     CO.sub. 2 Et                                                                         OCF.sub.2 H                                                                        Me     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Et     CH.sub.2 OMe                                                      OCF.sub.2 H                                                                        Et     CH.sub.2 CHCH.sub.2                                               Cl   n-Pr   H      OCF.sub.3                                                                          n-Pr   COEt                                           Br   n-Pr   H      Cl   n-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           n-Pr   H      Br   n-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          n-Pr   H      CF.sub.3                                                                           n-Pr   CO.sub.2 Me                                    Cl   n-Pr   Me     OCF.sub.3                                                                          n-Pr   CO.sub.2 Me                                    Br   n-Pr   Me     Cl   n-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           n-Pr   Me     Br   n-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          n-Pr   Me     CF.sub.3                                                                           n-Pr   CO.sub.2 Et                                    Cl   n-Pr   Et     OCF.sub.3                                                                          n-Pr   CO.sub.2 Et                                    Br   n-Pr   Et     Cl   n-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           n-Pr   Et     Br   n-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          n-Pr   Et     CF.sub.3                                                                           n-Pr   CH.sub.2 OMe                                   Cl   n-Pr   n-Pr   OCF.sub.3                                                                          n-Pr   CH.sub.2 OMe                                   Br   n-Pr   n-Pr   Cl   n-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           n-Pr   n-Pr   Br   n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          n-Pr   n-Pr   CF.sub.3                                                                           n-Pr   CH.sub.2 CHCH.sub.2                            Cl   n-Pr   COMe   OCF.sub.3                                                                          n-Pr   CH.sub.2 CHCH.sub.2                            Br   n-Pr   COMe   Cl   n-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           n-Pr   COMe   Br   n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub. 3                                                                         n-Pr   COMe   CF.sub.3                                                                           n-Pr   CH.sub.2 SCH.sub.3                             Cl   n-Pr   COEt   OCF.sub.3                                                                          n-Pr   CH.sub.2 SCH.sub.3                             Br   n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   COEt                                           CF.sub.3                                                                           n-Pr   COEt   OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        n-Pr   H      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        n-Pr   Me     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        n-Pr   Et     OCF.sub.2 H                                                                        n-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        n-Pr   n-Pr   OCF.sub.2 H                                                                        n-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        n-Pr   COMe                                                              Cl   i-Pr   H      OCF.sub.3                                                                          i-Pr   COEt                                           Br   i-Pr   H      Cl   i-Pr   CO.sub.2 Me                                    CF.sub.3                                                                           i-Pr   H      Br   i-Pr   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Pr   H      CF.sub.3                                                                           i-Pr   CO.sub.2 Me                                    Cl   i-Pr   Me     OCF.sub.3                                                                          i-Pr   CO.sub.2 Me                                    Br   i-Pr   Me     Cl   i-Pr   CO.sub.2 Et                                    CF.sub.3                                                                           i-Pr   Me     Br   i-Pr   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Pr   Me     CF.sub.3                                                                           i-Pr   CO.sub.2 Et                                    Cl   i-Pr   Et     OCF.sub.3                                                                          i-Pr   CO.sub.2 Et                                    Br   i-Pr   Et     Cl   i-Pr   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Pr   Et     Br   i-Pr   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Pr   Et     CF.sub.3                                                                           i-Pr   CH.sub.2 OMe                                   Cl   i-Pr   n-Pr   OCF.sub.3                                                                          i-Pr   CH.sub.2 OMe                                   Br   i-Pr   n-Pr   Cl   i-Pr   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Pr   n-Pr   Br   i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Pr   n-Pr   CF.sub.3                                                                           i-Pr   CH.sub.2 CHCH.sub.2                            Cl   i-Pr   COMe   OCF.sub.3                                                                          i-Pr   CH.sub.2 CHCH.sub.2                            Br   i-Pr   COMe   Cl   i-Pr   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Pr   COMe   Br   i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Pr   COMe   CF.sub.3                                                                           i-Pr   CH.sub.2 SCH.sub.3                             Cl   i-Pr   COEt   OCF.sub.3                                                                          i-Pr   CH.sub.2 SCH.sub.3                             Br   i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   COEt                                           CF.sub.3                                                                           i-Pr   COEt   OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Pr   H      OCF.sub.2 H                                                                        i-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Pr   Me     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        i-Pr   Et     OCF.sub.2 H                                                                        i-Pr   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Pr   n-Pr   OCF.sub.2 H                                                                        i-Pr   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Pr   COMe                                                              Cl   i-Bu   H      OCF.sub.3                                                                          i-Bu   COEt                                           Br   i-Bu   H      Cl   i-Bu   CO.sub.2 Me                                    CF.sub.3                                                                           i-Bu   H      Br   i-Bu   CO.sub.2 Me                                    OCF.sub.3                                                                          i-Bu   H      CF.sub.3                                                                           i-Bu   CO.sub.2 Me                                    Cl   i-Bu   Me     OCF.sub.3                                                                          i-Bu   CO.sub.2 Me                                    Br   i-Bu   Me     Cl   i-Bu   CO.sub.2 Et                                    CF.sub.3                                                                           i-Bu   Me     Br   i-Bu   CO.sub.2 Et                                    OCF.sub.3                                                                          i-Bu   Me     CF.sub.3                                                                           i-Bu   CO.sub.2 Et                                    Cl   i-Bu   Et     OCF.sub.3                                                                          i-Bu   CO.sub.2 Et                                    Br   i-Bu   Et     Cl   i-Bu   CH.sub.2 OMe                                   CF.sub.3                                                                           i-Bu   Et     Br   i-Bu   CH.sub.2 OMe                                   OCF.sub.3                                                                          i-Bu   Et     CF.sub.3                                                                           i-Bu   CH.sub.2 OMe                                   Cl   i-Bu   n-Pr   OCF.sub.3                                                                          i-Bu   CH.sub.2 OMe                                   Br   i-Bu   n-Pr   Cl   i-Bu   CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           i-Bu   n-Pr   Br   i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          i-Bu   n-Pr   CF.sub.3                                                                           i-Bu   CH.sub.2 CHCH.sub.2                            Cl   i-Bu   COMe   OCF.sub.3                                                                          i-Bu   CH.sub.2 CHCH.sub.2                            Br   i-Bu   COMe   Cl   i-Bu   CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           i-Bu   COMe   Br   i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          i-Bu   COMe   CF.sub.3                                                                           i-Bu   CH.sub.2 SCH.sub.3                             Cl   i-Bu   COEt   OCF.sub.3                                                                          i-Bu   CH.sub.2 SCH.sub.3                             Br   i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   COEt                                           CF.sub.3                                                                           i-Bu   COEt   OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Me                                    OCF.sub.2 H                                                                        i-Bu   H      OCF.sub.2 H                                                                        i-Bu   CO.sub.2 Et                                    OCF.sub.2 H                                                                        i-Bu   Me     OCF.sub.2 H                                                                        i-Bu   CH.sub.2 OMe                                   OCF.sub.2 H                                                                        i-Bu   Et     OCF.sub.2 H                                                                        i-Bu   CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        i-Bu   n-Pr   OCF.sub.2 H                                                                        i-Bu   CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        i-Bu   COMe                                                              Cl   CO.sub.2 Me                                                                          H      OCF.sub.3                                                                          CO.sub.2 Me                                                                          COEt                                           Br   CO.sub.2 Me                                                                          H      Cl   CO.sub.2 Me                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          H      Br   CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          H      CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Me                                                                          Me     Cl   CO.sub.2 Me                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Me                                                                          Me     Br   CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Me                                                                          Me     CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Me                                                                          Et     Cl   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Me                                                                          Et     Br   CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Me                                                                          Et     CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Me                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                                   Br   CO.sub.2 Me                                                                          n-Pr   Cl   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Me                                                                          n-Pr   Br   CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Me                                                                          COMe   Cl   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Me                                                                          COMe   Br   CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          COMe                                                              Cl   CO.sub.2 Et                                                                          H      OCF.sub.3                                                                          CO.sub.2 Et                                                                          COEt                                           Br   CO.sub.2 Et                                                                          H      Cl   CO.sub.2 Et                                                                          CO.sub.2 Me                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          H      Br   CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          H      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Me                                    Cl   CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                    Br   CO.sub.2 Et                                                                          Me     Cl   CO.sub.2 Et                                                                          CO.sub.2 Et                                    CF.sub.3                                                                           CO.sub.2 Et                                                                          Me     Br   CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                          CO.sub.2 Et                                                                          Me     CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 Et                                    Cl   CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                    Br   CO.sub.2 Et                                                                          Et     Cl   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   CF.sub.3                                                                           CO.sub.2 Et                                                                          Et     Br   CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.3                                                                          CO.sub.2 Et                                                                          Et     CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Cl   CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                                   Br   CO.sub.2 Et                                                                          n-Pr   Cl   CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CO.sub.2 Et                                                                          n-Pr   Br   CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Cl   CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            Br   CO.sub.2 Et                                                                          COMe   Cl   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CO.sub.2 Et                                                                          COMe   Br   CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                           CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Cl   CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             Br   CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COEt                                           CF.sub.3                                                                           CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Me                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 Et                                    OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          COMe                                                              Cl   Ph     H      OCF.sub.3                                                                          Ph     COEt                                           Br   Ph     H      Cl   Ph     CO.sub.2 Me                                    CF.sub.3                                                                           Ph     H      Br   Ph     CO.sub.2 Me                                    OCF.sub.3                                                                          Ph     H      CF.sub.3                                                                           Ph     CO.sub.2 Me                                    Cl   Ph     Me     OCF.sub.3                                                                          Ph     CO.sub.2 Me                                    Br   Ph     Me     Cl   Ph     CO.sub.2 Et                                    CF.sub.3                                                                           Ph     Me     Br   Ph     CO.sub.2 Et                                    OCF.sub.3                                                                          Ph     Me     CF.sub.3                                                                           Ph     CO.sub.2 Et                                    Cl   Ph     Et     OCF.sub.3                                                                          Ph     CO.sub.2 Et                                    Br   Ph     Et     Cl   Ph     CH.sub.2 OMe                                   CF.sub.3                                                                           Ph     Et     Br   Ph     CH.sub.2 OMe                                   OCF.sub.3                                                                          Ph     Et     CF.sub.3                                                                           Ph     CH.sub.2 OMe                                   Cl   Ph     n-Pr   OCF.sub.3                                                                          Ph     CH.sub.2 OMe                                   Br   Ph     n-Pr   Cl   Ph     CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           Ph     n-Pr   Br   Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          Ph     n-Pr   CF.sub.3                                                                           Ph     CH.sub.2 CHCH.sub.2                            Cl   Ph     COMe   OCF.sub.3                                                                          Ph     CH.sub.2 CHCH.sub.2                            Br   Ph     COMe   Cl   Ph     CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           Ph     COMe   Br   Ph     CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          Ph     COMe   CF.sub.3                                                                           Ph     CH.sub.2 SCH.sub.3                             Cl   Ph     COEt   OCF.sub.3                                                                          Ph     CH.sub.2 SCH.sub.3                             Br   Ph     COEt   OCF.sub.2 H                                                                        Ph     COEt                                           CF.sub.3                                                                           Ph     COEt   OCF.sub.2 H                                                                        Ph     CO.sub.2 Me                                    OCF.sub.2 H                                                                        Ph     H      OCF.sub.2 H                                                                        Ph     CO.sub.2 Et                                    OCF.sub.2 H                                                                        Ph     Me     OCF.sub.2 H                                                                        Ph     CH.sub.2 OMe                                   OCF.sub.2 H                                                                        Ph     Et     OCF.sub.2 H                                                                        Ph     CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        Ph     n-Pr   OCF.sub.2 H                                                                        Ph     CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        Ph     COMe                                                              Cl   4-ClPh H      OCF.sub.3                                                                          4-ClPh COEt                                           Br   4-ClPh H      Cl   4-ClPh CO.sub.2 Me                                    CF.sub.3                                                                           4-ClPh H      Br   4-ClPh CO.sub.2 Me                                    OCF.sub.3                                                                          4-ClPh H      CF.sub.3                                                                           4-ClPh CO.sub.2 Me                                    Cl   4-ClPh Me     OCF.sub.3                                                                          4-ClPh CO.sub.2 Me                                    Br   4-ClPh Me     Cl   4-ClPh CO.sub.2 Et                                    CF.sub.3                                                                           4-ClPh Me     Br   4-ClPh CO.sub.2 Et                                    OCF.sub.3                                                                          4-ClPh Me     CF.sub.3                                                                           4-ClPh CO.sub.2 Et                                    Cl   4-ClPh Et     OCF.sub.3                                                                          4-ClPh CO.sub.2 Et                                    Br   4-ClPh Et     Cl   4-ClPh CH.sub.2 OMe                                   CF.sub.3                                                                           4-ClPh Et     Br   4-ClPh CH.sub.2 OMe                                   OCF.sub.3                                                                          4-ClPh Et     CF.sub.3                                                                           4-ClPh CH.sub.2 OMe                                   Cl   4-ClPh n-Pr   OCF.sub.3                                                                          4-ClPh CH.sub.2 OMe                                   Br   4-ClPh n-Pr   Cl   4-ClPh CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-ClPh n-Pr   Br   4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-ClPh n-Pr   CF.sub.3                                                                           4-ClPh CH.sub.2 CHCH.sub.2                            Cl   4-ClPh COMe   OCF.sub.3                                                                          4-ClPh CH.sub.2 CHCH.sub.2                            Br   4-ClPh COMe   Cl   4-ClPh CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-ClPh COMe   Br   4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-ClPh COMe   CF.sub.3                                                                           4-ClPh CH.sub.2 SCH.sub.3                             Cl   4-ClPh COEt   OCF.sub.3                                                                          4-ClPh CH.sub.2 SCH.sub.3                             Br   4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh COEt                                           CF.sub.3                                                                           4-ClPh COEt   OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-ClPh H      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-ClPh Me     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-ClPh Et     OCF.sub.2 H                                                                        4-ClPh CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-ClPh n-Pr   OCF.sub.2 H                                                                        4-ClPh CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-ClPh COMe                                                              Cl   4-FPh  H      OCF.sub.3                                                                          4-FPh  COEt                                           Br   4-FPh  H      Cl   4-FPh  CO.sub. 2 Me                                   CF.sub.3                                                                           4-FPh  H      Br   4-FPh  CO.sub.2 Me                                    OCF.sub.3                                                                          4-FPh  H      CF.sub.3                                                                           4-FPh  CO.sub.2 Me                                    Cl   4-FPh  Me     OCF.sub.3                                                                          4-FPh  CO.sub.2 Me                                    Br   4-FPh  Me     Cl   4-FPh  CO.sub.2 Et                                    CF.sub.3                                                                           4-FPh  Me     Br   4-FPh  CO.sub.2 Et                                    OCF.sub.3                                                                          4-FPh  Me     CF.sub.3                                                                           4-FPh  CO.sub.2 Et                                    Cl   4-FPh  Et     OCF.sub.3                                                                          4-FPh  CO.sub.2 Et                                    Br   4-FPh  Et     Cl   4-FPh  CH.sub.2 OMe                                   CF.sub.3                                                                           4-FPh  Et     Br   4-FPh  CH.sub.2 OMe                                   OCF.sub.3                                                                          4-FPh  Et     CF.sub.3                                                                           4-FPh  CH.sub.2 OMe                                   Cl   4-FPh  n-Pr   OCF.sub.3                                                                          4-FPh  CH.sub.2 OMe                                   Br   4-FPh  n-Pr   Cl   4-FPh  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           4-FPh  n-Pr   Br   4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          4-FPh  n-Pr   CF.sub.3                                                                           4-FPh  CH.sub.2 CHCH.sub.2                            Cl   4-FPh  COMe   OCF.sub.3                                                                          4-FPh  CH.sub.2 CHCH.sub.2                            Br   4-FPh  COMe   Cl   4-FPh  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           4-FPh  COMe   Br   4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          4-FPh  COMe   CF.sub.3                                                                           4-FPh  CH.sub.2 SCH.sub.3                             Cl   4-FPh  COEt   OCF.sub.3                                                                          4-FPh  CH.sub.2 SCH.sub.3                             Br   4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  COEt                                           CF.sub.3                                                                           4-FPh  COEt   OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Me                                    OCF.sub.2 H                                                                        4-FPh  H      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 Et                                    OCF.sub.2 H                                                                        4-FPh  Me     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        4-FPh  Et     OCF.sub.2 H                                                                        4-FPh  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        4-FPh  n-Pr   OCF.sub.2 H                                                                        4-FPh  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        4-FPh  COMe                                                              Cl   CHCH.sub.2                                                                           H      OCF.sub.3                                                                          CHCH.sub.2                                                                           COEt                                           Br   CHCH.sub.2                                                                           H      Cl   CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                           CHCH.sub.2                                                                           H      Br   CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           H      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                    Cl   CHCH.sub.2                                                                           Me     OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                    Br   CHCH.sub.2                                                                           Me     Cl   CHCH.sub.2                                                                           CO.sub.2 Et                                    CF.sub.3                                                                           CHCH.sub.2                                                                           Me     Br   CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.3                                                                          CHCH.sub.2                                                                           Me     CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Et                                    Cl   CHCH.sub.2                                                                           Et     OCF.sub.3                                                                          CHCH.sub. 2                                                                          CO.sub.2 Et                                    Br   CHCH.sub.2                                                                           Et     Cl   CHCH.sub.2                                                                           CH.sub.2 OMe                                   CF.sub.3                                                                           CHCH.sub.2                                                                           Et     Br   CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.3                                                                          CHCH.sub.2                                                                           Et     CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 OMe                                   Cl   CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 OMe                                   Br   CHCH.sub.2                                                                           n-Pr   Cl   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           CHCH.sub.2                                                                           n-Pr   Br   CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Cl   CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            Br   CHCH.sub.2                                                                           COMe   Cl   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           CHCH.sub.2                                                                           COMe   Br   CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          CHCH.sub.2                                                                           COMe   CF.sub.3                                                                           CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Cl   CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             Br   CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COEt                                           CF.sub.3                                                                           CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CO.sub.2 Et                                    OCF.sub.2 H                                                                        CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 OMe                                   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           Et     OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                        CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        CHCH.sub.2                                                                           COMe                                                              Cl   C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                           Br   C(CH.sub.3)CH.sub.2                                                                  H      Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  H      Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Br   C(CH.sub.3)CH.sub.2                                                                  Me     Cl   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Me     Br   C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Cl   C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    Br   C(CH.sub.3)CH.sub.2                                                                  Et     Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Et     Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Cl   C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   Br   C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Cl   C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            Br   C(CH.sub.3)CH.sub.2                                                                  COMe   Cl   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COMe   Br   C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Cl   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             Br   C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COEt                                           CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                            OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                             OCF.sub.2 H                                                                        C(CH.sub.3)CH.sub.2                                                                  COMe                                                              CF.sub.3                                                                           Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Me     CO (n-Pr)                                                                            CF.sub.3                                                                           n-Pr   CO (n-Pr)                                      CF.sub.3                                                                           Me     CO (i-Pr)                                                                            CF.sub.3                                                                           n-Pr   CO (i-Pr)                                      CF.sub.3                                                                           Me     CO (t-Bu)                                                                            CF.sub.3                                                                           n-Pr   CO (t-Bu)                                      CF.sub.3                                                                           Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           n-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Me     CO(n-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Me     CO(i-Pr)                                                                             OCF.sub.3                                                                          n-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Me     CO(t-Bu)                                                                             OCF.sub.3                                                                          n-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          n-Pr   CO.sub.2 (t-Bu)                                CF.sub.3                                                                           Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (n-Pr)                                CF.sub.3                                                                           Et     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           Et     CO(n-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(n-Pr)                                       CF.sub.3                                                                           Et     CO(i-Pr)                                                                             CF.sub.3                                                                           i-Pr   CO(i-Pr)                                       CF.sub.3                                                                           Et     CO(t-Bu)                                                                             CF.sub.3                                                                           i-Pr   CO(t-Bu)                                       CF.sub.3                                                                           Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          Et     CO(n-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(n-Pr)                                       OCF.sub.3                                                                          Et     CO(i-Pr)                                                                             OCF.sub.3                                                                          i-Pr   CO(i-Pr)                                       OCF.sub.3                                                                          Et     CO(t-Bu)                                                                             OCF.sub.3                                                                          i-Pr   CO(t-Bu)                                       OCF.sub.3                                                                          Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          i-Pr   CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(i-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                        Et     CO(t-Bu)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        Et     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(n-Pr)                                       OCF.sub.2 H                                                                        Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                        n-Pr   CO(i-Pr)                                       OCF.sub.2 H                                                                        Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (i-Pr)                                CF.sub.3                                                                           i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                CF.sub.3                                                                           i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                CF.sub.3                                                                           i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(n-Pr)                                       CF.sub.3                                                                           i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(i-Pr)                                       CF.sub.3                                                                           i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                           CO.sub.2 Et                                                                          CO(t-Bu)                                       CF.sub.3                                                                           i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                       OCF.sub.3                                                                          i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                       OCF.sub.3                                                                          i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (n-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (i-Pr)                                CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                           Ph     CO(n-Pr)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                           Ph     CO(i-Pr)                                       CF.sub. 3                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                           Ph     CO(t-Bu)                                       CF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           Ph     CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(n-Pr)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                          Ph     CO(i-Pr)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                          Ph     CO(t-Bu)                                       OCF.sub.3                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          Ph     CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(i-Pr)                                       OCF.sub.2 H                                                                        n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(t-Bu)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(n-Pr)                                       OCF.sub.2 H                                                                        i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(n-Pr)                                       CF.sub.3                                                                           4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(i-Pr)                                       CF.sub.3                                                                           4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                           CHCH.sub.2                                                                           CO(t-Bu)                                       CF.sub.3                                                                           4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(n-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(i-Pr)                                       OCF.sub.3                                                                          4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                          CHCH.sub.2                                                                           CO(t-Bu)                                       OCF.sub.3                                                                          4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                CF.sub.3                                                                           4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                CF.sub.3                                                                           4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                           4-FPh  CO(i-Pr)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       CF.sub.3                                                                           4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       CF.sub.3                                                                           4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                OCF.sub.3                                                                          4-FPh  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                OCF.sub.3                                                                          4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.3                                                                          4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.3                                                                          4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-ClPh CO(t-Bu)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (t-Bu)                                OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(n-Pr)                                       OCF.sub.2 H                                                                        CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (n-Pr)                                OCF.sub.2 H                                                                        4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(i-Pr)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub. 2 H                                                                       4-FPh  CO.sub.2 (i-Pr)                                OCF.sub.2 H                                                                        4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                        4-FPh  CO(t-Bu)                                       OCF.sub.2 H                                                                        4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                        4-FPh  CO.sub.2 (t-Bu)                                __________________________________________________________________________

                                      TABLE 5                                     __________________________________________________________________________     ##STR42##                                                                    R.sup.1                                                                              R.sup.3                                                                              Y      R.sup.1                                                                              R.sup.3                                                                              Y                                          __________________________________________________________________________    Cl     Me     H      OCF.sub.3                                                                            Me     COEt                                       Br     Me     H      Cl     Me     CO.sub.2 Me                                CF.sub.3                                                                             Me     H      Br     Me     CO.sub.2 Me                                OCF.sub.3                                                                            Me     H      CF.sub.3                                                                             Me     CO.sub.2 Me                                Cl     Me     Me     OCF.sub.3                                                                            Me     CO.sub.2 Me                                Br     Me     Me     Cl     Me     CO.sub.2 Et                                CF.sub.3                                                                             Me     Me     Br     Me     CO.sub.2 Et                                OCF.sub.3                                                                            Me     Me     CF.sub.3                                                                             Me     CO.sub.2 Et                                Cl     Me     Et     OCF.sub.3                                                                            Me     CO.sub.2 Et                                Br     Me     Et     Cl     Me     CH.sub.2 OMe                               CF.sub.3                                                                             Me     Et     Br     Me     CH.sub.2 OMe                               OCF.sub.3                                                                            Me     Et     CF.sub.3                                                                             Me     CH.sub.2 OMe                               Cl     Me     n-Pr   OCF.sub.3                                                                            Me     CH.sub.2 OMe                               Br     Me     n-Pr   Cl     Me     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Me     n-Pr   Br     Me     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Me     n-Pr   CF.sub.3                                                                             Me     CH.sub.2 CHCH.sub.2                        Cl     Me     COMe   OCF.sub.3                                                                            Me     CH.sub.2 CHCH.sub.2                        Br     Me     COMe   Cl     Me     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Me     COMe   Br     Me     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Me     COMe   CF.sub.3                                                                             Me     CH.sub.2 SCH.sub.3                         Cl     Me     COEt   OCF.sub.3                                                                            Me     CH.sub.2 SCH.sub.3                         Br     Me     COEt   OCF.sub.2 H                                                                          Me     H                                          CF.sub.3                                                                             Me     COEt   OCF.sub.2 H                                                                          Me     Me                                         Cl     Et     H      OCF.sub.3                                                                            Et     COEt                                       Br     Et     H      Cl     Et     CO.sub.2 Me                                CF.sub.3                                                                             Et     H      Br     Et     CO.sub.2 Me                                OCF.sub.3                                                                            Et     H      CF.sub.3                                                                             Et     CO.sub.2 Me                                Cl     Et     Me     OCF.sub.3                                                                            Et     CO.sub.2 Me                                Br     Et     Me     Cl     Et     CO.sub.2 Et                                CF.sub.3                                                                             Et     Me     Br     Et     CO.sub.2 Et                                OCF.sub.3                                                                            Et     Me     CF.sub.3                                                                             Et     CO.sub.2 Et                                Cl     Et     Et     OCF.sub.3                                                                            Et     CO.sub.2 Et                                Br     Et     Et     Cl     Et     CH.sub.2 OMe                               CF.sub.3                                                                             Et     Et     Br     Et     CH.sub.2 OMe                               OCF.sub.3                                                                            Et     Et     CF.sub.3                                                                             Et     CH.sub.2 OMe                               Cl     Et     n-Pr   OCF.sub.3                                                                            Et     CH.sub.2 OMe                               Br     Et     n-Pr   Cl     Et     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Et     n-Pr   Br     Et     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Et     n-Pr   CF.sub.3                                                                             Et     CH.sub.2 CHCH.sub.2                        Cl     Et     COMe   OCF.sub.3                                                                            Et     CH.sub.2 CHCH.sub.2                        Br     Et     COMe   Cl     Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COMe   Br     Et     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Et     COMe   CF.sub.3                                                                             Et     CH.sub.2 SCH.sub.3                         Cl     Et     COEt   OCF.sub.3                                                                            Et     CH.sub.2 SCH.sub.3                         Br     Et     COEt   OCF.sub.2 H                                                                          Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COEt   OCF.sub.2 H                                                                          Me     Et                                         OCF.sub.2 H                                                                          Et     H      OCF.sub.2 H                                                                          Me     n-Pr                                       OCF.sub.2 H                                                                          Et     Me     OCF.sub.2 H                                                                          Me     COMe                                       OCF.sub.2 H                                                                          Et     Et     OCF.sub.2 H                                                                          Me     COEt                                       OCF.sub.2 H                                                                          Et     n-Pr   OCF.sub.2 H                                                                          Me     CO.sub.2 Me                                OCF.sub.2 H                                                                          Et     Me     OCF.sub.2 H                                                                          Me     CO.sub.2 Et                                OCF.sub.2 H                                                                          Et     COEt   OCF.sub.2 H                                                                          Me     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                          Me     CH.sub. 2 CHCH.sub.2                       OCF.sub.2 H                                                                          Et     CO.sub.2 Et                                                                          OCF.sub.2 H                                                                          Me     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Et     CH.sub.2 OMe                                                    OCF.sub.2 H                                                                          Et     CH.sub.2 CHCH.sub.2                                             Cl     n-Pr   H      OCF.sub.3                                                                            n-Pr   COEt                                       Br     n-Pr   H      Cl     n-Pr   CO.sub.2 Me                                CF.sub.3                                                                             n-Pr   H      Br     n-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            n-Pr   H      CF.sub.3                                                                             n-Pr   CO.sub.2 Me                                Cl     n-Pr   Me     OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                                Br     n-Pr   Me     Cl     n-Pr   CO.sub.2 Et                                CF.sub.3                                                                             n-Pr   Me     Br     n-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            n-Pr   Me     CF.sub.3                                                                             n-Pr   CO.sub.2 Et                                Cl     n-Pr   Et     OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                                Br     n-Pr   Et     Cl     n-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             n-Pr   Et     Br     n-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            n-Pr   Et     CF.sub.3                                                                             n-Pr   CH.sub.2 OMe                               Cl     n-Pr   n-Pr   OCF.sub.3                                                                            n-Pr   CH.sub.2 OMe                               Br     n-Pr   n-Pr   Cl     n-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             n-Pr   n-Pr   Br     n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            n-Pr   n-Pr   CF.sub.3                                                                             n-Pr   CH.sub.2 CHCH.sub.2                        Cl     n-Pr   COMe   OCF.sub.3                                                                            n-Pr   CH.sub.2 CHCH.sub.2                        Br     n-Pr   COMe   Cl     n-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             n-Pr   COMe   Br     n-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            n-Pr   COMe   CF.sub.3                                                                             n-Pr   CH.sub.2 SCH.sub.3                         Cl     n-Pr   COEt   OCF.sub.3                                                                            n-Pr   CH.sub.2 SCH.sub.3                         Br     n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   COEt                                       CF.sub.3                                                                             n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Me                                OCF.sub.2 H                                                                          n-Pr   H      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Et                                OCF.sub.2 H                                                                          n-Pr   Me     OCF.sub.2 H                                                                          n-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          n-Pr   Et     OCF.sub.2 H                                                                          n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          n-Pr   n-Pr   OCF.sub.2 H                                                                          n-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          n-Pr   COMe                                                            Cl     i-Pr   H      OCF.sub.3                                                                            i-Pr   COEt                                       Br     i-Pr   H      Cl     i-Pr   CO.sub.2 Me                                CF.sub.3                                                                             i-Pr   H      Br     i-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            i-Pr   H      CF.sub.3                                                                             i-Pr   CO.sub.2 Me                                Cl     i-Pr   Me     OCF.sub.3                                                                            i-Pr   CO.sub.2 Me                                Br     i-Pr   Me     Cl     i-Pr   CO.sub.2 Et                                CF.sub.3                                                                             i-Pr   Me     Br     i-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            i-Pr   Me     CF.sub.3                                                                             i-Pr   CO.sub.2 Et                                Cl     i-Pr   Et     OCF.sub.3                                                                            i-Pr   CO.sub.2 Et                                Br     i-Pr   Et     Cl     i-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             i-Pr   Et     Br     i-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Pr   Et     CF.sub.3                                                                             i-Pr   CH.sub.2 OMe                               Cl     i-Pr   n-Pr   OCF.sub.3                                                                            i-Pr   CH.sub.2 OMe                               Br     i-Pr   n-Pr   Cl     i-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Pr   n-Pr   Br     i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Pr   n-Pr   CF.sub.3                                                                             i-Pr   CH.sub.2 CHCH.sub.2                        Cl     i-Pr   COMe   OCF.sub.3                                                                            i-Pr   CH.sub.2 CHCH.sub.2                        Br     i-Pr   COMe   Cl     i-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Pr   COMe   Br     i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Pr   COMe   CF.sub.3                                                                             i-Pr   CH.sub.2 SCH.sub.3                         Cl     i-Pr   COEt   OCF.sub.3                                                                            i-Pr   CH.sub.2 SCH.sub.3                         Br     i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   COEt                                       CF.sub.3                                                                             i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Pr   H      OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Pr   Me     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Pr   Et     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Pr   n-Pr   OCF.sub.2 H                                                                          i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Pr   COMe                                                            Cl     i-Bu   H      OCF.sub.3                                                                            i-Bu   COEt                                       Br     i-Bu   H      Cl     i-Bu   CO.sub.2 Me                                CF.sub.3                                                                             i-Bu   H      Br     i-Bu   CO.sub.2 Me                                OCF.sub.3                                                                            i-Bu   H      CF.sub. 3                                                                            i-Bu   CO.sub.2 Me                                Cl     i-Bu   Me     OCF.sub.3                                                                            i-Bu   CO.sub.2 Me                                Br     i-Bu   Me     Cl     i-Bu   CO.sub.2 Et                                CF.sub.3                                                                             i-Bu   Me     Br     i-Bu   CO.sub.2 Et                                OCF.sub.3                                                                            i-Bu   Me     CF.sub.3                                                                             i-Bu   CO.sub.2 Et                                Cl     i-Bu   Et     OCF.sub.3                                                                            i-Bu   CO.sub.2 Et                                Br     i-Bu   Et     Cl     i-Bu   CH.sub.2 OMe                               CF.sub.3                                                                             i-Bu   Et     Br     i-Bu   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Bu   Et     CF.sub.3                                                                             i-Bu   CH.sub.2 OMe                               Cl     i-Bu   n-Pr   OCF.sub.3                                                                            i-Bu   CH.sub.2 OMe                               Br     i-Bu   n-Pr   Cl     i-Bu   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Bu   n-Pr   Br     i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Bu   n-Pr   CF.sub.3                                                                             i-Bu   CH.sub.2 CHCH.sub.2                        Cl     i-Bu   COMe   OCF.sub.3                                                                            i-Bu   CH.sub.2 CHCH.sub.2                        Br     i-Bu   COMe   Cl     i-Bu   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Bu   COMe   Br     i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Bu   COMe   CF.sub.3                                                                             i-Bu   CH.sub.2 SCH.sub.3                         Cl     i-Bu   COEt   OCF.sub.3                                                                            i-Bu   CH.sub.2 SCH.sub.3                         Br     i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   COEt                                       CF.sub.3                                                                             i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Bu   H      OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Bu   Me     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Bu   Et     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Bu   n-Pr   OCF.sub.2 H                                                                          i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Bu   COMe                                                            Cl     CO.sub.2 Me                                                                          H      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                       Br     CO.sub.2 Me                                                                          H      Cl     CO.sub.2 Me                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Me                                                                          H      Br     CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          H      CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                                Br     CO.sub.2 Me                                                                          Me     Cl     CO.sub.2 Me                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Me                                                                          Me     Br     CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me     CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                                Br     CO.sub.2 Me                                                                          Et     Cl     CO.sub.2 Me                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Me                                                                          Et     Br     CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et     CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Me                                                                          n-Pr   OCF.sub. 3                                                                           CO.sub.2 Me                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Me                                                                          n-Pr   Cl     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr   Br     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Me                                                                          COMe   Cl     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe   Br     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COMe                                                            Cl     CO.sub.2 Et                                                                          H      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COEt                                       Br     CO.sub.2 Et                                                                          H      Cl     CO.sub.2 Et                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Et                                                                          H      Br     CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          H      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                                Br     CO.sub.2 Et                                                                          Me     Cl     CO.sub.2 Et                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Et                                                                          Me     Br     CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me     CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Et                                Br     CO.sub.2 Et                                                                          Et     Cl     CO.sub.2 Et                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Et                                                                          Et     Br     CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et     CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Et                                                                          n-Pr   Cl     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        CF.sub. 3                                                                            CO.sub.2 Et                                                                          n-Pr   Br     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Et                                                                          COMe   Cl     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe   Br     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COMe                                                            Cl     Ph     H      OCF.sub.3                                                                            Ph     COEt                                       Br     Ph     H      Cl     Ph     CO.sub.2 Me                                CF.sub.3                                                                             Ph     H      Br     Ph     CO.sub.2 Me                                OCF.sub.3                                                                            Ph     H      CF.sub.3                                                                             Ph     CO.sub.2 Me                                Cl     Ph     Me     OCF.sub.3                                                                            Ph     CO.sub.2 Me                                Br     Ph     Me     Cl     Ph     CO.sub.2 Et                                CF.sub.3                                                                             Ph     Me     Br     Ph     CO.sub.2 Et                                OCF.sub.3                                                                            Ph     Me     CF.sub.3                                                                             Ph     CO.sub.2 Et                                Cl     Ph     Et     OCF.sub.3                                                                            Ph     CO.sub.2 Et                                Br     Ph     Et     Cl     Ph     CH.sub.2 OMe                               CF.sub.3                                                                             Ph     Et     Br     Ph     CH.sub.2 OMe                               OCF.sub.3                                                                            Ph     Et     CF.sub.3                                                                             Ph     CH.sub.2 OMe                               Cl     Ph     n-Pr   OCF.sub.3                                                                            Ph     CH.sub.2 OMe                               Br     Ph     n-Pr   Cl     Ph     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Ph     n-Pr   Br     Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Ph     n-Pr   CF.sub.3                                                                             Ph     CH.sub.2 CHCH.sub.2                        Cl     Ph     COMe   OCF.sub.3                                                                            Ph     CH.sub.2 CHCH.sub.2                        Br     Ph     COMe   Cl     Ph     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Ph     COMe   Br     Ph     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Ph     COMe   CF.sub.3                                                                             Ph     CH.sub.2 SCH.sub.3                         Cl     Ph     COEt   OCF.sub.3                                                                            Ph     CH.sub.2 SCH.sub.3                         Br     Ph     COEt   OCF.sub.2 H                                                                          Ph     COEt                                       CF.sub.3                                                                             Ph     COEt   OCF.sub.2 H                                                                          Ph     CO.sub.2 Me                                OCF.sub.2 H                                                                          Ph     H      OCF.sub.2 H                                                                          Ph     CO.sub.2 Et                                OCF.sub.2 H                                                                          Ph     Me     OCF.sub.2 H                                                                          Ph     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Ph     Et     OCF.sub.2 H                                                                          Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          Ph     n-Pr   OCF.sub.2 H                                                                          Ph     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Ph     COMe                                                            Cl     4-ClPh H      OCF.sub.3                                                                            4-ClPh COEt                                       Br     4-ClPh H      Cl     4-ClPh CO.sub.2 Me                                CF.sub.3                                                                             4-ClPh H      Br     4-ClPh CO.sub.2 Me                                OCF.sub.3                                                                            4-ClPh H      CF.sub.3                                                                             4-ClPh CO.sub.2 Me                                Cl     4-ClPh Me     OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                                Br     4-ClPh Me     Cl     4-ClPh CO.sub.2 Et                                CF.sub.3                                                                             4-ClPh Me     Br     4-ClPh CO.sub.2 Et                                OCF.sub.3                                                                            4-ClPh Me     CF.sub.3                                                                             4-ClPh CO.sub.2 Et                                Cl     4-ClPh Et     OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                                Br     4-ClPh Et     Cl     4-ClPh CH.sub.2 OMe                               CF.sub.3                                                                             4-ClPh Et     Br     4-ClPh CH.sub.2 OMe                               OCF.sub.3                                                                            4-ClPh Et     CF.sub.3                                                                             4-ClPh CH.sub.2 OMe                               Cl     4-Cl Ph                                                                              n-Pr   OCF.sub.3                                                                            4-ClPh CH.sub.2 OMe                               Br     4-ClPh n-Pr   Cl     4-ClPh CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-ClPh n-Pr   Br     4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-ClPh n-Pr   CF.sub.3                                                                             4-ClPh CH.sub.2 CHCH.sub.2                        Cl     4-ClPh COMe   OCF.sub.3                                                                            4-ClPh CH.sub.2 CHCH.sub.2                        Br     4-ClPh COMe   Cl     4-ClPh CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-ClPh COMe   Br     4-ClPh CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            4-ClPh COMe   CF.sub.3                                                                             4-ClPh CH.sub.2 SCH.sub.3                         Cl     4-ClPh COEt   OCF.sub.3                                                                            4-ClPh CH.sub.2 SCH.sub.3                         Br     4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh COEt                                       CF.sub.3                                                                             4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Me                                OCF.sub.2 H                                                                          4-ClPh H      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Et                                OCF.sub.2 H                                                                          4-ClPh Me     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 OMe                               OCF.sub.2 H                                                                          4-ClPh Et     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-ClPh n-Pr   OCF.sub.2 H                                                                          4-ClPh CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          4-ClPh COMe                                                            Cl     4-FPh  H      OCF.sub.3                                                                            4-FPh  COEt                                       Br     4-FPh  H      Cl     4-FPh  CO.sub.2 Me                                CF.sub.3                                                                             4-FPh  H      Br     4-FPh  CO.sub.2 Me                                OCF.sub.3                                                                            4-FPh  H      CF.sub.3                                                                             4-FPh  CO.sub.2 Me                                Cl     4-FPh  Me     OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                                Br     4-FPh  Me     Cl     4-FPh  CO.sub.2 Et                                CF.sub.3                                                                             4-FPh  Me     Br     4-FPh  CO.sub.2 Et                                OCF.sub.3                                                                            4-FPh  Me     CF.sub.3                                                                             4-FPh  CO.sub.2 Et                                Cl     4-FPh  Et     OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                                Br     4-FPh  Et     Cl     4-FPh  CH.sub.2 OMe                               CF.sub.3                                                                             4-FPh  Et     Br     4-FPh  CH.sub.2 OMe                               OCF.sub.3                                                                            4-FPh  Et     CF.sub.3                                                                             4-FPh  CH.sub.2 OMe                               Cl     4-FPh  n-Pr   OCF.sub.3                                                                            4-FPh  CH.sub.2 OMe                               Br     4-FPh  n-Pr   Cl     4-FPh  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-FPh  n-Pr   Br     4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-FPh  n-Pr   CF.sub.3                                                                             4-FPh  CH.sub.2 CHCH.sub.2                        Cl     4-FPh  COMe   OCF.sub.3                                                                            4-FPh  CH.sub.2 CHCH.sub.2                        Br     4-FPh  COMe   Cl     4-FPh  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-FPh  COMe   Br     4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            4-FPh  COMe   CF.sub.3                                                                             4-FPh  CH.sub.2 SCH.sub.3                         Cl     4-FPh  COEt   OCF.sub.3                                                                            4-FPh  CH.sub.2 SCH.sub.3                         Br     4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  COEt                                       CF.sub.3                                                                             4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                                OCF.sub.2 H                                                                          4-FPh  Me     OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                                OCF.sub.2 H                                                                          4-FPh  Me     OCF.sub.2 H                                                                          4-FPh  CH.sub.2 OMe                               OCF.sub.2 H                                                                          4-FPh  Et     OCF.sub.2 H                                                                          4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-FPh  n-Pr   OCF.sub.2 H                                                                          4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          4-FPh  COMe                                                            Cl     CHCH.sub.2                                                                           H      OCF.sub.3                                                                            CHCH.sub.2                                                                           COEt                                       Br     CHCH.sub.2                                                                           H      Cl     CHCH.sub.2                                                                           CO.sub.2 Me                                CF.sub.3                                                                             CHCH.sub.2                                                                           H      Br     CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.3                                                                            CHCH.sub.2                                                                           H      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Me                                Cl     CHCH.sub.2                                                                           Me     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Me                                Br     CHCH.sub.2                                                                           Me     Cl     CHCH.sub.2                                                                           CO.sub.2 Et                                CF.sub.3                                                                             CHCH.sub.2                                                                           Me     Br     CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.3                                                                            CHCH.sub.2                                                                           Me     CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub. 2 Et                               Cl     CHCH.sub.2                                                                           Et     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Et                                Br     CHCH.sub.2                                                                           Et     Cl     CHCH.sub.2                                                                           CH.sub.2 OMe                               CF.sub.3                                                                             CHCH.sub.2                                                                           Et     Br     CHCH.sub.2                                                                           CH.sub.2 OMe                               OCF.sub.3                                                                            CHCH.sub.2                                                                           Et     CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 OMe                               Cl     CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 OMe                               Br     CHCH.sub.2                                                                           n-Pr   Cl     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CHCH.sub.2                                                                           n-Pr   Br     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Cl     CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Br     CHCH.sub.2                                                                           COMe   Cl     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CHCH.sub.2                                                                           COMe   Br     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CHCH.sub.2                                                                           COMe   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Cl     CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Br     CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COEt                                       CF.sub.3                                                                             CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                          CHCH.sub. 2                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Et     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COMe                                                            Cl     C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COEt                                       Br     C(CH.sub.3)CH.sub.2                                                                  H      Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  H      Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Cl     C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Br     C(CH.sub.3)CH.sub.2                                                                  Me     Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Me     Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Cl     C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Br     C(CH.sub.3)CH.sub.2                                                                  Et     Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Et     Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub. 2 OMe                              OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Et     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Cl     C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Br     C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Cl     C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Br     C(CH.sub.3)CH.sub.2                                                                  COMe   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COMe   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Cl     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Br     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe                                                            CF.sub.3                                                                             Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (n-Pr)                            CF.sub.3                                                                             Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Me     CO(n-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Me     CO(i-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Me     CO(t-Bu)                                                                             CF.sub.3                                                                             n-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Me     CO(n-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Me     CO(i-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Me     CO(t-Bu)                                                                             OCF.sub.3                                                                            n-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (t-Bu)                            CF.sub.3                                                                             Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (n-Pr)                            CF.sub.3                                                                             Et     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Et     CO(n-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Et     CO(i-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Et     CO(t-Bu)                                                                             CF.sub.3                                                                             i-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Et     CO(n-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Et     CO(i-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Et     CO(t-Bu)                                                                             OCF.sub.3                                                                            i-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(i-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(t-Bu)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(n-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(i-Pr)                                   OCF.sub.2 H                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                                   CF.sub.3                                                                             i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                                   CF.sub.3                                                                             i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                                   CF.sub.3                                                                             i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(i-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(t-Bu)                                   OCF.sub.3                                                                            i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (n-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (i-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                             Ph     CO(n-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                             Ph     CO(i-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                             Ph     CO(t-Bu)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (t-Bu)                            OCF.sub.3.                                                                           CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(n-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(i-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                            Ph     CO(t-Bu)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(n-Pr)                                   CF.sub.3                                                                             4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(i-Pr)                                   CF.sub.3                                                                             4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(t-Bu)                                   CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(n-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(i-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(t-Bu)                                   OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   CF.sub.3                                                                             4-FPh  CO(i-Pr)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                   CF.sub.3                                                                             4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-ClPh CO(t-Bu)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub. 2 (n-Pr)                                                                     OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (t-Bu)                            __________________________________________________________________________

                                      TABLE 6                                     __________________________________________________________________________     ##STR43##                                                                    R.sup.1                                                                              R.sup.3                                                                              Y      R.sup.1                                                                              R.sup.3                                                                              Y                                          __________________________________________________________________________    Cl     Me     H      OCF.sub.3                                                                            Me     COEt                                       Br     Me     H      Cl     Me     CO.sub.2 Me                                CF.sub.3                                                                             Me     H      Br     Me     CO.sub.2 Me                                OCF.sub.3                                                                            Me     H      CF.sub.3                                                                             Me     CO.sub.2 Me                                Cl     Me     Me     OCF.sub.3                                                                            Me     CO.sub.2 Me                                Br     Me     Me     Cl     Me     CO.sub.2 Et                                CF.sub.3                                                                             Me     Me     Br     Me     CO.sub.2 Et                                OCF.sub.3                                                                            Me     Me     CF.sub.3                                                                             Me     CO.sub.2 Et                                Cl     Me     Et     OCF.sub.3                                                                            Me     CO.sub.2 Et                                Br     Me     Et     Cl     Me     CH.sub.2 OMe                               CF.sub.3                                                                             Me     Et     Br     Me     CH.sub.2 OMe                               OCF.sub.3                                                                            Me     Et     CF.sub.3                                                                             Me     CH.sub.2 OMe                               Cl     Me     n-Pr   OCF.sub.3                                                                            Me     CH.sub.2 OMe                               Br     Me     n-Pr   Cl     Me     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Me     n-Pr   Br     Me     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Me     n-Pr   CF.sub.3                                                                             Me     CH.sub.2 CHCH.sub.2                        Cl     Me     COMe   OCF.sub.3                                                                            Me     CH.sub.2 CHCH.sub.2                        Br     Me     COMe   Cl     Me     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Me     COMe   Br     Me     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Me     COMe   CF.sub.3                                                                             Me     CH.sub.2 SCH.sub.3                         Cl     Me     COEt   OCF.sub.3                                                                            Me     CH.sub.2 SCH.sub.3                         Br     Me     COEt   OCF.sub.2 H                                                                          Me     H                                          CF.sub.3                                                                             Me     COEt   OCF.sub.2 H                                                                          Me     Me                                         Cl     Et     H      OCF.sub.3                                                                            Et     COEt                                       Br     Et     H      Cl     Et     CO.sub.2 Me                                CF.sub.3                                                                             Et     H      Br     Et     CO.sub.2 Me                                OCF.sub.3                                                                            Et     H      CF.sub.3                                                                             Et     CO.sub.2 Me                                Cl     Et     Me     OCF.sub.3                                                                            Et     CO.sub.2 Me                                Br     Et     Me     Cl     Et     CO.sub.2 Et                                CF.sub.3                                                                             Et     Me     Br     Et     CO.sub.2 Et                                OCF.sub.3                                                                            Et     Me     CF.sub.3                                                                             Et     CO.sub.2 Et                                Cl     Et     Et     OCF.sub.3                                                                            Et     CO.sub.2 Et                                Br     Et     Et     Cl     Et     CH.sub.2 OMe                               CF.sub.3                                                                             Et     Et     Br     Et     CH.sub.2 OMe                               OCF.sub. 3                                                                           Et     Et     CF.sub.3                                                                             Et     CH.sub.2 OMe                               Cl     Et     n-Pr   OCF.sub.3                                                                            Et     CH.sub.2 OMe                               Br     Et     n-Pr   Cl     Et     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Et     n-Pr   Br     Et     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Et     n-Pr   CF.sub.3                                                                             Et     CH.sub.2 CHCH.sub.2                        Cl     Et     COMe   OCF.sub.3                                                                            Et     CH.sub.2 CHCH.sub.2                        Br     Et     COMe   Cl     Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COMe   Br     Et     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Et     COMe   CF.sub.3                                                                             Et     CH.sub.2 SCH.sub.3                         Cl     Et     COEt   OCF.sub.3                                                                            Et     CH.sub.2 SCH.sub.3                         Br     Et     COEt   OCF.sub.2 H                                                                          Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COEt   OCF.sub.2 H                                                                          Me     Et                                         OCF.sub.2 H                                                                          Et     H      OCF.sub.2 H                                                                          Me     n-Pr                                       OCF.sub.2 H                                                                          Et     Me     OCF.sub.2 H                                                                          Me     COMe                                       OCF.sub.2 H                                                                          Et     Et     OCF.sub.2 H                                                                          Me     COEt                                       OCF.sub.2 H                                                                          Et     n-Pr   OCF.sub.2 H                                                                          Me     CO.sub.2 Me                                OCF.sub.2 H                                                                          Et     COMe   OCF.sub.2 H                                                                          Me     CO.sub.2 Et                                OCF.sub.2 H                                                                          Et     COEt   OCF.sub.2 H                                                                          Me     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                          Me     CH.sub.2 CHCH.sub.2                        OCF.sub. 2 H                                                                         Et     CO.sub.2 Et                                                                          OCF.sub.2 H                                                                          Me     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Et     CH.sub.2 OMe                                                                         OCF.sub.3                                                                            n-Pr   COEt                                       OCF.sub.2 H                                                                          Et     CH.sub.2 CHCH.sub.2                                                                  Cl     n-Pr   CO.sub.2 Me                                Cl     n-Pr   H      Br     n-Pr   CO.sub.2 Me                                Br     n-Pr   H      CF.sub.3                                                                             n-Pr   CO.sub.2 Me                                CF.sub.3                                                                             n-Pr   H      OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            n-Pr   H      Cl     n-Pr   CO.sub.2 Et                                Cl     n-Pr   Me     Br     n-Pr   CO.sub.2 Et                                Br     n-Pr   Me     CF.sub.3                                                                             n-Pr   CO.sub.2 Et                                CF.sub.3                                                                             n-Pr   Me     OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            n-Pr   Me     Cl     n-Pr   CH.sub.2 OMe                               Cl     n-Pr   Et     Br     n-Pr   CH.sub.2 OMe                               Br     n-Pr   Et     CF.sub.3                                                                             n-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             n-Pr   Et     OCF.sub.3                                                                            n-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            n-Pr   Et     Cl     n-Pr   CH.sub.2 CHCH.sub.2                        Cl     n-Pr   n-Pr   Br     n-Pr   CH.sub.2 CHCH.sub.2                        Br     n-Pr   n-Pr   CF.sub.3                                                                             n-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             n-Pr   n-Pr   OCF.sub.3                                                                            n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            n-Pr   n-Pr   Cl     n-Pr   CH.sub.2 SCH.sub.3                         Cl     n-Pr   COMe   Br     n-Pr   CH.sub.2 SCH.sub.3                         Br     n-Pr   COMe   CF.sub. 3                                                                            n-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             n-Pr   COMe   OCF.sub.3                                                                            n-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            n-Pr   COMe   OCF.sub.2 H                                                                          n-Pr   COEt                                       Cl     n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Me                                Br     n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Et                                CF.sub.3                                                                             n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          n-Pr   H      OCF.sub.2 H                                                                          n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          n-Pr   Me     OCF.sub.2 H                                                                          n-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          n-Pr   Et                                                              OCF.sub.2 H                                                                          n-Pr   n-Pr                                                            OCF.sub.2 H                                                                          n-Pr   COMe                                                            Cl     i-Pr   H      OCF.sub.3                                                                            i-Pr   COEt                                       Br     i-Pr   H      Cl     i-Pr   CO.sub.2 Me                                CF.sub.3                                                                             i-Pr   H      Br     i-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            i-Pr   H      CF.sub.3                                                                             i-Pr   CO.sub.2 Me                                Cl     i-Pr   Me     OCF.sub.3                                                                            i-Pr   CO.sub.2 Me                                Br     i-Pr   Me     Cl     i-Pr   CO.sub.2 Et                                CF.sub.3                                                                             i-Pr   Me     Br     i-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            i-Pr   Me     CF.sub.3                                                                             i-Pr   CO.sub.2 Et                                Cl     i-Pr   Et     OCF.sub.3                                                                            i-Pr   CO.sub.2 Et                                Br     i-Pr   Et     Cl     i-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             i-Pr   Et     Br     i-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Pr   Et     CF.sub.3                                                                             i-Pr   CH.sub.2 OMe                               Cl     i-Pr   n-Pr   OCF.sub.3                                                                            i-Pr   CH.sub.2 OMe                               Br     i-Pr   n-Pr   Cl     i-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Pr   n-Pr   Br     i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Pr   n-Pr   CF.sub.3                                                                             i-Pr   CH.sub.2 CHCH.sub.2                        Cl     i-Pr   COMe   OCF.sub.3                                                                            i-Pr   CH.sub.2 CHCH.sub.2                        Br     i-Pr   COMe   Cl     i-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Pr   COMe   Br     i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Pr   COMe   CF.sub.3                                                                             i-Pr   CH.sub.2 SCH.sub.3                         Cl     i-Pr   COEt   OCF.sub.3                                                                            i-Pr   CH.sub.2 SCH.sub.3                         Br     i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   COEt                                       CF.sub.3                                                                             i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Pr   H      OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Pr   Me     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Pr   Et     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Pr   n-Pr   OCF.sub.2 H                                                                          i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Pr   COMe                                                            Cl     i-Bu   H      OCF.sub.3                                                                            i-Bu   COEt                                       Br     i-Bu   H      Cl     i-Bu   CO.sub.2 Me                                CF.sub.3                                                                             i-Bu   H      Br     i-Bu   CO.sub.2 Me                                OCF.sub.3                                                                            i-Bu   H      CF.sub.3                                                                             i-Bu   CO.sub.2 Me                                Cl     i-Bu   Me     OCF.sub.3                                                                            i-Bu   CO.sub.2 Me                                Br     i-Bu   Me     Cl     i-Bu   CO.sub.2 Et                                CF.sub.3                                                                             i-Bu   Me     Br     i-Bu   CO.sub.2 Et                                OCF.sub.3                                                                            i-Bu   Me     CF.sub.3                                                                             i-Bu   CO.sub.2 Et                                Cl     i-Bu   Et     OCF.sub.3                                                                            i-Bu   CO.sub.2 Et                                Br     i-Bu   Et     Cl     i-Bu   CH.sub.2 OMe                               CF.sub.3                                                                             i-Bu   Et     Br     i-Bu   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Bu   Et     CF.sub.3                                                                             i-Bu   CH.sub.2 OMe                               Cl     i-Bu   n-Pr   OCF.sub.3                                                                            i-Bu   CH.sub.2 OMe                               Br     i-Bu   n-Pr   Cl     i-Bu   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Bu   n-Pr   Br     i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Bu   n-Pr   CF.sub.3                                                                             i-Bu   CH.sub.2 CHCH.sub.2                        Cl     i-Bu   COMe   OCF.sub.3                                                                            i-Bu   CH.sub.2 CHCH.sub.2                        Br     i-Bu   COMe   Cl     i-Bu   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Bu   COMe   Br     i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Bu   COMe   CF.sub.3                                                                             i-Bu   CH.sub.2 SCH.sub.3                         Cl     i-Bu   COEt   OCF.sub.3                                                                            i-Bu   CH.sub.2 SCH.sub.3                         Br     i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   COEt                                       CF.sub.3                                                                             i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Bu   H      OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Bu   Me     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Bu   Et     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Bu   n-Pr   OCF.sub.2 H                                                                          i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Bu   COMe                                                            Cl     CO.sub.2 Me                                                                          H      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                       Br     CO.sub.2 Me                                                                          H      Cl     CO.sub.2 Me                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Me                                                                          H      Br     CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          H      CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                                Br     CO.sub.2 Me                                                                          Me     Cl     CO.sub.2 Me                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Me                                                                          Me     Br     CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me     CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                                Br     CO.sub.2 Me                                                                          Et     Cl     CO.sub.2 Me                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Me                                                                          Et     Br     CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et     CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Me                                                                          n-Pr   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Me                                                                          n-Pr   Cl     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr   Br     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Me                                                                          COMe   Cl     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe   Br     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COMe                                                            Cl     CO.sub.2 Et                                                                          H      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COEt                                       Br     CO.sub.2 Et                                                                          H      Cl     CO.sub.2 Et                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Et                                                                          H      Br     CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          H      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                                Br     CO.sub.2 Et                                                                          Me     Cl     CO.sub.2 Et                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Et                                                                          Me     Br     CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me     CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Et                                Br     CO.sub.2 Et                                                                          Et     Cl     CO.sub.2 Et                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Et                                                                          Et     Br     CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et     CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Et                                                                          n-Pr   Cl     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CO.sub.2 Et                                                                          n-Pr   Br     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Et                                                                          COMe   Cl     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe   Br     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COMe                                                            Cl     Ph     H      OCF.sub.3                                                                            Ph     COEt                                       Br     Ph     H      Cl     Ph     CO.sub.2 Me                                CF.sub.3                                                                             Ph     H      Br     Ph     CO.sub.2 Me                                OCF.sub.3                                                                            Ph     H      CF.sub.3                                                                             Ph     CO.sub.2 Me                                Cl     Ph     Me     OCF.sub.3                                                                            Ph     CO.sub.2 Me                                Br     Ph     Me     Cl     Ph     CO.sub.2 Et                                CF.sub.3                                                                             Ph     Me     Br     Ph     CO.sub.2 Et                                OCF.sub.3                                                                            Ph     Me     CF.sub.3                                                                             Ph     CO.sub.2 Et                                Cl     Ph     Et     OCF.sub.3                                                                            Ph     CO.sub.2 Et                                Br     Ph     Et     Cl     Ph     CH.sub.2 OMe                               CF.sub.3                                                                             Ph     Et     Br     Ph     CH.sub.2 OMe                               OCF.sub.3                                                                            Ph     Et     CF.sub.3                                                                             Ph     CH.sub.2 OMe                               Cl     Ph     n-Pr   OCF.sub.3                                                                            Ph     CH.sub.2 OMe                               Br     Ph     n-Pr   Cl     Ph     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Ph     n-Pr   Br     Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Ph     n-Pr   CF.sub.3                                                                             Ph     CH.sub.2 CHCH.sub.2                        Cl     Ph     COMe   OCF.sub.3                                                                            Ph     CH.sub.2 CHCH.sub.2                        Br     Ph     COMe   Cl     Ph     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Ph     COMe   Br     Ph     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Ph     COMe   CF.sub.3                                                                             Ph     CH.sub.2 SCH.sub.3                         Cl     Ph     COEt   OCF.sub.3                                                                            Ph     CH.sub.2 SCH.sub.3                         Br     Ph     COEt   OCF.sub.2 H                                                                          Ph     COEt                                       CF.sub.3                                                                             Ph     COEt   OCF.sub.2 H                                                                          Ph     CO.sub.2 Me                                OCF.sub.2 H                                                                          Ph     H      OCF.sub.2 H                                                                          Ph     CO.sub.2 Et                                OCF.sub.2 H                                                                          Ph     Me     OCF.sub.2 H                                                                          Ph     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Ph     Et     OCF.sub.2 H                                                                          Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          Ph     n-Pr   OCF.sub.2 H                                                                          Ph     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Ph     COMe                                                            Cl     4-ClPh H      OCF.sub.3                                                                            4-ClPh COEt                                       Br     4-ClPh H      Cl     4-ClPh CO.sub.2 Me                                CF.sub.3                                                                             4-ClPh H      Br     4-ClPh CO.sub.2 Me                                OCF.sub.3                                                                            4-ClPh H      CF.sub.3                                                                             4-ClPh CO.sub.2 Me                                Cl     4-ClPh Me     OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                                Br     4-ClPh Me     Cl     4-ClPh CO.sub.2 Et                                CF.sub.3                                                                             4-ClPh Me     Br     4-ClPh CO.sub.2 Et                                OCF.sub.3                                                                            4-ClPh Me     CF.sub.3                                                                             4-ClPh CO.sub.2 Et                                Cl     4-ClPh Et     OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                                Br     4-ClPh Et     Cl     4-ClPh CH.sub.2 OMe                               CF.sub.3                                                                             4-ClPh Et     Br     4-ClPh CH.sub.2 OMe                               OCF.sub.3                                                                            4-ClPh Et     CF.sub.3                                                                             4-ClPh CH.sub.2 OMe                               Cl     4-ClPh n-Pr   OCF.sub.3                                                                            4-Cl Ph                                                                              CH.sub.2 OMe                               Br     4-ClPh n-Pr   Cl     4-ClPh CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-ClPh n-Pr   Br     4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-ClPh n-Pr   CF.sub.3                                                                             4-ClPh CH.sub.2 CHCH.sub.2                        Cl     4-ClPh COMe   OCF.sub.3                                                                            4-ClPh CH.sub.2 CHCH.sub.2                        Br     4-ClPh COMe   Cl     4-ClPh CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-ClPh COMe   Br     4-ClPh CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            4-ClPh COMe   CF.sub.3                                                                             4-ClPh CH.sub.2 SCH.sub.3                         Cl     4-ClPh COEt   OCF.sub.3                                                                            4-ClPh CH.sub.2 SCH.sub.3                         Br     4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh COEt                                       CF.sub.3                                                                             4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Me                                OCF.sub.2 H                                                                          4-ClPh H      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Et                                OCF.sub.2 H                                                                          4-ClPh Me     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 OMe                               OCF.sub.2 H                                                                          4-ClPh Et     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-ClPh n-Pr   OCF.sub.2 H                                                                          4-ClPh CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          4-ClPh COMe                                                            Cl     4-FPh  H      OCF.sub.3                                                                            4-FPh  COEt                                       Br     4-FPh  H      Cl     4-FPh  CO.sub.2 Me                                CF.sub.3                                                                             4-FPh  H      Br     4-FPh  CO.sub.2 Me                                OCF.sub.3                                                                            4-FPh  H      CF.sub.3                                                                             4-FPh  CO.sub.2 Me                                Cl     4-FPh  Me     OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                                Br     4-FPh  Me     Cl     4-FPh  CO.sub.2 Et                                CF.sub.3                                                                             4-FPh  Me     Br     4-FPh  CO.sub.2 Et                                OCF.sub.3                                                                            4-FPh  Me     CF.sub.3                                                                             4-FPh  CO.sub.2 Et                                Cl     4-FPh  Et     OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                                Br     4-FPh  Et     Cl     4-FPh  CH.sub.2 OMe                               CF.sub.3                                                                             4-FPh  Et     Br     4-FPh  CH.sub.2 OMe                               OCF.sub.3                                                                            4-FPh  Et     CF.sub.3                                                                             4-FPh  CH.sub.2 OMe                               Cl     4-FPh  n-Pr   OCF.sub.3                                                                            4-FPh  CH.sub.2 OMe                               Br     4-FPh  n-Pr   Cl     4-FPh  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-FPh  n-Pr   Br     4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-FPh  n-Pr   CF.sub.3                                                                             4-FPh  CH.sub.2 CHCH.sub.2                        Cl     4-FPh  COMe   OCF.sub.3                                                                            4-FPh  CH.sub.2 CHCH.sub.2                        Br     4-FPh  COMe   Cl     4-FPh  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-FPh  COMe   Br     4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub. 3                                                                           4-FPh  COMe   CF.sub.3                                                                             4-FPh  CH.sub.2 SCH.sub.3                         Cl     4-FPh  COEt   OCF.sub.3                                                                            4-FPh  CH.sub.2 SCH.sub.3                         Br     4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  COEt                                       CF.sub.3                                                                             4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                                OCF.sub.2 H                                                                          4-FPh  H      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                                OCF.sub.2 H                                                                          4-FPh  Me     OCF.sub.2 H                                                                          4-FPh  CH.sub.2 OMe                               OCF.sub.2 H                                                                          4-FPh  Et     OCF.sub.2 H                                                                          4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-FPh  n-Pr   OCF.sub.2 H                                                                          4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          4-FPh  COMe                                                            Cl     CHCH.sub.2                                                                           H      OCF.sub.3                                                                            CHCH.sub.2                                                                           COEt                                       Br     CHCH.sub.2                                                                           H      Cl     CHCH.sub.2                                                                           CO.sub.2 Me                                CF.sub.3                                                                             CHCH.sub.2                                                                           H      Br     CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.3                                                                            CHCH.sub.2                                                                           H      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Me                                Cl     CHCH.sub.2                                                                           Me     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Me                                Br     CHCH.sub.2                                                                           Me     Cl     CHCH.sub.2                                                                           CO.sub.2 Et                                CF.sub.3                                                                             CHCH.sub.2                                                                           Me     Br     CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.3                                                                            CHCH.sub.2                                                                           Me     CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Et                                Cl     CHCH.sub.2                                                                           Et     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Et                                Br     CHCH.sub.2                                                                           Et     Cl     CHCH.sub.2                                                                           CH.sub.2 OMe                               CF.sub.3                                                                             CHCH.sub.2                                                                           Et     Br     CHCH.sub.2                                                                           CH.sub.2 OMe                               OCF.sub.3                                                                            CHCH.sub.2                                                                           Et     CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 OMe                               Cl     CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 OMe                               Br     CHCH.sub.2                                                                           n-Pr   Cl     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CHCH.sub.2                                                                           n-Pr   Br     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Cl     CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Br     CHCH.sub.2                                                                           COMe   Cl     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CHCH.sub.2                                                                           COMe   Br     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CHCH.sub.2                                                                           COMe   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Cl     CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Br     CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COEt                                       CF.sub.3                                                                             CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 OMe                               OCF.sub. 2 H                                                                         CHCH.sub.2                                                                           Et     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COMe                                                            Cl     C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COEt                                       Br     C(CH.sub.3)CH.sub.2                                                                  H      Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  H      Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Cl     C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Br     C(CH.sub.3)CH.sub.2                                                                  Me     Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Me     Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Cl     C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Br     C(CH.sub.3)CH.sub.2                                                                  Et     Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Et     Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               OCF.sub.3                                                                            C(CH.sub. 3)CH.sub.2                                                                 Et     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Cl     C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Br     C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Cl     C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Br     C(CH.sub.3)CH.sub.2                                                                  COMe   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COMe   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Cl     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Br     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                          C(CH.sub. 3)CH.sub.2                                                                 CO.sub.2 Et                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe                                                            CF.sub.3                                                                             Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (n-Pr)                            CF.sub.3                                                                             Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Me     CO(n-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Me     CO(i-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Me     CO(t-Bu)                                                                             CF.sub.3                                                                             n-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Me     CO(n-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Me     CO(i-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Me     CO(t-Bu)                                                                             OCF.sub.3                                                                            n-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (t-Bu)                            CF.sub.3                                                                             Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub. 2 (n-Pr)                           CF.sub.3                                                                             Et     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Et     CO(n-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Et     CO(i-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Et     CO(t-Bu)                                                                             CF.sub.3                                                                             i-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Et     CO(n-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Et     CO(i-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Et     CO(t-Bu)                                                                             OCF.sub.3                                                                            i-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(i-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(t-Bu)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(n-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(i-Pr)                                   OCF.sub.2 H                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub. 2 H                                                                         n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                                   CF.sub.3                                                                             i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                                   CF.sub.3                                                                             i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                                   CF.sub.3                                                                             i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(i-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(t-Bu)                                   OCF.sub.3                                                                            i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (n-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (i-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                             Ph     CO(n-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                             Ph     CO(i-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                             Ph     CO(t-Bu)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(n-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(i-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                            Ph     CO(t-Bu)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(n-Pr)                                   CF.sub.3                                                                             4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(i-Pr)                                   CF.sub.3                                                                             4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(t-Bu)                                   CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(n-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(i-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(t-Bu)                                   OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   CF.sub.3                                                                             4-FPh  CO(i-Pr)                                                                             CF.sub. 3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                   CF.sub.3                                                                             4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-ClPh CO(t-Bu)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (t-Bu)                            __________________________________________________________________________

                                      TABLE 7                                     __________________________________________________________________________     ##STR44##                                                                    R.sup.1                                                                              R.sup.3                                                                              Y      R.sup.1                                                                              R.sup.3                                                                              Y                                          __________________________________________________________________________    Cl     Me     H      OCF.sub.3                                                                            Me     COEt                                       Br     Me     H      Cl     Me     CO.sub.2 Me                                CF.sub.3                                                                             Me     H      Br     Me     CO.sub.2 Me                                OCF.sub.3                                                                            Me     H      CF.sub.3                                                                             Me     CO.sub.2 Me                                Cl     Me     Me     OCF.sub.3                                                                            Me     CO.sub.2 Me                                Br     Me     Me     Cl     Me     CO.sub.2 Et                                CF.sub.3                                                                             Me     Me     Br     Me     CO.sub.2 Et                                OCF.sub.3                                                                            Me     Me     CF.sub.3                                                                             Me     CO.sub.2 Et                                Cl     Me     Et     OCF.sub.3                                                                            Me     CO.sub.2 Et                                Br     Me     Et     Cl     Me     CH.sub.2 OMe                               CF.sub.3                                                                             Me     Et     Br     Me     CH.sub.2 OMe                               OCF.sub.3                                                                            Me     Et     CF.sub.3                                                                             Me     CH.sub.2 OMe                               Cl     Me     n-Pr   OCF.sub.3                                                                            Me     CH.sub.2 OMe                               Br     Me     n-Pr   Cl     Me     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Me     n-Pr   Br     Me     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Me     n-Pr   CF.sub.3                                                                             Me     CH.sub.2 CHCH.sub.2                        Cl     Me     COMe   OCF.sub.3                                                                            Me     CH.sub.2 CHCH.sub.2                        Br     Me     COMe   Cl     Me     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Me     COMe   Br     Me     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Me     COMe   CF.sub.3                                                                             Me     CH.sub.2 SCH.sub.3                         Cl     Me     COEt   OCF.sub.3                                                                            Me     CH.sub.2 SCH.sub.3                         Br     Me     COEt   OCF.sub.2 H                                                                          Me     H                                          CF.sub.3                                                                             Me     COEt   OCF.sub.2 H                                                                          Me     Me                                         Cl     Et     H      OCF.sub.3                                                                            Et     COEt                                       Br     Et     H      Cl     Et     CO.sub.2 Me                                CF.sub.3                                                                             Et     H      Br     Et     CO.sub.2 Me                                OCF.sub.3                                                                            Et     H      CF.sub.3                                                                             Et     CO.sub.2 Me                                Cl     Et     Me     OCF.sub.3                                                                            Et     CO.sub.2 Me                                Br     Et     Me     Cl     Et     CO.sub.2 Et                                CF.sub.3                                                                             Et     Me     Br     Et     CO.sub.2 Et                                OCF.sub.3                                                                            Et     Me     CF.sub.3                                                                             Et     CO.sub.2 Et                                Cl     Et     Et     OCF.sub.3                                                                            Et     CO.sub.2 Et                                Br     Et     Et     Cl     Et     CH.sub.2 OMe                               CF.sub.3                                                                             Et     Et     Br     Et     CH.sub.2 OMe                               OCF.sub. 3                                                                           Et     Et     CF.sub.3                                                                             Et     CH.sub.2 OMe                               Cl     Et     n-Pr   OCF.sub.3                                                                            Et     CH.sub.2 OMe                               Br     Et     n-Pr   Cl     Et     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Et     n-Pr   Br     Et     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Et     n-Pr   CF.sub.3                                                                             Et     CH.sub.2 CHCH.sub.2                        Cl     Et     COMe   OCF.sub.3                                                                            Et     CH.sub.2 CHCH.sub.2                        Br     Et     COMe   Cl     Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COMe   Br     Et     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Et     COMe   CF.sub.3                                                                             Et     CH.sub.2 SCH.sub.3                         Cl     Et     COEt   OCF.sub.3                                                                            Et     CH.sub.2 SCH.sub.3                         Br     Et     COEt   OCF.sub.2 H                                                                          Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COEt   OCF.sub.2 H                                                                          Me     Et                                         OCF.sub.2 H                                                                          Et     H      OCF.sub.2 H                                                                          Me     n-Pr                                       OCF.sub.2 H                                                                          Et     Me     OCF.sub.2 H                                                                          Me     COMe                                       OCF.sub.2 H                                                                          Et     Et     OCF.sub.2 H                                                                          Me     COEt                                       OCF.sub.2 H                                                                          Et     n-Pr   OCF.sub.2 H                                                                          Me     CO.sub.2 Me                                OCF.sub.2 H                                                                          Et     COMe   OCF.sub.2 H                                                                          Me     CO.sub.2 Et                                OCF.sub.2 H                                                                          Et     COEt   OCF.sub.2 H                                                                          Me     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                          Me     CH.sub.2 CHCH.sub.2                        OCF.sub. 2 H                                                                         Et     CO.sub.2 Et                                                                          OCF.sub.2 H                                                                          Me     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Et     CH.sub.2 OMe                                                                         OCF.sub.3                                                                            n-Pr   COEt                                       OCF.sub.2 H                                                                          Et     CH.sub.2 CHCH.sub.2                                                                  Cl     n-Pr   CO.sub.2 Me                                Cl     n-Pr   H      Br     n-Pr   CO.sub.2 Me                                Br     n-Pr   H      CF.sub.3                                                                             n-Pr   CO.sub.2 Me                                CF.sub.3                                                                             n-Pr   H      OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            n-Pr   H      Cl     n-Pr   CO.sub.2 Et                                Cl     n-Pr   Me     Br     n-Pr   CO.sub.2 Et                                Br     n-Pr   Me     CF.sub.3                                                                             n-Pr   CO.sub.2 Et                                CF.sub.3                                                                             n-Pr   Me     OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            n-Pr   Me     Cl     n-Pr   CH.sub.2 OMe                               Cl     n-Pr   Et     Br     n-Pr   CH.sub.2 OMe                               Br     n-Pr   Et     CF.sub.3                                                                             n-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             n-Pr   Et     OCF.sub.3                                                                            n-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            n-Pr   Et     Cl     n-Pr   CH.sub.2 CHCH.sub.2                        Cl     n-Pr   n-Pr   Br     n-Pr   CH.sub.2 CHCH.sub.2                        Br     n-Pr   n-Pr   CF.sub.3                                                                             n-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             n-Pr   n-Pr   OCF.sub.3                                                                            n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            n-Pr   n-Pr   Cl     n-Pr   CH.sub.2 SCH.sub.3                         Cl     n-Pr   COMe   Br     n-Pr   CH.sub.2 SCH.sub.3                         Br     n-Pr   COMe   CF.sub. 3                                                                            n-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             n-Pr   COMe   OCF.sub.3                                                                            n-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            n-Pr   COMe   OCF.sub.2 H                                                                          n-Pr   COEt                                       Cl     n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Me                                Br     n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Et                                CF.sub.3                                                                             n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          n-Pr   H      OCF.sub.2 H                                                                          n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          n-Pr   Me     OCF.sub.2 H                                                                          n-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          n-Pr   Et                                                              OCF.sub.2 H                                                                          n-Pr   n-Pr                                                            OCF.sub.2 H                                                                          n-Pr   COMe                                                            Cl     i-Pr   H      OCF.sub.3                                                                            i-Pr   COEt                                       Br     i-Pr   H      Cl     i-Pr   CO.sub.2 Me                                CF.sub.3                                                                             i-Pr   H      Br     i-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            i-Pr   H      CF.sub.3                                                                             i-Pr   CO.sub.2 Me                                Cl     i-Pr   Me     OCF.sub.3                                                                            i-Pr   CO.sub.2 Me                                Br     i-Pr   Me     Cl     i-Pr   CO.sub.2 Et                                CF.sub.3                                                                             i-Pr   Me     Br     i-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            i-Pr   Me     CF.sub.3                                                                             i-Pr   CO.sub.2 Et                                Cl     i-Pr   Et     OCF.sub.3                                                                            i-Pr   CO.sub.2 Et                                Br     i-Pr   Et     Cl     i-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             i-Pr   Et     Br     i-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Pr   Et     CF.sub.3                                                                             i-Pr   CH.sub.2 OMe                               Cl     i-Pr   n-Pr   OCF.sub.3                                                                            i-Pr   CH.sub.2 OMe                               Br     i-Pr   n-Pr   Cl     i-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Pr   n-Pr   Br     i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Pr   n-Pr   CF.sub.3                                                                             i-Pr   CH.sub.2 CHCH.sub.2                        Cl     i-Pr   COMe   OCF.sub.3                                                                            i-Pr   CH.sub.2 CHCH.sub.2                        Br     i-Pr   COMe   Cl     i-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Pr   COMe   Br     i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Pr   COMe   CF.sub.3                                                                             i-Pr   CH.sub.2 SCH.sub.3                         Cl     i-Pr   COEt   OCF.sub.3                                                                            i-Pr   CH.sub.2 SCH.sub.3                         Br     i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   COEt                                       CF.sub.3                                                                             i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Pr   H      OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Pr   Me     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Pr   Et     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Pr   n-Pr   OCF.sub.2 H                                                                          i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Pr   COMe                                                            Cl     i-Bu   H      OCF.sub.3                                                                            i-Bu   COEt                                       Br     i-Bu   H      Cl     i-Bu   CO.sub.2 Me                                CF.sub.3                                                                             i-Bu   H      Br     i-Bu   CO.sub.2 Me                                OCF.sub.3                                                                            i-Bu   H      CF.sub.3                                                                             i-Bu   CO.sub.2 Me                                Cl     i-Bu   Me     OCF.sub.3                                                                            i-Bu   CO.sub.2 Me                                Br     i-Bu   Me     Cl     i-Bu   CO.sub.2 Et                                CF.sub.3                                                                             i-Bu   Me     Br     i-Bu   CO.sub.2 Et                                OCF.sub.3                                                                            i-Bu   Me     CF.sub.3                                                                             i-Bu   CO.sub.2 Et                                Cl     i-Bu   Et     OCF.sub.3                                                                            i-Bu   CO.sub.2 Et                                Br     i-Bu   Et     Cl     i-Bu   CH.sub.2 OMe                               CF.sub.3                                                                             i-Bu   Et     Br     i-Bu   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Bu   Et     CF.sub.3                                                                             i-Bu   CH.sub.2 OMe                               Cl     i-Bu   n-Pr   OCF.sub.3                                                                            i-Bu   CH.sub.2 OMe                               Br     i-Bu   n-Pr   Cl     i-Bu   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Bu   n-Pr   Br     i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Bu   n-Pr   CF.sub.3                                                                             i-Bu   CH.sub.2 CHCH.sub.2                        Cl     i-Bu   COMe   OCF.sub.3                                                                            i-Bu   CH.sub.2 CHCH.sub.2                        Br     i-Bu   COMe   Cl     i-Bu   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Bu   COMe   Br     i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Bu   COMe   CF.sub.3                                                                             i-Bu   CH.sub.2 SCH.sub.3                         Cl     i-Bu   COEt   OCF.sub.3                                                                            i-Bu   CH.sub.2 SCH.sub.3                         Br     i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   COEt                                       CF.sub.3                                                                             i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Bu   H      OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Bu   Me     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Bu   Et     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Bu   n-Pr   OCF.sub.2 H                                                                          i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Bu   COMe                                                            Cl     CO.sub.2 Me                                                                          H      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                       Br     CO.sub.2 Me                                                                          H      Cl     CO.sub.2 Me                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Me                                                                          H      Br     CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          H      CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                                Br     CO.sub.2 Me                                                                          Me     Cl     CO.sub.2 Me                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Me                                                                          Me     Br     CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me     CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                                Br     CO.sub.2 Me                                                                          Et     Cl     CO.sub.2 Me                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Me                                                                          Et     Br     CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et     CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Me                                                                          n-Pr   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Me                                                                          n-Pr   Cl     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr   Br     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Me                                                                          COMe   Cl     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe   Br     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COMe                                                            Cl     CO.sub.2 Et                                                                          H      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COEt                                       Br     CO.sub.2 Et                                                                          H      Cl     CO.sub.2 Et                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Et                                                                          H      Br     CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          H      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                                Br     CO.sub.2 Et                                                                          Me     Cl     CO.sub.2 Et                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Et                                                                          Me     Br     CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me     CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Et                                Br     CO.sub.2 Et                                                                          Et     Cl     CO.sub.2 Et                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Et                                                                          Et     Br     CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et     CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Et                                                                          n-Pr   Cl     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CO.sub.2 Et                                                                          n-Pr   Br     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Et                                                                          COMe   Cl     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe   Br     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COMe                                                            Cl     Ph     H      OCF.sub.3                                                                            Ph     COEt                                       Br     Ph     H      Cl     Ph     CO.sub.2 Me                                CF.sub.3                                                                             Ph     H      Br     Ph     CO.sub.2 Me                                OCF.sub.3                                                                            Ph     H      CF.sub.3                                                                             Ph     CO.sub.2 Me                                Cl     Ph     Me     OCF.sub.3                                                                            Ph     CO.sub.2 Me                                Br     Ph     Me     Cl     Ph     CO.sub.2 Et                                CF.sub.3                                                                             Ph     Me     Br     Ph     CO.sub.2 Et                                OCF.sub.3                                                                            Ph     Me     CF.sub.3                                                                             Ph     CO.sub.2 Et                                Cl     Ph     Et     OCF.sub.3                                                                            Ph     CO.sub.2 Et                                Br     Ph     Et     Cl     Ph     CH.sub.2 OMe                               CF.sub.3                                                                             Ph     Et     Br     Ph     CH.sub.2 OMe                               OCF.sub.3                                                                            Ph     Et     CF.sub.3                                                                             Ph     CH.sub.2 OMe                               Cl     Ph     n-Pr   OCF.sub.3                                                                            Ph     CH.sub.2 OMe                               Br     Ph     n-Pr   Cl     Ph     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Ph     n-Pr   Br     Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Ph     n-Pr   CF.sub.3                                                                             Ph     CH.sub.2 CHCH.sub.2                        Cl     Ph     COMe   OCF.sub.3                                                                            Ph     CH.sub.2 CHCH.sub.2                        Br     Ph     COMe   Cl     Ph     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Ph     COMe   Br     Ph     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Ph     COMe   CF.sub.3                                                                             Ph     CH.sub.2 SCH.sub.3                         Cl     Ph     COEt   OCF.sub.3                                                                            Ph     CH.sub.2 SCH.sub.3                         Br     Ph     COEt   OCF.sub.2 H                                                                          Ph     COEt                                       CF.sub.3                                                                             Ph     COEt   OCF.sub.2 H                                                                          Ph     CO.sub.2 Me                                OCF.sub.2 H                                                                          Ph     H      OCF.sub.2 H                                                                          Ph     CO.sub.2 Et                                OCF.sub.2 H                                                                          Ph     Me     OCF.sub.2 H                                                                          Ph     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Ph     Et     OCF.sub.2 H                                                                          Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          Ph     n-Pr   OCF.sub.2 H                                                                          Ph     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Ph     COMe                                                            Cl     4-ClPh H      OCF.sub.3                                                                            4-ClPh COEt                                       Br     4-ClPh H      Cl     4-ClPh CO.sub.2 Me                                CF.sub.3                                                                             4-ClPh H      Br     4-ClPh CO.sub.2 Me                                OCF.sub.3                                                                            4-ClPh H      CF.sub.3                                                                             4-ClPh CO.sub.2 Me                                Cl     4-ClPh Me     OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                                Br     4-ClPh Me     Cl     4-ClPh CO.sub.2 Et                                CF.sub.3                                                                             4-ClPh Me     Br     4-ClPh CO.sub.2 Et                                OCF.sub.3                                                                            4-ClPh Me     CF.sub.3                                                                             4-ClPh CO.sub.2 Et                                Cl     4-ClPh Et     OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                                Br     4-ClPh Et     Cl     4-ClPh CH.sub.2 OMe                               CF.sub.3                                                                             4-ClPh Et     Br     4-ClPh CH.sub.2 OMe                               OCF.sub.3                                                                            4-ClPh Et     CF.sub.3                                                                             4-ClPh CH.sub.2 OMe                               Cl     4-ClPh n-Pr   OCF.sub.3                                                                            4-ClPh CH.sub.2 OMe                               Br     4-ClPh n-Pr   Cl     4-ClPh CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-ClPh n-Pr   Br     4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-ClPh n-Pr   CF.sub.3                                                                             4-ClPh CH.sub.2 CHCH.sub.2                        Cl     4-ClPh COMe   OCF.sub.3                                                                            4-ClPh CH.sub.2 CHCH.sub.2                        Br     4-ClPh COMe   Cl     4-ClPh CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-ClPh COMe   Br     4-ClPh CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            4-ClPh COMe   CF.sub.3                                                                             4-ClPh CH.sub.2 SCH.sub.3                         Cl     4-ClPh COEt   OCF.sub.3                                                                            4-ClPh CH.sub.2 SCH.sub.3                         Br     4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh COEt                                       CF.sub.3                                                                             4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Me                                OCF.sub.2 H                                                                          4-ClPh H      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Et                                OCF.sub.2 H                                                                          4-ClPh Me     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 OMe                               OCF.sub.2 H                                                                          4-ClPh Et     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-ClPh n-Pr   OCF.sub.2 H                                                                          4-ClPh CH.sub.2 SCH.sub.2                         OCF.sub.2 H                                                                          4-ClPh COMe                                                            Cl     4-FPh  H      OCF.sub.3                                                                            4-FPh  COEt                                       Br     4-FPh  H      Cl     4-FPh  CO.sub.2 Me                                CF.sub.3                                                                             4-FPh  H      Br     4-FPh  CO.sub.2 Me                                OCF.sub.3                                                                            4-FPh  H      CF.sub.3                                                                             4-FPh  CO.sub.2 Me                                Cl     4-FPh  Me     OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                                Br     4-FPh  Me     Cl     4-FPh  CO.sub.2 Et                                CF.sub.3                                                                             4-FPh  Me     Br     4-FPh  CO.sub.2 Et                                OCF.sub.3                                                                            4-FPh  Me     CF.sub.3                                                                             4-FPh  CO.sub.2 Et                                Cl     4-FPh  Et     OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                                Br     4-FPh  Et     Cl     4-FPh  CH.sub.2 OMe                               CF.sub.3                                                                             4-FPh  Et     Br     4-FPh  CH.sub.2 OMe                               OCF.sub.3                                                                            4-FPh  Et     CF.sub.3                                                                             4-FPh  CH.sub.2 OMe                               Cl     4-FPh  n-Pr   OCF.sub.3                                                                            4-FPh  CH.sub.2 OMe                               Br     4-FPh  n-Pr   Cl     4-FPh  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-FPh  n-Pr   Br     4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-FPh  n-Pr   CF.sub.3                                                                             4-FPh  CH.sub.2 CHCH.sub.2                        Cl     4-FPh  COMe   OCF.sub.3                                                                            4-FPh  CH.sub.2 CHCH.sub.2                        Br     4-FPh  COMe   Cl     4-FPh  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-FPh  COMe   Br     4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            4-FPh  COMe   CF.sub.3                                                                             4-FPh  CH.sub.2 SCH.sub.3                         Cl     4-FPh  COEt   OCF.sub.3                                                                            4-FPh  CH.sub.2 SCH.sub.3                         Br     4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  COEt                                       CF.sub.3                                                                             4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                                OCF.sub.2 H                                                                          4-FPh  H      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                                OCF.sub.2 H                                                                          4-FPh  Me     OCF.sub.2 H                                                                          4-FPh  CH.sub.2 OMe                               OCF.sub.2 H                                                                          4-FPh  Et     OCF.sub.2 H                                                                          4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-FPh  n-Pr   OCF.sub.2 H                                                                          4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          4-FPh  COMe                                                            Cl     CHCH.sub.2                                                                           H      OCF.sub.3                                                                            CHCH.sub.2                                                                           COEt                                       Br     CHCH.sub.2                                                                           H      Cl     CHCH.sub.2                                                                           CO.sub.2 Me                                CF.sub.3                                                                             CHCH.sub.2                                                                           H      Br     CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.3                                                                            CHCH.sub.2                                                                           H      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Me                                Cl     CHCH.sub.2                                                                           Me     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Me                                Br     CHCH.sub.2                                                                           Me     Cl     CHCH.sub.2                                                                           CO.sub.2 Et                                CF.sub.3                                                                             CHCH.sub.2                                                                           Me     Br     CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.3                                                                            CHCH.sub.2                                                                           Me     CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Et                                Cl     CHCH.sub. 2                                                                          Et     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Et                                Br     CHCH.sub.2                                                                           Et     Cl     CHCH.sub.2                                                                           CH.sub.2 OMe                               CF.sub.3                                                                             CHCH.sub.2                                                                           Et     Br     CHCH.sub.2                                                                           CH.sub.2 OMe                               OCF.sub.3                                                                            CHCH.sub.2                                                                           Et     CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 OMe                               Cl     CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 OMe                               Br     CHCH.sub.2                                                                           n-Pr   Cl     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CHCH.sub.2                                                                           n-Pr   Br     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Cl     CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Br     CHCH.sub.2                                                                           COMe   Cl     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CHCH.sub.2                                                                           COMe   Br     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CHCH.sub.2                                                                           COMe   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Cl     CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Br     CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COEt                                       CF.sub.3                                                                             CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 OMe                               OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Et     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COMe                                                            Cl     C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COEt                                       Br     C(CH.sub.3)CH.sub.2                                                                  H      Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  H      Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Cl     C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Br     C(CH.sub.3)CH.sub.2                                                                  Me     Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Me     Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Cl     C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Br     C(CH.sub.3)CH.sub.2                                                                  Et     Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Et     Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Et     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Cl     C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Br     C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Cl     C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Br     C(CH.sub.3)CH.sub.2                                                                  COMe   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COMe   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Cl     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Br     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                          C(CH.sub. 3)CH.sub.2                                                                 CO.sub.2 Et                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe                                                            CF.sub.3                                                                             Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (n-Pr)                            CF.sub.3                                                                             Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Me     CO(n-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Me     CO(i-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Me     CO(t-Bu)                                                                             CF.sub.3                                                                             n-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Me     CO(n-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Me     CO(i-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Me     CO(t-Bu)                                                                             OCF.sub.3                                                                            n-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (t-Bu)                            CF.sub.3                                                                             Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub. 2 (n-Pr)                           CF.sub.3                                                                             Et     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Et     CO(n-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Et     CO(i-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Et     CO(t-Bu)                                                                             CF.sub.3                                                                             i-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Et     CO(n-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Et     CO(i-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Et     CO(t-Bu)                                                                             OCF.sub.3                                                                            i-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(i-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(t-Bu)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(n-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(i-Pr)                                   OCF.sub.2 H                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub. 2 H                                                                         n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                                   CF.sub.3                                                                             i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                                   CF.sub.3                                                                             i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                                   CF.sub.3                                                                             i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(i-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(t-Bu)                                   OCF.sub.3                                                                            i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (n-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (i-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                             Ph     CO(n-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                             Ph     CO(i-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                             Ph     CO(t-Bu)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(n-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(i-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                            Ph     CO(t-Bu)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(n-Pr)                                   CF.sub.3                                                                             4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(i-Pr)                                   CF.sub.3                                                                             4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(t-Bu)                                   CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(n-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(i-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(t-Bu)                                   OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   CF.sub.3                                                                             4-FPh  CO(i-Pr)                                                                             CF.sub. 3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                   CF.sub.3                                                                             4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-ClPh CO(t-Bu)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (t-Bu)                            __________________________________________________________________________

                                      TABLE 8                                     __________________________________________________________________________     ##STR45##                                                                    R.sup.1                                                                              R.sup.3                                                                              Y      R.sup.1                                                                              R.sup.3                                                                              Y                                          __________________________________________________________________________    Cl     Me     H      OCF.sub.3                                                                            Me     COEt                                       Br     Me     H      Cl     Me     CO.sub.2 Me                                CF.sub.3                                                                             Me     H      Br     Me     CO.sub.2 Me                                OCF.sub.3                                                                            Me     H      CF.sub.3                                                                             Me     CO.sub.2 Me                                Cl     Me     Me     OCF.sub.3                                                                            Me     CO.sub.2 Me                                Br     Me     Me     Cl     Me     CO.sub.2 Et                                CF.sub.3                                                                             Me     Me     Br     Me     CO.sub.2 Et                                OCF.sub.3                                                                            Me     Me     CF.sub.3                                                                             Me     CO.sub.2 Et                                Cl     Me     Et     OCF.sub.3                                                                            Me     CO.sub.2 Et                                Br     Me     Et     Cl     Me     CH.sub.2 OMe                               CF.sub.3                                                                             Me     Et     Br     Me     CH.sub.2 OMe                               OCF.sub.3                                                                            Me     Et     CF.sub.3                                                                             Me     CH.sub.2 OMe                               Cl     Me     n-Pr   OCF.sub.3                                                                            Me     CH.sub.2 OMe                               Br     Me     n-Pr   Cl     Me     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Me     n-Pr   Br     Me     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Me     n-Pr   CF.sub.3                                                                             Me     CH.sub.2 CHCH.sub.2                        Cl     Me     COMe   OCF.sub.3                                                                            Me     CH.sub.2 CHCH.sub.2                        Br     Me     COMe   Cl     Me     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Me     COMe   Br     Me     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Me     COMe   CF.sub.3                                                                             Me     CH.sub.2 SCH.sub.3                         Cl     Me     COEt   OCF.sub.3                                                                            Me     CH.sub.2 SCH.sub.3                         Br     Me     COEt   OCF.sub.2 H                                                                          Me     H                                          CF.sub.3                                                                             Me     COEt   OCF.sub.2 H                                                                          Me     Me                                         Cl     Et     H      OCF.sub.3                                                                            Et     COEt                                       Br     Et     H      Cl     Et     CO.sub.2 Me                                CF.sub.3                                                                             Et     H      Br     Et     CO.sub.2 Me                                OCF.sub.3                                                                            Et     H      CF.sub.3                                                                             Et     CO.sub.2 Me                                Cl     Et     Me     OCF.sub.3                                                                            Et     CO.sub.2 Me                                Br     Et     Me     Cl     Et     CO.sub.2 Et                                CF.sub.3                                                                             Et     Me     Br     Et     CO.sub.2 Et                                OCF.sub.3                                                                            Et     Me     CF.sub.3                                                                             Et     CO.sub.2 Et                                Cl     Et     Et     OCF.sub.3                                                                            Et     CO.sub.2 Et                                Br     Et     Et     Cl     Et     CH.sub.2 OMe                               CF.sub.3                                                                             Et     Et     Br     Et     CH.sub.2 OMe                               OCF.sub. 3                                                                           Et     Et     CF.sub.3                                                                             Et     CH.sub.2 OMe                               Cl     Et     n-Pr   OCF.sub.3                                                                            Et     CH.sub.2 OMe                               Br     Et     n-Pr   Cl     Et     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Et     n-Pr   Br     Et     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Et     n-Pr   CF.sub.3                                                                             Et     CH.sub.2 CHCH.sub.2                        Cl     Et     COMe   OCF.sub.3                                                                            Et     CH.sub.2 CHCH.sub.2                        Br     Et     COMe   Cl     Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COMe   Br     Et     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Et     COMe   CF.sub.3                                                                             Et     CH.sub.2 SCH.sub.3                         Cl     Et     COEt   OCF.sub.3                                                                            Et     CH.sub.2 SCH.sub.3                         Br     Et     COEt   OCF.sub.2 H                                                                          Et     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Et     COEt   OCF.sub.2 H                                                                          Me     Et                                         OCF.sub.2 H                                                                          Et     H      OCF.sub.2 H                                                                          Me     n-Pr                                       OCF.sub.2 H                                                                          Et     Me     OCF.sub.2 H                                                                          Me     COMe                                       OCF.sub.2 H                                                                          Et     Et     OCF.sub.2 H                                                                          Me     COEt                                       OCF.sub.2 H                                                                          Et     n-Pr   OCF.sub.2 H                                                                          Me     CO.sub.2 Me                                OCF.sub.2 H                                                                          Et     COMe   OCF.sub.2 H                                                                          Me     CO.sub.2 Et                                OCF.sub.2 H                                                                          Et     COEt   OCF.sub.2 H                                                                          Me     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Et     CO.sub.2 Me                                                                          OCF.sub.2 H                                                                          Me     CH.sub.2 CHCH.sub.2                        OCF.sub. 2 H                                                                         Et     CO.sub.2 Et                                                                          OCF.sub.2 H                                                                          Me     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Et     CH.sub.2 OMe                                                    OCF.sub.2 H                                                                          Et     CH.sub.2 CHCH.sub.2                                             Cl     n-Pr   H      OCF.sub.3                                                                            n-Pr   COEt                                       Br     n-Pr   H      Cl     n-Pr   CO.sub.2 Me                                CF.sub.3                                                                             n-Pr   H      Br     n-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            n-Pr   H      CF.sub.3                                                                             n-Pr   CO.sub.2 Me                                Cl     n-Pr   Me     OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                                Br     n-Pr   Me     Cl     n-Pr   CO.sub.2 Et                                CF.sub.3                                                                             n-Pr   Me     Br     n-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            n-Pr   Me     CF.sub.3                                                                             n-Pr   CO.sub.2 Et                                Cl     n-Pr   Et     OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                                Br     n-Pr   Et     Cl     n-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             n-Pr   Et     Br     n-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            n-Pr   Et     CF.sub.3                                                                             n-Pr   CH.sub.2 OMe                               Cl     n-Pr   n-Pr   OCF.sub.3                                                                            n-Pr   CH.sub.2 OMe                               Br     n-Pr   n-Pr   Cl     n-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             n-Pr   n-Pr   Br     n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            n-Pr   n-Pr   CF.sub.3                                                                             n-Pr   CH.sub.2 CHCH.sub.2                        Cl     n-Pr   COMe   OCF.sub.3                                                                            n-Pr   CH.sub.2 CHCH.sub.2                        Br     n-Pr   COMe   Cl     n-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             n-Pr   COMe   Br     n-Pr   CH.sub. 2 SCH.sub.3                        OCF.sub.3                                                                            n-Pr   COMe   CF.sub.3                                                                             n-Pr   CH.sub.2 SCH.sub.3                         Cl     n-Pr   COEt   OCF.sub.3                                                                            n-Pr   CH.sub.2 SCH.sub.3                         Br     n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   COEt                                       CF.sub.3                                                                             n-Pr   COEt   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Me                                OCF.sub.2 H                                                                          n-Pr   H      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Et                                OCF.sub.2 H                                                                          n-Pr   Me     OCF.sub.2 H                                                                          n-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          n-Pr   Et     OCF.sub.2 H                                                                          n-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          n-Pr   n-Pr   OCF.sub.2 H                                                                          n-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          n-Pr   COMe                                                            Cl     i-Pr   H      OCF.sub.3                                                                            i-Pr   COEt                                       Br     i-Pr   H      Cl     i-Pr   CO.sub.2 Me                                CF.sub.3                                                                             i-Pr   H      Br     i-Pr   CO.sub.2 Me                                OCF.sub.3                                                                            i-Pr   H      CF.sub.3                                                                             i-Pr   CO.sub.2 Me                                Cl     i-Pr   Me     OCF.sub.3                                                                            i-Pr   CO.sub.2 Me                                Br     i-Pr   Me     Cl     i-Pr   CO.sub.2 Et                                CF.sub.3                                                                             i-Pr   Me     Br     i-Pr   CO.sub.2 Et                                OCF.sub.3                                                                            i-Pr   Me     CF.sub.3                                                                             i-Pr   CO.sub.2 Et                                Cl     i-Pr   Et     OCF.sub.3                                                                            i-Pr   CO.sub.2 Et                                Br     i-Pr   Et     Cl     i-Pr   CH.sub.2 OMe                               CF.sub.3                                                                             i-Pr   Et     Br     i-Pr   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Pr   Et     CF.sub.3                                                                             i-Pr   CH.sub.2 OMe                               Cl     i-Pr   n-Pr   OCF.sub.3                                                                            i-Pr   CH.sub.2 OMe                               Br     i-Pr   n-Pr   Cl     i-Pr   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Pr   n-Pr   Br     i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Pr   n-Pr   CF.sub.3                                                                             i-Pr   CH.sub.2 CHCH.sub.2                        Cl     i-Pr   COMe   OCF.sub.3                                                                            i-Pr   CH.sub.2 CHCH.sub.2                        Br     i-Pr   COMe   Cl     i-Pr   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Pr   COMe   Br     i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Pr   COMe   CF.sub.3                                                                             i-Pr   CH.sub.2 SCH.sub.3                         Cl     i-Pr   COEt   OCF.sub.3                                                                            i-Pr   CH.sub.2 SCH.sub.3                         Br     i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   COEt                                       CF.sub.3                                                                             i-Pr   COEt   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Pr   H      OCF.sub.2 H                                                                          i-Pr   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Pr   Me     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Pr   Et     OCF.sub.2 H                                                                          i-Pr   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Pr   n-Pr   OCF.sub.2 H                                                                          i-Pr   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Pr   COMe                                                            Cl     i-Bu   H      OCF.sub.3                                                                            i-Bu   COEt                                       Br     i-Bu   H      Cl     i-Bu   CO.sub.2 Me                                CF.sub.3                                                                             i-Bu   H      Br     i-Bu   CO.sub.2 Me                                OCF.sub.3                                                                            i-Bu   H      CF.sub.3                                                                             i-Bu   CO.sub.2 Me                                Cl     i-Bu   Me     OCF.sub.3                                                                            i-Bu   CO.sub.2 Me                                Br     i-Bu   Me     Cl     i-Bu   CO.sub.2 Et                                CF.sub.3                                                                             i-Bu   Me     Br     i-Bu   CO.sub.2 Et                                OCF.sub.3                                                                            i-Bu   Me     CF.sub.3                                                                             i-Bu   CO.sub.2 Et                                Cl     i-Bu   Et     OCF.sub.3                                                                            i-Bu   CO.sub.2 Et                                Br     i-Bu   Et     Cl     i-Bu   CH.sub.2 OMe                               CF.sub.3                                                                             i-Bu   Et     Br     i-Bu   CH.sub.2 OMe                               OCF.sub.3                                                                            i-Bu   Et     CF.sub.3                                                                             i-Bu   CH.sub.2 OMe                               Cl     i-Bu   n-Pr   OCF.sub.3                                                                            i-Bu   CH.sub.2 OMe                               Br     i-Bu   n-Pr   Cl     i-Bu   CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             i-Bu   n-Pr   Br     i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            i-Bu   n-Pr   CF.sub.3                                                                             i-Bu   CH.sub.2 CHCH.sub.2                        Cl     i-Bu   COMe   OCF.sub.3                                                                            i-Bu   CH.sub.2 CHCH.sub.2                        Br     i-Bu   COMe   Cl     i-Bu   CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             i-Bu   COMe   Br     i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            i-Bu   COMe   CF.sub.3                                                                             i-Bu   CH.sub.2 SCH.sub.3                         Cl     i-Bu   COEt   OCF.sub.3                                                                            i-Bu   CH.sub.2 SCH.sub.3                         Br     i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   COEt                                       CF.sub.3                                                                             i-Bu   COEt   OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Me                                OCF.sub.2 H                                                                          i-Bu   H      OCF.sub.2 H                                                                          i-Bu   CO.sub.2 Et                                OCF.sub.2 H                                                                          i-Bu   Me     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 OMe                               OCF.sub.2 H                                                                          i-Bu   Et     OCF.sub.2 H                                                                          i-Bu   CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          i-Bu   n-Pr   OCF.sub.2 H                                                                          i-Bu   CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          i-Bu   COMe                                                            Cl     CO.sub.2 Me                                                                          H      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                       Br     CO.sub.2 Me                                                                          H      Cl     CO.sub.2 Me                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Me                                                                          H      Br     CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          H      CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Me                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                                Br     CO.sub.2 Me                                                                          Me     Cl     CO.sub.2 Me                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Me                                                                          Me     Br     CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me     CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Me                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                                Br     CO.sub.2 Me                                                                          Et     Cl     CO.sub.2 Me                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Me                                                                          Et     Br     CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et     CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Me                                                                          n-Pr   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Me                                                                          n-Pr   Cl     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr   Br     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Me                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Me                                                                          COMe   Cl     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe   Br     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Me                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COMe                                                            Cl     CO.sub.2 Et                                                                          H      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COEt                                       Br     CO.sub.2 Et                                                                          H      Cl     CO.sub.2 Et                                                                          CO.sub.2 Me                                CF.sub.3                                                                             CO.sub.2 Et                                                                          H      Br     CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          H      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                                Cl     CO.sub.2 Et                                                                          Me     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                                Br     CO.sub.2 Et                                                                          Me     Cl     CO.sub.2 Et                                                                          CO.sub.2 Et                                CF.sub.3                                                                             CO.sub.2 Et                                                                          Me     Br     CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me     CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                                Cl     CO.sub.2 Et                                                                          Et     OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Et                                Br     CO.sub.2 Et                                                                          Et     Cl     CO.sub.2 Et                                                                          CH.sub.2 OMe                               CF.sub.3                                                                             CO.sub.2 Et                                                                          Et     Br     CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et     CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 OMe                               Cl     CO.sub.2 Et                                                                          n-Pr   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 OMe                               Br     CO.sub.2 Et                                                                          n-Pr   Cl     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CO.sub.2 Et                                                                          n-Pr   Br     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Cl     CO.sub.2 Et                                                                          COMe   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        Br     CO.sub.2 Et                                                                          COMe   Cl     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe   Br     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe   CF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Cl     CO.sub.2 Et                                                                          COEt   OCF.sub.3                                                                            CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         Br     CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COEt                                       CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Me                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          H      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 Et                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Me     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 OMe                               OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Et     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          n-Pr   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COMe                                                            Cl     Ph     H      OCF.sub.3                                                                            Ph     COEt                                       Br     Ph     H      Cl     Ph     CO.sub.2 Me                                CF.sub.3                                                                             Ph     H      Br     Ph     CO.sub.2 Me                                OCF.sub.3                                                                            Ph     H      CF.sub.3                                                                             Ph     CO.sub.2 Me                                Cl     Ph     Me     OCF.sub.3                                                                            Ph     CO.sub.2 Me                                Br     Ph     Me     Cl     Ph     CO.sub.2 Et                                CF.sub.3                                                                             Ph     Me     Br     Ph     CO.sub.2 Et                                OCF.sub.3                                                                            Ph     Me     CF.sub.3                                                                             Ph     CO.sub.2 Et                                Cl     Ph     Et     OCF.sub.3                                                                            Ph     CO.sub.2 Et                                Br     Ph     Et     Cl     Ph     CH.sub.2 OMe                               CF.sub.3                                                                             Ph     Et     Br     Ph     CH.sub.2 OMe                               OCF.sub.3                                                                            Ph     Et     CF.sub.3                                                                             Ph     CH.sub.2 OMe                               Cl     Ph     n-Pr   OCF.sub.3                                                                            Ph     CH.sub.2 OMe                               Br     Ph     n-Pr   Cl     Ph     CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             Ph     n-Pr   Br     Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            Ph     n-Pr   CF.sub.3                                                                             Ph     CH.sub.2 CHCH.sub.2                        Cl     Ph     COMe   OCF.sub.3                                                                            Ph     CH.sub.2 CHCH.sub.2                        Br     Ph     COMe   Cl     Ph     CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             Ph     COMe   Br     Ph     CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            Ph     COMe   CF.sub.3                                                                             Ph     CH.sub.2 SCH.sub.3                         Cl     Ph     COEt   OCF.sub.3                                                                            Ph     CH.sub.2 SCH.sub.3                         Br     Ph     COEt   OCF.sub.2 H                                                                          Ph     COEt                                       CF.sub.3                                                                             Ph     COEt   OCF.sub.2 H                                                                          Ph     CO.sub.2 Me                                OCF.sub.2 H                                                                          Ph     H      OCF.sub.2 H                                                                          Ph     CO.sub.2 Et                                OCF.sub.2 H                                                                          Ph     Me     OCF.sub.2 H                                                                          Ph     CH.sub.2 OMe                               OCF.sub.2 H                                                                          Ph     Et     OCF.sub.2 H                                                                          Ph     CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          Ph     n-Pr   OCF.sub.2 H                                                                          Ph     CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          Ph     COMe                                                            Cl     4-ClPh H      OCF.sub.3                                                                            4-ClPh COEt                                       Br     4-ClPh H      Cl     4-ClPh CO.sub.2 Me                                CF.sub.3                                                                             4-ClPh H      Br     4-ClPh CO.sub.2 Me                                OCF.sub.3                                                                            4-ClPh H      CF.sub.3                                                                             4-ClPh CO.sub.2 Me                                Cl     4-ClPh Me     OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                                Br     4-ClPh Me     Cl     4-ClPh CO.sub.2 Et                                CF.sub.3                                                                             4-ClPh Me     Br     4-ClPh CO.sub.2 Et                                OCF.sub.3                                                                            4-ClPh Me     CF.sub.3                                                                             4-ClPh CO.sub.2 Et                                Cl     4-ClPh Et     OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                                Br     4-ClPh Et     Cl     4-ClPh CH.sub.2 OMe                               CF.sub.3                                                                             4-ClPh Et     Br     4-ClPh CH.sub.2 OMe                               OCF.sub.3                                                                            4-ClPh Et     CF.sub.3                                                                             4-ClPh CH.sub.2 OMe                               Cl     4-ClPh n-Pr   OCF.sub.3                                                                            4-ClPh CH.sub.2 OMe                               Br     4-ClPh n-Pr   Cl     4-ClPh CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-ClPh n-Pr   Br     4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-ClPh n-Pr   CF.sub.3                                                                             4-ClPh CH.sub.2 CHCH.sub.2                        Cl     4-ClPh COMe   OCF.sub.3                                                                            4-ClPh CH.sub.2 CHCH.sub.2                        Br     4-ClPh COMe   Cl     4-ClPh CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-ClPh COMe   Br     4-ClPh CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            4-ClPh COMe   CF.sub.3                                                                             4-ClPh CH.sub.2 SCH.sub.3                         Cl     4-ClPh COEt   OCF.sub.3                                                                            4-ClPh CH.sub.2 SCH.sub.3                         Br     4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh COEt                                       CF.sub.3                                                                             4-ClPh COEt   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Me                                OCF.sub.2 H                                                                          4-ClPh H      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 Et                                OCF.sub.2 H                                                                          4-ClPh Me     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 OMe                               OCF.sub.2 H                                                                          4-ClPh Et     OCF.sub.2 H                                                                          4-ClPh CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-ClPh n-Pr   OCF.sub.2 H                                                                          4-ClPh CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          4-ClPh COMe                                                            Cl     4-FPh  H      OCF.sub.3                                                                            4-FPh  COEt                                       Br     4-FPh  H      Cl     4-FPh  CO.sub.2 Me                                CF.sub.3                                                                             4-FPh  H      Br     4-FPh  CO.sub.2 Me                                OCF.sub.3                                                                            4-FPh  H      CF.sub.3                                                                             4-FPh  CO.sub.2 Me                                Cl     4-FPh  Me     OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                                Br     4-FPh  Me     Cl     4-FPh  CO.sub.2 Et                                CF.sub.3                                                                             4-FPh  Me     Br     4-FPh  CO.sub.2 Et                                OCF.sub.3                                                                            4-FPh  Me     CF.sub.3                                                                             4-FPh  CO.sub.2 Et                                Cl     4-FPh  Et     OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                                Br     4-FPh  Et     Cl     4-FPh  CH.sub.2 OMe                               CF.sub.3                                                                             4-FPh  Et     Br     4-FPh  CH.sub.2 OMe                               OCF.sub.3                                                                            4-FPh  Et     CF.sub.3                                                                             4-FPh  CH.sub.2 OMe                               Cl     4-FPh  n-Pr   OCF.sub.3                                                                            4-FPh  CH.sub.2 OMe                               Br     4-FPh  n-Pr   Cl     4-FPh  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             4-FPh  n-Pr   Br     4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            4-FPh  n-Pr   CF.sub.3                                                                             4-FPh  CH.sub.2 CHCH.sub.2                        Cl     4-FPh  COMe   OCF.sub.3                                                                            4-FPh  CH.sub.2 CHCH.sub.2                        Br     4-FPh  COMe   Cl     4-FPh  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             4-FPh  COMe   Br     4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            4-FPh  COMe   CF.sub.3                                                                             4-FPh  CH.sub.2 SCH.sub.3                         Cl     4-FPh  COEt   OCF.sub.3                                                                            4-FPh  CH.sub.2 SCH.sub.3                         Br     4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  COEt                                       CF.sub.3                                                                             4-FPh  COEt   OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                                OCF.sub.2 H                                                                          4-FPh  H      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                                OCF.sub.2 H                                                                          4-FPh  Me     OCF.sub.2 H                                                                          4-FPh  CO.sub.2 OMe                               OCF.sub.2 H                                                                          4-FPh  Et     OCF.sub.2 H                                                                          4-FPh  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          4-FPh  n-Pr   OCF.sub.2 H                                                                          4-FPh  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          4-FPh  COMe                                                            Cl     CHCH.sub.2                                                                           H      OCF.sub.3                                                                            CHCH.sub.2                                                                           COEt                                       Br     CHCH.sub.2                                                                           H      Cl     CHCH.sub.2                                                                           CO.sub.2 Me                                CF.sub.3                                                                             CHCH.sub.2                                                                           H      Br     CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.3                                                                            CHCH.sub.2                                                                           H      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Me                                Cl     CHCH.sub.2                                                                           Me     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Me                                Br     CHCH.sub.2                                                                           Me     Cl     CHCH.sub.2                                                                           CO.sub.2 Et                                CF.sub.3                                                                             CHCH.sub.2                                                                           Me     Br     CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.3                                                                            CHCH.sub.2                                                                           Me     CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Et                                Cl     CHCH.sub. 2                                                                          Et     OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Et                                Br     CHCH.sub.2                                                                           Et     Cl     CHCH.sub.2                                                                           CH.sub.2 OMe                               CF.sub.3                                                                             CHCH.sub.2                                                                           Et     Br     CHCH.sub.2                                                                           CH.sub.2 OMe                               OCF.sub.3                                                                            CHCH.sub.2                                                                           Et     CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 OMe                               Cl     CHCH.sub.2                                                                           n-Pr   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 OMe                               Br     CHCH.sub.2                                                                           n-Pr   Cl     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             CHCH.sub.2                                                                           n-Pr   Br     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            CHCH.sub.2                                                                           n-Pr   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Cl     CHCH.sub.2                                                                           COMe   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        Br     CHCH.sub.2                                                                           COMe   Cl     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             CHCH.sub.2                                                                           COMe   Br     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            CHCH.sub.2                                                                           COMe   CF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Cl     CHCH.sub.2                                                                           COEt   OCF.sub.3                                                                            CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         Br     CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COEt                                       CF.sub.3                                                                             CHCH.sub.2                                                                           COEt   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Me                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           H      OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CO.sub.2 Et                                OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Me     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 OMe                               OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Et     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          CHCH.sub.2                                                                           n-Pr   OCF.sub.2 H                                                                          CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COMe                                                            Cl     C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COEt                                       Br     C(CH.sub.3)CH.sub.2                                                                  H      Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  H      Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Cl     C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                Br     C(CH.sub.3)CH.sub.2                                                                  Me     Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Me     Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Cl     C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                Br     C(CH.sub.3)CH.sub.2                                                                  Et     Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Et     Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Et     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Cl     C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               Br     C(CH.sub.3)CH.sub.2                                                                  n-Pr   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  n-Pr   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Cl     C(CH.sub.3)CH.sub.2                                                                  COMe   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        Br     C(CH.sub.3)CH.sub.2                                                                  COMe   Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COMe   Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe   CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Cl     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         Br     C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COEt                                       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COEt   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  H      OCF.sub.2 H                                                                          C(CH.sub. 3)CH.sub.2                                                                 CO.sub.2 Et                                OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Me     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                               OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Et     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr   OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                         OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe                                                            CF.sub.3                                                                             Me     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (n-Pr)                            CF.sub.3                                                                             Me     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Me     CO(n-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Me     CO(i-Pr)                                                                             CF.sub.3                                                                             n-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Me     CO(t-Bu)                                                                             CF.sub.3                                                                             n-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Me     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             n-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Me     CO(n-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Me     CO(i-Pr)                                                                             OCF.sub.3                                                                            n-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Me     CO(t-Bu)                                                                             OCF.sub.3                                                                            n-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            n-Pr   CO.sub.2 (t-Bu)                            CF.sub.3                                                                             Et     CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (n-Pr)                            CF.sub.3                                                                             Et     CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             Et     CO(n-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(n-Pr)                                   CF.sub.3                                                                             Et     CO(i-Pr)                                                                             CF.sub.3                                                                             i-Pr   CO(i-Pr)                                   CF.sub.3                                                                             Et     CO(t-Bu)                                                                             CF.sub.3                                                                             i-Pr   CO(t-Bu)                                   CF.sub.3                                                                             Et     CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            i-pr   CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            Et     CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            Et     CO(n-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(n-Pr)                                   OCF.sub.3                                                                            Et     CO(i-Pr)                                                                             OCF.sub.3                                                                            i-Pr   CO(i-Pr)                                   OCF.sub.3                                                                            Et     CO(t-Bu)                                                                             OCF.sub.3                                                                            i-Pr   CO(t-Bu)                                   OCF.sub.3                                                                            Et     CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            i-Pr   CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(i-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          Me     CO(i-Pr)                                                                             OCF.sub.2 H                                                                          Et     CO(t-Bu)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          Et     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          Me     CO(t-Bu)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(n-Pr)                                   OCF.sub.2 H                                                                          Me     CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          Et     CO(n-Pr)                                                                             OCF.sub.2 H                                                                          n-Pr   CO(i-Pr)                                   OCF.sub.2 H                                                                          Et     CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             i-Bu   CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            CF.sub.3                                                                             i-Bu   CO(n-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                                   CF.sub.3                                                                             i-Bu   CO(i-Pr)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                                   CF.sub.3                                                                             i-Bu   CO(t-Bu)                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                                   CF.sub.3                                                                             i-Bu   CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            i-Bu   CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            i-Bu   CO(n-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(i-Pr)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(i-Pr)                                   OCF.sub.3                                                                            i-Bu   CO(t-Bu)                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(t-Bu)                                   OCF.sub.3                                                                            i-Bu   CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (n-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (i-Pr)                            CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                             Ph     CO(n-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                             Ph     CO(i-Pr)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                             Ph     CO(t-Bu)                                   CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             Ph     CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(n-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                            Ph     CO(i-Pr)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                            Ph     CO(t-Bu)                                   OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            Ph     CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          n-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(i-Pr)                                   OCF.sub.2 H                                                                          n-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(i-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          i-Pr   CO(t-Bu)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          i-Pr   CO(n-Pr)                                                                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(n-Pr)                                   OCF.sub.2 H                                                                          i-Pr   CO.sub.2 (n-Pr)                                                                      OCF.sub. 2 H                                                                         CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-ClPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-ClPh CO(n-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(n-Pr)                                   CF.sub.3                                                                             4-ClPh CO(i-Pr)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(i-Pr)                                   CF.sub.3                                                                             4-ClPh CO(t-Bu)                                                                             CF.sub.3                                                                             CHCH.sub.2                                                                           CO(t-Bu)                                   CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(n-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(i-Pr)                                   OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                                                             OCF.sub.3                                                                            CHCH.sub.2                                                                           CO(t-Bu)                                   OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            CF.sub.3                                                                             4-FPh  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            CF.sub.3                                                                             4-FPh  CO(n-Pr)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   CF.sub.3                                                                             4-FPh  CO(i-Pr)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   CF.sub.3                                                                             4-FPh  CO(t-Bu)                                                                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                            OCF.sub.3                                                                            4-FPh  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                            OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                   OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                                                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                   OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-ClPh CO(t-Bu)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (t-Bu)                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                                   OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (n-Pr)                            OCF.sub.2 H                                                                          4-ClPh CO(n-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 i-Pr)                             OCF.sub.2 H                                                                          4-ClPh CO(i-Pr)                                                                             OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                                   OCF.sub.2 H                                                                          4-ClPh CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                          4-FPh  CO.sub.2 (t-Bu)                            __________________________________________________________________________

                                      TABLE 9                                     __________________________________________________________________________     ##STR46##                                                                    R.sup.1                                                                             R.sup.3                                                                             Y     R.sup.1                                                                             R.sup.3                                                                              Y                                              __________________________________________________________________________    Cl    Ph    H     Cl    4-ClPh H                                              Br    Ph    H     Br    4-ClPh H                                              CF.sub.3                                                                            Ph    H     CF.sub.3                                                                            4-ClPh H                                              OCF.sub.3                                                                           Ph    H     OCF.sub.3                                                                           4-ClPh H                                              Cl    Ph    Me    Cl    4-ClPh Me                                             Br    Ph    Me    Br    4-ClPh Me                                             CF.sub.3                                                                            Ph    Me    CF.sub.3                                                                            4-ClPh Me                                             OCF.sub.3                                                                           Ph    Me    OCF.sub.3                                                                           4-ClPh Me                                             Cl    Ph    Et    Cl    4-ClPh Et                                             Br    Ph    Et    Br    4-ClPh Et                                             CF.sub.3                                                                            Ph    Et    CF.sub.3                                                                            4-ClPh Et                                             OCF.sub.3                                                                           Ph    Et    OCF.sub.3                                                                           4-ClPh-                                                                              Et                                             Cl    Ph    COMe  Cl    4-ClPh COMe                                           Br    Ph    COMe  Br    4-ClPh COMe                                           CF.sub.3                                                                            Ph    COMe  CF.sub. 3                                                                           4-ClPh COMe                                           OCF.sub.3                                                                           Ph    COMe  OCF.sub.3                                                                           4-ClPh COMe                                           Cl    Ph    CO.sub.2 Me                                                                         Cl    4-ClPh CO.sub.2 Me                                    Br    Ph    CO.sub.2 Me                                                                         Br    4-ClPh CO.sub.2 Me                                    CF.sub.3                                                                            Ph    CO.sub.2 Me                                                                         CF.sub.3                                                                            4-ClPh CO.sub.2 Me                                    OCF.sub.3                                                                           Ph    CO.sub.2 Me                                                                         OCF.sub.3                                                                           4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    H     OCF.sub.2 H                                                                         Ph     COMe                                           OCF.sub.2 H                                                                         Ph    Me    OCF.sub.2 H                                                                         Ph     CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    Et    OCF.sub.2 H                                                                         Ph     COEt                                           OCF.sub.2 H                                                                         Ph    n-Pr  OCF.sub.2 H                                                                         Ph     CO.sub.2 Et                                    Cl    4-FPh H     OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                             Br    4-FPh H     Cl    CO.sub.2 Me                                                                          Et                                             CF.sub.3                                                                            4-FPh H     Br    CO.sub.2 Me                                                                          Et                                             OCF.sub.3                                                                           4-FPh H     CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                             Cl    4-FPh Me    OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                             Br    4-FPh Me    Cl    CO.sub.2 Me                                                                          COMe                                           CF.sub.3                                                                            4-FPh Me    Br    CO.sub.2 Me                                                                          COMe                                           OCF.sub.3                                                                           4-FPh Me    CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                           Cl    4-FPh Et    OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                           Br    4-FPh Et    Cl    CO.sub.2 Me                                                                          CO.sub.2 Me                                    CF.sub.3                                                                            4-FPh Et    Br    CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                           4-FPh Et    CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                                    Cl    4-FPh COMe  OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                    Br    4-FPh COMe  Cl    n-Pr   H                                              CF.sub.3                                                                            4-FPh COMe  Br    n-Pr   H                                              OCF.sub.3                                                                           4-FPh COMe  CF.sub.3                                                                            n-Pr   H                                              Cl    4-FPh CO.sub.2 Me                                                                         OCF.sub.3                                                                           n-Pr   H                                              Br    4-FPh CO.sub.2 Me                                                                         Cl    n-Pr   Me                                             CF.sub.3                                                                            4-FPh CO.sub.2 Me                                                                         Br    n-Pr   Me                                             OCF.sub.3                                                                           4-FPh CO.sub.2 Me                                                                         CF.sub.3                                                                            n-Pr   Me                                             Cl    CO.sub.2 Me                                                                         H     OCF.sub.3                                                                           n-Pr   Me                                             Br    CO.sub.2 Me                                                                         H     Cl    n-Pr   Et                                             CF.sub.3                                                                            CO.sub.2 Me                                                                         H     Br    n-Pr   Et                                             OCF.sub.3                                                                           CO.sub.2 Me                                                                         H     CF.sub.3                                                                            n-Pr   Et                                             Cl    CO.sub.2 Me                                                                         Me    OCF.sub.3                                                                           n-Pr   Et                                             Br    CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh Et                                             CF.sub.3                                                                            CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh n-Pr                                           OCF.sub.2 H                                                                         Ph    CO(n-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh COMe                                           OCF.sub.2 H                                                                         Ph    CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh CO.sub.2 Me                                    OCF.sub. 2 H                                                                        Ph    CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-ClPh COEt                                           OCF.sub.2 H                                                                         4-ClPh                                                                              H     OCF.sub.2 H                                                                         4-ClPh CO.sub.2 Et                                    OCF.sub.2 H                                                                         4-ClPh                                                                              Me    OCF.sub.2 H                                                                         4-ClPh CO(n-Pr)                                       Cl    n-Pr  COMe  Cl    CHCH.sub.2                                                                           CO.sub.2 Me                                    Br    n-Pr  COMe  Br    CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                            n-Pr  COMe  CF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.3                                                                           n-Pr  COMe  OCF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                    Cl    n-Pr  CO.sub.2 Me                                                                         Cl    C(CH.sub.3)CH.sub.2                                                                  H                                              Br    n-Pr  CO.sub.2 Me                                                                         Br    C(CH.sub.3)CH.sub.2                                                                  H                                              CF.sub.3                                                                            n-Pr  CO.sub.2 Me                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H                                              OCF.sub.3                                                                           n-Pr  CO.sub.2 Me                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  H                                              Cl    CHCH.sub.2                                                                          H     Cl    C(CH.sub.3)CH.sub.2                                                                  Me                                             Br    CHCH.sub.2                                                                          H     Br    C(CH.sub.3)CH.sub.2                                                                  Me                                             CF.sub.3                                                                            CHCH.sub.2                                                                          H     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          H     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Me                                             Cl    CHCH.sub.2                                                                          Me    Cl    C(CH.sub.3)CH.sub.2                                                                  Et                                             Br    CHCH.sub.2                                                                          Me    Br    C(CH.sub.3)CH.sub.2                                                                  Et                                             CF.sub.3                                                                            CHCH.sub.2                                                                          Me    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Et                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          Me    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Et                                             Cl    CHCH.sub.2                                                                          Et    Cl    C(CH.sub.3)CH.sub.2                                                                  COMe                                           Br    CHCH.sub.2                                                                          Et    Br    C(CH.sub.3)CH.sub.2                                                                  COMe                                           CF.sub.3                                                                            CHCH.sub.2                                                                          Et    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          Et    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COMe                                           Cl    CHCH.sub.2                                                                          COMe  Cl    C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Br    CHCH.sub.2                                                                          COMe  Br    C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    CF.sub.3                                                                            CHCH.sub.2                                                                          COMe  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.3                                                                           CHCH.sub.2                                                                          COMe  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                         4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-FPh  COEt                                           OCF.sub.2 H                                                                         4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-FPh  CO.sub.2 Et                                    OCF.sub.2 H                                                                         4-FPh H     OCF.sub.2 H                                                                         4-FPh  CO(n-Pr)                                       OCF.sub.2 H                                                                         4-FPh Me    OCF.sub.2 H                                                                         4-FPh  CO(i-Pr)                                       OCF.sub.2 H                                                                         4-FPh Et    OCF.sub.2 H                                                                         4-FPh  CO(t-Bu)                                       OCF.sub.2 H                                                                         4-FPh n-Pr  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          H                                              OCF.sub.2 H                                                                         4-FPh COMe  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          Me                                             OCF.sub.2 H                                                                         4-F Ph                                                                              CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          Et                                             CF.sub.3                                                                            Ph    COEt  CF.sub.3                                                                            4-FPh  COEt                                           CF.sub.3                                                                            Ph    CO.sub.2 Et                                                                         CF.sub.3                                                                            4-FPh  CO.sub.2 Et                                    CF.sub.3                                                                            Ph    CO(n-Pr)                                                                            CF.sub.3                                                                            4-FPh  CO(n-Pr)                                       CF.sub.3                                                                            Ph    CO(i-Pr)                                                                            CF.sub.3                                                                            4-FPh  CO(i-Pr)                                       CF.sub.3                                                                            Ph    CO(t-Bu)                                                                            CF.sub.3                                                                            4-FPh  CO(t-Bu)                                       CF.sub.3                                                                            Ph    n-Pr  CF.sub.3                                                                            4-FPh  n-Pr                                           OCF.sub.3                                                                           Ph    COEt  OCF.sub.3                                                                           4-FPh  COEt                                           OCF.sub.3                                                                           Ph    CO.sub.2 Et                                                                         OCF.sub.3                                                                           4-FPh  CO.sub.2 Et                                    OCF.sub.3                                                                           Ph    CO(n-Pr)                                                                            OCF.sub.3                                                                           4-FPh  CO(n-Pr)                                       OCF.sub.3                                                                           Ph    CO(i-Pr)                                                                            OCF.sub.3                                                                           4-FPh  CO(i-Pr)                                       OCF.sub.3                                                                           Ph    CO(t-Bu)                                                                            OCF.sub.3                                                                           4-FPh  CO(t-Bu)                                       OCF.sub.3                                                                           Ph    n-Pr  OCF.sub.3                                                                           4-FPh  n-Pr                                           CF.sub.3                                                                            4-ClPh                                                                              COEt  CF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                           CF.sub.3                                                                            4-ClPh                                                                              CO.sub.2 Et                                                                         CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                                    CF.sub.3                                                                            4-ClPh                                                                              CO(n-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                       CF.sub.3                                                                            4-ClPh                                                                              CO(i-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                       CF.sub.3                                                                            4-ClPh                                                                              CO(t-Bu)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                       CF.sub.3                                                                            4-ClPh                                                                              n-Pr  CF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr                                           OCF.sub.3                                                                           4-ClPh                                                                              COEt  OCF.sub.3                                                                           CO.sub.2 Me                                                                          COEt                                           OCF.sub.3                                                                           4-ClPh                                                                              CO.sub.2 Et                                                                         OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                           4-ClPh                                                                              CO(n-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                       OCF.sub.3                                                                           4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                       OCF.sub.3                                                                           4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(t-Bu)                                       OCF.sub.3                                                                           4-ClPh                                                                              n-Pr  OCF.sub.3                                                                           CO.sub.2 Me                                                                          n-Pr                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         n-Pr  OCF.sub.2 H                                                                         n-Pr   H                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COMe  OCF.sub.2 H                                                                         n-Pr   Me                                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         n-Pr   Et                                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COEt  OCF.sub.2 H                                                                         n-Pr   n-Pr                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         n-Pr   COMe                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(n-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(i-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr   COEt                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(t-Bu)                                                                            OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Et                                    CF.sub.3                                                                            n-Pr  COEt  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COEt                                           CF.sub.3                                                                            n-Pr  CO.sub.2 Et                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    CF.sub.3                                                                            n-Pr  CO(n-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                            n-Pr  CO(i-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       CF.sub.3                                                                            n-Pr  CO(t-Bu)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       CF.sub.3                                                                            n-Pr  n-Pr  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           OCF.sub.3                                                                           n-Pr  COEt  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt                                           OCF.sub.3                                                                           n-Pr  CO.sub.2 Et                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.3                                                                           n-Pr  CO(n-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.3                                                                           n-Pr  CO(i-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.3                                                                           n-Pr  CO(t-Bu)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.3                                                                           n-Pr  n-Pr  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           CF.sub.3                                                                            CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                            CHCH.sub.2                                                                          CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         CHCH.sub.2                                                                           COEt                                           CF.sub.3                                                                            CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO.sub.2 Et                                    CF.sub.3                                                                            CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(n-Pr)                                       CF.sub.3                                                                            CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(i-Pr)                                       CF.sub.3                                                                            CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(t-Bu)                                       OCF.sub.3                                                                           CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  H                                              OCF.sub.3                                                                           CHCH.sub. 2                                                                         CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  Me                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  Et                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  COMe                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                         n-Pr  CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  COEt                                           OCF.sub.2 H                                                                         n-Pr  CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.2 H                                                                         n-Pr  CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          H     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Me    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Et                                                                OCF.sub.2 H                                                                         CHCH.sub.2                                                                          n-Pr                                                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                          COMe                                                              __________________________________________________________________________

                                      TABLE 10                                    __________________________________________________________________________     ##STR47##                                                                    R.sup.1                                                                             R.sup.3                                                                             Y     R.sup.1                                                                             R.sup.3                                                                              Y                                              __________________________________________________________________________    Cl    Ph    H     Cl    4-ClPh H                                              Br    Ph    H     Br    4-ClPh H                                              CF.sub.3                                                                            Ph    H     CF.sub.3                                                                            4-ClPh H                                              OCF.sub.3                                                                           Ph    H     OCF.sub.3                                                                           4-ClPh H                                              Cl    Ph    Me    Cl    4-ClPh Me                                             Br    Ph    Me    Br    4-ClPh Me                                             CF.sub.3                                                                            Ph    Me    CF.sub.3                                                                            4-ClPh Me                                             OCF.sub.3                                                                           Ph    Me    OCF.sub.3                                                                           4-ClPh Me                                             Cl    Ph    Et    Cl    4-ClPh Et                                             Br    Ph    Et    Br    4-ClPh Et                                             CF.sub.3                                                                            Ph    Et    CF.sub.3                                                                            4-ClPh Et                                             OCF.sub.3                                                                           Ph    Et    OCF.sub.3                                                                           4-ClPh Et                                             Cl    Ph    COMe  Cl    4-ClPh COMe                                           Br    Ph    COMe  Br    4-ClPh COMe                                           CF.sub.3                                                                            Ph    COMe  CF.sub.3                                                                            4-ClPh COMe                                           OCF.sub.3                                                                           Ph    COMe  OCF.sub.3                                                                           4-ClPh COMe                                           Cl    Ph    CO.sub.2 Me                                                                         Cl    4-ClPh CO.sub.2 Me                                    Br    Ph    CO.sub.2 Me                                                                         Br    4-ClPh CO.sub.2 Me                                    CF.sub.3                                                                            Ph    CO.sub.2 Me                                                                         CF.sub.3                                                                            4-ClPh CO.sub.2 Me                                    OCF.sub.3                                                                           Ph    CO.sub.2 Me                                                                         OCF.sub.3                                                                           4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    H     OCF.sub.2 H                                                                         Ph     COMe                                           OCF.sub.2 H                                                                         Ph    Me    OCF.sub.2 H                                                                         Ph     CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    Et    OCF.sub.2 H                                                                         Ph     COEt                                           OCF.sub.2 H                                                                         Ph    n-Pr  OCF.sub.2 H                                                                         Ph     CO.sub.2 Et                                    Cl    4-FPh H     OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                             Br    4-FPh H     Cl    CO.sub.2 Me                                                                          Et                                             CF.sub.3                                                                            4-FPh H     Br    CO.sub.2 Me                                                                          Et                                             OCF.sub.3                                                                           4-FPh H     CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                             Cl    4-FPh Me    OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                             Br    4-FPh Me    Cl    CO.sub.2 Me                                                                          COMe                                           CF.sub.3                                                                            4-FPh Me    Br    CO.sub.2 Me                                                                          COMe                                           OCF.sub.3                                                                           4-FPh Me    CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                           Cl    4-FPh Et    OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                           Br    4-FPh Et    Cl    CO.sub.2 Me                                                                          CO.sub.2 Me                                    CF.sub.3                                                                            4-FPh Et    Br    CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                           4-FPh Et    CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                                    Cl    4-FPh COMe  OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                    Br    4-FPh COMe  Cl    n-Pr   H                                              CF.sub.3                                                                            4-FPh COMe  Br    n-Pr   H                                              OCF.sub.3                                                                           4-FPh COMe  CF.sub.3                                                                            n-Pr   H                                              Cl    4-FPh CO.sub.2 Me                                                                         OCF.sub.3                                                                           n-Pr   H                                              Br    4-FPh CO.sub.2 Me                                                                         Cl    n-Pr   Me                                             CF.sub.3                                                                            4-FPh CO.sub.2 Me                                                                         Br    n-Pr   Me                                             OCF.sub.3                                                                           4-FPh CO.sub.2 Me                                                                         CF.sub.3                                                                            n-Pr   Me                                             Cl    CO.sub.2 Me                                                                         H     OCF.sub.3                                                                           n-Pr   Me                                             Br    CO.sub.2 Me                                                                         H     Cl    n-Pr   Et                                             CF.sub.3                                                                            CO.sub.2 Me                                                                         H     Br    n-Pr   Et                                             OCF.sub.3                                                                           CO.sub.2 Me                                                                         H     CF.sub.3                                                                            n-Pr   Et                                             Cl    CO.sub.2 Me                                                                         Me    OCF.sub.3                                                                           n-Pr   Et                                             Br    CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh Et                                             CF.sub.3                                                                            CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh n-Pr                                           OCF.sub.2 H                                                                         Ph    CO(n-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh COMe                                           OCF.sub.2 H                                                                         Ph    CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-ClPh COEt                                           OCF.sub.2 H                                                                         4-ClPh                                                                              H     OCF.sub.2 H                                                                         4-ClPh CO.sub.2 Et                                    OCF.sub.2 H                                                                         4-ClPh                                                                              Me    OCF.sub.2 H                                                                         4-ClPh CO(n-Pr)                                       Cl    n-Pr  COMe  Cl    CHCH.sub.2                                                                           CO.sub.2 Me                                    Br    n-Pr  COMe  Br    CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                            n-Pr  COMe  CF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.3                                                                           n-Pr  COMe  OCF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                    Cl    n-Pr  CO.sub.2 Me                                                                         Cl    C(CH.sub.3)CH.sub.2                                                                  H                                              Br    n-Pr  CO.sub.2 Me                                                                         Br    C(CH.sub.3)CH.sub.2                                                                  H                                              CF.sub.3                                                                            n-Pr  CO.sub.2 Me                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H                                              OCF.sub.3                                                                           n-Pr  CO.sub.2 Me                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  H                                              Cl    CHCH.sub.2                                                                          H     Cl    C(CH.sub.3)CH.sub.2                                                                  Me                                             Br    CHCH.sub.2                                                                          H     Br    C(CH.sub.3)CH.sub.2                                                                  Me                                             CF.sub.3                                                                            CHCH.sub.2                                                                          H     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          H     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Me                                             Cl    CHCH.sub.2                                                                          Me    Cl    C(CH.sub.3)CH.sub.2                                                                  Et                                             Br    CHCH.sub.2                                                                          Me    Br    C(CH.sub.3)CH.sub.2                                                                  Et                                             CF.sub.3                                                                            CHCH.sub.2                                                                          Me    CF.sub.3                                                                            C(CH.sub.3)CH.sub. 2                                                                 Et                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          Me    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Et                                             Cl    CHCH.sub.2                                                                          Et    Cl    C(CH.sub.3)CH.sub.2                                                                  COMe                                           Br    CHCH.sub.2                                                                          Et    Br    C(CH.sub.3)CH.sub.2                                                                  COMe                                           CF.sub.3                                                                            CHCH.sub.2                                                                          Et    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          Et    0CF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COMe                                           Cl    CHCH.sub.2                                                                          COMe  Cl    C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Br    CHCH.sub.2                                                                          COMe  Br    C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    CF.sub.3                                                                            CHCH.sub.2                                                                          COMe  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.3                                                                           CHCH.sub.2                                                                          COMe  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                         4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-FPh  COEt                                           OCF.sub.2 H                                                                         4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-FPh  CO.sub.2 Et                                    OCF.sub.2 H                                                                         4-FPh H     OCF.sub.2 H                                                                         4-FPh  CO(n-Pr)                                       OCF.sub.2 H                                                                         4-FPh Me    OCF.sub.2 H                                                                         4-FPh  CO(i-Pr)                                       OCF.sub.2 H                                                                         4-FPh Et    OCF.sub.2 H                                                                         4-FPh  CO(t-Bu)                                       OCF.sub.2 H                                                                         4-FPh n-Pr  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          H                                              OCF.sub.2 H                                                                         4-FPh COMe  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          Me                                             OCF.sub.2 H                                                                         4-FPh CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          Et                                             CF.sub.3                                                                            Ph    COEt  CF.sub.3                                                                            4-FPh  COEt                                           CF.sub.3                                                                            Ph    CO.sub.2 Et                                                                         CF.sub.3                                                                            4-FPh  CO.sub.2 Et                                    CF.sub.3                                                                            Ph    CO(n-Pr)                                                                            CF.sub.3                                                                            4-FPh  CO(n-Pr)                                       CF.sub.3                                                                            Ph    CO(i-Pr)                                                                            CF.sub.3                                                                            4-FPh  CO(i-Pr)                                       CF.sub.3                                                                            Ph    CO(t-Bu)                                                                            CF.sub.3                                                                            4-FPh  CO(t-Bu)                                       CF.sub.3                                                                            Ph    n-Pr  CF.sub.3                                                                            4-FPh  n-Pr                                           OCF.sub.3                                                                           Ph    COEt  OCF.sub.3                                                                           4-FPh  COEt                                           OCF.sub.3                                                                           Ph    CO.sub.2 Et                                                                         OCF.sub.3                                                                           4-FPh  CO.sub.2 Et                                    OCF.sub.3                                                                           Ph    CO(n-Pr)                                                                            OCF.sub.3                                                                           4-FPh  CO(n-Pr)                                       OCF.sub.3                                                                           Ph    CO(i-Pr)                                                                            OCF.sub.3                                                                           4-FPh  CO(i-Pr)                                       OCF.sub.3                                                                           Ph    CO(t-Bu)                                                                            OCF.sub.3                                                                           4-FPh  CO(t-Bu)                                       OCF.sub.3                                                                           Ph    n-Pr  OCF.sub.3                                                                           4-FPh  n-Pr                                           CF.sub.3                                                                            4-ClPh                                                                              COEt  CF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                           CF.sub.3                                                                            4-ClPh                                                                              CO.sub.2 Et                                                                         CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                                    CF.sub.3                                                                            4-ClPh                                                                              CO(n-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                       CF.sub.3                                                                            4-ClPh                                                                              CO(i-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                       CF.sub.3                                                                            4-ClPh                                                                              CO(t-Bu)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                       CF.sub.3                                                                            4-ClPh                                                                              n-Pr  CF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr                                           OCF.sub. 3                                                                          4-ClPh                                                                              COEt  OCF.sub.3                                                                           CO.sub.2 Me                                                                          COEt                                           OCF.sub.3                                                                           4-ClPh                                                                              CO.sub.2 Et                                                                         OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                           4-ClPh                                                                              CO(n-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                       OCF.sub.3                                                                           4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                       OCF.sub.3                                                                           Me    CO.sub.2 Et                                                                         OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(t-Bu)                                       OCF.sub.3                                                                           Me    CO(n-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          n-Pr                                           OCF.sub.3                                                                           Me    CO(i-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr   H                                              OCF.sub.3                                                                           Me    CO(t-Bu)                                                                            OCF.sub.2 H                                                                         n-Pr   Me                                             OCF.sub.3                                                                           Me    n-Pr  OCF.sub.2 H                                                                         n-Pr   Et                                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         Et    OCF.sub.2 H                                                                         n-Pr   n-Pr                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         n-Pr  OCF.sub.2 H                                                                         n-Pr   COMe                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COMe  OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         n-Pr   COEt                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COEt  OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Et                                    OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Et                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(n-Pr)                                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(i-Pr)                                                          CF.sub.3                                                                            n-Pr  COEt  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COEt                                           CF.sub.3                                                                            n-Pr  CO.sub. 2 Et                                                                        CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    CF.sub.3                                                                            n-Pr  CO(n-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                            n-Pr  CO(i-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                            n-Pr  CO(t-Bu)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       CF.sub.3                                                                            n-Pr  n-Pr  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           OCF.sub.3                                                                           n-Pr  COEt  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt                                           OCF.sub.3                                                                           n-Pr  CO.sub.2 Et                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.3                                                                           n-Pr  CO(n-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.3                                                                           n-Pr  CO(i-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.3                                                                           n-Pr  CO(t-Bu)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.3                                                                           n-Pr  n-Pr  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           CF.sub.3                                                                            CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                            CHCH.sub.2                                                                          CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         CHCH.sub.2                                                                           COEt                                           CF.sub.3                                                                            CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO.sub.2 Et                                    CF.sub.3                                                                            CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(n-Pr)                                       CF.sub.3                                                                            CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(i-Pr)                                       CF.sub.3                                                                            CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(t-Bu)                                       OCF.sub.3                                                                           CHCH.sub. 2                                                                         COEt  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  H                                              OCF.sub.3                                                                           CHCH.sub.2                                                                          CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  Me                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  Et                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  COMe                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                         n-Pr  CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  COEt                                           OCF.sub.2 H                                                                         n-Pr  CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.2 H                                                                         n-Pr  CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          H     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Me    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Et                                                                OCF.sub.2 H                                                                         CHCH.sub.2                                                                          n-Pr                                                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                          COMe                                                              __________________________________________________________________________

                                      TABLE 11                                    __________________________________________________________________________     ##STR48##                                                                    R.sup.1                                                                             R.sup.3                                                                             Y     R.sup.1                                                                             R.sup.3 Y                                             __________________________________________________________________________    Cl    Ph    H     Cl    4-ClPh  H                                             Br    Ph    H     Br    4-ClPh  H                                             CF.sub.3                                                                            Ph    H     CF.sub.3                                                                            4-ClPh  H                                             OCF.sub.3                                                                           Ph    H     OCF.sub.3                                                                           4-ClPh  H                                             Cl    Ph    Me    Cl    4-ClPh  Me                                            Br    Ph    Me    Br    4-ClPh  Me                                            CF.sub.3                                                                            Ph    Me    CF.sub.3                                                                            4-ClPh  Me                                            OCF.sub.3                                                                           Ph    Me    OCF.sub.3                                                                           4-ClPh  Me                                            Cl    Ph    Et    Cl    4-ClPh  Et                                            Br    Ph    Et    Br    4-ClPh  Et                                            CT3   Ph    Et    CF.sub.3                                                                            4-ClPh  Et                                            OCF.sub.3                                                                           Ph    Et    OCF.sub.3                                                                           4-ClPh  Et                                            Cl    Ph    COMe  Cl    4-ClPh  COMe                                          Br    Ph    COMe  Br    4-ClPh  COMe                                          CF.sub.3                                                                            Ph    COMe  CF.sub.3                                                                            4-ClPh  COMe                                          OCF.sub.3                                                                           Ph    COMe  OCF.sub.3                                                                           4-ClPh  COMe                                          Cl    Ph    CO.sub.2 Me                                                                         Cl    4-ClPh  CO.sub.2 Me                                   Br    Ph    CO.sub.2 Me                                                                         Br    4-ClPh  CO.sub.2 Me                                   CF.sub.3                                                                            Ph    CO.sub.2 Me                                                                         CF.sub.3                                                                            4-ClPh  CO.sub.2 Me                                   OCF.sub.3                                                                           Ph    CO.sub.2 Me                                                                         OCF.sub.3                                                                           4-ClPh  CO.sub.2 Me                                   OCF.sub.2 H                                                                         Ph    H     OCF.sub.2 H                                                                         Ph      COMe                                          OCF.sub.2 H                                                                         Ph    Me    OCF.sub.2 H                                                                         Ph      CO.sub.2 Me                                   OCF.sub.2 H                                                                         Ph    Et    OCF.sub.2 H                                                                         Ph      COEt                                          OCF.sub.2 H                                                                         Ph    n-Pr  OCF.sub.2 H                                                                         Ph      CO.sub.2 Et                                   Cl    4-FPh H     OCF.sub.3                                                                           CO.sub.2 Me                                                                           Me                                            Br    4-FPh H     Cl    CO.sub.2 Me                                                                           Et                                            CF.sub.3                                                                            4-FPh H     Br    CO.sub.2 Me                                                                           Et                                            OCF.sub.3                                                                           4-FPh H     CF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                            Cl    4-FPh Me    OCF.sub.3                                                                           CO.sub.2 Me                                                                           Et                                            Br    4-FPh Me    Cl    CO.sub.2 Me                                                                           COMe                                          CF.sub.3                                                                            4-FPh Me    Br    CO.sub.2 Me                                                                           COMe                                          OCF.sub.3                                                                           4-FPh Me    CF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                          Cl    4-FPh Et    OCF.sub.3                                                                           CO.sub.2 Me                                                                           COMe                                          Br    4-FPh Et    Cl    CO.sub.2 Me                                                                           CO.sub.2 Me                                   CF.sub.3                                                                            4-FPh Et    Br    CO.sub.2 Me                                                                           CO.sub.2 Me                                   OCF.sub.3                                                                           4-FPh Et    CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                                   Cl    4-FPh COMe  OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Me                                   Br    4-FPh COMe  Cl    n-Pr    H                                             CF.sub.3                                                                            4-FPh COMe  Br    n-Pr    H                                             OCF.sub.3                                                                           4-FPh COMe  CF.sub.3                                                                            n-Pr    H                                             Cl    4-FPh CO.sub.2 Me                                                                         OCF.sub.3                                                                           n-Pr    H                                             Br    4-FPh CO.sub.2 Me                                                                         Cl    n-Pr    Me                                            CF.sub.3                                                                            4-FPh CO.sub.2 Me                                                                         Br    n-Pr    Me                                            OCF.sub.3                                                                           4-FPh CO.sub.2 Me                                                                         CF.sub.3                                                                            n-Pr    Me                                            Cl    CO.sub.2 Me                                                                         H     OCF.sub.3                                                                           n-Pr    Me                                            Br    CO.sub.2 Me                                                                         H     Cl    n-Pr    Et                                            CF.sub.3                                                                            CO.sub.2 Me                                                                         H     Br    n-Pr    Et                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                         H     CF.sub.3                                                                            n-Pr    Et                                            Cl    CO.sub.2 Me                                                                         Me    OCF.sub.3                                                                           n-Pr    Et                                            Br    CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh  Et                                            CF.sub.3                                                                            CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh  n-Pr                                          OCF.sub.2 H                                                                         Ph    CO(n-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh  COMe                                          OCF.sub.2 H                                                                         Ph    CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh  CO.sub.2 Me                                   OCF.sub.2 H                                                                         Ph    CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-ClPh  COEt                                          OCF.sub.2 H                                                                         4-ClPh                                                                              H     OCF.sub.2 H                                                                         4-ClPh  CO.sub.2 Et                                   OCF.sub.2 H                                                                         4-ClPh                                                                              Me    OCF.sub.2 H                                                                         4-ClPh  CO(n-Pr)                                      Cl    n-Pr  COMe  Cl    CHCH.sub.2                                                                            CO.sub.2 Me                                   Br    n-Pr  COMe  Br    CHCH.sub.2                                                                            CO.sub.2 Me                                   CF.sub.3                                                                            n-Pr  COMe  CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Me                                   OCF.sub.3                                                                           n-Pr  COMe  OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Me                                   Cl    n-Pr  CO.sub.2 Me                                                                         Cl    C(CH.sub.3)CH.sub.2                                                                   H                                             Br    n-Pr  CO.sub.2 Me                                                                         Br    C(CH.sub.3)CH.sub.2                                                                   H                                             CF.sub.3                                                                            n-Pr  CO.sub.2 Me                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   H                                             OCF.sub.3                                                                           n-Pr  CO.sub.2 Me                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   H                                             Cl    CHCH.sub.2                                                                          H     Cl    C(CH.sub.3)CH.sub.2                                                                   Me                                            Br    CHCH.sub.2                                                                          H     Br    C(CH.sub.3)CH.sub.2                                                                   Me                                            CF.sub.3                                                                            CHCH.sub.2                                                                          H     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Me                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          H     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Me                                            Cl    CHCH.sub.2                                                                          Me    Cl    C(CH.sub.3)CH.sub.2                                                                   Et                                            Br    CHCH.sub.2                                                                          Me    Br    C(CH.sub.3)CH.sub.2                                                                   Et                                            CF.sub.3                                                                            CHCH.sub.2                                                                          He    CF.sub.3                                                                            C(CH.sub.3)CH.sub. 2                                                                  Et                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          Me    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Et                                            Cl    CHCH.sub.2                                                                          Et    Cl    C(CH.sub.3)CH.sub.2                                                                   COMe                                          Br    CHCH.sub.2                                                                          Et    Br    C(CH.sub.3)CH.sub.2                                                                   COMe                                          CF.sub.3                                                                            CHCH.sub.2                                                                          Et    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COMe                                          OCF.sub.3                                                                           CHCH.sub.2                                                                          Et    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COMe                                          Cl    CHCH.sub.2                                                                          COMe  Cl    C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   Br    CHCH.sub.2                                                                          COMe  Br    C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   CF.sub.3                                                                            CHCH.sub.2                                                                          COMe  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   OCF.sub.3                                                                           CHCH.sub.2                                                                          COMe  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   OCF.sub.2 H                                                                         4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-FPh   COEt                                          OCF.sub.2 H                                                                         4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-FPh   CO.sub.2 Et                                   OCF.sub.2 H                                                                         4-FPh H     OCF.sub.2 H                                                                         4-FPh   CO(n-Pr)                                      OCF.sub.2 H                                                                         4-FPh Me    OCF.sub.2 H                                                                         4-FPh   CO(i-Pr)                                      OCF.sub.2 H                                                                         4-FPh Et    OCF.sub.2 H                                                                         4-FPh   CO(t-Bu)                                      OCF.sub.2 H                                                                         4-FPh n-Pr  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           H                                             OCF.sub.2 H                                                                         4-FPh COMe  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Me                                            OCF.sub.2 H                                                                         4-FPh CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Et                                            CF.sub.3                                                                            Ph    COEt  CF.sub.3                                                                            4-FPh   COEt                                          CF.sub.3                                                                            Ph    CO.sub.2 Et                                                                         CF.sub.3                                                                            4-FPh   CO.sub.2 Et                                   CF.sub.3                                                                            Ph    CO(n-Pr)                                                                            CF.sub.3                                                                            4-FPh   CO(n-Pr)                                      CF.sub.3                                                                            Ph    CO(i-Pr)                                                                            CF.sub.3                                                                            4-FPh   CO(i-Pr)                                      CF.sub.3                                                                            Ph    CO(t-Bu)                                                                            CF.sub.3                                                                            4-FPh   CO(t-Bu)                                      CF.sub.3                                                                            Ph    n-Pr  CF.sub.3                                                                            4-FPh   n-Pr                                          OCF.sub.3                                                                           Ph    COEt  OCF.sub.3                                                                           4-FPh   COEt                                          OCF.sub.3                                                                           Ph    CO.sub.2 Et                                                                         OCF.sub.3                                                                           4-FPh   CO.sub.2 Et                                   OCF.sub.3                                                                           Ph    CO(n-Pr)                                                                            OCF.sub.3                                                                           4-FPh   CO(n-Pr)                                      OCF.sub.3                                                                           Ph    CO(i-Pr)                                                                            OCF.sub.3                                                                           4-FPh   CO(i-Pr)                                      OCF.sub.3                                                                           Ph    CO(t-Bu)                                                                            OCF.sub.3                                                                           4-FPh   CO(t-Bu)                                      OCF.sub.3                                                                           Ph    n-Pr  OCF.sub.3                                                                           4-FPh   n-Pr                                          CF.sub.3                                                                            4-ClPh                                                                              COEt  CF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                          CF.sub.3                                                                            4-ClPh                                                                              CO.sub.2 Et                                                                         CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                                   CF.sub.3                                                                            4-ClPh                                                                              CO(n-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                      CF.sub.3                                                                            4-ClPh                                                                              CO(i-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                      CF.sub.3                                                                            4-ClPh                                                                              CO(t-Bu)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                      CF.sub.3                                                                            4-ClPh                                                                              n-Pr  CF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                          OCF.sub.3                                                                           4-ClPh                                                                              COEt  OCF.sub.3                                                                           CO.sub.2 Me                                                                           COEt                                          OCF.sub.3                                                                           4-ClPh                                                                              CO.sub.2 Et                                                                         OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Et                                   OCF.sub.3                                                                           4-ClPh                                                                              CO(n-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(n-Pr)                                      OCF.sub.3                                                                           4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(i-Pr)                                      OCF.sub.3                                                                           4-ClPh                                                                              CO(t-BU)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                                      OCF.sub.3                                                                           4-ClPh                                                                              n-Pr  OCF.sub.3                                                                           CO.sub.2 Me                                                                           n-Pr                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         n-Pr  OCF.sub.2 H                                                                         n-Pr    H                                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COMe  OCF.sub.2 H                                                                         n-Pr    Me                                            OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         n-Pr    Et                                            OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COEt  H     n-Pr    n-Pr                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         n-Pr    COMe                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(n-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr    CO.sub.2 Me                                   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(i-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr    COEt                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(t-Bu)                                                                            OCF.sub.2 H                                                                         n-Pr    CO.sub.2 Et                                   CF.sub.3                                                                            n-Pr  COEt  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COEt                                          CF.sub.3                                                                            n-Pr  CO.sub.2 Et                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                   CF.sub.3                                                                            n-Pr  CO(n-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                      CF.sub.3                                                                            n-Pr  CO(i-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                      CF.sub.3                                                                            n-Pr  CO(t-Bu)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                      CF.sub.3                                                                            n-Pr  n-Pr  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   n-Pr                                          OCF.sub.3                                                                           n-Pr  COEt  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COEt                                          OCF.sub.3                                                                           n-Pr  CO.sub.2 Et                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                   OCF.sub.3                                                                           n-Pr  CO(n-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                      OCF.sub.3                                                                           n-Pr  CO(i-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                      OCF.sub.3                                                                           n-Pr  CO(t-Bu)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                      OCF.sub.3                                                                           n-Pr  n-Pr  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   n-Pr                                          CF.sub.3                                                                            CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Me                                   CF.sub.3                                                                            CHCH.sub.2                                                                          CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COEt                                          CF.sub.3                                                                            CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Et                                   CF.sub.3                                                                            CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO(n-Pr)                                      CF.sub.3                                                                            CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO(i-Pr)                                      CF.sub.3                                                                            CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO(t-Bu)                                      OCF.sub.3                                                                           CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   H                                             OCF.sub.3                                                                           CHCH.sub. 2                                                                         CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Me                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Et                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   n-Pr                                          OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COMe                                          OCF.sub.3                                                                           CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   OCF.sub.2 H                                                                         n-Pr  CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COEt                                          OCF.sub.2 H                                                                         n-Pr  CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                   OCF.sub.2 H                                                                         n-Pr  CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                      OCF.sub.2 H                                                                         CHCH.sub.2                                                                          H     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                      OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Me    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                      OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Et                                                                OCF.sub.2 H                                                                         CHCH.sub.2                                                                          n-Pr                                                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                          COMe                                                              __________________________________________________________________________

                                      TABLE 12                                    __________________________________________________________________________     ##STR49##                                                                    R.sup.1                                                                             R.sup.3                                                                             Y     R.sup.1                                                                             R.sup.3 Y                                             __________________________________________________________________________    Cl    Ph    H     Cl    4-ClPh  H                                             Br    Ph    H     Br    4-ClPh  H                                             CF.sub.3                                                                            Ph    H     CF.sub.3                                                                            4-ClPh  H                                             OCF.sub.3                                                                           Ph    H     OCF.sub.3                                                                           4-ClPh  H                                             Cl    Ph    Me    Cl    4-ClPh  Me                                            Br    Ph    Me    Br    4-ClPh  Me                                            CF.sub.3                                                                            Ph    Me    CF.sub.3                                                                            4-ClPh  Me                                            OCF.sub.3                                                                           Ph    Me    OCF.sub.3                                                                           4-ClPh  Me                                            Cl    Ph    Et    Cl    4-ClPh  Et                                            Br    Ph    Et    Br    4-ClPh  Et                                            CF.sub.3                                                                            Ph    Et    CF.sub.3                                                                            4-ClPh  Et                                            OCF.sub.3                                                                           Ph    Et    OCF.sub.3                                                                           4-ClPh  Et                                            Cl    Ph    COMe  Cl    4-ClPh  COMe                                          Br    Ph    COMe  Br    4-ClPh  COMe                                          CF.sub.3                                                                            Ph    COMe  CF.sub. 3                                                                           4-ClPh  COMe                                          OCF.sub.3                                                                           Ph    COMe  OCF.sub.3                                                                           4-ClPh  COMe                                          Cl    Ph    CO.sub.2 Me                                                                         Cl    4-ClPh  CO.sub.2 Me                                   Br    Ph    CO.sub.2 Me                                                                         Br    4-ClPh  CO.sub.2 Me                                   CF.sub.3                                                                            Ph    CO.sub.2 Me                                                                         CF.sub.3                                                                            4-ClPh  CO.sub.2 Me                                   OCF.sub.3                                                                           Ph    CO.sub.2 Me                                                                         OCF.sub.3                                                                           4-ClPh  CO.sub.2 Me                                   OCF.sub.2 H                                                                         Ph    H     OCF.sub.2 H                                                                         Ph      COMe                                          OCF.sub.2 H                                                                         Ph    Me    OCF.sub.2 H                                                                         Ph      CO.sub.2 Me                                   OCF.sub.2 H                                                                         Ph    Et    OCF.sub.2 H                                                                         Ph      COEt                                          OCF.sub.2 H                                                                         Ph    n-Pr  OCF.sub.2 H                                                                         Ph      CO.sub.2 Et                                   Cl    4-FPh H     OCF.sub.3                                                                           CO.sub.2 Me                                                                           Me                                            Br    4-FPh H     Cl    CO.sub.2 Me                                                                           Et                                            CF.sub.3                                                                            4-FPh H     Br    CO.sub.2 Me                                                                           Et                                            OCF.sub.3                                                                           4-FPh H     CF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                            Cl    4-FPh Me    OCF.sub.3                                                                           CO.sub.2 Me                                                                           Et                                            Br    4-FPh Me    Cl    CO.sub.2 Me                                                                           COMe                                          CF.sub.3                                                                            4-FPh Me    Br    CO.sub.2 Me                                                                           COMe                                          OCF.sub.3                                                                           4-FPh Me    CF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                          Cl    4-FPh Et    OCF.sub.3                                                                           CO.sub.2 Me                                                                           COMe                                          Br    4-FPh Et    Cl    CO.sub.2 Me                                                                           CO.sub.2 Me                                   CF.sub.3                                                                            4-FPh Et    Br    CO.sub.2 Me                                                                           CO.sub.2 Me                                   OCF.sub.3                                                                           4-FPh Et    CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                                   Cl    4-FPh COMe  OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Me                                   Br    4-FPh COMe  Cl    n-Pr    H                                             CF.sub.3                                                                            4-FPh COMe  Br    n-Pr    H                                             OCF.sub.3                                                                           4-FPh COMe  CF.sub.3                                                                            n-Pr    H                                             Cl    4-FPh CO.sub.2 Me                                                                         OCF.sub.3                                                                           n-Pr    H                                             Br    4-FPh CO.sub.2 Me                                                                         Cl    n-Pr    Me                                            CF.sub.3                                                                            4-FPh CO.sub.2 Me                                                                         Br    n-Pr    Me                                            OCF.sub.3                                                                           4-FPh CO.sub.2 Me                                                                         CF.sub.3                                                                            n-Pr    Me                                            Cl    CO.sub.2 Me                                                                         H     OCF.sub.3                                                                           n-Pr    Me                                            Br    CO.sub.2 Me                                                                         H     Cl    n-Pr    Et                                            CF.sub.3                                                                            CO.sub.2 Me                                                                         H     Br    n-Pr    Et                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                         H     CF.sub.3                                                                            n-Pr    Et                                            Cl    CO.sub.2 Me                                                                         Me    OCF.sub.3                                                                           n-Pr    Et                                            Br    CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh  Et                                            CF.sub.3                                                                            CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh  n-Pr                                          OCF.sub.2 H                                                                         Ph    CO(n-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh  COMe                                          OCF.sub.2 H                                                                         Ph    CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh  CO.sub.2 Me                                   OCF.sub. 2 H                                                                        Ph    CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-ClPh  COEt                                          OCF.sub.2 H                                                                         4-ClPh                                                                              H     OCF.sub.2 H                                                                         4-ClPh  CO.sub.2 Et                                   OCF.sub.2 H                                                                         4-ClPh                                                                              Me    OCF.sub.2 H                                                                         4-ClPh  CO(n-Pr)                                      Cl    n-Pr  COMe  Cl    CHCH.sub.2                                                                            CO.sub.2 Me                                   Br    n-Pr  COMe  Br    CHCH.sub.2                                                                            CO.sub.2 Me                                   CF.sub.3                                                                            n-Pr  COMe  CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Me                                   OCF.sub.3                                                                           n-Pr  COMe  OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Me                                   Cl    n-Pr  CO.sub.2 Me                                                                         Cl    C(CH.sub.3)CH.sub.2                                                                   H                                             Br    n-Pr  CO.sub.2 Me                                                                         Br    C(CH.sub.3)CH.sub.2                                                                   H                                             CF.sub.3                                                                            n-Pr  CO.sub.2 Me                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   H                                             OCF.sub.3                                                                           n-Pr  CO.sub.2 Me                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   H                                             Cl    CHCH.sub.2                                                                          H     Cl    C(CH.sub.3)CH.sub.2                                                                   Me                                            Br    CHCH.sub.2                                                                          H     Br    C(CH.sub.3)CH.sub.2                                                                   Me                                            CF.sub.3                                                                            CHCH.sub.2                                                                          H     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Me                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          H     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Me                                            Cl    CHCH.sub.2                                                                          Me    Cl    C(CH.sub.3)CH.sub.2                                                                   Et                                            Br    CHCH.sub.2                                                                          Me    Br    C(CH.sub.3)CH.sub.2                                                                   Et                                            CF.sub.3                                                                            CHCH.sub.2                                                                          Me    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Et                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          Me    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Et                                            Cl    CHCH.sub.2                                                                          Et    Cl    C(CH.sub.3)CH.sub.2                                                                   COMe                                          Br    CHCH.sub.2                                                                          Et    Br    C(CH.sub.3)CH.sub.2                                                                   COMe                                          CF.sub.3                                                                            CHCH.sub.2                                                                          Et    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COMe                                          OCF.sub.3                                                                           CHCH.sub.2                                                                          Et    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COMe                                          Cl    CHCH.sub.2                                                                          COMe  Cl    C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   Br    CHCH.sub.2                                                                          COMe  Br    C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   CF.sub.3                                                                            CHCH.sub.2                                                                          COMe  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   OCF.sub.3                                                                           CHCH.sub.2                                                                          COMe  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   OCF.sub.2 H                                                                         4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-FPh   COEt                                          OCF.sub.2 H                                                                         4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-FPh   CO.sub.2 Et                                   OCF.sub.2 H                                                                         4-FPh H     OCF.sub.2 H                                                                         4-FPh   CO(n-Pr)                                      OCF.sub.2 H                                                                         4-FPh Me    OCF.sub.2 H                                                                         4-FPh   CO(i-Pr)                                      OCF.sub.2 H                                                                         4-FPh Et    OCF.sub.2 H                                                                         4-FPh   CO(t-Bu)                                      OCF.sub.2 H                                                                         4-FPh n-Pr  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           H                                             OCF.sub.2 H                                                                         4-FPh COMe  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Me                                            OCF.sub.2 H                                                                         4-F Ph                                                                              CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Et                                            CF.sub.3                                                                            Ph    COEt  CF.sub.3                                                                            4-FPh   COEt                                          CF.sub.3                                                                            Ph    CO.sub.2 Et                                                                         CF.sub.3                                                                            4-FPh   CO.sub.2 Et                                   CF.sub.3                                                                            Ph    CO(n-Pr)                                                                            CF.sub.3                                                                            4-FPh   CO (n-Pr)                                     CF.sub.3                                                                            Ph    CO(i-Pr)                                                                            CF.sub.3                                                                            4-FPh   CO(i-Pr)                                      CF.sub.3                                                                            Ph    CO(t-Bu)                                                                            CF.sub.3                                                                            4-FPh   CO(t-Bu)                                      CF.sub.3                                                                            Ph    n-Pr  CF.sub.3                                                                            4-FPh   n-Pr                                          OCF.sub.3                                                                           Ph    COEt  OCF.sub.3                                                                           4-FPh   COEt                                          OCF.sub.3                                                                           Ph    CO.sub.2 Et                                                                         OCF.sub.3                                                                           4-FPh   CO.sub.2 Et                                   OCF.sub.3                                                                           Ph    CO(n-Pr)                                                                            OCF.sub.3                                                                           4-FPh   CO(n-Pr)                                      OCF.sub.3                                                                           Ph    CO(i-Pr)                                                                            OCF.sub.3                                                                           4-FPh   CO(i-Pr)                                      OCF.sub.3                                                                           Ph    CO(t-Bu)                                                                            OCF.sub.3                                                                           4-FPh   CO(t-Bu)                                      OCF.sub.3                                                                           Ph    n-Pr  OCF.sub.3                                                                           4-FPh   n-Pr                                          CF.sub.3                                                                            4-ClPh                                                                              COEt  CF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                          CF.sub.3                                                                            4-ClPh                                                                              CO.sub.2 Et                                                                         CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                                   CF.sub.3                                                                            4-ClPh                                                                              CO(n-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                      CF.sub.3                                                                            4-ClPh                                                                              CO(i-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                      CF.sub.3                                                                            4-ClPh                                                                              CO(t-Bu)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                      CF.sub.3                                                                            4-ClPh                                                                              n-Pr  CF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                          OCF.sub.3                                                                           4-ClPh                                                                              COEt  OCF.sub.3                                                                           CO.sub.2 Me                                                                           COEt                                          OCF.sub.3                                                                           4-ClPh                                                                              CO.sub.2 Et                                                                         OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Et                                   OCF.sub.3                                                                           4-ClPh                                                                              CO(n-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(n-Pr)                                      OCF.sub.3                                                                           4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(i-Pr)                                      OCF.sub.3                                                                           4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                                      OCF.sub.3                                                                           4-ClPh                                                                              n-Pr  OCF.sub.3                                                                           CO.sub.2 Me                                                                           n-Pr                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         n-Pr  OCF.sub.2 H                                                                         n-Pr    H                                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COMe  OCF.sub.2 H                                                                         n-Pr    Me                                            OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         n-Pr    Et                                            OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COEt  OCF.sub.2 H                                                                         n-Pr    n-Pr                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         n-Pr    COMe                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(n-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr    CO.sub.2 Me                                   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(i-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr    COMe                                          OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(t-Bu)                                                                            OCF.sub.2 H                                                                         n-Pr    CO.sub.2 Et                                   CF.sub.3                                                                            n-Pr  COEt  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COEt                                          CF.sub.3                                                                            n-Pr  CO.sub.2 Et                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                   CF.sub.3                                                                            n-Pr  CO(n-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                      CF.sub.3                                                                            n-Pr  CO(i-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                      CF.sub.3                                                                            n-Pr  CO(t-Bu)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                      CF.sub.3                                                                            n-Pr  n-Pr  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   n-Pr                                          OCF.sub.3                                                                           n-Pr  COEt  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COEt                                          OCF.sub.3                                                                           n-Pr  CO.sub.2 Et                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                   OCF.sub.3                                                                           n-Pr  CO(n-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                      OCF.sub.3                                                                           n-Pr  CO(i-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                      OCF.sub.3                                                                           n-Pr  CO(t-Bu)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                      OCF.sub.3                                                                           n-Pr  n-Pr  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   n-Pr                                          CF.sub.3                                                                            CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Me                                   CF.sub.3                                                                            CHCH.sub.2                                                                          CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COEt                                          CF.sub.3                                                                            CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Et                                   CF.sub.3                                                                            CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO(n-Pr)                                      CF.sub.3                                                                            CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO(i-Pr)                                      CF.sub.3                                                                            CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO(t-Bu)                                      OCF.sub.3                                                                           CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   H                                             OCF.sub.3                                                                           CHCH.sub. 2                                                                         CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Me                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Et                                            OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   n-Pr                                          OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COMe                                          OCF.sub.3                                                                           CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                   OCF.sub.2 H                                                                         n-Pr  CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COEt                                          OCF.sub.2 H                                                                         n-Pr  CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                   OCF.sub.2 H                                                                         n-Pr  CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                      OCF.sub.2 H                                                                         CHCH.sub.2                                                                          H     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                      OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Me    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                      OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Et                                                                OCF.sub.2 H                                                                         CHCH.sub.2                                                                          n-Pr                                                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                          COMe                                                              __________________________________________________________________________

                                      TABLE 13                                    __________________________________________________________________________     ##STR50##                                                                    R.sup.1                                                                             R.sup.3                                                                             Y     R.sup.1                                                                             R.sup.3                                                                              Y                                              __________________________________________________________________________    Cl    Ph    H     Cl    4-ClPh H                                              Br    Ph    H     Br    4-ClPh H                                              CF.sub.3                                                                            Ph    H     CF.sub.3                                                                            4-ClPh H                                              OCF.sub.3                                                                           Ph    H     OCF.sub.3                                                                           4-ClPh H                                              Cl    Ph    Me    Cl    4-ClPh Me                                             Br    Ph    Me    Br    4-ClPh Me                                             CF.sub.3                                                                            Ph    Me    CF.sub.3                                                                            4-ClPh Me                                             OCF.sub.3                                                                           Ph    Me    OCF.sub.3                                                                           4-ClPh Me                                             Cl    Ph    Et    Cl    4-ClPh Et                                             Br    Ph    Et    Br    4-ClPh Et                                             CF.sub.3                                                                            Ph    Et    CF.sub.3                                                                            4-ClPh Et                                             OCF.sub.3                                                                           Ph    Et    OCF.sub.3                                                                           4-ClPh Et                                             Cl    Ph    COMe  Cl    4-ClPh COMe                                           Br    Ph    COMe  Br    4-ClPh COMe                                           CF.sub.3                                                                            Ph    COMe  CF.sub.3                                                                            4-ClPh COMe                                           OCF.sub.3                                                                           Ph    COMe  OCF.sub.3                                                                           4-ClPh COMe                                           Cl    Ph    CO.sub.2 Me                                                                         Cl    4-ClPh CO.sub.2 Me                                    Br    Ph    CO.sub.2 Me                                                                         Br    4-ClPh CO.sub.2 Me                                    CF.sub.3                                                                            Ph    CO.sub.2 Me                                                                         CF.sub.3                                                                            4-ClPh CO.sub.2 Me                                    OCF.sub.3                                                                           Ph    CO.sub.2 Me                                                                         OCF.sub.3                                                                           4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    H     OCF.sub.2 H                                                                         Ph     COMe                                           OCF.sub.2 H                                                                         Ph    Me    OCF.sub.2 H                                                                         Ph     CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    Et    OCF.sub.2 H                                                                         Ph     COEt                                           OCF.sub.2 H                                                                         Ph    n-Pr  OCF.sub.2 H                                                                         Ph     CO.sub.2 Et                                    Cl    4-FPh H     OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                             Br    4-FPh H     Cl    CO.sub.2 Me                                                                          Et                                             CF.sub.3                                                                            4-FPh H     Br    CO.sub.2 Me                                                                          Et                                             OCF.sub.3                                                                           4-FPh H     CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                             Cl    4-FPh Me    OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                             Br    4-FPh Me    Cl    CO.sub.2 Me                                                                          COMe                                           CF.sub.3                                                                            4-FPh Me    Br    CO.sub.2 Me                                                                          COMe                                           OCF.sub.3                                                                           4-FPh Me    CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                           Cl    4-FPh Et    OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                           Br    4-FPh Et    Cl    CO.sub. 2 Me                                                                         CO.sub.2 Me                                    CF.sub.3                                                                            4-FPh Et    Br    CO.sub.2 Me                                                                          CO.sub.2 Me                                    OCF.sub.3                                                                           4-FPh Et    CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                                    Cl    4-FPh COMe  OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                    Br    4-FPh COMe  Cl    n-Pr   H                                              CF.sub.3                                                                            4-FPh COMe  Br    n-Pr   H                                              OCF.sub.3                                                                           4-FPh COMe  CF.sub.3                                                                            n-Pr   H                                              Cl    4-FPh CO.sub.2 Me                                                                         OCF.sub.3                                                                           n-Pr   H                                              Br    4-FPh CO.sub.2 Me                                                                         Cl    n-Pr   Me                                             CF.sub.3                                                                            4-FPh CO.sub.2 Me                                                                         Br    n-Pr   Me                                             OCF.sub.3                                                                           4-FPh CO.sub.2 Me                                                                         CF.sub.3                                                                            n-Pr   Me                                             Cl    CO.sub.2 Me                                                                         H     OCF.sub.3                                                                           n-Pr   Me                                             Br    CO.sub.2 Me                                                                         H     Cl    n-Pr   Et                                             CF.sub.3                                                                            CO.sub.2 Me                                                                         H     Br    n-Pr   Et                                             OCF.sub.3                                                                           CO.sub.2 Me                                                                         H     CF.sub.3                                                                            n-Pr   Et                                             Cl    CO.sub.2 Me                                                                         Me    OCF.sub.3                                                                           n-Pr   Et                                             Br    CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh Et                                             CF.sub.3                                                                            CO.sub.2 Me                                                                         Me    OCF.sub.2 H                                                                         4-ClPh n-Pr                                           OCF.sub.2 H                                                                         Ph    CO(n-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh COMe                                           OCF.sub.2 H                                                                         Ph    CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-ClPh CO.sub.2 Me                                    OCF.sub.2 H                                                                         Ph    CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-ClPh COEt                                           OCF.sub.2 H                                                                         4-ClPh                                                                              H     OCF.sub.2 H                                                                         4-ClPh CO.sub.2 Et                                    OCF.sub.2 H                                                                         4-ClPh                                                                              Me    OCF.sub.2 H                                                                         4-ClPh CO(n-Pr)                                       Cl    n-Pr  COMe  Cl    CHCH.sub.2                                                                           CO.sub.2 Me                                    Br    n-Pr  COMe  Br    CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                            n-Pr  COMe  CF.sub.3                                                                            CHCH.sub.2                                                                           CO.sub.2 Me                                    OCF.sub.3                                                                           n-Pr  COMe  OCF.sub.3                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                    Cl    n-Pr  CO.sub.2 Me                                                                         Cl    C(CH.sub.3)CH.sub.2                                                                  H                                              Br    n-Pr  CO.sub.2 Me                                                                         Br    C(CH.sub.3)CH.sub.2                                                                  H                                              CF.sub.3                                                                            n-Pr  CO.sub.2 Me                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H                                              OCF.sub.3                                                                           n-Pr  CO.sub.2 Me                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  H                                              Cl    CHCH.sub.2                                                                          H     Cl    C(CH.sub.3)CH.sub.2                                                                  Me                                             Br    CHCH.sub.2                                                                          H     Br    C(CH.sub.3)CH.sub.2                                                                  Me                                             CF.sub.3                                                                            CHCH.sub.2                                                                          H     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          H     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Me                                             Cl    CHCH.sub.2                                                                          Me    Cl    C(CH.sub.3)CH.sub.2                                                                  Et                                             Br    CHCH.sub.2                                                                          Me    Br    C(CH.sub.3)CH.sub.2                                                                  Et                                             CF.sub.3                                                                            CHCH.sub.2                                                                          Me    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Et                                             OCF.sub. 3                                                                          CHCH.sub.2                                                                          Me    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  Et                                             Cl    CHCH.sub.2                                                                          Et    Cl    C(CH.sub.3)CH.sub.2                                                                  COMe                                           Br    CHCH.sub.2                                                                          Et    Br    C(CH.sub.3)CH.sub.2                                                                  COMe                                           CF.sub.3                                                                            CHCH.sub.2                                                                          Et    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          Et    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COMe                                           Cl    CHCH.sub.2                                                                          COMe  Cl    C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    Br    CHCH.sub.2                                                                          COMe  Br    C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    CF.sub.3                                                                            CHCH.sub.2                                                                          COMe  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.3                                                                           CHCH.sub.2                                                                          COMe  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                         4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.2 H                                                                         4-FPh  COEt                                           OCF.sub.2 H                                                                         4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.2 H                                                                         4-FPh  CO.sub.2 Et                                    OCF.sub.2 H                                                                         4-FPh H     OCF.sub.2 H                                                                         4-FPh  CO(n-Pr)                                       OCF.sub.2 H                                                                         4-FPh Me    OCF.sub.2 H                                                                         4-FPh  CO(i-Pr)                                       OCF.sub.2 H                                                                         4-FPh Et    OCF.sub.2 H                                                                         4-FPh  CO(t-Bu)                                       OCF.sub.2 H                                                                         4-FPh n-Pr  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          H                                              OCF.sub.2 H                                                                         4-FPh COMe  OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          Me                                             OCF.sub.2 H                                                                         4-FPh CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         CO.sub.2 Me                                                                          Et                                             CF.sub.3                                                                            Ph    COEt  CF.sub.3                                                                            4-FPh  COEt                                           CF.sub.3                                                                            Ph    CO.sub.2 Et                                                                         CF.sub.3                                                                            4-FPh  CO.sub.2 Et                                    CF.sub.3                                                                            Ph    CO(n-Pr)                                                                            CF.sub.3                                                                            4-FPh  CO(n-Pr)                                       CF.sub.3                                                                            Ph    CO(i-Pr)                                                                            CF.sub.3                                                                            4-FPh  CO(i-Pr)                                       CF.sub.3                                                                            Ph    CO(t-Bu)                                                                            CF.sub.3                                                                            4-FPh  CO(t-Bu)                                       CF.sub.3                                                                            Ph    n-Pr  CF.sub.3                                                                            4-FPh  n-Pr                                           OCF.sub.3                                                                           Ph    COEt  OCF.sub.3                                                                           4-FPh  COEt                                           OCF.sub.3                                                                           Ph    CO.sub.2 Et                                                                         OCF.sub.3                                                                           4-FPh  CO.sub.2 Et                                    OCF.sub.3                                                                           Ph    CO(n-Pr)                                                                            OCF.sub.3                                                                           4-FPh  CO(n-Pr)                                       OCF.sub.3                                                                           Ph    CO(i-Pr)                                                                            OCF.sub.3                                                                           4-FPh  CO(i-Pr)                                       OCF.sub.3                                                                           Ph    CO(t-Bu)                                                                            OCF.sub.3                                                                           4-FPh  CO(t-Bu)                                       OCF.sub.3                                                                           Ph    n-Pr  OCF.sub.3                                                                           4-FPh  n-Pr                                           CF.sub.3                                                                            4-ClPh                                                                              COEt  CF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                           CF.sub.3                                                                            4-ClPh                                                                              CO.sub.2 Et                                                                         CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                                    CF.sub.3                                                                            4-ClPh                                                                              CO(n-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                       CF.sub.3                                                                            4-ClPh                                                                              CO(i-Pr)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                       CF.sub.3                                                                            4-ClPh                                                                              CO(t-Bu)                                                                            CF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                       CF.sub.3                                                                            4-ClPh                                                                              n-Pr  CF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr                                           OCF.sub.3                                                                           4-ClPh                                                                              COEt  OCF.sub.3                                                                           CO.sub.2 Me                                                                          COEt                                           OCF.sub.3                                                                           4-ClPh                                                                              CO.sub.2 Et                                                                         OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                    OCF.sub.3                                                                           4-ClPh                                                                              CO(n-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                       OCF.sub.3                                                                           4-ClPh                                                                              CO(i-Pr)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                       OCF.sub.3                                                                           4-ClPh                                                                              CO(t-Bu)                                                                            OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO(t-Bu)                                       OCF.sub.3                                                                           4-ClPh                                                                              n-Pr  OCF.sub.3                                                                           CO.sub.2 Me                                                                          n-Pr                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         n-Pr  OCF.sub.2 H                                                                         n-Pr   H                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COMe  OCF.sub.2 H                                                                         n-Pr   Me                                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Me                                                                         OCF.sub.2 H                                                                         n-Pr   Et                                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         COEt  OCF.sub.2 H                                                                         n-Pr   n-Pr                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         n-Pr   COMe                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(n-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Me                                    OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(i-Pr)                                                                            OCF.sub.2 H                                                                         n-Pr   COEt                                           OCF.sub.2 H                                                                         CO.sub.2 Me                                                                         CO(t-Bu)                                                                            OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Et                                    CF.sub.3                                                                            n-Pr  COEt  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COEt                                           CF.sub.3                                                                            n-Pr  CO.sub.2 Et                                                                         CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    CF.sub.3                                                                            n-Pr  CO(n-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       CF.sub.3                                                                            n-Pr  CO(i-Pr)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       CF.sub.3                                                                            n-Pr  CO(t-Bu)                                                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       CF.sub.3                                                                            n-Pr  n-Pr  CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           OCF.sub.3                                                                           n-Pr  COEt  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt                                           OCF.sub.3                                                                           n-Pr  CO.sub.2 Et                                                                         OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.3                                                                           n-Pr  CO(n-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.3                                                                           n-Pr  CO(i-Pr)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.3                                                                           n-Pr  CO(t-Bu)                                                                            OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.3                                                                           n-Pr  n-Pr  OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           CF.sub.3                                                                            CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO.sub.2 Me                                    CF.sub.3                                                                            CHCH.sub.2                                                                          CO.sub.2 Et                                                                         OCF.sub.2 H                                                                         CHCH.sub.2                                                                           COEt                                           CF.sub.3                                                                            CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO.sub.2 Et                                    CF.sub.3                                                                            CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(n-Pr)                                       CF.sub.3                                                                            CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(i-Pr)                                       CF.sub.3                                                                            CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         CHCH.sub.2                                                                           CO(t-Bu)                                       OCF.sub.3                                                                           CHCH.sub.2                                                                          COEt  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  H                                              OCF.sub.3                                                                           CHCH.sub.2                                                                          CO.sub. 2 Et                                                                        OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  Me                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  Et                                             OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  n-Pr                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  COMe                                           OCF.sub.3                                                                           CHCH.sub.2                                                                          n-Pr  OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                    OCF.sub.2 H                                                                         n-Pr  CO(n-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  COEt                                           OCF.sub.2 H                                                                         n-Pr  CO(i-Pr)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                    OCF.sub.2 H                                                                         n-Pr  CO(t-Bu)                                                                            OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          H     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Me    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                       OCF.sub.2 H                                                                         CHCH.sub.2                                                                          Et                                                                OCF.sub.2 H                                                                         CHCH.sub.2                                                                          n-Pr                                                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                          COMe                                                              __________________________________________________________________________

                  TABLE 14                                                        ______________________________________                                         ##STR51##                                                                    R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                              Y                                     ______________________________________                                        CF.sub.3                                                                             Ph       H         CF.sub.3                                                                             4-FPh  H                                     CF.sub.3                                                                             Ph       Me        CF.sub.3                                                                             4-FPh  Me                                    CF.sub.3                                                                             Ph       Et        CF.sub.3                                                                             4-FPh  Et                                    CF.sub.3                                                                             Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                  CF.sub.3                                                                             Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Me                           OCF.sub.3                                                                            Ph       H         OCF.sub.3                                                                            4-FPh  H                                     OCF.sub.3                                                                            Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                    OCF.sub.3                                                                            Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                    OCF.sub.3                                                                            Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                  OCF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                           CF.sub.3                                                                             4-ClPh   H         CF.sub.3                                                                             n-Pr   H                                     CF.sub.3                                                                             4-ClPh   Me        CF.sub.3                                                                             n-Pr   Me                                    CF.sub.3                                                                             4-ClPh   Et        CF.sub.3                                                                             n-Pr   Et                                    CF.sub.3                                                                             4-ClPh   COMe      CF.sub.3                                                                             n-Pr   COMe                                  CF.sub.3                                                                             4-ClPh   CO.sub.2 Me                                                                             CF.sub.3                                                                             n-Pr   CO.sub.2 Me                           OCF.sub.3                                                                            4-ClPh   H         OCF.sub.3                                                                            n-Pr   H                                     OCF.sub.3                                                                            4-ClPh   Me        OCF.sub.3                                                                            n-Pr   Me                                    OCF.sub.3                                                                            4-ClPh   Et        OCF.sub.3                                                                            n-Pr   Et                                    OCF.sub.3                                                                            4-ClPh   COMe      OCF.sub.3                                                                            n-Pr   COMe                                  OCF.sub.3                                                                            4-ClPh   CO.sub.2 Me                                                                             OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                           CF.sub.3                                                                             Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                  CF.sub.3                                                                             Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Et                           CF.sub.3                                                                             Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                              CF.sub.3                                                                             Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                              CF.sub.3                                                                             Ph-      CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                              CF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                  OCF.sub.3                                                                            Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                  OCF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                           OCF.sub.3                                                                            Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                              OCF.sub.3                                                                            Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                              OCF.sub.3                                                                            Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                              OCF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                  CF.sub.3                                                                             4-ClPh   COEt      CF.sub.3                                                                             n-Pr   COEt                                  CF.sub.3                                                                             4-ClPh   CO.sub.2 Et                                                                             CF.sub.3                                                                             n-Pr   CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh   CO(n-Pr)  CF.sub.3                                                                             n-Pr   CO(n-Pr)                              CF.sub.3                                                                             4-ClPh   CO(i-Pr)  CF.sub.3                                                                             n-Pr   CO(i-Pr)                              CF.sub.3                                                                             4-ClPh   CO(t-Bu)  CF.sub.3                                                                             n-Pr   CO(t-Bu)                              CF.sub.3                                                                             4-ClPh   n-Pr      CF.sub.3                                                                             n-Pr   n-Pr                                  OCF.sub.3                                                                            4-ClPh   COEt      OCF.sub.3                                                                            n-Pr   COEt                                  OCF.sub.3                                                                            4-ClPh   CO.sub.2 Et                                                                             OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                           OCF.sub.3                                                                            4-ClPh   CO(n-Pr)  OCF.sub.3                                                                            n-Pr   CO(n-Pr)                              OCF.sub.3                                                                            4-ClPh   CO(i-Pr)  OCF.sub.3                                                                            n-Pr   CO(i-Pr)                              OCF.sub.3                                                                            4-ClPh   CO(t-Bu)  OCF.sub.3                                                                            n-Pr   CO(t-Bu)                              OCF.sub.3                                                                            4-ClPh   n-Pr      OCF.sub.3                                                                            n-Pr   n-Pr                                  ______________________________________                                    

                  TABLE 15                                                        ______________________________________                                         ##STR52##                                                                    R.sup.1                                                                             R.sup.3   Y         R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            Ph        H         CF.sub.3                                                                            4-FPh  H                                      CF.sub.3                                                                            Ph        Me        CF.sub.3                                                                            4-FPh  Me                                     CF.sub.3                                                                            Ph        Et        CF.sub.3                                                                            4-FPh  Et                                     CF.sub.3                                                                            Ph        COMe      CF.sub.3                                                                            4-FPh  COMe                                   CF.sub.3                                                                            Ph        CO.sub.2 Me                                                                             CF.sub.3                                                                            4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                           Ph        H         OCF.sub.3                                                                           4-FPh  H                                      OCF.sub.3                                                                           Ph        Me        OCF.sub.3                                                                           4-FPh  Me                                     OCF.sub.3                                                                           Ph        Et        OCF.sub.3                                                                           4-FPh  Et                                     OCF.sub.3                                                                           Ph        COMe      OCF.sub.3                                                                           4-FPh  COMe                                   OCF.sub.3                                                                           Ph        CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-FPh  CO.sub.2 Me                            CF.sub.3                                                                            4-ClPh    H         CF.sub. 3                                                                           n-Pr   H                                      CF.sub.3                                                                            4-ClPh    Me        CF.sub.3                                                                            n-Pr   Me                                     CF.sub.3                                                                            4-ClPh    Et        CF.sub.3                                                                            n-Pr   Et                                     CF.sub.3                                                                            4-ClPh    COMe      CF.sub.3                                                                            n-Pr   COMe                                   CF.sub.3                                                                            4-ClPh    CO.sub.2 Me                                                                             CF.sub.3                                                                            n-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-ClPh    H         OCF.sub.3                                                                           n-Pr   H                                      OCF.sub.3                                                                           4-ClPh    Me        OCF.sub.3                                                                           n-Pr   Me                                     OCF.sub.3                                                                           4-ClPh    Et        OCF.sub.3                                                                           n-Pr   Et                                     OCF.sub.3                                                                           4-ClPh    COMe      OCF.sub.3                                                                           n-Pr   COMe                                   OCF.sub.3                                                                           4-ClPh    CO.sub.2 Me                                                                             OCF.sub.3                                                                           n-Pr   CO.sub.2 Me                            CF.sub.3                                                                            Ph        COEt      CF.sub.3                                                                            4-FPh  COEt                                   CF.sub.3                                                                            Ph        CO.sub.2 Et                                                                             CF.sub.3                                                                            4-FPh  CO.sub.2 Et                            CF.sub.3                                                                            Ph        CO(n-Pr)  CF.sub.3                                                                            4-FPh  CO(n-Pr)                               CF.sub.3                                                                            Ph        CO(i-Pr)  CF.sub.3                                                                            4-FPh  CO(i-Pr)                               CF.sub.3                                                                            Ph        CO(t-Bu)  CF.sub.3                                                                            4-FPh  CO(t-Bu)                               CF.sub.3                                                                            Ph        n-Pr      CF.sub.3                                                                            4-FPh  n-Pr                                   OCF.sub.3                                                                           Ph        COEt      OCF.sub.3                                                                           4-FPh  COEt                                   OCF.sub.3                                                                           Ph        CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                           Ph        CO(n-Pr)  OCF.sub.3                                                                           4-FPh  CO(n-Pr)                               OCF.sub.3                                                                           Ph        CO(i-Pr)  OCF.sub.3                                                                           4-FPh  CO(i-Pr)                               OCF.sub.3                                                                           Ph        CO(t-Bu)  OCF.sub.3                                                                           4-FPh  CO(t-Bu)                               OCF.sub. 3                                                                          Ph        n-Pr      OCF.sub.3                                                                           4-FPh  n-Pr                                   CF.sub.3                                                                            4-ClPh    COEt      CF.sub.3                                                                            n-Pr   COEt                                   CF.sub.3                                                                            4-ClPh    CO.sub.2 Et                                                                             CF.sub.3                                                                            n-Pr   CO.sub.2 Et                            CF.sub.3                                                                            4-ClPh    CO(n-Pr)  CF.sub.3                                                                            n-Pr   CO(n-Pr)                               CF.sub.3                                                                            4-ClPh    CO(i-Pr)  CF.sub.3                                                                            n-Pr   CO(i-Pr)                               CF.sub.3                                                                            4-ClPh    CO(t-Bu)  CF.sub.3                                                                            n-Pr   CO(t-Bu)                               CF.sub.3                                                                            4-ClPh    n-Pr      CF.sub.3                                                                            n-Pr   n-Pr                                   OCF.sub.3                                                                           4-ClPh    COEt      OCF.sub.3                                                                           n-Pr   COEt                                   OCF.sub.3                                                                           4-ClPh    CO.sub.2 Et                                                                             OCF.sub.3                                                                           n-Pr   CO.sub.2 Et                            OCF.sub.3                                                                           4-ClPh    CO(n-Pr)  OCF.sub.3                                                                           n-Pr   CO(n-Pr)                               OCF.sub.3                                                                           4-ClPh    CO(i-Pr)  OCF.sub.3                                                                           n-Pr   CO(i-Pr)                               OCF.sub.3                                                                           4-ClPh    CO(t-Bu)  OCF.sub.3                                                                           n-Pr   CO(t-Bu)                               OCF.sub.3                                                                           4-ClPh    n-Pr      OCF.sub.3                                                                           n-Pr   n-Pr                                   ______________________________________                                    

                  TABLE 16                                                        ______________________________________                                         ##STR53##                                                                    R.sup.1                                                                             R.sup.3   Y         R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            Ph        H         CF.sub.3                                                                            4-FPh  H                                      CF.sub.3                                                                            Ph        Me        CF.sub.3                                                                            4-FPh  Me                                     CF.sub.3                                                                            Ph        Et        CF.sub.3                                                                            4-FPh  Et                                     CF.sub.3                                                                            Ph        COMe      CF.sub.3                                                                            4-FPh  COMe                                   CF.sub.3                                                                            Ph        CO.sub.2 Me                                                                             CF.sub.3                                                                            4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                           Ph        H         OCF.sub.3                                                                           4-FPh  H                                      OCF.sub.3                                                                           Ph        Me        OCF.sub.3                                                                           4-FPh  Me                                     OCF.sub.3                                                                           Ph        Et        OCF.sub.3                                                                           4-FPh  Et                                     OCF.sub.3                                                                           Ph        COMe      OCF.sub.3                                                                           4-FPh  COMe                                   OCF.sub.3                                                                           Ph        CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-FPh  CO.sub.2 Me                            CF.sub.3                                                                            4-ClPh    H         CF.sub.3                                                                            n-Pr   H                                      CF.sub.3                                                                            4-ClPh    Me        CF.sub.3                                                                            n-Pr   Me                                     CF.sub.3                                                                            4-ClPh    Et        CF.sub.3                                                                            n-Pr   Et                                     CF.sub.3                                                                            4-ClPh    COMe      CF.sub.3                                                                            n-Pr   COMe                                   CF.sub.3                                                                            4-ClPh    CO.sub.2 Me                                                                             CF.sub.3                                                                            n-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-ClPh    H         OCF.sub.3                                                                           n-Pr   H                                      OCF.sub.3                                                                           4-ClPh    Me        OCF.sub.3                                                                           n-Pr   Me                                     OCF.sub.3                                                                           4-ClPh    Et        OCF.sub.3                                                                           n-Pr   Et                                     OCF.sub.3                                                                           4-ClPh    COMe      OCF.sub.3                                                                           n-Pr   COMe                                   OCF.sub.3                                                                           4-ClPh    CO.sub.2 Me                                                                             OCF.sub.3                                                                           n-Pr   CO.sub.2 Me                            CF.sub.3                                                                            Ph        COEt      CF.sub.3                                                                            4-FPh  COEt                                   CF.sub.3                                                                            Ph        CO.sub.2 Et                                                                             CF.sub.3                                                                            4-FPh  CO.sub.2 Et                            CF.sub.3                                                                            Ph        CO(n-Pr)  CF.sub.3                                                                            4-FPh  CO(n-Pr)                               CF.sub.3                                                                            Ph        CO(i-Pr)  CF.sub.3                                                                            4-FPh  CO(i-Pr)                               CF.sub.3                                                                            Ph        CO(t-Bu)  CF.sub.3                                                                            4-FPh  CO(t-Bu)                               CF.sub.3                                                                            Ph        n-Pr      CF.sub.3                                                                            4-FPh  n-Pr                                   OCF.sub.3                                                                           Ph        COEt      OCF.sub.3                                                                           4-FPh  COEt                                   OCF.sub.3                                                                           Ph        CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                           Ph        CO(n-Pr)  OCF.sub.3                                                                           4-FPh  CO(n-Pr)                               OCF.sub.3                                                                           Ph        CO(i-Pr)  OCF.sub.3                                                                           4-FPh  CO(i-Pr)                               OCF.sub.3                                                                           Ph        CO(t-Bu)  OCF.sub.3                                                                           4-FPh  CO(t-Bu)                               OCF.sub.3                                                                           Ph        n-Pr      OCF.sub.3                                                                           4-FPh  n-Pr                                   CF.sub.3                                                                            4-ClPh    COEt      CF.sub.3                                                                            n-Pr   COEt                                   CF.sub.3                                                                            4-ClPh    CO.sub.2 Et                                                                             CF.sub.3                                                                            n-Pr   CO.sub.2 Et                            CF.sub.3                                                                            4-ClPh    CO(n-Pr)  CF.sub.3                                                                            n-Pr   CO(n-Pr)                               CF.sub.3                                                                            4-ClPh    CO(i-Pr)  CF.sub.3                                                                            n-Pr   CO(i-Pr)                               CF.sub.3                                                                            4-ClPh    CO(t-Bu)  CF.sub.3                                                                            n-Pr   CO(t-Bu)                               CF.sub.3                                                                            4-ClPh    n-Pr      CF.sub.3                                                                            n-Pr   n-Pr                                   OCF.sub.3                                                                           4-ClPh    COEt      OCF.sub.3                                                                           n-Pr   COEt                                   OCF.sub.3                                                                           4-ClPh    CO.sub.2 Et                                                                             OCF.sub.3                                                                           n-Pr   CO.sub.2 Et                            OCF.sub.3                                                                           4-ClPh    CO(n-Pr)  OCF.sub.3                                                                           n-Pr   CO(n-Pr)                               OCF.sub.3                                                                           4-ClPh    CO(i-Pr)  OCF.sub.3                                                                           n-Pr   CO(i-Pr)                               OCF.sub.3                                                                           4-ClPh    CO(t-Bu)  OCF.sub.3                                                                           n-Pr   CO(t-Bu)                               OCF.sub.3                                                                           4-ClPh    n-Pr      OCF.sub.3                                                                           n-Pr   n-Pr                                   ______________________________________                                    

                  TABLE 17                                                        ______________________________________                                         ##STR54##                                                                    R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                              Y                                     ______________________________________                                        CF.sub.3                                                                             Et       H         CF.sub.3                                                                             4-ClPh H                                     CF.sub.3                                                                             Et       Me        CF.sub.3                                                                             4-ClPh Me                                    CF.sub.3                                                                             Et       Et        CF.sub.3                                                                             4-ClPh Et                                    CF.sub.3                                                                             Et       COMe      CF.sub.3                                                                             4-ClPh COMe                                  CF.sub.3                                                                             Et       CO.sub.2 Me                                                                             CF.sub.3                                                                             4-ClPh CO.sub.2 Me                           OCF.sub.3                                                                            Et       H         OCF.sub.3                                                                            4-ClPh H                                     OCF.sub.3                                                                            Et       Me        OCF.sub.3                                                                            4-ClPh Me                                    OCF.sub.3                                                                            Et       Et        OCF.sub.3                                                                            4-ClPh Et                                    OCF.sub.3                                                                            Et       COMe      OCF.sub.3                                                                            4-ClPh COMe                                  OCF.sub.3                                                                            Et       CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                           CF.sub.3                                                                             n-Pr     H         CF.sub.3                                                                             4-F Ph H                                     CF.sub.3                                                                             n-Pr     Me        CF.sub.3                                                                             4-FPh  Me                                    CF.sub.3                                                                             n-Pr     Et        CF.sub.3                                                                             4-FPh  Et                                    CF.sub.3                                                                             n-Pr     COMe      CF.sub.3                                                                             4-FPh  COMe                                  CF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Me                           OCF.sub.3                                                                            n-Pr     H         OCF.sub.3                                                                            4-FPh  H                                     OCF.sub.3                                                                            n-Pr     Me        OCF.sub.3                                                                            4-FPh  Me                                    OCF.sub.3                                                                            n-Pr     Et        OCF.sub.3                                                                            4-FPh  Et                                    OCF.sub.3                                                                            n-Pr     COMe      OCF.sub.3                                                                            4-FPh  COMe                                  OCF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       H         OCF.sub.2 H                                                                          Et     COMe                                  OCF.sub.2 H                                                                          Et       Me        OCF.sub.2 H                                                                          Et     CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       Et        OCF.sub.2 H                                                                          Et     COEt                                  OCF.sub.2 H                                                                          Et       n-Pr      OCF.sub.2 H                                                                          Et     CO.sub.2 Et                           CF.sub.3                                                                             Et       COEt      CF.sub.3                                                                             4-ClPh COEt                                  CF.sub.3                                                                             Et       CO.sub.2 Et                                                                             CF.sub.3                                                                             4-ClPh CO.sub.2 Et                           CF.sub.3                                                                             Et       CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                              CF.sub.3                                                                             Et       CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                              CF.sub.3                                                                             Et       CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                              CF.sub.3                                                                             Et       n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                  OCF.sub.3                                                                            Et       COEt      OCF.sub.3                                                                            4-Cl Ph                                                                              COEt                                  OCF.sub.3                                                                            Et       CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                           OCF.sub.3                                                                            Et       CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                              OCF.sub.3                                                                            Et       CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                              OCF.sub.3                                                                            Et       CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                              OCF.sub.3                                                                            Et       n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                  CF.sub.3                                                                             n-Pr     COEt      CF.sub.3                                                                             4-FPh  COEt                                  CF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Et                           CF.sub.3                                                                             n-Pr     CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                              CF.sub.3                                                                             n-Pr     CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                              CF.sub.3                                                                             n-Pr     CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                              CF.sub.3                                                                             n-Pr     n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                  OCF.sub.3                                                                            n-Pr     COEt      OCF.sub.3                                                                            4-FPh  COEt                                  OCF.sub.3                                                                            n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                           OCF.sub.3                                                                            n-Pr     CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                              OCF.sub.3                                                                            n-Pr     CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                              OCF.sub.3                                                                            n-Pr     CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                              OCF.sub.3                                                                            n-Pr     n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                  OCF.sub.2 H                                                                          Et       CO(n-Pr)  OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       CO(i-Pr)  OCF.sub.2 H                                                                          n-Pr   COEt                                  OCF.sub.2 H                                                                          Et       CO(t-Bu)  OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Et                           OCF.sub.2 H                                                                          n-Pr     H         OCF.sub.2 H                                                                          n-Pr   CO(n-Pr)                              OCF.sub.2 H                                                                          n-Pr     Me        OCF.sub.2 H                                                                          n-Pr   CO(i-Pr)                              OCF.sub.2 H                                                                          n-Pr     Et        OCF.sub.2 H                                                                          n-Pr   CO(t-Bu)                              OCF.sub.2 H                                                                          n-Pr     n-Pr      OCF.sub.2 H                                                                          4-ClPh H                                     OCF.sub.2 H                                                                          n-Pr     COMe      OCF.sub.2 H                                                                          4-ClPh Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            H         CF.sub.3                                                                             Ph     H                                     CF.sub.3                                                                             CO.sub.2 Me                                                                            Me        CF.sub.3                                                                             Ph     Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            Et        CF.sub.3                                                                             Ph     Et                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                             Ph     COMe                                  CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                             Ph     CO.sub.2 Me                           OCF.sub.3                                                                            CO.sub.2 Me                                                                            H         OCF.sub.3                                                                            Ph     H                                     OCF.sub.3                                                                            CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                            Ph     Me                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                            Ph     Et                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                            Ph     COMe                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                            Ph     CO.sub.2 Me                           CF.sub.3                                                                             Me       H         CF.sub.3                                                                             CO.sub.2 Et                                                                          H                                     CF.sub.3                                                                             Me       Me        CF.sub.3                                                                             CO.sub.2 Et                                                                          Me                                    CF.sub.3                                                                             Me       Et        CF.sub.3                                                                             CO.sub.2 Et                                                                          Et                                    CF.sub.3                                                                             Me       COMe      CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe                                  CF.sub.3                                                                             Me       CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.3                                                                            Me       H         OCF.sub.3                                                                            CO.sub.2 Et                                                                          H                                     OCF.sub.3                                                                            Me       Me        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me                                    OCF.sub.3                                                                            Me       Et        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et                                    OCF.sub.3                                                                            Me       COMe      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe                                  OCF.sub.3                                                                            Me       CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   Et        OCF.sub.2 H                                                                          4-FPh  Et                                    OCF.sub.2 H                                                                          4-ClPh   n-Pr      OCF.sub.2 H                                                                          4-FPh  n-Pr                                  OCF.sub.2 H                                                                          4-ClPh   COMe      OCF.sub.2 H                                                                          4-FPh  COMe                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   COEt      OCF.sub.2 H                                                                          4-FPh  COEt                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                           OCF.sub.2 H                                                                          4-ClPh   CO(n-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(i-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(t-Bu)  OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                              OCF.sub.2 H                                                                          4-FPh    H         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H                                     OCF.sub.2 H                                                                          4-FPh    Me        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                             Ph     COEt                                  CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                             Ph     CO.sub.2 Et                           CF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                             Ph     CO(n-Pr)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                             Ph     CO(i-Pr)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                             Ph     CO(t-Bu)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                             Ph     n-Pr                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                            Ph     COEt                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                            Ph     CO.sub.2 Et                           OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                            Ph     CO(n-Pr)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                            Ph     CO(i-Pr)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                            Ph     CO(t-Bu)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                            Ph     n-Pr                                  CF.sub.3                                                                             Me       COEt      CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt                                  CF.sub.3                                                                             Me       CO.sub.2 Et                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                           CF.sub.3                                                                             Me       CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                              CF.sub.3                                                                             Me       CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                              CF.sub.3                                                                             Me       CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                              CF.sub.3                                                                             Me       n-Pr      CF.sub.3                                                                             CO.sub. 2 Et                                                                         n-Pr                                  OCF.sub.3                                                                            Me       COEt      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COEt                                  OCF.sub.3                                                                            Me       CO.sub.2 Et                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Et                           OCF.sub.3                                                                            Me       CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(n-Pr)                              OCF.sub.3                                                                            Me       CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(i-Pr)                              OCF.sub.3                                                                            Me       CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(t-Bu)                              OCF.sub.3                                                                            Me       n-Pr      OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr                                  OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            Et        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                              OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            n-Pr                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COMe                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Me                                                   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COEt                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Et                                                   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(n-Pr)                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(i-Pr)                                                      ______________________________________                                    

                  TABLE 18                                                        ______________________________________                                         ##STR55##                                                                    R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                              Y                                     ______________________________________                                        CF.sub.3                                                                             Et       H         CF.sub.3                                                                             4-ClPh H                                     CF.sub.3                                                                             Et       Me        CF.sub.3                                                                             4-ClPh Me                                    CF.sub.3                                                                             Et       Et        CF.sub.3                                                                             4-ClPh Et                                    CF.sub.3                                                                             Et       COMe      CF.sub.3                                                                             4-ClPh COMe                                  CF.sub.3                                                                             Et       CO.sub.2 Me                                                                             CF.sub.3                                                                             4-ClPh CO.sub.2 Me                           OCF.sub.3                                                                            Et       H         OCF.sub.3                                                                            4-ClPh H                                     OCF.sub.3                                                                            Et       Me        OCF.sub.3                                                                            4-ClPh Me                                    OCF.sub.3                                                                            Et       Et        OCF.sub.3                                                                            4-ClPh Et                                    OCF.sub.3                                                                            Et       COMe      OCF.sub.3                                                                            4-ClPh COMe                                  OCF.sub.3                                                                            Et       CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                           CF.sub.3                                                                             n-Pr     H         CF.sub.3                                                                             4-F Ph H                                     CF.sub.3                                                                             n-Pr     Me        CF.sub.3                                                                             4-FPh  Me                                    CF.sub.3                                                                             n-Pr     Et        CF.sub.3                                                                             4-FPh  Et                                    CF.sub.3                                                                             n-Pr     COMe      CF.sub.3                                                                             4-FPh  COMe                                  CF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Me                           OCF.sub.3                                                                            n-Pr     H         OCF.sub.3                                                                            4-FPh  H                                     OCF.sub.3                                                                            n-Pr     Me        OCF.sub.3                                                                            4-FPh  Me                                    OCF.sub.3                                                                            n-Pr     Et        OCF.sub.3                                                                            4-FPh  Et                                    OCF.sub.3                                                                            n-Pr     COMe      OCF.sub.3                                                                            4-FPh  COMe                                  OCF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       H         OCF.sub.2 H                                                                          Et     COMe                                  OCF.sub.2 H                                                                          Et       Me        OCF.sub.2 H                                                                          Et     CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       Et        OCF.sub.2 H                                                                          Et     COEt                                  OCF.sub.2 H                                                                          Et       n-Pr      OCF.sub.2 H                                                                          Et     CO.sub.2 Et                           CF.sub.3                                                                             Et       COEt      CF.sub.3                                                                             4-ClPh COEt                                  CF.sub.3                                                                             Et       CO.sub.2 Et                                                                             CF.sub.3                                                                             4-ClPh CO.sub.2 Et                           CF.sub.3                                                                             Et       CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                              CF.sub.3                                                                             Et       CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                              CF.sub.3                                                                             Et       CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                              CF.sub.3                                                                             Et       n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                  OCF.sub.3                                                                            Et       COEt      OCF.sub.3                                                                            4-Cl Ph                                                                              COEt                                  OCF.sub.3                                                                            Et       CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                           OCF.sub.3                                                                            Et       CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                              OCF.sub.3                                                                            Et       CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                              OCF.sub.3                                                                            Et       CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                              OCF.sub.3                                                                            Et       n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                  CF.sub.3                                                                             n-Pr     COEt      CF.sub.3                                                                             4-FPh  COEt                                  CF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Et                           CF.sub.3                                                                             n-Pr     CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                              CF.sub.3                                                                             n-Pr     CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                              CF.sub.3                                                                             n-Pr     CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                              CF.sub.3                                                                             n-Pr     n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                  OCF.sub.3                                                                            n-Pr     COEt      OCF.sub.3                                                                            4-FPh  COEt                                  OCF.sub.3                                                                            n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                           OCF.sub.3                                                                            n-Pr     CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                              OCF.sub.3                                                                            n-Pr     CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                              OCF.sub.3                                                                            n-Pr     CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                              OCF.sub.3                                                                            n-Pr     n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                  OCF.sub.2 H                                                                          Et       CO(n-Pr)  OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       CO(i-Pr)  OCF.sub.2 H                                                                          n-Pr   COEt                                  OCF.sub.2 H                                                                          Et       CO(t-Bu)  OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Et                           OCF.sub.2 H                                                                          n-Pr     H         OCF.sub.2 H                                                                          n-Pr   CO(n-Pr)                              OCF.sub.2 H                                                                          n-Pr     Me        OCF.sub.2 H                                                                          n-Pr   CO(i-Pr)                              OCF.sub.2 H                                                                          n-Pr     Et        OCF.sub.2 H                                                                          n-Pr   CO(t-Bu)                              OCF.sub.2 H                                                                          n-Pr     n-Pr      OCF.sub.2 H                                                                          4-ClPh H                                     OCF.sub.2 H                                                                          n-Pr     COMe      OCF.sub.2 H                                                                          4-ClPh Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            H         CF.sub.3                                                                             Ph     H                                     CF.sub.3                                                                             CO.sub.2 Me                                                                            Me        CF.sub.3                                                                             Ph     Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            Et        CF.sub.3                                                                             Ph     Et                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                             Ph     COMe                                  CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                             Ph     CO.sub.2 Me                           OCF.sub.3                                                                            CO.sub.2 Me                                                                            H         OCF.sub.3                                                                            Ph     H                                     OCF.sub.3                                                                            CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                            Ph     Me                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                            Ph     Et                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                            Ph     COMe                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                            Ph     CO.sub.2 Me                           CF.sub.3                                                                             Me       H         CF.sub.3                                                                             CO.sub.2 Et                                                                          H                                     CF.sub.3                                                                             Me       Me        CF.sub.3                                                                             CO.sub.2 Et                                                                          Me                                    CF.sub.3                                                                             Me       Et        CF.sub.3                                                                             CO.sub.2 Et                                                                          Et                                    CF.sub.3                                                                             Me       COMe      CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe                                  CF.sub.3                                                                             Me       CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.3                                                                            Me       H         OCF.sub.3                                                                            CO.sub.2 Et                                                                          H                                     OCF.sub.3                                                                            Me       Me        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me                                    OCF.sub.3                                                                            Me       Et        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et                                    OCF.sub.3                                                                            Me       COMe      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe                                  OCF.sub.3                                                                            Me       CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   Et        OCF.sub.2 H                                                                          4-FPh  Et                                    OCF.sub.2 H                                                                          4-ClPh   n-Pr      OCF.sub.2 H                                                                          4-FPh  n-Pr                                  OCF.sub.2 H                                                                          4-ClPh   COMe      OCF.sub.2 H                                                                          4-FPh  COMe                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   COEt      OCF.sub.2 H                                                                          4-FPh  COEt                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                           OCF.sub.2 H                                                                          4-ClPh   CO(n-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(i-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(t-Bu)  OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                              OCF.sub.2 H                                                                          4-FPh    H         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H                                     OCF.sub.2 H                                                                          4-FPh    Me        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                             Ph     COEt                                  CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                             Ph     CO.sub.2 Et                           CF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                             Ph     CO(n-Pr)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO (i-Pr) CF.sub.3                                                                             Ph     CO(i-Pr)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO (t-Bu) CF.sub.3                                                                             Ph     CO(t-Bu)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                             Ph     n-Pr                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                            Ph     COEt                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                            Ph     CO.sub.2 Et                           OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                            Ph     CO(n-Pr)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                            Ph     CO(i-Pr)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                            Ph     CO(t-Bu)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                            Ph     n-Pr                                  CF.sub.3                                                                             Me       COEt      CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt                                  CF.sub.3                                                                             Me       CO.sub.2 Et                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                           CF.sub.3                                                                             Me       CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                              CF.sub.3                                                                             Me       CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                              CF.sub.3                                                                             Me       CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                              CF.sub.3                                                                             Me       n-Pr      CF.sub. 3                                                                            CO.sub.2 Et                                                                          n-Pr                                  OCF.sub.3                                                                            Me       COEt      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COEt                                  OCF.sub.3                                                                            Me       CO.sub.2 Et                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Et                           OCF.sub.3                                                                            Me       CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(n-Pr)                              OCF.sub.3                                                                            Me       CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(i-Pr)                              OCF.sub.3                                                                            Me       CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(t-Bu)                              OCF.sub.3                                                                            Me       n-Pr      OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr                                  OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            Et        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                              OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            n-Pr                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COMe                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Me                                                   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COEt                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Et                                                   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(n-Pr)                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(i-Pr)                                                      ______________________________________                                    

                  TABLE 19                                                        ______________________________________                                         ##STR56##                                                                    R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                              Y                                     ______________________________________                                        CF.sub.3                                                                             Et       H         CF.sub.3                                                                             4-ClPh H                                     CF.sub.3                                                                             Et       Me        CF.sub.3                                                                             4-ClPh Me                                    CF.sub.3                                                                             Et       Et        CF.sub.3                                                                             4-ClPh Et                                    CF.sub.3                                                                             Et       COMe      CF.sub.3                                                                             4-ClPh COMe                                  CF.sub.3                                                                             Et       CO.sub.2 Me                                                                             CF.sub.3                                                                             4-ClPh CO.sub.2 Me                           OCF.sub.3                                                                            Et       H         OCF.sub.3                                                                            4-ClPh H                                     OCF.sub.3                                                                            Et       Me        OCF.sub.3                                                                            4-ClPh Me                                    OCF.sub.3                                                                            Et       Et        OCF.sub.3                                                                            4-ClPh Et                                    OCF.sub.3                                                                            Et       COMe      OCF.sub.3                                                                            4-ClPh COMe                                  OCF.sub.3                                                                            Et       CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                           CF.sub.3                                                                             n-Pr     R         CF.sub. 3                                                                            4-FPh  H                                     CF.sub.3                                                                             n-Pr     Me        CF.sub.3                                                                             4-FPh  Me                                    CF.sub.3                                                                             n-Pr     Et        CF.sub.3                                                                             4-FPh  Et                                    CF.sub.3                                                                             n-Pr     COMe      CF.sub.3                                                                             4-FPh  COMe                                  CF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Me                           OCF.sub.3                                                                            n-Pr     H         OCF.sub.3                                                                            4-FPh  H                                     OCF.sub.3                                                                            n-Pr     Me        OCF.sub.3                                                                            4-FPh  Me                                    OCF.sub.3                                                                            n-Pr     Et        OCF.sub.3                                                                            4-FPh  Et                                    OCF.sub.3                                                                            n-Pr     COMe      OCF.sub.3                                                                            4-FPh  COMe                                  OCF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       H         OCF.sub.2 H                                                                          Et     COMe                                  OCF.sub.2 H                                                                          Et       Me        OCF.sub.2 H                                                                          Et     CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       Et        OCF.sub.2 H                                                                          Et     COEt                                  OCF.sub.2 H                                                                          Et       n-Pr      OCF.sub.2 H                                                                          Et     CO.sub.2 Et                           CF.sub.3                                                                             Et       COEt      CF.sub.3                                                                             4-ClPh COEt                                  CF.sub.3                                                                             Et       CO.sub.2 Et                                                                             CF.sub.3                                                                             4-ClPh CO.sub.2 Et                           CF.sub.3                                                                             Et       CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                              CF.sub.3                                                                             Et       CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                              CF.sub.3                                                                             Et       CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                              CF.sub.3                                                                             Et       n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                  OCF.sub.3                                                                            Et       COEt      OCF.sub. 3                                                                           4-ClPh COEt                                  OCF.sub.3                                                                            Et       CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                           OCF.sub.3                                                                            Et       CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                              OCF.sub.3                                                                            Et       CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                              OCF.sub.3                                                                            Et       CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Eu)                              OCF.sub.3                                                                            Et       n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                  CF.sub.3                                                                             n-Pr     COEt      CF.sub.3                                                                             4-FPh  COEt                                  CF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                             4-FPh  CO.sub.2 Et                           CF.sub.3                                                                             n-Pr     CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                              CF.sub.3                                                                             n-Pr     CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                              CF.sub.3                                                                             n-Pr     CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                              CF.sub.3                                                                             n-Pr     n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                  OCF.sub.3                                                                            n-Pr     COEt      OCF.sub.3                                                                            4-FPh  COEt                                  OCF.sub.3                                                                            n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                           OCF.sub.3                                                                            n-Pr     CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                              OCF.sub.3                                                                            n-Pr     CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                              OCF.sub.3                                                                            n-Pr     CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                              OCF.sub.3                                                                            n-Pr     n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                  OCF.sub.2 H                                                                          Et       CO(n-Pr)  OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Me                           OCF.sub.2 H                                                                          Et       CO(i-Pr)  OCF.sub.2 H                                                                          n-Pr   COEt                                  OCF.sub.2 H                                                                          Et       CO(t-Bu)  OCF.sub.2 H                                                                          n-Pr   CO.sub.2 Et                           OCF.sub.2 H                                                                          n-Pr     H         OCF.sub.2 H                                                                          n-Pr   CO(n-Pr)                              OCF.sub.2 H                                                                          n-Pr     Me        OCF.sub.2 H                                                                          n-Pr   CO(i-Pr)                              OCF.sub.2 H                                                                          n-Pr     Et        OCF.sub.2 H                                                                          n-Pr   CO(t-Bu)                              OCF.sub.2 H                                                                          n-Pr     n-Pr      OCF.sub.2 H                                                                          4-ClPh H                                     OCF.sub.2 H                                                                          n-Pr     COMe      OCF.sub.2 H                                                                          4-ClPh Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            H         CF.sub.3                                                                             Ph     H                                     CF.sub.3                                                                             CO.sub.2 Me                                                                            Me        CF.sub.3                                                                             Ph     Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            Et        CF.sub.3                                                                             Ph     Et                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                             Ph     COMe                                  CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                             Ph     CO.sub.2 Me                           OCF.sub.3                                                                            CO.sub.2 Me                                                                            H         OCF.sub.3                                                                            Ph     H                                     OCF.sub.3                                                                            CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                            Ph     Me                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                            Ph     Et                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                            Ph     COMe                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                            Ph     CO.sub.2 Me                           CF.sub.3                                                                             Me       H         CF.sub.3                                                                             CO.sub.2 Et                                                                          H                                     CF.sub.3                                                                             Me       Me        CF.sub.3                                                                             CO.sub.2 Et                                                                          Me                                    CF.sub.3                                                                             Me       Et        CF.sub.3                                                                             CO.sub.2 Et                                                                          Et                                    CF.sub.3                                                                             Me       COMe      CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe                                  CF.sub.3                                                                             Me       CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.3                                                                            Me       H         OCF.sub.3                                                                            CO.sub.2 Et                                                                          H                                     OCF.sub.3                                                                            Me       Me        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me                                    OCF.sub.3                                                                            Me       Et        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et                                    OCF.sub.3                                                                            Me       COMe      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe                                  OCF.sub.3                                                                            Me       CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   Et        OCF.sub.2 H                                                                          4-FPh  Et                                    OCF.sub.2 H                                                                          4-ClPh   n-Pr      OCF.sub.2 H                                                                          4-FPh  n-Pr                                  OCF.sub.2 H                                                                          4-ClPh   COMe      OCF.sub.2 H                                                                          4-FPh  COMe                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   COEt      OCF.sub.2 H                                                                          4-FPh  COEt                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                           OCF.sub.2 H                                                                          4-ClPh   CO(n-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(i-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(t-Bu)  OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                              OCF.sub.2 H                                                                          4-FPh    H         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H                                     OCF.sub.2 H                                                                          4-FPh    Me        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            H         CF.sub.3                                                                             Ph     H                                     CF.sub.3                                                                             CO.sub.2 Me                                                                            Me        CF.sub.3                                                                             Ph     Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            Et        CF.sub.3                                                                             Ph     Et                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                             Ph     COMe                                  CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                             Ph     CO.sub.2 Me                           OCF.sub.3                                                                            CO.sub.2 Me                                                                            H         OCF.sub.3                                                                            Ph     H                                     OCF.sub.3                                                                            CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                            Ph     Me                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                            Ph     Et                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                            Ph     COMe                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                            Ph     CO.sub.2 Me                           CF.sub.3                                                                             Me       H         CF.sub.3                                                                             CO.sub.2 Et                                                                          H                                     CF.sub.3                                                                             Me       Me        CF.sub.3                                                                             CO.sub.2 Et                                                                          Me                                    CF.sub.3                                                                             Me       Et        CF.sub.3                                                                             CO.sub.2 Et                                                                          Et                                    CF.sub.3                                                                             Me       COMe      CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe                                  CF.sub.3                                                                             Me       CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.3                                                                            Me       H         OCF.sub.3                                                                            CO.sub.2 Et                                                                          H                                     OCF.sub.3                                                                            Me       Me        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me                                    OCF.sub.3                                                                            Me       Et        OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et                                    OCF.sub.3                                                                            Me       COMe      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe                                  OCF.sub.3                                                                            Me       CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   Et        OCF.sub.2 H                                                                          4-FPh  Et                                    OCF.sub.2 H                                                                          4-ClPh   n-Pr      COF.sub.2 H                                                                          4-FPh  n-Pr                                  OCF.sub.2 H                                                                          4-ClPh   COMe      OCF.sub.2 H                                                                          4-FPh  COMe                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Me                           OCF.sub.2 H                                                                          4-ClPh   COEt      OCF.sub.2 H                                                                          4-FPh  COEt                                  OCF.sub.2 H                                                                          4-ClPh   CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          4-FPh  CO.sub.2 Et                           OCF.sub.2 H                                                                          4-ClPh   CO(n-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(n-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(i-Pr)  OCF.sub.2 H                                                                          4-FPh  CO(i-Pr)                              OCF.sub.2 H                                                                          4-ClPh   CO(t-Bu)  OCF.sub.2 H                                                                          4-FPh  CO(t-Bu)                              OCF.sub.2 H                                                                          4-FPh    H         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H                                     OCF.sub.2 H                                                                          4-FPh    Me        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me                                    CF.sub.3                                                                             CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                             Ph     COEt                                  CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                             Ph     CO.sub.2 Et                           CF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                             Ph     CO(n-Pr)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                             Ph     CO(i-Pr)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                             Ph     CO(t-Bu)                              CF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                             Ph     n-Pr                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                            Ph     COEt                                  OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                            Ph     CO.sub.2 Et                           OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                            Ph     CO(n-Pr)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                            Ph     CO(i-Pr)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                            Ph     CO(t-Bu)                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                            Ph     n-Pr                                  CF.sub.3                                                                             Me       COEt      CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt                                  CF.sub.3                                                                             Me       CO.sub.2 Et                                                                             CF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                           CF.sub.3                                                                             Me       CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                              CF.sub.3                                                                             Me       CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                              CF.sub.3                                                                             Me       CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                              CF.sub.3                                                                             Me       n-Pr      CF.sub.3                                                                             CO.sub.2 Et                                                                          n-Pr                                  OCF.sub.3                                                                            Me       COEt      OCF.sub.3                                                                            CO.sub.2 Et                                                                          COEt                                  OCF.sub.3                                                                            Me       CO.sub.2 Et                                                                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO.sub.2 Et                           OCF.sub.3                                                                            Me       CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(n-Pr)                              OCF.sub.3                                                                            Me       CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(i-Pr)                              OCF.sub.3                                                                            Me       CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Et                                                                          CO(t-Bu)                              OCF.sub.3                                                                            Me       n-Pr      OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr                                  OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            Et        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          CO(t-Bu)                              OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            n-Pr                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COMe                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Me                                                   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COEt                                                          OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Et                                                   OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(n-Pr)                                                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(i-Pr)                                                      ______________________________________                                    

                  TABLE 20                                                        ______________________________________                                         ##STR57##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub.3                                                                            6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-F      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 21                                                        ______________________________________                                         ##STR58##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub.3                                                                            6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-F      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 22                                                        ______________________________________                                         ##STR59##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub.3                                                                            6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-F      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 23                                                        ______________________________________                                         ##STR60##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub. 3                                                                           6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-F      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 24                                                        ______________________________________                                         ##STR61##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub.3                                                                            6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-r      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 25                                                        ______________________________________                                         ##STR62##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub.3                                                                            6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-F      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 26                                                        ______________________________________                                         ##STR63##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub.3                                                                            6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-F      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 27                                                        ______________________________________                                         ##STR64##                                                                    R.sup.1                                                                             R.sup.2  R.sup.3    R.sup.1                                                                              R.sup.2                                                                             R.sup.3                                ______________________________________                                        CF.sub.3                                                                            6-Cl     Me         CF.sub.3                                                                             7-Cl  Me                                     CF.sub.3                                                                            6-Cl     Et         CF.sub.3                                                                             7-Cl  Et                                     CF.sub.3                                                                            6-Cl     n-Pr       CF.sub.3                                                                             7-Cl  n-Pr                                   CF.sub.3                                                                            6-Cl     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                            CF.sub.3                                                                            6-Cl     4-F-Ph     CF.sub.3                                                                             7-Cl  4-F-Ph                                 OCF.sub.3                                                                           6-Cl     Me         OCF.sub.3                                                                            7-Cl  Me                                     OCF.sub.3                                                                           6-Cl     Et         OCF.sub.3                                                                            7-Cl  Et                                     OCF.sub.3                                                                           6-Cl     n-Pr       OCF.sub.3                                                                            7-Cl  n-Pr                                   OCF.sub.3                                                                           6-Cl     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                            OCF.sub.3                                                                           6-Cl     4-F-Ph     OCF.sub.3                                                                            7-Cl  4-F-Ph                                 CF.sub.3                                                                            6-F      Me         CF.sub.3                                                                             7-F   Me                                     CF.sub. 3                                                                           6-F      Et         CF.sub.3                                                                             7-F   Et                                     CF.sub.3                                                                            6-F      n-Pr       CF.sub.3                                                                             7-F   n-Pr                                   CF.sub.3                                                                            6-F      CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                            CF.sub.3                                                                            6-F      4-F-Ph     CF.sub.3                                                                             7-F   4-F-Ph                                 OCF.sub.3                                                                           6-F      Me         OCF.sub.3                                                                            7-F   Me                                     OCF.sub.3                                                                           6-F      Et         OCF.sub.3                                                                            7-F   Et                                     OCF.sub.3                                                                           6-F      n-Pr       OCF.sub.3                                                                            7-F   n-Pr                                   OCF.sub.3                                                                           6-F      CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                            OCF.sub.3                                                                           6-F      4-F-Ph     OCF.sub.3                                                                            7-F   4-F-Ph                                 ______________________________________                                    

                  TABLE 28                                                        ______________________________________                                         ##STR65##                                                                    R.sup.1                                                                              R.sup.3                                                                              Y          R.sup.1                                                                             R.sup.3 Y                                      ______________________________________                                        CF.sub.3                                                                             Et     H          CF.sub.3                                                                            CO.sub.2 Me                                                                           H                                      CF.sub.3                                                                             Et     Me         CF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                     CF.sub.3                                                                             Et     Et         CF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                     CF.sub.3                                                                             Et     COMe       CF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                   CF.sub.3                                                                             Et     CO.sub.2 Me                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                            OCF.sub.3                                                                            Et     H          OCF.sub.3                                                                           CO.sub.2 Me                                                                           H                                      OCF.sub.3                                                                            Et     Me         OCF.sub.3                                                                           CO.sub.2 Me                                                                           Me                                     OCF.sub.3                                                                            Et     Et         OCF.sub.3                                                                           CO.sub.2 Me                                                                           Et                                     OCF.sub.3                                                                            Et     COMe       OCF.sub.3                                                                           CO.sub.2 Me                                                                           COMe                                   OCF.sub.3                                                                            Et     CO.sub.2 Me                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Me                            CF.sub. 3                                                                            n-Pr   H          CF.sub.3                                                                            4-F-Ph  H                                      CF.sub.3                                                                             n-Pr   Me         CF.sub.3                                                                            4-F-Ph  Me                                     CF.sub.3                                                                             n-Pr   Et         CF.sub.3                                                                            4-F-Ph  Et                                     CF.sub.3                                                                             n-Pr   COMe       CF.sub.3                                                                            4-F-Ph  COMe                                   CF.sub.3                                                                             n-Pr   CO.sub.2 Me                                                                              CF.sub.3                                                                            4-F-Ph  CO.sub.2 Me                            OCF.sub.3                                                                            n-Pr   H          OCF.sub.3                                                                           4-F-Ph  H                                      OCF.sub.3                                                                            n-Pr   Me         OCF.sub.3                                                                           4-F-Ph  Me                                     OCF.sub.3                                                                            n-Pr   Et         OCF.sub.3                                                                           4-F-Ph  Et                                     OCF.sub.3                                                                            n-Pr   COMe       OCF.sub.3                                                                           4-F-Ph  COMe                                   OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                                                                              OCF.sub.3                                                                           4-F-Ph  CO.sub.2 Me                            CF.sub.3                                                                             Et     COEt       CF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                   CF.sub.3                                                                             Et     CO.sub.2 Et                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                            CF.sub.3                                                                             Et     CO(n-Pr)   CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                               CF.sub.3                                                                             Et     CO(i-Pr)   CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                               CF.sub.3                                                                             Et     CO(t-Bu)   CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                               CF.sub.3                                                                             Et     n-Pr       CF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                   OCF.sub.3                                                                            Et     COEt       OCF.sub.3                                                                           CO.sub.2 Me                                                                           COEt                                   OCF.sub.3                                                                            Et     CO.sub.2 Et                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Et                            OCF.sub.3                                                                            Et     CO(n-Pr)   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(n-Pr)                               OCF.sub.3                                                                            Et     CO(i-Pr)   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(i-Pr)                               OCF.sub.3                                                                            Et     CO(t-Bu)   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                               OCF.sub.3                                                                            Et     n-Pr       OCF.sub.3                                                                           CO.sub.2 Me                                                                           n-Pr                                   CF.sub.3                                                                             n-Pr   COEt       CF.sub.3                                                                            4-F-Ph  COEt                                   CF.sub.3                                                                             n-Pr   CO.sub.2 Et                                                                              CF.sub.3                                                                            4-F-Ph  CO.sub.2 Et                            CF.sub.3                                                                             n-Pr   CO(n-Pr)   CF.sub.3                                                                            4-F-Ph  CO(n-Pr)                               CF.sub.3                                                                             n-Pr   CO(i-Pr)   CF.sub.3                                                                            4-F-Ph  CO(i-Pr)                               CF.sub.3                                                                             n-Pr   CO(t-Bu)   CF.sub.3                                                                            4-F-Ph  CO(t-Bu)                               CF.sub.3                                                                             n-Pr   n-Pr       CF.sub.3                                                                            4-F-Ph  n-Pr                                   OCF.sub.3                                                                            n-Pr   COEt       OCF.sub.3                                                                           4-F-Ph  COEt                                   OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                                                                              OCF.sub.3                                                                           4-F-Ph  CO.sub.2 Et                            OCF.sub.3                                                                            n-Pr   CO(n-Pr)   OCF.sub.3                                                                           4-F-Ph  CO(n-Pr)                               OCF.sub.3                                                                            n-Pr   CO(i-Pr)   OCF.sub.3                                                                           4-F-Ph  CO(i-Pr)                               OCF.sub.3                                                                            n-Pr   CO(t-Bu)   OCF.sub.3                                                                           4-F-Ph  CO(t-Bu)                               OCF.sub.3                                                                            n-Pr   n-Pr       OCF.sub.3                                                                           4-F-Ph  n-Pr                                   ______________________________________                                    

                  TABLE 29                                                        ______________________________________                                         ##STR66##                                                                    R.sup.1                                                                             R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                          H                                       CF.sub.3                                                                            Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                          Me                                      CF.sub.3                                                                            Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                          Et                                      CF.sub.3                                                                            Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe                                    CF.sub.3                                                                            Et      CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                             OCF.sub.3                                                                           Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                          H                                       OCF.sub.3                                                                           Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                      OCF.sub.3                                                                           Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                      OCF.sub.3                                                                           Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                    OCF.sub.3                                                                           Et      CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                             CF.sub.3                                                                            n-Pr    H         CF.sub.3                                                                             4-F-Ph H                                       CF.sub.3                                                                            n-Pr    Me        CF.sub.3                                                                             4-F-Ph Me                                      CF.sub.3                                                                            n-Pr    Et        CF.sub.3                                                                             4-F-Ph Et                                      CF.sub.3                                                                            n-Pr    COMe      CF.sub.3                                                                             4-F-Ph COMe                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Me                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           n-Pr    H         OCF.sub.3                                                                            4-F-Ph H                                       OCF.sub.3                                                                           n-Pr    Me        OCF.sub.3                                                                            4-F-Ph Me                                      OCF.sub.3                                                                           n-Pr    Et        OCF.sub.3                                                                            4-F-Ph Et                                      OCF.sub.3                                                                           n-Pr    COMe      OCF.sub.3                                                                            4-F-Ph COMe                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt                                    CF.sub.3                                                                            Et      CO.sub.2 Et                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                             CF.sub.3                                                                            Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                CF.sub.3                                                                            Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                CF.sub.3                                                                            Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                CF.sub.3                                                                            Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr                                    OCF.sub.3                                                                           Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                    OCF.sub.3                                                                           Et      CO.sub.2 Et                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                             OCF.sub.3                                                                           Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                OCF.sub.3                                                                           Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                OCF.sub.3                                                                           Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub. 2 Me                                                                         CO(t-Bu)                                OCF.sub.3                                                                           Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr                                    CF.sub.3                                                                            n-Pr    COEt      CF.sub.3                                                                             4-F-Ph COEt                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Et                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            n-Pr    n-Pr      CF.sub.3                                                                             4-F-Ph n-Pr                                    OCF.sub.3                                                                           n-Pr    COEt      OCF.sub.3                                                                            4-F-Ph COEt                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           n-Pr    n-Pr      OCF.sub.3                                                                            4-F-Ph n-Pr                                    ______________________________________                                    

                  TABLE 30                                                        ______________________________________                                         ##STR67##                                                                    R.sup.1                                                                             R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                          H                                       CF.sub.3                                                                            Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                          Me                                      CF.sub.3                                                                            Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                          Et                                      CF.sub.3                                                                            Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe                                    CF.sub.3                                                                            Et      CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                             OCF.sub.3                                                                           Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                          H                                       OCF.sub.3                                                                           Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                      OCF.sub.3                                                                           Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                      OCF.sub.3                                                                           Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                    OCF.sub.3                                                                           Et      CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                             CF.sub.3                                                                            n-Pr    H         CF.sub.3                                                                             4-F-Ph H                                       CF.sub.3                                                                            n-Pr    Me        CF.sub.3                                                                             4-F-Ph Me                                      CF.sub.3                                                                            n-Pr    Et        CF.sub.3                                                                             4-F-Ph Et                                      CF.sub.3                                                                            n-Pr    COMe      CF.sub.3                                                                             4-F-Ph COMe                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Me                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           n-Pr    H         OCF.sub.3                                                                            4-F-Ph H                                       OCF.sub.3                                                                           n-Pr    Me        OCF.sub.3                                                                            4-F-Ph Me                                      OCF.sub.3                                                                           n-Pr    Et        OCF.sub.3                                                                            4-F-Ph Et                                      OCF.sub.3                                                                           n-Pr    COMe      OCF.sub.3                                                                            4-F-Ph COMe                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt                                    CF.sub.3                                                                            Et      CO.sub.2 Et                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                             CF.sub.3                                                                            Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                CF.sub.3                                                                            Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                CF.sub.3                                                                            Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                CF.sub.3                                                                            Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr                                    OCF.sub.3                                                                           Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                    OCF.sub.3                                                                           Et      CO.sub.2 Et                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                             OCF.sub.3                                                                           Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                OCF.sub.3                                                                           Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                OCF.sub.3                                                                           Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                OCF.sub.3                                                                           Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr                                    CF.sub.3                                                                            n-Pr    COEt      CF.sub.3                                                                             4-F-Ph COEt                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Et                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            n-Pr    n-Pr      CF.sub.3                                                                             4-F-Ph n-Pr                                    OCF.sub.3                                                                           n-Pr    COEt      OCF.sub.3                                                                            4-F-Ph COEt                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           n-Pr    n-Pr      OCF.sub.3                                                                            4-F-Ph n-Pr                                    ______________________________________                                    

                  TABLE 31                                                        ______________________________________                                         ##STR68##                                                                    R.sup.1                                                                             R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                          H                                       CF.sub.3                                                                            Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                          Me                                      CF.sub.3                                                                            Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                          Et                                      CF.sub.3                                                                            Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe                                    CF.sub.3                                                                            Et      CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                             OCF.sub.3                                                                           Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                          H                                       OCF.sub.3                                                                           Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                      OCF.sub.3                                                                           Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                      OCF.sub.3                                                                           Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                    OCF.sub.3                                                                           Et      CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                             CF.sub.3                                                                            n-Pr    H         CF.sub.3                                                                             4-F-Ph H                                       CF.sub.3                                                                            n-Pr    Me        CF.sub.3                                                                             4-F-Ph Me                                      CF.sub.3                                                                            n-Pr    Et        CF.sub.3                                                                             4-F-Ph Et                                      CF.sub.3                                                                            n-Pr    COMe      CF.sub.3                                                                             4-F-Ph COMe                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Me                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           n-Pr    H         OCF.sub.3                                                                            4-F-Ph H                                       OCF.sub.3                                                                           n-Pr    Me        OCF.sub.3                                                                            4-F-Ph Me                                      OCF.sub.3                                                                           n-Pr    Et        OCF.sub.3                                                                            4-F-Ph Et                                      OCF.sub.3                                                                           n-Pr    COMe      OCF.sub.3                                                                            4-F-Ph COMe                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt                                    CF.sub.3                                                                            Et      CO.sub.2 Et                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                             CF.sub.3                                                                            Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                CF.sub.3                                                                            Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                CF.sub.3                                                                            Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                CF.sub.3                                                                            Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr                                    OCF.sub.3                                                                           Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                    OCF.sub.3                                                                           Et      CO.sub.2 Et                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                             OCF.sub.3                                                                           Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                OCF.sub.3                                                                           Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                OCF.sub.3                                                                           Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                OCF.sub.3                                                                           Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr                                    CF.sub.3                                                                            n-Pr    COEt      CF.sub.3                                                                             4-F-Ph COEt                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Et                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            n-Pr    n-Pr      CF.sub.3                                                                             4-F-Ph n-Pr                                    OCF.sub.3                                                                           n-Pr    COEt      OCF.sub.3                                                                            4-F-Ph COEt                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-F-Ph CO(t-Eu)                                OCF.sub.3                                                                           n-Pr    n-Pr      OCF.sub.3                                                                            4-F-Ph n-Pr                                    ______________________________________                                    

                  TABLE 32                                                        ______________________________________                                         ##STR69##                                                                    R.sup.1                                                                             R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                          H                                       CF.sub.3                                                                            Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                          H                                       CF.sub.3                                                                            Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                          Me                                      CF.sub.3                                                                            Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                          Et                                      CF.sub.3                                                                            Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe                                    CF.sub.3                                                                            Et      CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                             OCF.sub.3                                                                           Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                          H                                       OCF.sub.3                                                                           Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                      OCF.sub.3                                                                           Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                      OCF.sub.3                                                                           Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                    OCF.sub.3                                                                           Et      CO.sub. 2 Me                                                                            OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                             CF.sub.3                                                                            n-Pr    H         CF.sub.3                                                                             4-F-Ph H                                       CF.sub.3                                                                            n-Pr    Me        CF.sub.3                                                                             4-F-Ph Me                                      CF.sub.3                                                                            n-Pr    Et        CF.sub.3                                                                             4-F-Ph Et                                      CF.sub.3                                                                            n-Pr    COMe      CF.sub.3                                                                             4-F-Ph COMe                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Me                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           n-Pr    H         OCF.sub.3                                                                            4-F-Ph H                                       OCF.sub.3                                                                           n-Pr    Me        OCF.sub.3                                                                            4-F-Ph Me                                      OCF.sub.3                                                                           n-Pr    Et        OCF.sub.3                                                                            4-F-Ph Et                                      OCF.sub.3                                                                           n-Pr    COMe      OCF.sub.3                                                                            4-F-Ph COMe                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Me                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt                                    CF.sub.3                                                                            Et      CO.sub.2 Et                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                             CF.sub.3                                                                            Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                CF.sub.3                                                                            Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                CF.sub.3                                                                            Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                CF.sub.3                                                                            Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr                                    OCF.sub.3                                                                           Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                          COEt                                    OCF.sub.3                                                                           Et      CO.sub.2 Et                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Et                             OCF.sub.3                                                                           Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                OCF.sub.3                                                                           Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                OCF.sub.3                                                                           Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                OCF.sub.3                                                                           Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr                                    CF.sub.3                                                                            n-Pr    COEt      CF.sub.3                                                                             4-F-Ph COEt                                    CF.sub.3                                                                            n-Pr    CO.sub.2 Et                                                                             CF.sub.3                                                                             4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            n-Pr    n-Pr      CF.sub.3                                                                             4-F-Ph n-Pr                                    OCF.sub.3                                                                           n-Pr    COEt      OCF.sub.3                                                                            4-F-Ph COEt                                    OCF.sub.3                                                                           n-Pr    CO.sub.2 Et                                                                             OCF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           n-Pr    n-Pr      OCF.sub.3                                                                            4-F-Ph n-Pr                                    ______________________________________                                    

                  TABLE 33                                                        ______________________________________                                         ##STR70##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-BU)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Eu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 34                                                        ______________________________________                                         ##STR71##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 35                                                        ______________________________________                                         ##STR72##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 36                                                        ______________________________________                                         ##STR73##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 37                                                        ______________________________________                                         ##STR74##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 38                                                        ______________________________________                                         ##STR75##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub. 2 Me                                                                            OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 39                                                        ______________________________________                                         ##STR76##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub. 2 Me                                                                            OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 40                                                        ______________________________________                                         ##STR77##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF   4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO (t-Bu) OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph.                                                                              n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 41                                                        ______________________________________                                         ##STR78##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COET      CF.sub.3                                                                            4-Cl-Ph                                                                              COET                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Eu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      CCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 42                                                        ______________________________________                                         ##STR79##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub. 3                                                                           Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 43                                                        ______________________________________                                         ##STR80##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 44                                                        ______________________________________                                         ##STR81##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 45                                                        ______________________________________                                         ##STR82##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub. 2 Me                                                                            OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             Cr3   Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Eu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub. 3                                                                           Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 46                                                        ______________________________________                                         ##STR83##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub. 2 Me                                                                            OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF3  4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub. 2 Me                                                                           CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub. 3                                                                           Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 47                                                        ______________________________________                                         ##STR84##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub. 2 Me                                                                           CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO (i-Pr)                               OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 48                                                        ______________________________________                                         ##STR85##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Eu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub. 2 Me                                                                           CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-BU)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub. 3                                                                           Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 49                                                        ______________________________________                                         ##STR86##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub. 2 Me                                                                           CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub. 3                                                                           Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 50                                                        ______________________________________                                         ##STR87##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub. 2 Me                                                                           CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub. 3                                                                           Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 51                                                        ______________________________________                                         ##STR88##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 He                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub. 2 Me                                                                           CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO (t-Bu)                               CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 52                                                        ______________________________________                                         ##STR89##                                                                    R.sup.1                                                                             R.sup.3  Y         R.sup.1                                                                             R.sup.3                                                                              Y                                       ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H         CF.sub.3                                                                            4-Cl-Ph                                                                              H                                       CF.sub.3                                                                            CO.sub.2 Me                                                                            Me        CF.sub.3                                                                            4-Cl-Ph                                                                              Me                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Et        CF.sub.3                                                                            4-Cl-Ph                                                                              Et                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                            4-Cl-Ph                                                                              COMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Me                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            H         OCF.sub.3                                                                           4-Cl-Ph                                                                              H                                       OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                           4-Cl-Ph                                                                              Me                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                           4-Cl-Ph                                                                              Et                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                           4-Cl-Ph                                                                              COMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub. 2 Me                                                                            OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Me                             CF.sub.3                                                                            Ph       H         CF.sub.3                                                                            4-F-Ph H                                       CF.sub.3                                                                            Ph       Me        CF.sub.3                                                                            4-F-Ph Me                                      CF.sub.3                                                                            Ph       Et        CF.sub.3                                                                            4-F-Ph Et                                      CF.sub.3                                                                            Ph       COMe      CF.sub.3                                                                            4-F-Ph COMe                                    CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                           Ph       H         OCF.sub.3                                                                           4-F-Ph H                                       OCF.sub.3                                                                           Ph       Me        OCF.sub.3                                                                           4-F-Ph Me                                      OCF.sub.3                                                                           Ph       Et        OCF.sub.3                                                                           4-F-Ph Et                                      OCF.sub.3                                                                           Ph       COMe      OCF.sub.3                                                                           4-F-Ph COMe                                    OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                            4-Cl-Ph                                                                              COEt                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 Et                             CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(n-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(i-Pr)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                            4-Cl-Ph                                                                              CO(t-Bu)                                CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                           4-Cl-Ph                                                                              COEt                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 Et                             OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(n-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(i-Pr)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                           4-Cl-Ph                                                                              CO(t-Bu)                                OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-Cl-Ph                                                                              CO.sub.2 (t-Bu)                         CF.sub.3                                                                            Ph       COEt      CF.sub.3                                                                            4-F-Ph COEt                                    CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                            Ph       CO(n-Pr)  CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                CF.sub.3                                                                            Ph       CO(i-Pr)  CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                CF.sub.3                                                                            Ph       CO(t-Bu)  CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                         OCF.sub.3                                                                           Ph       COEt      OCF.sub.3                                                                           4-F-Ph COEt                                    OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                           Ph       CO(n-Pr)  OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                           Ph       CO(i-Pr)  OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                           Ph       CO(t-Bu)  OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                         CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                            4-Cl-Ph                                                                              n-Pr                                    CF.sub.3                                                                            CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                            4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                           4-Cl-Ph                                                                              n-Pr                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                           4-Cl-Ph                                                                              i-Bu                                    OCF.sub.3                                                                           Ph       n-Pr      CF.sub.3                                                                            4-F-Ph n-Pr                                    OCF.sub.3                                                                           Ph       i-Bu      CF.sub.3                                                                            4-F-Ph i-Bu                                    CF.sub.3                                                                            Ph       n-Pr      OCF.sub.3                                                                           4-F-Ph n-Pr                                    CF.sub.3                                                                            Ph       i-Bu      OCF.sub.3                                                                           4-F-Ph i-Bu                                    ______________________________________                                    

                  TABLE 53                                                        ______________________________________                                         ##STR90##                                                                    R.sup.1                                                                             R.sup.3  Y          R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            CO.sub.2 Me                                                                            H          CF.sub.3                                                                            4-ClPh H                                      CF.sub.3                                                                            CO.sub.2 Me                                                                            Me         CF.sub.3                                                                            4-ClPh Me                                     CF.sub.3                                                                            CO.sub.2 Me                                                                            Et         CF.sub.3                                                                            4-ClPh Et                                     CF.sub.3                                                                            CO.sub.2 Me                                                                            COMe       CF.sub.3                                                                            4-ClPh COMe                                   CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              CF.sub.3                                                                            4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                           CO.sub.2 Me                                                                            H          OCF.sub.3                                                                           4-ClPh H                                      OCF.sub.3                                                                           CO.sub.2 Me                                                                            Me         OCF.sub.3                                                                           4-ClPh Me                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                            Et         OCF.sub.3                                                                           4-ClPh Et                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                            COMe       OCF.sub.3                                                                           4-ClPh COMe                                   OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              OCF.sub.3                                                                           4-ClPh CO.sub.2 Me                            CF.sub.3                                                                            Ph       H          CF.sub.3                                                                            4-FPh  H                                      CF.sub.3                                                                            Ph       Me         Clr3  4-FPh  Me                                     CF.sub.3                                                                            Ph       Et         CF.sub.3                                                                            4-FPh  Et                                     CF.sub.3                                                                            Ph       COMe       CF.sub.3                                                                            4-FPh  COMe                                   CF.sub.3                                                                            Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                            4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                           Ph       H          OCF.sub.3                                                                           4-FPh  H                                      OCF.sub.3                                                                           Ph       Me         OCF.sub.3                                                                           4-FPh  Me                                     OCF.sub.3                                                                           Ph       Et         OCF.sub.3                                                                           4-FPh  Et                                     OCF.sub.3                                                                           Ph       COMe       OCF.sub.3                                                                           4-FPh  COMe                                   OCF.sub.3                                                                           Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                           4-FPh  CO.sub.2 Me                            CF.sub.3                                                                            CO.sub.2 Me                                                                            COEt       CF.sub.3                                                                            4-ClPh COEt                                   CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              CF.sub.3                                                                            4-ClPh CO.sub.2 Et                            CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(n-Pr)   CF.sub.3                                                                            4-ClPh CO(n-Pr)                               CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(i-Pr)   CF.sub.3                                                                            4-ClPh CO(i-Pr)                               CF.sub.3                                                                            CO.sub.2 Me                                                                            CO(t-Bu)   CF.sub.3                                                                            4-ClPh CO(t-Bu)                               CF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                           CO.sub.2 Me                                                                            COEt       OCF.sub.3                                                                           4-ClPh COEt                                   OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              OCF.sub.3                                                                           4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(n-Pr)   OCF.sub.3                                                                           4-ClPh CO(n-Pr)                               OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(i-Pr)   OCF.sub.3                                                                           4-ClPh CO(i-Pr)                               OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO(t-Bu)   OCF.sub.3                                                                           4-ClPh CO(t-Bu)                               OCF.sub.3                                                                           CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                           4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                            Ph       COEt       CF.sub.3                                                                            4-FPh  COEt                                   CF.sub.3                                                                            Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                            4-FPh  CO.sub.2 Et                            CF.sub.3                                                                            Ph       CO(n-Pr)   CF.sub.3                                                                            4-FPh  CO(n-Pr)                               CF.sub.3                                                                            Ph       CO(i-Pr)   CF.sub.3                                                                            4-FPh  CO(i-Pr)                               CF.sub.3                                                                            Ph       CO(t-Bu)   CF.sub.3                                                                            4-FPh  CO(t-Bu)                               CF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                           Ph       COEt       OCF.sub.3                                                                           4-FPh  COEt                                   OCF.sub.3                                                                           Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                           4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                           Ph       CO(n-Pr)   OCF.sub.3                                                                           4-FPh  CO(n-Pr)                               OCF.sub.3                                                                           Ph       CO(i-Pr)   OCF.sub.3                                                                           4-FPh  CO(i-Pr)                               OCF.sub.3                                                                           Ph       CO(t-Bu)   OCF.sub.3                                                                           4-FPh  CO(t-Bu)                               OCF.sub.3                                                                           Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                           4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                            CO.sub.2 Me                                                                            n-Pr       CF.sub.3                                                                            4-ClPh n-Pr                                   CF.sub. 3                                                                           CO.sub.2 Me                                                                            i-Bu       CF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                           CO.sub.2 Me                                                                            n-Pr       OCF.sub.3                                                                           4-ClPh n-Pr                                   OCF.sub.3                                                                           CO.sub.2 Me                                                                            i-Bu       OCF.sub.3                                                                           4-ClPh i-Bu                                   OCF.sub.3                                                                           Ph       n-Pr       CF.sub.3                                                                            4-FPh  n-Pr                                   OCF.sub.3                                                                           Ph       i-Bu       CF.sub.3                                                                            4-FPh  i-Bu                                   CF.sub.3                                                                            Ph       n-Pr       OCF.sub.3                                                                           4-FPh  n-Pr                                   CF.sub.3                                                                            Ph       i-Bu       OCF.sub.3                                                                           4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 54                                                        ______________________________________                                         ##STR91##                                                                    R.sup.1                                                                             R.sup.3  Y          R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            4-FPh    H          CF.sub.3                                                                            i-Pr   H                                      CF.sub.3                                                                            4-FPh    Me         CF.sub.3                                                                            i-Pr   Me                                     CF.sub.3                                                                            4-FPh    Et         CF.sub.3                                                                            i-Pr   Et                                     CF.sub.3                                                                            4-FPh    COMe       CF.sub.3                                                                            i-Pr   COMe                                   CF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                            i-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-FPh    H          OCF.sub.3                                                                           i-Pr   H                                      OCF.sub.3                                                                           4-FPh    Me         OCF.sub.3                                                                           i-Pr   Me                                     OCF.sub.3                                                                           4-FPh    Et         OCF.sub.3                                                                           i-Pr   Et                                     OCF.sub.3                                                                           4-FPh    COMe       OCF.sub.3                                                                           i-Pr   COMe                                   OCF.sub.3                                                                           4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                            CF.sub.3                                                                            n-Pr     H          CF.sub.3                                                                            CO.sub.2 Me                                                                          H                                      CF.sub.3                                                                            n-Pr     Me         CF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                     CF.sub.3                                                                            n-Pr     Et         CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                     CF.sub.3                                                                            n-Pr     COMe       CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                   CF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                            OCF.sub.3                                                                           n-Pr     H          OCF.sub.3                                                                           CO.sub.2 Me                                                                          H                                      OCF.sub.                                                                            n-Pr     Me         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                     OCF.sub.3                                                                           n-Pr     Et         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                     OCF.sub.3                                                                           n-Pr     COMe       OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                   OCF.sub.3                                                                           n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                            ______________________________________                                    

                  TABLE 55                                                        ______________________________________                                         ##STR92##                                                                    R.sup.1                                                                             R.sup.3  Y          R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            4-FPh    H          CF.sub.3                                                                            i-Pr   H                                      CF.sub.3                                                                            4-FPh    Me         CF.sub.3                                                                            i-Pr   Me                                     CF.sub.3                                                                            4-FPh    Et         CF.sub.3                                                                            i-Pr   Et                                     CF.sub.3                                                                            4-FPh    COMe       CF.sub.3                                                                            i-Pr   COMe                                   CF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                            i-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-FPh    H          OCF.sub.3                                                                           i-Pr   H                                      OCF.sub.3                                                                           4-FPh    Me         OCF.sub.3                                                                           i-Pr   Me                                     OCF.sub.3                                                                           4-FPh    Et         OCF.sub.3                                                                           i-Pr   Et                                     OCF.sub.3                                                                           4-FPh    COMe       OCF.sub.3                                                                           i-Pr   COMe                                   OCF.sub.3                                                                           4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                            CF.sub.3                                                                            n-Pr     H          CF.sub. 3                                                                           CO.sub.2 Me                                                                          H                                      CF.sub.3                                                                            n-Pr     Me         CF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                     CF.sub.3                                                                            n-Pr     Et         CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                     CF.sub.3                                                                            n-Pr     COMe       CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                   CF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                            OCF.sub.3                                                                           n-Pr     H          OCF.sub.3                                                                           CO.sub.2 Me                                                                          H                                      OCF.sub.3                                                                           n-Pr     Me         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                     OCF.sub.3                                                                           n-Pr     Et         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                     OCF.sub.3                                                                           n-Pr     COMe       OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                   OCF.sub.3                                                                           n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                            ______________________________________                                    

                  TABLE 56                                                        ______________________________________                                         ##STR93##                                                                    R.sup.1                                                                             R.sup.3  Y          R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            4-FPh    H          CF.sub.3                                                                            i-Pr   H                                      CF.sub.3                                                                            4-FPh    Me         CF.sub.3                                                                            i-Pr   Me                                     CF.sub.3                                                                            4-FPh    Et         CF.sub.3                                                                            i-Pr   Et                                     CF.sub.3                                                                            4-FPh    COMe       CF.sub.3                                                                            i-Pr   COMe                                   CF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                            i-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-FPh    H          OCF.sub.3                                                                           i-Pr   H                                      OCF.sub.3                                                                           4-FPh    Me         OCF.sub.3                                                                           i-Pr   Me                                     OCF.sub.3                                                                           4-FPh    Et         OCF.sub.3                                                                           i-Pr   Et                                     OCF.sub.3                                                                           4-FPh    COMe       OCF.sub.3                                                                           i-Pr   COMe                                   OCF.sub.3                                                                           4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                            CF.sub.3                                                                            n-Pr     H          CF.sub. 3                                                                           CO.sub.2 Me                                                                          H                                      CF.sub.3                                                                            n-Pr     Me         CF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                     CF.sub.3                                                                            n-Pr     Et         CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                     CF.sub.3                                                                            n-Pr     COMe       CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                   CF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                            OCF.sub.3                                                                           n-Pr     H          OCF.sub.3                                                                           CO.sub.2 Me                                                                          H                                      OCF.sub.3                                                                           n-Pr     Me         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                     OCF.sub.3                                                                           n-Pr     Et         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                     OCF.sub.3                                                                           n-Pr     COMe       OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                   OCF.sub.3                                                                           n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                            ______________________________________                                    

                  TABLE 57                                                        ______________________________________                                         ##STR94##                                                                    R.sup.1                                                                             R.sup.3  Y          R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            4-FPh    H          CF.sub.3                                                                            i-Pr   H                                      CF.sub.3                                                                            4-FPh    Me         CF.sub.3                                                                            i-Pr   Me                                     CF.sub.3                                                                            4-FPh    Et         CF.sub.3                                                                            i-Pr   Et                                     CF.sub.3                                                                            4-FPh    COMe       CF.sub.3                                                                            i-Pr   COMe                                   CF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                            i-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-FPh    H          OCF.sub.3                                                                           i-Pr   H                                      OCF.sub.3                                                                           4-FPh    Me         OCF.sub.3                                                                           i-Pr   Me                                     OCF.sub.3                                                                           4-FPh    Et         OCF.sub.3                                                                           i-Pr   Et                                     OCF.sub.3                                                                           4-FPh    COMe       OCF.sub.3                                                                           i-Pr   COMe                                   OCF.sub.3                                                                           4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                            CF.sub.3                                                                            n-Pr     H          CF.sub.3                                                                            CO.sub.2 Me                                                                          H                                      CF.sub.3                                                                            n-Pr     Me         CF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                     CF.sub.3                                                                            n-Pr     Et         CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                     CF.sub.3                                                                            n-Pr     COMe       CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                   CF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                            OCF.sub.3                                                                           n-Pr     H          OCF.sub.3                                                                           CO.sub.2 Me                                                                          H                                      OCF.sub.3                                                                           n-Pr     Me         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                     OCF.sub.3                                                                           n-Pr     Et         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                     OCF.sub.3                                                                           n-Pr     COMe       OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                   OCF.sub.3                                                                           n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                            ______________________________________                                    

                  TABLE 58                                                        ______________________________________                                         ##STR95##                                                                    R.sup.1                                                                             R.sup.3  Y          R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            4-FPh    H          CF.sub.3                                                                            i-Pr   H                                      CF.sub.3                                                                            4-FPh    Me         CF.sub.3                                                                            i-Pr   Me                                     CF.sub.3                                                                            4-FPh    Et         CF.sub.3                                                                            i-Pr   Et                                     CF.sub.3                                                                            4-FPh    COMe       CF.sub.3                                                                            i-Pr   COMe                                   CF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                            i-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-FPh    H          OCF.sub.3                                                                           i-Pr   H                                      OCF.sub.3                                                                           4-FPh    Me         OCF.sub.3                                                                           i-Pr   Me                                     OCF.sub.3                                                                           4-FPh    Et         OCF.sub.3                                                                           i-Pr   Et                                     OCF.sub.3                                                                           4-FPh    COMe       OCF.sub.3                                                                           i-Pr   COMe                                   OCF.sub.3                                                                           4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                            CF.sub.3                                                                            n-Pr     H          CF.sub.3                                                                            CO.sub.2 Me                                                                          H                                      CF.sub.3                                                                            n-Pr     Me         CF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                     CF.sub.3                                                                            n-Pr     Et         CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                     CF.sub.3                                                                            n-Pr     COMe       CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                   CF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                            OCF.sub.3                                                                           n-Pr     H          OCF.sub.3                                                                           CO.sub.2 Me                                                                          H                                      OCF.sub.3                                                                           n-Pr     Me         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                     OCF.sub.3                                                                           n-Pr     Et         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                     OCF.sub.3                                                                           n-Pr     COMe       OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                   OCF.sub.3                                                                           n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                            ______________________________________                                    

                  TABLE 59                                                        ______________________________________                                         ##STR96##                                                                    R.sup.1                                                                             R.sup.3  Y          R.sup.1                                                                             R.sup.3                                                                              Y                                      ______________________________________                                        CF.sub.3                                                                            4-FPh    H          CF.sub.3                                                                            i-Pr   H                                      CF.sub.3                                                                            4-FPh    Me         CF.sub.3                                                                            i-Pr   Me                                     CF.sub.3                                                                            4-FPh    Et         CF.sub.3                                                                            i-Pr   Et                                     CF.sub.3                                                                            4-FPh    COMe       CF.sub.3                                                                            i-Pr   COMe                                   CF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                            i-Pr   CO.sub.2 Me                            OCF.sub.3                                                                           4-FPh    H          OCF.sub.3                                                                           i-Pr   H                                      OCF.sub.3                                                                           4-FPh    Me         OCF.sub.3                                                                           i-Pr   Me                                     OCF.sub.3                                                                           4-FPh    Et         OCF.sub.3                                                                           i-Pr   Et                                     OCF.sub.3                                                                           4-FPh    COMe       OCF.sub.3                                                                           i-pr   COMe                                   OCF.sub.3                                                                           4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                            CF.sub.3                                                                            n-Pr     H          CF.sub.3                                                                            CO.sub.2 Me                                                                          H                                      CF.sub.3                                                                            n-Pr     Me         CF.sub.3                                                                            CO.sub.2 Me                                                                          Me                                     CF.sub.3                                                                            n-Pr     Et         CF.sub.3                                                                            CO.sub.2 Me                                                                          Et                                     CF.sub.3                                                                            n-Pr     COMe       CF.sub.3                                                                            CO.sub.2 Me                                                                          COMe                                   CF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 Me                            OCF.sub.3                                                                           n-Pr     H          OCF.sub.3                                                                           CO.sub.2 Me                                                                          H                                      OCF.sub.3                                                                           n-Pr     Me         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Me                                     OCF.sub.3                                                                           n-Pr     Et         OCF.sub.3                                                                           CO.sub.2 Me                                                                          Et                                     OCF.sub.3                                                                           n-Pr     COMe       OCF.sub.3                                                                           CO.sub.2 Me                                                                          COMe                                   OCF.sub.3                                                                           n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                            ______________________________________                                    

                  TABLE 60                                                        ______________________________________                                         ##STR97##                                                                    R.sup.2                                                                             R.sup.3   Y         R.sup.2                                                                             R.sup.3 Y                                     ______________________________________                                        6-Cl  CO.sub.2 Me                                                                             H         7-F   CO.sub.2 Me                                                                           H                                     6-Cl  CO.sub.2 Me                                                                             Me        7-F   CO.sub.2 Me                                                                           Me                                    6-Cl  CO.sub.2 Me                                                                             Et        7-F   CO.sub.2 Me                                                                           Et                                    6-Cl  CO.sub.2 Me                                                                             COMe      7-F   CO.sub.2 Me                                                                           COMe                                  6-Cl  CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             7-F   CO.sub.2 Me                                                                           CO.sub.2 Me                           6-Cl  CO.sub.2 Me                                                                             COEt      7-F   CO.sub.2 Me                                                                           COEt                                  6-Cl  CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             7-F   CO.sub.2 Me                                                                           CO.sub.2 Et                           7-Cl  CO.sub.2 Me                                                                             H         6-Cl  4-ClPh  H                                     7-Cl  CO.sub.2 Me                                                                             Me        6-Cl  4-ClPh  Me                                    7-Cl  CO.sub.2 Me                                                                             Et        6-Cl  4-ClPh  Et                                    7-Cl  CO.sub.2 Me                                                                             COMe      6-Cl  4-ClPh  COMe                                  7-Cl  CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             6-Cl  4-ClPh  CO.sub.2 Me                           7-Cl  CO.sub.2 Me                                                                             COEt      6-Cl  4-ClPh  COEt                                  7-Cl  CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             6-Cl  4-ClPh  CO.sub.2 Et                           6-F   CO.sub.2 Me                                                                             H         7-Cl  4-ClPh  H                                     6-F   CO.sub.2 Me                                                                             Me        7-Cl  4-ClPh  Me                                    6-F   CO.sub.2 Me                                                                             Et        7-Cl  4-ClPh  Et                                    6-F   CO.sub.2 Me                                                                             COMe      7-Cl  4-ClPh  COMe                                  6-F   CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             7-Cl  4-ClPh  CO.sub.2 Me                           6-F   CO.sub.2 Me                                                                             COEt      7-Cl  4-ClPh  COEt                                  6-F   CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             7-Cl  4-ClPh  CO.sub.2 Et                           6-F   4-ClPh    H         6-F   4-FPh   H                                     6-F   4-ClPh    Me        6-F   4-FPh   Me                                    6-F   4-ClPh    Et        6-F   4-FPh   Et                                    6-F   4-ClPh    COMe      6-F   4-FPh   COMe                                  6-F   4-ClPh    CO.sub.2 Me                                                                             6-F   4-FPh   CO.sub.2 Me                           6-F   4-ClPh    COEt      6-F   4-FPh   COEt                                  6-F   4-ClPh    CO.sub.2 Et                                                                             6-F   4-FPh   CO.sub.2 Et                           7-F   4-ClPh    H         7-F   4-FPh   H                                     7-F   4-ClPh    Me        7-F   4-FPh   Me                                    7-F   4-ClPh    Et        7-F   4-FPh   Et                                    7-F   4-ClPh    COMe      7-F   4-FPh   COMe                                  7-F   4-ClPh    CO.sub.2 Me                                                                             7-F   4-FPh   CO.sub.2 Me                           7-F   4-ClPh    COEt      7-T   4-FPh   COEt                                  7-F   4-ClPh    CO.sub.2 Et                                                                             7-F   4-FPh   CO.sub.2 Et                           6-Cl  4-FPh     H         7-Cl  4-FPh   H                                     6-Cl  4-FPh     Me        7-Cl  4-FPh   Me                                    6-Cl  4-FPh     Et        7-Cl  4-FPh   Et                                    6-Cl  4-FPh     COMe      7-Cl  4-FPh   COMe                                  6-Cl  4-FPh     CO.sub.2 Me                                                                             7-Cl  4-FPh   CO.sub.2 Me                           6-Cl  4-FPh     COEt      7-Cl  4-FPh   COEt                                  6-Cl  4-FPh     CO.sub.2 Et                                                                             7-Cl  4-FPh   CO.sub.2 Et                           ______________________________________                                    

                  TABLE 61                                                        ______________________________________                                         ##STR98##                                                                    R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub.2 Cl                           CF.sub. 3                                                                            t-Bu           OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                            CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub.2 Et                            OCF.sub. 3                                                                           CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 62                                                        ______________________________________                                         ##STR99##                                                                    R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub.2 Cl                           CF.sub. 3                                                                            t-Bu           OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                            CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr) CO.sub.2 Et                                                                         OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CFS    SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub.2 Et                            OCF.sub. 3                                                                           CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 63                                                        ______________________________________                                         ##STR100##                                                                   R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub.2 Cl                           CF.sub.3                                                                             t-Bu           OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                            CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub.2 Et                            OCF.sub.3                                                                            CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 64                                                        ______________________________________                                         ##STR101##                                                                   R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub.2 Cl                           CF.sub.3                                                                             t-Bu           OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                            CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub.2 Et                            OCF.sub.3                                                                            CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 65                                                        ______________________________________                                         ##STR102##                                                                   R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub.2 Cl                           CF.sub.3                                                                             t-Bu           OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                            CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub.2 Et                            OCF.sub.3                                                                            CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 66                                                        ______________________________________                                         ##STR103##                                                                   R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SMe.sub.3                                                                           CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub. 2 Cl                          CF.sub.3                                                                             t-Bu           OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                            CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub. 2 Et                           OCF.sub.3                                                                            CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 67                                                        ______________________________________                                         ##STR104##                                                                   R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub.2 Cl                           CF.sub.3                                                                             t-Bu           OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                            CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub.2 Et                            OCF.sub.3                                                                            CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 68                                                        ______________________________________                                         ##STR105##                                                                   R.sup.1                                                                              Y              R.sup.1  Y                                              ______________________________________                                        CF.sub.3                                                                             CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                       CF.sub.3                                                                             CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                CF.sub.3                                                                             CH.sub.2 CCH   CF.sub.3 CO(i-Bu)                                       CF.sub.3                                                                             CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                CF.sub.3                                                                             CH.sub.2 CN    CF.sub.3 CO(4-ClPh)                                     CF.sub.3                                                                             i-Pr           CF.sub.3 CO.sub.2 Ph                                    CF.sub.3                                                                             Ph             CF.sub.3 CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             4-ClPh         CF.sub.3 CH.sub.2 CH.sub.2 CN                           CF.sub.3                                                                             4-OMePh        CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                  CF.sub.3                                                                             4-FPh          CF.sub.3 CH.sub.2 CH.sub.2 Cl                           CF.sub.3                                                                             t-Bu           OCF.sub.3                                                                              CH.sub. 2 SiMe.sub.3                           CF.sub.3                                                                             CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                              CF.sub.3                                                                             CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                   CF.sub.3                                                                             SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                           CF.sub.3                                                                             SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                    CF.sub.3                                                                             SN(n-Bu).sub.2 OCF.sub.3                                                                              i-Pr                                           CF.sub.3                                                                             SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                             CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                         CF.sub.3                                                                             SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                        CF.sub.3                                                                             n-Bu           CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                   CF.sub.3                                                                             i-Bu           OCF.sub.3                                                                              n-Bu                                           OCF.sub.3                                                                            4-FPh          Br       CH.sub.2 CO.sub.2 Me                           OCF.sub.3                                                                            t-Bu           Br       CH.sub.2 CN                                    OCF.sub.3                                                                            CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                           OCF.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                             OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 Et                                                                          Br       4-ClPh                                         OCF.sub.3                                                                            SN(Me)CO.sub.2 Et                                                                            Br       4-OMePh                                        OCF.sub.3                                                                            SN(n-Bu).sub.2 Br       4-FPh                                          OCF.sub.3                                                                            SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                           OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                            OCF.sub.3                                                                            SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                     OCF.sub.3                                                                            CO(n-Bu)       Br       SN(i-Pr)CO.sub.2 Et                            OCF.sub.3                                                                            CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                              OCF.sub.3                                                                            CO(i-Bu)       Br       SN(n-Bu).sub.2                                 OCF.sub.3                                                                            CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                            CO(4-ClPh)     Br       SN(i-Pr)CO.sub.2 (n-Bu)                        OCF.sub.3                                                                            CO.sub.2 Ph    Br       SN(i-Pr)CO.sub.2 (n-Pr)                        OCF.sub.3                                                                            CH.sub.2 CO.sub.2 Et                                                                         Er       CO(n-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                OCF.sub.3                                                                            CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                       OCF.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                OCF.sub.3                                                                            CH.sub.2 Ph    Br       CO(4-ClPh)                                     OCF.sub.3                                                                            COPh           Br       CO.sub.2 Ph                                    CF.sub.3                                                                             CH.sub.2 Ph    Br       CH.sub.2 CO.sub.2 Et                           CF.sub.3                                                                             COPh           Br       CH.sub.2 CH.sub.2 CN                           Br     CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                  Br     CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                    Br     CH.sub.2 CCH   Br       COPh                                           OCF.sub.3                                                                            i-Bu           Br       n-Bu                                           CF.sub.3                                                                             s-Bu           Br       i-Bu                                           OCF.sub.3                                                                            s-Bu           Br       s-Bu                                           OCF.sub.3                                                                            CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                    ______________________________________                                    

                  TABLE 69                                                        ______________________________________                                         ##STR106##                                                                   R.sup.1                                                                             R.sup.2   R.sup.3  R.sup.1                                                                             R.sup.2  R.sup.3                               ______________________________________                                        Cl    7-Cl      Me       Cl    7-CF.sub.3                                                                             Ph                                    Cl    7-Cl      Et       Cl    7-CF.sub.3                                                                             4-ClPh                                Cl    7-Cl      n-Pr     Cl    7-CF.sub.3                                                                             4-FPh                                 Cl    7-Cl      i-Pr     Cl    7-OCH.sub.2 CF.sub.3                                                                   Me                                    Cl    7-Cl      CO.sub.2 Me                                                                            Cl    7-OCH.sub.2 CF.sub.3                                                                   Et                                    Cl    7-Cl      CO.sub.2 Et                                                                            Cl    7-OCH.sub.2 CF.sub.3                                                                   n-Pr                                  Cl    7-Cl      Ph       Cl    7-OCH.sub.2 CF.sub.3                                                                   CO.sub.2 Me                           Cl    7-Cl      4-ClPh   Cl    7-OCH.sub.2 CF.sub.3                                                                   CO.sub.2 Et                           Cl    7-Cl      4-FPh    Cl    7-OCH.sub.2 CF.sub.3                                                                   Ph                                    Cl    7-F       Me       Cl    7-OCH.sub.2 CF.sub.3                                                                   4-ClPh                                Cl    7-F       Et       Cl    7-OCH.sub.2 CF.sub.3                                                                   4-FPh                                 Cl    7-F       n-Pr     Cl    6-Cl     Me                                    Cl    7-F       i-Pr     Cl    6-Cl     Et                                    Cl    7-F       CO.sub.2 Me                                                                            Cl    6-Cl     n-Pr                                  Cl    7-F       CO.sub.2 Et                                                                            Cl    6-Cl     CO.sub.2 Me                           Cl    7-F       Ph       Cl    6-Cl     CO.sub.2 Et                           Cl    7-F       4-ClPh   Cl    6-Cl     Ph                                    Cl    7-F       4-FPh    Cl    6-Cl     4-ClPh                                Cl    7-CF.sub.3                                                                              Me       Cl    6-Cl     4-FPh                                 Cl    7-CF.sub.3                                                                              Et       Br    7-Cl     Me                                    Cl    7-CF.sub.3                                                                              n-Pr     Br    7-Cl     Et                                    Cl    7-CF.sub.3                                                                              i-Pr     Br    7-Cl     n-Pr                                  Cl    7-CF.sub.3                                                                              CO.sub.2 Me                                                                            Br    7-Cl     i-Pr                                  Cl    7-CF.sub.3                                                                              CO.sub.2 Et                                                                            Br    7-Cl     CO.sub.2 Me                           Br    7-Cl      CO.sub.2 Et                                                                            Br    7-OCH.sub.2 CF.sub.3                                                                   Ph                                    Br    7-Cl      Ph       Br    7-OCH.sub.2 CF.sub.3                                                                   4-ClPh                                Br    7-Cl      4-ClPh   Br    7-OCH.sub.2 CF.sub.3                                                                   4-FPh                                 Br    7-Cl      4-FPh    Br    6-Cl     Me                                    Br    7-F       Me       Br    6-Cl     Et                                    Br    7-F       Et       Br    6-Cl     n-Pr                                  Br    7-F       n-Pr     Br    6-Cl     i-Pr                                  Br    7-F       i-Pr     Br    6-Cl     CO.sub.2 Me                           Br    7-F       CO.sub.2 Me                                                                            Br    6-Cl     CO.sub.2 Et                           Br    7-F       CO.sub.2 Et                                                                            Br    6-Cl     Ph                                    Br    7-F       Ph       Br    6-Cl     4-Cl Ph                               Er    7-F       4-ClPh   Br    6-Cl     4-FPh                                 Br    7-F       4-FPh    CF.sub.3                                                                            7-Cl     Me                                    Br    7-CF.sub.3                                                                              Me       CF.sub.3                                                                            7-Cl     Et                                    Br    7-CF.sub.3                                                                              Et       CF.sub.3                                                                            7-Cl     n-Pr                                  Br    7-CF.sub.3                                                                              n-Pr     CF.sub.3                                                                            7-Cl     i-Pr                                  Br    7-CF.sub.3                                                                              i-Pr     CF.sub.3                                                                            7-Cl     CO.sub.2 Me                           Br    7-CF.sub.3                                                                              CO.sub.2 Me                                                                            CF.sub.3                                                                            7-Cl     CO.sub.2 Et                           Br    7-CF.sub.3                                                                              CO.sub.2 Et                                                                            CF.sub.3                                                                            7-Cl     Ph                                    Br    7-CF.sub.3                                                                              Ph       CF.sub.3                                                                            7-Cl     4-ClPh                                Br    7-CF.sub.3                                                                              4-ClPh   CF.sub.3                                                                            7-Cl     4-FPh                                 Br    7-CF.sub.3                                                                              4-FPh    CF.sub.3                                                                            7-F      Me                                    Br    7-        Me       CF.sub.3                                                                            7-F      Et                                          OCH.sub.2 CF.sub.3                                                      Br    7-        Et       CF.sub.3                                                                            7-F      n-Pr                                        OCH.sub.2 CF.sub.3                                                      Br    7-        n-Pr     CF.sub.3                                                                            7-F      i-Pr                                        OCH.sub.2 CF.sub.3                                                      Br    7-        i-Pr     CF.sub.3                                                                            7-F      CO.sub.2 Me                                 OCH.sub.2 CF.sub.3                                                      Br    7-        CO.sub.2 Me                                                                            CF.sub.3                                                                            7-F      CO.sub.2 Et                                 OCH.sub.2 CF.sub.3                                                      Br    7-CF.sub.3                                                                              CO.sub.2 Et                                                                            CF.sub.3                                                                            7-F      Ph                                    CF.sub.3                                                                            7-F       4-FPh    CF.sub.3                                                                            7-F      4-ClPh                                CF.sub.3                                                                            7-CF.sub.3                                                                              Me       OCF.sub.3                                                                           7-Cl     Me                                    CF.sub.3                                                                            7-CF.sub.3                                                                              Et       OCF.sub.3                                                                           7-Cl     Et                                    CF.sub.3                                                                            7-CF.sub.3                                                                              n-Pr     OCF.sub.3                                                                           7-Cl     n-Pr                                  CF.sub.3                                                                            7-CF.sub.3                                                                              i-Pr     OCF.sub.3                                                                           7-Cl     i-Pr                                  CF.sub.3                                                                            7-CF.sub.3                                                                              CO.sub.2 Me                                                                            OCF.sub.3                                                                           7-Cl     CO.sub.2 Me                           CF.sub.3                                                                            7-CF.sub.3                                                                              CO.sub.2 Et                                                                            OCF.sub.3                                                                           7-Cl     CO.sub.2 Et                           CF.sub.3                                                                            7-CF.sub.3                                                                              Ph       OCF.sub.3                                                                           7-Cl     Ph                                    CF.sub.3                                                                            7-CF.sub.3                                                                              4-ClPh   OCF.sub.3                                                                           7-Cl     4-ClPh                                CF.sub.3                                                                            7-CF.sub.3                                                                              4-FPh    OCF.sub.3                                                                           7-Cl     4-FPh                                 CF.sub.3                                                                            7-        Me       OCF.sub.3                                                                           7-F      Me                                          OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        Et       OCF.sub.3                                                                           7-F      Et                                          OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        n-Pr     OCF.sub.3                                                                           7-F      n-Pr                                        OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        i-Pr     OCF.sub.3                                                                           7-F      i-Pr                                        OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        CO.sub.2 Me                                                                            OCF.sub.3                                                                           7-F      CO.sub.2 Me                                 OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        CO.sub.2 Et                                                                            OCF.sub.3                                                                           7-F      CO.sub.2 Et                                 OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        Ph       OCF.sub.3                                                                           7-F      Ph                                          OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        4-ClPh   OCF.sub.3                                                                           7-F      4-ClPh                                      OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            7-        4-FPh    OCF.sub. 3                                                                          7-F      4-FPh                                       OCH.sub.2 CF.sub.3                                                      CF.sub.3                                                                            6-Cl      Me       OCF.sub.3                                                                           7-CF.sub.3                                                                             Me                                    CF.sub.3                                                                            6-Cl      Et       OCF.sub.3                                                                           7-CF.sub.3                                                                             Et                                    CF.sub.3                                                                            6-Cl      n-Pr     OCF.sub.3                                                                           7-CF.sub.3                                                                             n-Pr                                  CF.sub.3                                                                            6-Cl      i-Pr     OCF.sub.3                                                                           7-CF.sub.3                                                                             i-Pr                                  CF.sub.3                                                                            6-Cl      CO.sub.2 Me                                                                            OCF.sub.3                                                                           7-CF.sub.3                                                                             CO.sub.2 Me                           CF.sub.3                                                                            6-Cl      CO.sub.2 Et                                                                            OCF.sub.3                                                                           7-CF.sub.3                                                                             CO.sub.2 Et                           CF.sub.3                                                                            6-Cl      Ph       OCF.sub.3                                                                           7-CF.sub.3                                                                             Ph                                    CF.sub.3                                                                            6-Cl      4-ClPh   OCF.sub.3                                                                           7-CF.sub.3                                                                             4-ClPh                                CF.sub.3                                                                            6-Cl      4-FPh    OCF.sub.3                                                                           7-CF.sub.3                                                                             4-FPh                                 OCF.sub.3                                                                           7-        Et       OCF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                   Me                                          OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           7-        n-Pr                                                                OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           7-        i-Pr                                                                OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           7-        CO.sub.2 Me                                                         OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           7-        CO.sub.2 Et                                                         OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           7-        Ph                                                                  OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           7-        4-ClPh                                                              OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           7-        4-FPh                                                               OCH.sub.2 CF.sub.3                                                      OCF.sub.3                                                                           6-Cl      Me                                                            OCF.sub.3                                                                           6-Cl      Et                                                            OCF.sub.3                                                                           6-Cl      n-Pr                                                          OCF.sub. 3                                                                          6-Cl      i-Pr                                                          OCF.sub.3                                                                           6-Cl      CO.sub.2 Me                                                   OCF.sub.3                                                                           6-Cl      CO.sub.2 Et                                                   OCF.sub.3                                                                           6-Cl      Ph                                                            OCF.sub.3                                                                           6-Cl      4-ClPh                                                        OCF.sub.3                                                                           6-Cl      4-FPh                                                         Cl    7-        i-Pr                                                                OCH.sub.2 CF.sub.3                                                      Cl    6-Cl      i-Pr                                                          ______________________________________                                    

                                      TABLE 70                                    __________________________________________________________________________     ##STR107##                                                                   R.sup.1                                                                            R.sup.2 R.sup.3                                                                              R.sup.1                                                                            R.sup.2 R.sup.3                                      __________________________________________________________________________    Cl   7-Cl    Me     Cl   7-CF.sub.3                                                                            Ph                                           Cl   7-Cl    Et     Cl   7-CF.sub.3                                                                            4-ClPh                                       Cl   7-Cl    n-Pr   Cl   7-CF.sub.3                                                                            4-FPh                                        Cl   7-Cl    i-Pr   Cl   7-OCH.sub.2 CF.sub.3                                                                  Me                                           Cl   7-Cl    CO.sub.2 Me                                                                          Cl   7-OCH.sub.2 CF.sub.3                                                                  Et                                           Cl   7-Cl    CO.sub.2 Et                                                                          Cl   7-OCH.sub.2 CF.sub.3                                                                  n-Pr                                         Cl   7-Cl    Ph     Cl   7-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 Me                                  Cl   7-Cl    4-ClPh Cl   7-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 Et                                  Cl   7-Cl    4-FPh  Cl   7-OCH.sub.2 CF.sub.3                                                                  Ph                                           Cl   7-F     Me     Cl   7-OCH.sub.2 CF.sub.3                                                                  4-ClPh                                       Cl   7-F     Et     Cl   7-OCH.sub.2 CF.sub.3                                                                  4-FPh                                        Cl   7-F     n-Pr   Cl   6-Cl    Me                                           Cl   7-F     i-Pr   Cl   6-Cl    Et                                           Cl   7-F     CO.sub.2 Me                                                                          Cl   6-Cl    n-Pr                                         Cl   7-F     CO.sub.2 Et                                                                          Cl   6-Cl    CO.sub.2 Me                                  Cl   7-F     Ph     Cl   6-Cl    CO.sub.2 Et                                  Cl   7-F     4-ClPh Cl   6-Cl    Ph                                           Cl   7-F     4-FPh  Cl   6-Cl    4-ClPh                                       Cl   7-CF.sub.3                                                                            Me     Cl   6-Cl    4-FPh                                        Cl   7-CF.sub.3                                                                            Et     Br   7-Cl    Me                                           Cl   7-CF.sub.3                                                                            n-Pr   Br   7-Cl    Et                                           Cl   7-CF.sub.3                                                                            i-Pr   Br   7-Cl    n-Pr                                         Cl   7-CF.sub.3                                                                            CO.sub.2 Me                                                                          Br   7-Cl    i-Pr                                         Cl   7-CF.sub.3                                                                            CO.sub.2 Et                                                                          Br   7-Cl    CO.sub.2 Me                                  Br   7-Cl    CO.sub.2 Et                                                                          Br   7-OCH.sub.2 CF.sub.3                                                                  Ph                                           Br   7-Cl    Ph     Br   7-OCH.sub.2 CF.sub.3                                                                  4-ClPh                                       Br   7-Cl    4-ClPh Br   7-OCH.sub.2 CF.sub.3                                                                  4-FPh                                        Br   7-Cl    4-FPh  Br   6-Cl    Me                                           Br   7-F     Me     Br   6-Cl    Et                                           Br   7-F     Et     Br   6-Cl    n-Pr                                         Br   7-F     n-Pr   Br   6-Cl    i-Pr                                         Br   7-F     i-Pr   Br   6-Cl    CO.sub.2 Me                                  Br   7-F     CO.sub.2 Me                                                                          Br   6-Cl    CO.sub.2 Et                                  Br   7-F     CO.sub.2 Et                                                                          Br   6-Cl    Ph                                           Br   7-F     Ph     Br   6-Cl    4-ClPh                                       Br   7-F     4-ClPh Br   6-Cl    4-FPh                                        Br   7-F     4-FPh  CF.sub.3                                                                           7-Cl    Me                                           Br   7-CF.sub.3                                                                            Me     CF.sub.3                                                                           7-Cl    Et                                           Br   7-CF.sub.3                                                                            Et     CF.sub.3                                                                           7-Cl    n-Pr                                         Br   7-CF.sub.3                                                                            n-Pr   CF3  7-Cl    i-Pr                                         Br   7-CF.sub.3                                                                            i-Pr   CF.sub.3                                                                           7-Cl    CO.sub.2 Me                                  Br   7-CF.sub.3                                                                            CO.sub.2 Me                                                                          CF.sub.3                                                                           7-Cl    CO.sub.2 Et                                  Br   7-CF.sub.3                                                                            CO.sub.2 Et                                                                          CF3  7-Cl    Ph                                           Br   7-CF.sub.3                                                                            Ph     CF.sub.3                                                                           7-Cl    4-ClPh                                       Br   7-CF.sub.3                                                                            4-ClPh CF.sub.3                                                                           7-Cl    4-FPh                                        Br   7-CF.sub.3                                                                            4-FPh  CF.sub.3                                                                           7-F     Me                                           Br   7-OCH.sub.2 CF.sub.3                                                                  Me     CF.sub.3                                                                           7-F     Et                                           Br   7-OCH.sub.2 CF.sub.3                                                                  Et     CF.sub.3                                                                           7-F     n-Pr                                         Br   7-OCH.sub.2 CF.sub.3                                                                  n-Pr   CF.sub.3                                                                           7-F     i-Pr                                         Br   7-OCH.sub.2 CF.sub.3                                                                  i-Pr   CF.sub.3                                                                           7-F     CO.sub.2 Me                                  Br   7-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 Me                                                                          CF.sub.3                                                                           7-F     CO.sub.2 Et                                  Br   7-CF.sub.3                                                                            CO.sub.2 Et                                                                          CF.sub.3                                                                           7-F     Ph                                           CF.sub.3                                                                           7-F     4-FPh  CF.sub.3                                                                           7-F     4-ClPh                                       CF.sub.3                                                                           7-CF.sub.3                                                                            Me     OCF.sub.3                                                                          7-Cl    Me                                           CF.sub.3                                                                           7-CF.sub.3                                                                            Et     OCF.sub.3                                                                          7-Cl    Et                                           CF.sub.3                                                                           7-CF.sub.3                                                                            n-Pr   OCF.sub.3                                                                          7-Cl    n-Pr                                         CF.sub.3                                                                           7-CF.sub.3                                                                            i-Pr   OCF.sub.3                                                                          7-Cl    i-Pr                                         CF.sub.3                                                                           7-CF.sub.3                                                                            CO.sub.2 Me                                                                          OCF.sub.3                                                                          7-Cl    CO.sub.2 Me                                  CF.sub.3                                                                           7-CF.sub.3                                                                            CO.sub.2 Et                                                                          OCF.sub.3                                                                          7-Cl    CO.sub.2 Et                                  CF.sub.3                                                                           7-CF.sub.3                                                                            Ph     OCF.sub.3                                                                          7-Cl    Ph                                           CF.sub.3                                                                           7-CF.sub.3                                                                            4-ClPh OCF.sub.3                                                                          7-Cl    4-ClPh                                       CF.sub.3                                                                           7-CF.sub.3                                                                            4-FPh  OCF.sub.3                                                                          7-Cl    4-FPh                                        CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  Me     OCF.sub.3                                                                          7-F     Me                                           CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  Et     OCF.sub.3                                                                          7-F     Et                                           CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  n-Pr   OCF.sub.3                                                                          7-F     n-Pr                                         CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  i-Pr   OCF.sub.3                                                                          7-F     i-Pr                                         CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 Me                                                                          OCF.sub.3                                                                          7-F     CO.sub.2 Me                                  CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 Et                                                                          OCF.sub.3                                                                          7-F.    CO.sub.2 Et                                  CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  Ph     OCF.sub.3                                                                          7-F     Ph                                           CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  4-ClPh OCF.sub.3                                                                          7-F     4-ClPh                                       CF.sub.3                                                                           7-OCH.sub.2 CF.sub.3                                                                  4-FPh  OCF.sub.3                                                                          7-F     4-FPh                                        CF.sub.3                                                                           6-Cl    Me     OCF.sub.3                                                                          7-CF.sub.3                                                                            Me                                           CF.sub.3                                                                           6-Cl    Et     OCF.sub.3                                                                          7-CF.sub.3                                                                            Et                                           CF.sub.3                                                                           6-Cl    n-Pr   OCF.sub. 3                                                                         7-CF.sub.3                                                                            n-Pr                                         CF.sub.3                                                                           6-Cl    i-Pr   OCF.sub.3                                                                          7-CF.sub.3                                                                            i-Pr                                         CF.sub.3                                                                           6-Cl    CO.sub.2 Me                                                                          OCF.sub.3                                                                          7-CF.sub.3                                                                            CO.sub.2 Me                                  CF.sub.3                                                                           6-Cl    CO.sub.2 Et                                                                          OCF.sub.3                                                                          7-CF.sub.3                                                                            CO.sub.2 Et                                  CF.sub.3                                                                           6-Cl    Ph     OCF.sub.3                                                                          7-CF.sub.3                                                                            Ph                                           CF.sub.3                                                                           6-Cl    4-ClPh OCF.sub.3                                                                          7-CF.sub.3                                                                            4-ClPh                                       CF.sub.3                                                                           6-Cl    4-FPh  OCF.sub.3                                                                          7-CF.sub.3                                                                            4-FPh                                        OCF.sub.3                                                                          7-OCH.sub.2 CF.sub.3                                                                  Et     OCF.sub.3                                                                          7-OCH.sub.2 CF.sub.3                                                                  Me                                           OCF.sub.3                                                                          7-OCH.sub.2 CF.sub.3                                                                  n-Pr                                                             OCF.sub.3                                                                          7-OCH.sub.2 CH.sub.3                                                                  i-Pr                                                             OCF.sub.3                                                                          7-OCH.sub.2 CH.sub.3                                                                  CO.sub.2 Me                                                      OCF.sub.3                                                                          7-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 Et                                                      OCF.sub.3                                                                          7-OCH.sub.2 CF.sub.3                                                                  Ph                                                               OCF.sub.3                                                                          7-OCH.sub.2 CF.sub.3                                                                  4-ClPh                                                           OCF.sub.3                                                                          7-OCH.sub.2 CF.sub.3                                                                  4-FPh                                                            OCF.sub.3                                                                          6-Cl    Me                                                               OCF.sub.3                                                                          6-Cl    Et                                                               OCF.sub.3                                                                          6-Cl    n-Pr                                                             OCF.sub.3                                                                          6-Cl    i-Pr                                                             OCF.sub.3                                                                          6-Cl    CO.sub.2 Me                                                      OCF.sub.3                                                                          6-Cl    CO.sub.2 Et                                                      OCF.sub.3                                                                          6-Cl    Ph                                                               OCF.sub.3                                                                          6-Cl    4-ClPh                                                           OCF.sub.3                                                                          6-Cl    4-FPh                                                            Cl   7-OCH.sub.2 CF.sub.3                                                                  i-Pr                                                             Cl   6-Cl    i-Pr                                                             __________________________________________________________________________

                  TABLE 71                                                        ______________________________________                                         ##STR108##                                                                   R.sup.1  R.sup.2 R.sup.3   R.sup.1                                                                              R.sup.2                                                                             R.sup.3                               ______________________________________                                        CF.sub.3 7-Cl    Me        CF.sub.3                                                                             8-Cl  Me                                    CF.sub.3 7-Cl    Et        CF.sub.3                                                                             8-Cl  Et                                    CF.sub.3 7-Cl    n-Pr      CF.sub.3                                                                             8-Cl  n-Pr                                  CF.sub.3 7-Cl    CO.sub.2 Me                                                                             CF.sub.3                                                                             8-Cl  CO.sub.2 Me                           CF.sub.3 7-Cl    4-FPh     CF.sub.3                                                                             8-Cl  4-FPh                                 OCF.sub.3                                                                              7-Cl    Me        OCF.sub.3                                                                            8-Cl  Me                                    OCF.sub.3                                                                              7-Cl    Et        OCF.sub.3                                                                            8-Cl  Et                                    OCF.sub.3                                                                              7-Cl    n-Pr      OCF.sub.3                                                                            8-Cl  n-Pr                                  OCF.sub.3                                                                              7-Cl    CO.sub.2 Me                                                                             OCF.sub.3                                                                            8-Cl  CO.sub.2 Me                           OCF.sub.3                                                                              7-Cl    4-FPh     OCF.sub.3                                                                            8-Cl  4-FPh                                 CF.sub.3 7-F     Me        CF.sub.3                                                                             8-F   Me                                    CF.sub.3 7-F     Et        CF.sub.3                                                                             8-F   Et                                    CF.sub.3 7-F     n-Pr      CF.sub.3                                                                             8-F   n-Pr                                  CF.sub.3 7-F     CO.sub.2 Me                                                                             CF.sub.3                                                                             8-F   CO.sub.2 Me                           CF.sub.3 7-F     4-FPh     CF.sub.3                                                                             8-F   4-FPh                                 OCF.sub.3                                                                              7-F     Me        OCF.sub.3                                                                            8-F   Me                                    OCF.sub.3                                                                              7-F     Et        OCF.sub.3                                                                            8-F   Et                                    OCF.sub.3                                                                              7-F     n-Pr      OCF.sub.3                                                                            8-F   n-Pr                                  OCF.sub.3                                                                              7-F     CO.sub.2 Me                                                                             OCF.sub.3                                                                            8-F   CO.sub.2 Me                           OCF.sub.3                                                                              7-F     4-FPh     OCF.sub.3                                                                            8-F   4-FPh                                 ______________________________________                                    

                  TABLE 72                                                        ______________________________________                                         ##STR109##                                                                   R.sup.1  R.sup.2 R.sup.3   R.sup.1                                                                              R.sup.2                                                                             R.sup.3                               ______________________________________                                        CF.sub.3 7-Cl    Me        CF.sub.3                                                                             8-Cl  Me                                    CF.sub.3 7-Cl    Et        CF.sub.3                                                                             8-Cl  Et                                    CF.sub.3 7-Cl    n-Pr      CF.sub.3                                                                             8-Cl  n-Pr                                  CF.sub.3 7-Cl    CO.sub.2 Me                                                                             CF.sub.3                                                                             8-Cl  CO.sub.2 Me                           CF.sub.3 7-Cl    4-FPh     CF.sub.3                                                                             8-Cl  4-FPh                                 OCF.sub.3                                                                              7-Cl    Me        OCF.sub.3                                                                            8-Cl  Me                                    OCF.sub.3                                                                              7-Cl    Et        OCF.sub.3                                                                            8-Cl  Et                                    OCF.sub.3                                                                              7-Cl    n-Pr      OCF.sub.3                                                                            8-Cl  n-Pr                                  OCF.sub.3                                                                              7-Cl    CO.sub.2 Me                                                                             OCF.sub.3                                                                            8-Cl  CO.sub.2 Me                           OCF.sub.3                                                                              7-Cl    4-FPh     OCF.sub.3                                                                            8-Cl  4-FPh                                 CF.sub.3 7-F     Me        CF.sub.3                                                                             8-F   Me                                    CF.sub.3 7-F     Et        CF.sub.3                                                                             8-F   Et                                    CF.sub.3 7-F     n-Pr      CF.sub.3                                                                             8-F   n-Pr                                  CF.sub.3 7-F     CO.sub.2 Me                                                                             CF.sub.3                                                                             8-F   CO.sub.2 Me                           CF.sub.3 7-F     4-FPh     CF.sub.3                                                                             8-F   4-FPh                                 OCF.sub.3                                                                              7-F     Me        OCF.sub.3                                                                            8-F   Me                                    OCF.sub.3                                                                              7-F     Et        OCF.sub.3                                                                            8-F   Et                                    OCF.sub.3                                                                              7-F     n-Pr      OCF.sub.3                                                                            8-F   n-Pr                                  OCF.sub.3                                                                              7-F     CO.sub.2 Me                                                                             OCF.sub.3                                                                            8-F   CO.sub.2 Me                           OCF.sub.3                                                                              7-F     4-FPh     OCF.sub.3                                                                            8-F   4-FPh                                 ______________________________________                                    

Formulation and Use

The compounds of this invention will generally be used in formulationwith an agriculturally suitable carrier comprising a liquid or soliddiluent or an organic solvent. Useful formulations of the compounds ofFormulas I and II can be prepared in conventional ways. They includedusts, granules, baits, pellets, solutions, suspensions, emulsions,wettable powders, emulsifiable concentrates, dry flowables and the like.Many of these can be applied directly. Sprayable formulations can beextended in suitable media and used at spray volumes of from about oneto several hundred liters per hectare. High strength compositions areprimarily used as intermediates for further formulation. Theformulations, broadly, contain from less than about 1% to 99% by weightof active ingredient(s) and at least one of a) about 0.1% to 20%surfactant(s) and b) about 5% to 99% solid or liquid diluent(s). Morespecifically, they will contain effective amounts of these ingredientsin the following approximate proportions:

    ______________________________________                                                    Percent By Weight                                                             Active                                                                        Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            25-90     0-74      1-10                                        Oil Suspensions,                                                                             5-50     40-95     0-15                                        Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Dusts          1-25     70-99     0-5                                         Granules, Baits and                                                                         0.01-95   5-99      0-15                                        Pellets                                                                       High Strength 90-99     0-10      0-2                                         Compositions                                                                  ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J. The more absorptive diluents are preferred for wettablepowders and the denser ones for dusts. Typical liquid diluents andsolvents are described in Marsden, "Solvents Guide," 2nd Ed ,Interscience, New York, 1950. Solubility under 0.1% is preferred forsuspension concentrates; solution concentrates are preferably stableagainst phase separation at 0° C. "McCutcheon's Detergents andEmulsifiers Annual" Allured Publ Corp , Ridgewood, N.J., as well asSisely and Wood, "Encyclopedia of Surface Active Agents" Chemical Publ.Co., Inc., New York, 1964, list surfactants and recommended uses. Allformulations can contain minor amounts of additives to reduce foam,caking, corrosion, microbiological growth, etc. Preferably, ingredientsshould be approved by the U.S. Environmental Protection Agency for theuse intended.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example, U.S.Pat. No. 3,060,084). Granules and pellets can be made by spraying theactive material upon preformed granular carriers or by agglomerationtechniques See J. E. Browning, "Agglomeration" Chemical Engineering,Dec. 4, 1967, pages 147 and following, and "Perry's Chemical Engineer'sHandbook", 4th-Ed., McGraw-Hill, New York, 1963, pages 8 to 59 andfollowing.

EXAMPLE A

    ______________________________________                                        Emulsifiable Concentrate                                                      ______________________________________                                        7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                    N-[4-(trifluoromethyl)phenyl]indeno-                                          [1,2-e][1,3,4]-oxadiazine-2(3H)-carboxamide                                                            20%                                                  blend of oil soluble sulfonates                                               and polyoxyethylene ethers                                                                             10%                                                  isophorone               70%                                                  ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speedsolution. A fine screen filter is included in packaging operation toinsure the absence of any extraneous undissolved material in theproduct.

EXAMPLE B

    ______________________________________                                        Wettable Powder                                                               ______________________________________                                        7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             30%                                                  N-[4-(trifluoromethyl)phenyl]indeno-                                          [1,2-e][1,3,4]-oxadiazine-2(3H)-carboxamide                                   sodium alkylnaphthalenesulfonate                                                                       2%                                                   sodium ligninsulfonate   2%                                                   synthetic amorphous silica                                                                             3%                                                   kaolinite                63%                                                  ______________________________________                                    

The active ingredient is mixed with the inert materials in a blender.After grinding in a hammermill, the material is re-blended and siftedthrough a 50 mesh screen.

EXAMPLE C

    ______________________________________                                        Dust                                                                          ______________________________________                                        Wettable powder of Example B                                                                        10%                                                     pyrophyllite (powder) 90%                                                     ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blendedand then packaged. The product is suitable for use as a dust.

EXAMPLE D

    ______________________________________                                        Granule                                                                       ______________________________________                                        7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             10%                                                  N-[4-(trifluoromethyl)phenyl]indeno-                                          [1,2-e][1,3,4]-oxadiazine-2(3H)-                                              carboxamide                                                                   attapulgite granules (low volative                                                                     90%                                                  matter, 0.71/0.30 mm; U.S.S. No.                                              25-50 sieves)                                                                 ______________________________________                                    

The active ingredient is dissolved in a volatile solvent such as acetoneand sprayed upon dedusted and pre-warmed attapulgite granules in adouble cone blender. The acetone is then driven off by heating. Thegranules are then allowed to cool and are packaged.

EXAMPLE E

    ______________________________________                                        Granule                                                                       ______________________________________                                        Wettable powder of Example B                                                                        15%                                                     gypsum                69%                                                     potassium sulfate     16%                                                     ______________________________________                                    

The ingredients are blended in a rotating mixer and water sprayed on toaccomplish granulation. When most of the material has reached thedesired range of 0.1 to 0.42 mm (U.S.S. No. 18 to 40 sieves), thegranules are removed, dried, and screened. Oversize material is crushedto produce additional material in the desired range. These granulescontain 4.5% active ingredient.

EXAMPLE F

    ______________________________________                                        Solution                                                                      ______________________________________                                        7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             25%                                                  N-[4-(trifluoromethyl)phenyl]indeno-                                          [1,2-e][1,3,4]-oxadiazine-2(3H)-                                              carboxamide                                                                   N-methyl-pyrrolidone     75%                                                  ______________________________________                                    

The ingredients are combined and stirred to produce a solution suitablefor direct, low volume application.

EXAMPLE G

    ______________________________________                                        Aqueous Suspension                                                            ______________________________________                                        7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                               40%                                                N-[4-(trifluoromethyl)phenyl]indeno-                                          [1,2-e](1,3,4]-oxadiazine-2(3H)-                                              carboxamide                                                                   polyacrylic acid thickener 0.3%                                               dodecyclophenol polyethylene glycol ether                                                                0.5%                                               disodium phosphate         1.0%                                               monosodium phosphate       0.5%                                               polyvinyl alcohol          1.0%                                               water                      56.7%                                              ______________________________________                                    

The ingredients are blended and ground together in a sand mill toproduce particles substantially all under 5 microns in size.

EXAMPLE H

    ______________________________________                                        Oil Suspension                                                                ______________________________________                                        7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             35.0%                                                N-[4-(trifluoromethyl)phenyl]indeno-                                          [1,2-e][1,3,4]-oxadiazine-2(3H)-carboxamide                                   blend of polyalcohol carboxylic esters                                                                 6.0%                                                 and oil soluble petroleum sulfonates                                          xylene range solvent     59.0%                                                ______________________________________                                    

The ingredients are combined and ground together in a sand mill toproduce particles substantially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE I

    ______________________________________                                        Bait Granules                                                                 ______________________________________                                        7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             3.0%                                                 N-[4-(trifluoromethyl)phenyl]indeno-                                          [1,2-e][1,3,4]-oxadiazine-2(3H)-carboxamide                                   blend of polyethoxylated nonyl-phenols                                                                 9.0%                                                 and sodium dodecyl-benzene sulfonates                                         ground up corn cobs      88.0%                                                ______________________________________                                    

The active ingredient and surfactant blend are dissolved in a suitablesolvent such as acetone and sprayed onto the ground corn cobs. Thegranules are then dried and packaged.

Compounds of Formulas I and II can also be mixed with one or more otherinsecticides, fungicides, nematocides, bactericides, acaricides, orother biologically active compounds to form a multi-component pesticidegiving an even broader spectrum of effective agricultural protection.Examples of other agricultural protectants with which compounds of thisinvention can be formulated are:

Insecticides:

3-hydroxy-N-methylcrotonamide(dimethylphosphate)ester (monocrotophos)

methylcarbamic acid, ester with 2,3-dihydro-2,2-dimethyl-7-benzofuranol(carbofuran)

O-[2,4,5-trichloro-α-(chloromethyl)benzyl]phosphoric acid,O',O'-dimethyl ester (tetrachlorvinphos)

2-mercaptosuccinic acid, diethyl ester, S-ester with thionophosphoricacid, dimethyl ester (malathion)

phosphorothioic acid, O,O-dimethyl, O-p-nitrophenyl ester (methylparathion)

methylcarbamic acid, ester with a-naphthol (carbaryl) methylO-(methylcarbamoyl)thiolacetohydroxamate (methomyl)

N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlordimeform)

O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidylphosphorothioate(diazinon) octachlorocamphene (toxaphene)

0-ethyl-O-p-nitrophenyl phenylphosphonothioate (EPN)

(S)-α-cyano-m-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate(deltamethrin)

Methyl-N',N'-dimethyl-N-[(methylcarbamoyl)oxy]-1-thioox amimidate(oxamyl)

cyano (3-phenoxyphenyl)-methyl-4-chloro-a-(1-methylethyl)benzeneacetate(fenvalerate)

(3-phenoxyphenyl)methyl(+)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate(permethrin)

a-cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (cypermethrin)

O-ethyl-S-(p-chlorophenyl)ethylphosphonodithioate (profenofos)phosphorothiolothionic acid,

O-ethyl-O-[4-(methylthio)-phenyl]-S-n-propyl ester (sulprofos).

Additional insecticides are listed hereafter by their common names:triflumuron, diflubenzuron, methoprene, buprofezin, thiodicarb,acephate, azinphosmethyl, chlorpyrifos, dimethoate, fonophos,isofenphos, methidathion, methamidiphos, monocrotphos, phosmet,phosphamidon, phosalone, pirimicarb, phorate, terbufos, trichlorfon,methoxychlor, bifenthrin, biphenate, cyfluthrin, fenpropathrin,fluvalinate, flucythrinate, tralomethrin, metaldehyde and rotenone.

Fungicides:

methyl 2-benzimidazolecarbamate (carbendazim)

tetramethylthiuram disulfide (thiuram)

n-dodecylguanidine acetate (dodine)

manganese ethylenebisdithiocarbamate (maneb)

1,4-dichloro-2,5-dimethoxybenzene (chloroneb)

methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl)

1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole(propiconazole)

2-cyano-N-ethylcarbamoyl-2-methoxyiminoacetamide (cymoxanil)

1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone(triadimefon)

N-(trichloromethylthio)tetrahydrophthalimide (captan)

N-(trichloromethylthio)phthalimide (folpet)

1- [[[bis(4-fluorophenyl)][methyl]silyl]methyl]-1H-1,2,4-triazole

Nematicides:

S-methyl 1-(dimethylcarbamoyl)-N-(methylcarbamoyloxy)thioformimidate

S-methyl 1-carbamoyl-N-(methylcarbamoyloxy)thioformimidate

N-isopropylphosphoramidic acid O-ethylO'-[4-(methylthio)-m-tolyl]diester (fenamiphos)

Bactericides:

tribasic copper sulfate

streptomycin sulfate

Acaricides:

senecioic acid, ester with 2-sec-butyl-4,6-dinitrophenol (binapacryl)

6-methyl-1,3-cithiolo[4,5-β]quinoxalin-2-one (oxythioquinox)

ethyl 4,4'-dichlorobenzilate (chlorobenzilate)

1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol (dicofol)

bis(pentachloro-2,4-cyclopentadien-1-yl) (dienochlor)

tricyclohexyltin hydroxide (cyhexatin)

trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxothiazolidine-3-carboxamide(hexythiazox)

amitraz

propargite

fenbutatin-oxide

Biological

Bacillus thuringiensis

Avermectin B.

Utility

Some of the compounds of this invention are characterized by favorablemetabolic and/or soil residual patterns and exhibit activity against awide spectrum of foliar and soil inhabiting arthropods which are pestsof growing and stored agronomic crops, forestry, greenhouse crops,ornamentals, nursery crops, stored food and fiber products, livestock,household, and public and animal health. Those skilled in the art willrecognize that not all compounds are equally effective against allpests. For example, some of the compounds where Y is alkyl have enhancedfield efficacy. The compounds of this invention display activity againsteconomically important agronomic, forestry, greenhouse, ornamental foodand fiber product, stored product, domestic structure, and nurserypests, such as:

larvae of the order Lepidoptera including fall and beet armyworm andother Spodoptera spp., tobacco budworm, corn earworm and other Heliothisspp., European corn borer, navel orangeworm, stalk/stem borers and otherpyralids, cabbage and soybean loopers and other loopers, codling moth,grape berry moth and other tortricids, black cutworm, spotted cutworm,other cutworms and other noctuids, diamondback moth, green cloverworm,velvetbean caterpillar, green cloverworm, pink bollworm, gypsy moth, andspruce budworm;

foliar feeding larvae and adults of the order Coleoptera includingColorado potato beetle, Mexican bean beetle, flea beetle, Japanesebeetles, and other leaf beetles, boll weevil, rice water weevil, granaryweevil, rice weevil and other weevil pests, and soil inhabiting insectssuch as Western corn rootworm and other Diabrotica spp., Japanesebeetle, European chafer and other coleopteran grubs, and wireworms;

adults and larvae of the orders Hemiptera and Homoptera includingtarnished plant bug and other plant bugs (miridae), aster leafhopper andother leafhoppers (cicadellidae), rice planthopper, brown planthopper,and other planthoppers (fulgoroidea), psylids, whiteflies (aleurodidae),aphids scales (coccidae and diaspididae), lace bugs (tingidae), stinkbugs (pentatomidae), cinch bugs and other seed bugs (lygaeidae), cicadas(cicadidae), spittlebugs (cercopids), squash bugs (coreidae), red bugsand cotton stainers (pyrrhocoridae);

adults and larvae of the order acari (mites) including European redmite, two spotted spider mite, rust mites, McDaniel mite, and foliarfeeding mites;

adults and immatures of the order Orthoptera including grasshoppers;

adults and immatures of the order Diptera including leafminers, midges,fruit flies (tephritidae), and soil maggots;

adults and immatures of the order Thysanoptera including onion thripsand other foliar feeding thrips.

The compounds are also active against economically important livestock,household, public and animal health pests such as:

insect pests of the order Hymenoptera including carpenter ants, bees,hornets, and wasps;

insect pests of the order Diptera including house flies, stable flies,face flies, horn flies, blow flies, and other muscoid fly pests, horseflies, deer flies and other Brachycera, mosquitoes, black flies, bitingmidges, sand flies, sciarids, and other Nematocera;

insect pests of the order Orthoptera including cockroaches and crickets;

insect pests of the order Isoptera including the Eastern subterraneantermite and other termites;

insect pests of the order Mallophaga and Anoplura including the headlouse, body louse, chicken head louse and other sucking and chewingparasitic lice that attack man and animals;

insect pests of the order Siphonoptera including the cat flea, dog fleaand other fleas.

The specific species for which control is exemplified are: fallarmyworm, Spodoptera fruigiperda; tobacco budworm, Heliothis virescens;boll weevil, Anthonomus grandis; aster leafhopper, Macrostelesfascifrons; black bean aphid, (Aphis Fabae); southern corn rootworm,Diabrotica undecimpunctata. The pest control protection afforded by thecompounds of the present invention is not limited, however, to thesespecies. The compounds of this invention may also be utilized asrodenticides.

Application

Arthropod pests are controlled and protection of agronomic crops, animaland human health is achieved by applying one or more of the Formula I orII compounds of this invention, in an effective amount, to theenvironment of the pests including the agronomic and/or nonagronomiclocus of infestation, to the area to be protected, or directly on thepests to be controlled. Because of the diversity of habitat and behaviorof these arthropod pest species, many different methods of applicationare employed. A preferred method of application is by spraying withequipment that distributes the compound in the environment of the pests,on the foliage, animal, person, or premise, in the soil or animal, tothe plant part that is infested or needs to be protected. Alternatively,granular formulations of these toxicant compounds can be applied to orincorporated into the soil. Other methods of application can also beemployed including direct and residual sprays, aerial sprays, baits,eartags, boluses, foggers, aerosols, and many others. The compounds canbe incorporated into baits that are consumed by the arthropods or indevices such as traps and the like which entice them to ingest orotherwise contact the compounds.

The compounds of this invention can be applied in their pure state, butmost often application will be of a formulation comprising one or morecompounds with suitable carriers, diluents, and surfactants and possiblyin combination with a food depending on the contemplated end use. Apreferred method of application involves spraying a water dispersion orrefined oil solution of the compounds. Combinations with spray oils,spray oil concentrations, and synergists such as piperonyl butoxideoften enhance the efficacy of the compounds of Formulae I and II.

The rate of application of the Formula I and II compounds required foreffective control will depend on such factors as the species ofarthropod to be controlled, the pest's life cycle, life stage, its size,location, time of year, host crop or animal, feeding behavior, matingbehavior, ambient moisture, temperature, etc. In general, applicationrates of 0.01 to 2 kg of active ingredient per hectare are sufficient toprovide large-scale effective control of pests in agronomic ecosystemsunder normal circumstances, but as little as 0.001 kg/hectare or as muchas 8 kg hectare may be required. For nonagronomic applications,effective use rates will range from about 1.0 to 50 mg/square meter butas little as about 0.1 mg/square meter or as much as 150 mg/square metermay be required.

The following Tests demonstrate the control efficacy of compounds ofFormulae I and II on specific pests; see Index Tables A, B, C, D, E andF for compound descriptions.

                  INDEX TABLE A                                                   ______________________________________                                         ##STR110##                                                                   Cmpd     R.sup.1  R.sup.2  R.sup.3                                                                              mp (°C.)                             ______________________________________                                         1       CF.sub.3 Cl       4-ClPh 213-214                                      2       OCF.sub.3                                                                              Cl       CO.sub.2 Me                                                                          126.5-128                                    3       CF.sub.3 Cl       CO.sub.2 Me                                                                          153-155                                      4       Br       Cl       CO.sub.2 Me                                                                          168-170                                      5       Cl       Cl       CO.sub.2 Me                                                                          159-162                                      6       OCF.sub.3                                                                              F        4-FPh  158-160                                      7       Cl       F        4-FPh  189-190                                      8       Br       F        4-FPh  208-209                                      9       OCF.sub.3                                                                              Cl       Me     foam*                                       10       Br       Cl       Me     88-90                                       11       OCF.sub.3                                                                              Cl       n-Pr   oil*                                        12       Br       Cl       n-Pr   oil*                                        13       Cl       Cl       n-Pr   oil*                                        14       OCF.sub.3                                                                              CF.sub.3 CO.sub.2 Me                                                                          oil*                                        15       Cl       CF.sub.3 CO.sub.2 Me                                                                          176-181                                     16       CF.sub.3 F        CO.sub.2 Me                                                                          216-218                                     17       Br       F        CO.sub.2 Me                                                                          186-188                                     18       Cl       F        CO.sub.2 Me                                                                          179-180                                     19       OCF.sub.3                                                                              F        CO.sub.2 Me                                                                          174-176                                     20       Br       F        Ph     180-182                                     21       OCF.sub.3                                                                              F        Ph     154-156                                     51       CF.sub.3 F        4-FPh  182-190                                     52       OCF.sub.3                                                                              F        Et     44-48                                       53       CF.sub.3 F        Et     58-60                                       54       OCF.sub.3                                                                              F        Me     60-61                                       55       CF.sub.3 F        Me     61-62                                       63       OCF.sub.3                                                                              Cl       CO.sub.2 Et                                                                          122-124                                     64       CF.sub.3 CF.sub.3 CO.sub.2 Me                                                                          154-156                                     81       Cl       F        Me     oil*                                        ______________________________________                                    

                  INDEX TABLE B                                                   ______________________________________                                         ##STR111##                                                                   Cmpd  R.sup.1 R.sup.2                                                                              R.sup.3                                                                              R.sup.4                                                                            Y      mp (°C.)                       ______________________________________                                        22    OCF.sub.3                                                                             Cl     CO.sub.2 Me                                                                          H    Me     130-131                               23    OCF.sub.3                                                                             Cl     CO.sub.2 Me                                                                          Me   H      162-166                               24    OCF.sub.3                                                                             Cl     CO.sub.2 Me                                                                          H    CO.sub.2 Me                                                                          oil*                                  25    OCF.sub.3                                                                             Cl     CO.sub.2 Me                                                                          H    COMe   oil*                                  26    Br      F      4-FPh  H    Me     161-163                               27    Br      F      4-FPh  H    CO.sub.2 Me                                                                          187-189                               28    Br      F      4-FPh  H    COMe   91-93                                 29    Br      F      4-FPh  Me   H      198(dec)                              30    Br      F      4-FPh  Et   H      219-221                               31    OCF.sub.3                                                                             Cl     CO.sub.2 Me                                                                          Et   H      151-152                               32    CF.sub.3                                                                              F      CO.sub.2 Me                                                                          Me   H      168-171                               33    OCF.sub.3                                                                             F      CO.sub.2 Me                                                                          Me   H      155-157                               34    OCF.sub.3                                                                             F      4-FPh  Et   H      150-152                               35    OCF.sub.3                                                                             F      4-FPh  Me   H      149-151                               36    Br      Cl     CO.sub.2 Me                                                                          H    Me     114-116                               37    CF.sub.3                                                                              Cl     CO.sub.2 Me                                                                          H    Me     133-135                               38    CF.sub.3                                                                              F      CO.sub.2 Me                                                                          Et   H      168-170                               39    CF.sub.3                                                                              Cl     CO.sub.2 Me                                                                          H    COMe   gum*                                  40    Br      Cl     CO.sub.2 Me                                                                          H    CO.sub.2 Me                                                                          oil*                                  41    OCF.sub.3                                                                             F      CO.sub.2 Me                                                                          H    Me     143-145                               42    CF.sub.3                                                                              F      CO.sub.2 Me                                                                          H    Me     198-200                               43    OCF.sub.3                                                                             Cl     CO.sub.2 Et                                                                          H    Et     oil*                                  44    OCF.sub.3                                                                             Cl     CO.sub.2 Me                                                                          H    Et     120.5-122                             45    CF.sub.3                                                                              Cl     CO.sub.2 Et                                                                          H    Et     oil*                                  46    CF.sub.3                                                                              Cl     CO.sub.2 Me                                                                          H    Et     oil*                                  47    OCF.sub.3                                                                             Cl     CO.sub.2 Me                                                                          H    CO.sub.2 Et                                                                          oil*                                  48    Br      F      4-FPh  H    CO.sub.2 Et                                                                          oil*                                  49    Br      F      4-FPh  H    Et     177-178                               50    Br      F      4-F Ph H    COMe   oil*                                  65    OCF.sub.3                                                                             Cl     CO.sub.2 Et                                                                          H    Me     oil*                                  66    OCF.sub.3                                                                             F      4-FPh  H    CO.sub.2 Et                                                                          170-173                               67    OCF.sub.3                                                                             F      4-FPh  H    Et     164-166                               68    Br      F      4-FPh  H    CH.sub.2 SMe                                                                         158-160                               ______________________________________                                    

                  INDEX TABLE C                                                   ______________________________________                                         ##STR112##                                                                   Cmpd      R.sup.1   R.sup.2                                                                              R.sup.3                                                                              mp (°C.)                             ______________________________________                                        56        OCF.sub.3 F      4-FPh  180-184                                     57        OCF.sub.3 Cl     4-FPh  129-133                                     58        OCF.sub.3 F      Me     125-127                                     ______________________________________                                    

                  INDEX TABLE D                                                   ______________________________________                                         ##STR113##                                                                   Cmpd     R.sup.1  R.sup.2                                                                              R.sup.3 Y    mp (°C.)                         ______________________________________                                        58       OCF.sub.3                                                                              Cl     Me      H    115-117                                 59       CF.sub.3 Cl     Me      H    162-163                                 60       CF.sub.3 Cl     Et      H    132-133                                 61       CF.sub.3 F      Et      H    123-124                                 62       OCF.sub.3                                                                              F      Et      H    100-101                                 70       OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           H    160-161                                 71       CF.sub.3 Cl     CO.sub.2 Me                                                                           H    199-200                                 72       Br       Cl     CO.sub.2 Me                                                                           H    230(dec)                                73       Cl       Cl     CO.sub.2 Me                                                                           H    221-223                                 74       OCF.sub.3                                                                              F      CO.sub.2 Me                                                                           H    163-164                                 75       CF.sub.3 F      CO.sub.2 Me                                                                           H    199-200                                 76       Br       F      CO.sub.2 Me                                                                           H    205-207                                 77       Cl       F      CO.sub.2 Me                                                                           H    194-196                                 78       OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           Me   147-148                                 79       CF.sub.3 Cl     CO.sub.2 Me                                                                           Me   148-149                                 80       Br       Cl     CO.sub.2 Me                                                                           Me   178-179                                 ______________________________________                                    

                  INDEX TABLE E                                                   ______________________________________                                         ##STR114##                                                                   Cmpd     R.sup.1   R.sup.2                                                                              R.sup.3                                                                              mp (°C.)                              ______________________________________                                        82       OCF.sub.3 Cl     CO.sub.2 CH.sub.3                                                                    135-140(d)                                   ______________________________________                                    

                  INDEX TABLE F                                                   ______________________________________                                         ##STR115##                                                                   Cmpd      R.sup.1 R.sup.2 R.sup.3                                                                             E   mp (°C.)                           ______________________________________                                        83        H       H       Ph    H   oil*                                      ______________________________________                                         *See Table G for additional data on selected compounds of Tables A-F.    

                  TABLE G                                                         ______________________________________                                        CMPD     .sup.1 H NMR Data (200 MHz, CDCl.sub.3 solution)                     ______________________________________                                         9       δ 1.51 (s, 3H), 3.14 (abq, 2H), 5.20 (d, 1H),                           5.73 (d, 1H), 7.18 (d, 2H), 7.35 (d, 2H),                                     7.51-7.61 (m, 3H), 8.40 (s, 1H).                                     11       δ 0.92 (t, 3H), 1.22-1.62 (m, 3H), 1.8-2.0 (m,                          1H), 3.13 (abq, 2H), 5.19 (d, 1H), 5.56 (d,                                   1H), 7.18 (d, 2H), 7.33 (d, 2H), 7.51-7.62                                    (m, 3H) , 8.39 (s, 1H).                                              12       δ 0.92 (t, 3H), 1.3-1.6 (m, 3H), 1.8-2.0 (m,                            1H), 3.12 (abq, 2H), 5.19 (d, 1H), 5.55 (d,                                   1H), 7.31 (apparent d, 2H), 7.43 (apparent                                    s, 4H), 7.57 (d, 1H), 8.36 (s, 1H).                                  13       δ 0.92 (t, 3H), 1.2-1.6 (m, 3H), 1.8-2.0 (m,                            1H), 3.15 (abq, 2H), 5.18 (d, 1H), 5.55 (d,                                   1H), 7.24-7.38 (m, 4H), 7.50 (d, 2H), 7.57                                    (d, 1H), 8.36 (s, 1H).                                               14       δ 3.43 (abq, 2H), 3.74 (s, 3H), 5.07 (d, 1H),                           5.97 (d, 1H), 7.21 (d, 2H), 7.5-7.7 (m, 4H),                                  7.81 (d, 1H), 8.38 (br s, 1H).                                       24       δ 3.25 (d, 1H), 3.51 (d, 1H), 3.72 (s, 3H),                             3.73 (s, 3H), 5.22 (d, 1H), 5.72 (d, 1H),                                     7.20-7.42 (m, 6H), 7.53 (d, 1H).                                     25       δ 2.23 (s, 3H), 3.21 (d, 1H), 3.47 (d, 1H),                             3.66 (s, 3H), 5.22 (d, 1H), 5.65 (d, 1H),                                     7.18-7.45 (m, 7H).                                                   39       δ 2.27 (s, 3H), 3.20 (d, 1H), 3.44 (d, 1H),                             3.65 (s, 3H), 5.24 (d, 1H), 5.66 (d, 1H),                                     7.23-7.45 (m, 5H), 7.64 (d, 2H).                                     40       δ 3.39 (abq, 2H), 3.71 (s, 3H), 3.72 (s, 3H),                           5.21 (d, 1H), 5.69 (d, 1H), 7.18-7.38 (m,                                     4H), 7.43-7.57 (m, 3H).                                              43       δ 1.05-1.20 (m, 5H), 3.23 (abq, 2H), 3.65-3.95                          (m, 2H), 4.02-4.2 (m, 2H), 5.17 (d, 1H),                                      5.44 (d, 1H), 6.93 (d, 1H), 7.14 (apparent                                    s, 5H), 7.19 (apparent s, 1H).                                       45       δ 1.08-1.30 (m, 5H), 3.10 (d, 1H), 3.37 (d,                             1H), 3.70-3.95 (m, 2H), 4.0-4.2 (m, 2H),                                      5.17 (d, 1H), 5.47 (d, 1H), 6.72 (d, 1H),                                     7.19 (distorted t, 4H), 7.54 (d, 2H).                                46       δ 1.22 (t, 3H), 3.09 (d, 1H), 3.38 (d, 1H),                             3.67 (s, 3H), 3.72-3.98 (m, 2H), 5.20 (d,                                     1H), 5.42 (d, 1H), 6.75 (d, 1H), 7.19                                         (distorted t, 4H), 7.54 (d, 2H).                                     47       δ 1.16 (t, 3H), 3.38 (abq, 2H), 3.72 (s, 3H),                           4.05-4.25 (m, 2H), 5.20 (d, 1H), 5.76 (d,                                     1H), 7.10-7.26 (m, 2H), 7.36 (distorted t,                                    4H), 7.54 (d, 1H).                                                   48       δ 1.22 (t, 3H), 3.47 (abq, 2H), 4.23 (q, 2H),                           4.60 (d, 1H), 5.61 (d, 1H), 6.92-7.10 (m,                                     4H), 7.12-7.25 (m, 4H), 7.49 (distorted d,                                    2H), 7.63 (dd, 1H).                                                  50       δ 2.19 (s, 3H), 3.34 (abq, 2H), 3.66 (s, 3H),                           5.22 (d, 1H), 5.64 (d, 1H), 7.18-7.37 (m,                                     4H), 7.42-7.51 (m, 3H).                                              65       δ 1.15 (t, 3H), 3.13 (d, 1H), 3.35 (d, 1H) ,                            3.38 (s, 3H), 4.0-4.2 (m, 2H), 5.19 (d, 1H) ,                                 5.44 (d, 1H), 6.83 (d, 1H), 7.15 (apparent                                    s, 5H), 7.19 (br s, 1H) .                                            81       δ 1.51 (s, 3H), 3.17 (abq, 2H), 5.20 (d, 1H),                           5.72 (d, 1H), 7.02-7.17 (m, 2H), 7.43 (s,                                     4H), 7.62 (dd, 1H), 8.38 (br s, 1H).                                 83       δ 6.50 (s, 1H), 7.4-7.8 (m, 14H), 10.6 (bs,                             1H).                                                                 ______________________________________                                    

TEST A

Fall Armyworm

Test units, each consisting of an 8-ounce (230 mL) plastic cupcontaining a layer of wheat germ diet, approximately 0.5 cm thick, wereprepared. Ten third-instar larvae of fall armyworm (Spodopterafrugiperda) were placed into each cup. Solutions of each of the testcompounds (acetone/distilled water 75/25 solvent) were sprayed into thecups, a single solution per set of three cups. Spraying was accomplishedby passing the cups, on a conveyer belt, directly beneath a flat fanhydraulic nozzle which discharged the spray at a rate of 0.5 pounds ofactive ingredient per acre (about 0.55 kg/ha) at 30 p.s.i. (207 kPa).The cups were then covered and held at 27° C. and 50% relative humidityfor 72 hours, after which time readings were taken. Of the compoundstested, the following resulted in greater than or equal to 80%mortality: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 19, 20, 21,22, 23, 25, 26, 27, 28, 29, 31, 34, 35, 36, 37, 39, 40, 43, 44, 45, 46,47, 48, 49, 51, 52, 53, 54, 55, 56, 58, 61, 62, 63, 65, 70, 74, 78, 79,80.

TEST B

Tobacco Budworm

The test procedure of Test I was repeated for efficacy againstthird-instar larvae of the tobacco budworm (Heliothis virescens) exceptthat mortality was assessed at 48 hours. Of the compounds tested, thefollowing resulted in greater than or equal to 80% mortality: 2, 3, 4,6, 7, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27,28, 29, 32, 33, 34, 35, 37, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49,51, 52, 53, 54, 55, 56, 61, 62, 63, 65, 70, 71, 74, 79.

TEST C

Southern Corn Rootworm

Test units, each consisting of an 8-ounce (230 mL) plastic cupcontaining 1 sprouted corn seed, were prepared. Sets of three test unitswere sprayed as described in Test A with individual solutions of thetest compounds. After the spray on the cups had dried, five third-instarlarvae of the southern corn rootworm (Diabrotica undecimpunctatahowardi) were placed into each cup. A moistened dental wick was insertedinto each cup to prevent drying and the cups were then covered. The cupswere then held at 27° C. and 50% relative humidity for 48 hours, afterwhich time mortality readings were taken. Of the compounds tested, thefollowing resulted in greater than or equal to 80% mortality: 1, 2, 3,6, 7, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27,28, 32, 35, 36, 37, 39, 41, 42, 43, 44, 46, 47, 48, 49, 51, 52, 53, 54,55, 56, 59, 61, 62, 63, 65, 70, 71, 74, 75, 76, 77, 78, 79, 80.

TEST D

Aster Leafhopper

Test units were prepared from a series of 12-ounce (350 mL) cups, eachcontaining oat (Avena sativa) seedlings in a 1-inch (2.54 cm) layer ofsterilized soil. The test units were sprayed as described in Test A withindividual solutions of the below-listed compounds. After the oats haddried from the spraying, between 10 and 15 adult aster leafhoppers(Mascrosteles fascifrons) were aspirated into each of the covered cups.The cups were held at 27° C. and 50% relative humidity for 48 hours,after which time mortality readings were taken. Of the compounds tested,the following resulted in greater than or equal to 80% mortality: 2, 3,4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 21, 22, 25, 26,27, 28, 35, 36, 37, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53,54, 55, 56, 63, 65, 70, 71, 74, 76, 77, 78, 79.

TEST E

Boll Weevil

Five adult boll weevils (Anthonomus grandis grandis) were placed intoeach of a series of 9 ounce (260 mL) cups. The test procedure employedwas then otherwise the same as in Test A with three cups per treatment.Mortality readings were taken 48 hours after treatment. Of the compoundstested, the following resulted in greater than or equal to 80%mortality: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 18, 19,20, 21, 22, 23, 25, 26, 27, 28, 32, 33, 35, 37, 39, 41, 42, 43, 44, 45,46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 61, 62, 63, 65, 70, 71, 74, 75,76, 77, 78, 79, 80.

What is claimed is:
 1. A compound of Formula I or II: ##STR116##wherein: Q is selected from the group ##STR117## A and E are takentogether to form --CH₂ --, --CH₂ CH₂ --, substituted --CH₂ --, andsubstituted --CH₂ CH₂ -- the substituents independently selected from1-2 halogen and 1-2 methyl;G is selected from the group ##STR118## X isselected from the group O, S and N--X² ; X¹ is selected from the groupCl, Br, OR⁸, SR⁸ and NR⁸ R⁹ ; X² is selected from the group R⁸, OH, OR⁸,CN, SO₂ R⁸, SO₂ Ph, OC(O)NR⁹ R¹⁰, OC(O)OR⁸, NR⁹ R¹⁰ and phenyloptionally substituted with R¹¹ ; Y is selected from the group H; C₁ -C₆alkyl; benzyl; C₂ -C₆ alkoxyalkyl; C₂ -C₆ alkenyl; C₂ -C₆ alkynyl; C₁-C₆ alkyl optionally substituted by halogen, C₁ -C₃ alkoxy, C₁ -C₃haloalkoxy, CN, NO₂, S(O)_(r) R³², COR³², CO₂ R³², phenyl optionallysubstituted by halogen, CN, C₁ -C₂ haloalkyl and C₁ -C₂ haloalkoxy; C₃-C₆ cycloalkyl; C₃ -C₆ cyclohaloalkyl; C₃ -C₆ cycloalkylalkyl; CHO; C₂-C₆ alkylcarbonyl; C₂ -C₆ alkoxycarbonyl; C₂ -C₆ haloalkylcarbonyl;COR³⁶ ; CO₂ R³⁶ ; C₁ -C₆ alkylthio; C₁ -C₆ haloalkylthio; phenylthio;R¹² OC(O)N(R¹³)S-- and R¹⁴ (R¹⁵)NS--; A¹ is H; A¹ and Y can be takentogether to form --(CH₂)_(t) --; Z is C; Z¹ is O; R¹ and R² areindependently selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl,C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl,C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, halogen, CN, N₃, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)R¹⁷, S(O)₂R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸,NR¹⁷ R¹⁸, NR¹⁸ C(O)R¹⁷, OC(O)NHR¹⁷, NR¹⁸ C(O)NHR¹⁷, NR¹⁸ SO₂ R¹⁷, phenyloptionally substituted with 1 to 3 substituents independently selectedfrom W, and benzyl optionally substituted with 1 to 3 substituentsindependently selected from W; or when m or n is 2, (R¹)₂ can be takentogether, or (R²)₂ can be taken together as --OCH₂ O--, --OCF₂ O--,--OCH₂ CH₂ O--, --CH₂ C(CH₃)₂ O--, --CF₂ CF₂ O or --OCF₂ CF₂ O-- to forma cyclic bridge; provided that when R¹ or R² is S(O)R¹⁷, S(O)₂ R¹⁷,OC(O)R¹⁷ or OS(O)₂ R¹⁷ then R¹⁷ is other than H; R³ is selected from thegroup H, halogen, N(R²²)R²³, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₂ -C₆ alkoxylalkyl, CO₂R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, phenyl, phenyl substituted with 1 to 3substituents independently selected from halogen, C₁ -C₆ haloalkyl, C₂-C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₃-C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, CN, SCN, NO₂, OR¹⁷, SR¹⁷, CO₂R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸ and SO₂ NR¹⁷ R¹⁸ benzyl and benzylsubstituted with 1 to 3 substituents independently selected fromhalogen; R⁴ and R⁵ are independently selected from the group H, C₁ -C₄alkyl, COR²⁰ and C₂ -C₄ alkoxycarbonyl; or R⁴ and R⁵ can be takentogether to form ═O or ═S; R⁶ is selected from the group H, C₁ -C₄alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkylcarbonyl, C₂ -C₄haloalkoxycarbonyl, C₂ -C₄ alkoxycarbonyl C₂ -C₄ haloalkoxycarbonyl,COR³⁶, CO₂ R³⁶, C₂ -C₅ alkylaminocarbonyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, C₄ -C₇ alkylcycloalkyl, C₄ -C₇ haloalkylcycloalkyl, C₁-C₄ alkylsulfonyl, C₁ -C₄ haloalkylsulfonyl and SO₂ Ph optionallysubstituted with Cl, Br or CH₃ ; R⁸ is selected from the group C₁ -C₃alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, C₁ -C₃ haloalkyl, C₂ -C₄haloalkenyl, C₃ -C₆ cycloalkyl; C₁ -C₃ alkyl substituted with OCH₃, OCH₂CH₃, NO₂, CN, CO₂ CH₃, CO₂ CH₂ CH₃, SCH₃ or SCH₂ CH₃ and benzyloptionally substituted with R¹¹ ; R⁹ is selected from the group H, C₁-C₄ alkyl C₁ -C₄ haloalkyl, C₂ -C₄ alkoxycarbonyl, and optionallysubstituted phenyl and pyridine wherein the substituent(s) are selectedfrom R¹⁵ ; or R⁸ and R⁹ can be taken together to form --(CH₂)₄ --,--(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ -- each of which is optionally andindependently substituted with 1 or 2 CH₃ groups; R¹⁰ is selected fromthe group H and C₁ -C₄ alkyl; or R⁹ and R¹⁰ can be taken together toform --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ -- each of which isoptionally and independently substituted with 1 or 2 CH₃ groups; R¹¹ isselected from halogen, CN, C₁ -C₃ haloalkyl and C₁ -C₃ haloalkoxy; R¹²is C₁ -C₆ alkyl; R¹³ is C₁ -C₄ alkyl; R¹⁴ and R¹⁵ are independently C₁-C₄ alkyl; or R¹⁴ and R¹⁵ can be taken together as --CH₂ CH₂ CH₂ CH₂ CH₂-- or --CH₂ CH₂ OCH₂ CH₂ --; R¹⁷ is selected from the group H, C₁ -C₆alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl,C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆cycloalkyl, C₃ -C₆ halocycloalkyl, and optionally substituted phenyl andbenzyl wherein the substituents are 1 to 3 substituents independentlyselected from W; R¹⁸ is selected from the group H and C₁ -C₄ alkyl; orR¹⁷ and R¹⁸, when attached to the same atom, can be taken together as--(CH₂)₄ --, --(CH₂)₅ --, or --CH₂ CH₂ OCH₂ CH₂ --; R²⁰ is C₁ -C₃ alkyl;R²² is selected from the group H, C₂ -C₇ alkylcarbonyl, C₂ -C₇alkoxycarbonyl, optionally substituted C₁ -C₄ alkyl, optionallysubstituted C₂ -C₄ alkenyl, and optionally substituted C₂ -C₄ alkynyl,the substituents selected from C₁ -C₂ alkoxy, CN, C(O)R³⁰ and C(O)₂ R²⁷; R²³ is selected from the group H, C₁ -C₃ alkyl, phenyl, phenylsubstituted with W, benzyl and benzyl substituted with W; R²⁷ isselected from the group C₁ -C₃ alkyl, phenyl and phenyl substituted withW; R³⁰ is selected from the group H, C₁ -C₃ alkyl, phenyl and phenylsubstituted by W; R³² is selected from the group C₁ -C₃ alkyl; R³⁶ isselected from the group phenyl and phenyl substituted by W; W isselected from the group halogen, CN, NO₂, C₁ -C₂ alkyl, C₁ -C₂haloalkyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy, C₁ -C₂ alkylthio, C₁ -C₂haloalkylthio, C₁ -C₂ alkylsulfonyl and C₁ -C₂ haloalkylsulfonyl; m is 1to 3; n is 1 to 3; r is 0, 1 or 2; t is 2 or 3; and u is 1 or
 2. 2. Acompound according to claim 1 wherein:R¹ is selected from the group H,C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂-C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen,CN, SCN, NO₂, OR¹⁷, SR¹⁷, SO₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, phenyl optionallysubstituted with 1 to 3 substituents independently selected from W, andbenzyl optionally substituted with 1 to 3 substituents independentlyselected from W; with one R¹ substituent in the 4-position, or when m is2 then (R¹)₂ can be taken together as --CH₂ C(CH₃)₂ O--, --OCH₂ CH₂ O--,--OCF₂ CF₂ O--, or --CF₂ CF₂ O-- to form a 5- or 6-membered fused ring;R² is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷,OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸,phenyl optionally substituted with 1 to 3 substituents independentlyselected from W, and benzyl optionally substituted with 1 to 3substituents independently selected from W; R³ is selected from thegroup H, C₁ -C₄ alkyl, CO₂ R¹⁷, C(O)R¹⁷, phenyl and phenyl substitutedby 1 to 3 substituents independently selected from halogen; R¹⁷ isselected from the group C₁ -C₄ alkyl, C₁ -C₂ haloalkyl, C₃ -C₄ alkenyland propargyl; R¹⁸ is selected from the group H and CH₃ ; X¹ is selectedfrom the group Cl, OR⁸, SR⁸ and N(CH₃)₂ ; X² is selected from the groupR⁸, OR⁸ and N(CH₃)₂ ; m is 1 or 2; and n is 1 or
 2. 3. A compoundaccording to claim 2 wherein G is selected from the group G-2 and G-9.4. A compound according to claim 3 wherein A and E are taken together toform --CH₂ --, or --CH₂ CH₂ --.
 5. A compound according to claim 4wherein Q is Q-1.
 6. A compound according to claim 4 wherein Q is Q-2.7. A compound according to claim 4 wherein Y is C₁ -C₆ alkyl.
 8. Acompound according to claim 5 wherein Y is CO₂ R¹⁷ and R³ is CO₂ R¹⁷. 9.A compound according to claim 1:methyl7-chloro-2,3-dihydro-2-[[4-trifluoromethoxy)phenylamino]carbonyl]indeno[1,2-e]-[1,3,4]oxadiazine-4a(5H)-carboxylate.10. A compound according to claim 1:methyl7-chloro-2,5-dihydro-2-[N-methyl-N-[4-(trifluoromethoxy)phenyl]aminocarbonyl]indeno-[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate.11. A compound according to claim 1:methyl7-chloro-2,5-dihydro-2-[[N-methyl-N-[4-trifluoromethyl)phenyl]amino]carbonyl]indeno-[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate.12. A compound according to claim1:7-fluoro-4a-(4-fluorophenyl)-4a,5-dihydro-N-[4-(trifluoromethoxy)phenyl]indeno[1,2-e][1,3,4]-oxadiazine-2(3H)-carboxamide.13. A compound according to claim1:7-chloro-4a,5-dihydro-4a-methyl-N-[4-(trifluoro-methoxy)phenyl]indeno[1,2-e][1,3,4]oxadiazine-2(3H)-carboxamide.14. A compound according to claim 8: methyl7-chloro-2,5-dihydro-2-[N-(methoxycarbonyl)-N-[4-(trifluoromethoxy)phenylaminocarbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate.
 15. Anarthropodicidal composition comprising a compound according to any oneof claims 1 to 13 and claim 14 and a carrier therefor.
 16. A method forcontrolling arthropods comprising contacting them or their environmentwith an arthropodicidally effective amount of a compound according toany one of claims 1 to 13 and claim 14, said arthropods selected fromthe group household, foliar, and soil-inhabiting agronomic andnonagronomic pests.